EKS-SAH-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	321.4	5.6E-96	828	1100	273

Status

Unreviewed

Ensembl Protein

ENSSHAP00000005697

UniProt Accession

G3VR92;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK3

Gene Synonyms/Alias

JAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000004978	ENSSHAP00000005697	ENSSHAT00000005751

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1110

Protein Sequence
(FASTA)

MAPLGEETPL IEQRSYSLSS SESGSLQVFL CPQSSGSPQI LTFSFGEYSA EELCVKAAKA 60

CGILPVCHAL FALATEDLSC WFPPNHVFTV EDSTIQVLLY RIRFFFPNWF GLEKCYRFGL 120

QKDRANAILD LPVLKYLFAQ SRSDFINGRM NLTLNLKEQG ECLSLAVLDL TRMAQEQGIR 180

PKEILRRISY KTCIPGSFRR LIQSLSFMTR KRYRQMVSRA LQSVASCQAD VYSIMLKYLM 240

DLERLKPTRN LETFTGRAPG ATSGQDPRCL IHVAGDSGIS WTPAGSQSPQ PFCDFPEIVD 300

IGIKQACRDG HLSENRLVTV TKTDNRILEV EFPTLREALS FISLVDGYYR LTTDAHHYFC 360

KEVAPPQLLE NIENQCHGPI KSEFAVNKLK MGGSVPGSYV LRQSPQDFDS FLLTVCIQTP 420

LGPDYKGCLI HRDLSGNLFL SGLSQPHSSL RQLLESSWSC GLLVDGTALS LSCCYPPRPK 480

EKSNLIIVRR DCNQLPPSPA LAAAQAWPHP QRQLSQMMFH KIPPDSLEWH ENLGHGSFTK 540

IYRGSRLDNV DGETHKIEVL LKVMDSTHQN CIESFLEAAS VMSQVSHQHL VLLHGVCMAG 600

DSIMVQEFVR WGALDTHLRK CGPLVPASWK LQVAKQLSYA LNYLEDKGII HGNISSKKVL 660

LAREGAGGSP PFIKLSDPGV SPTVLTKEML TDRIPWVAPE CLWDAKLLSL ESDKWSFGAT 720

LWEIFSGGTM PLSTLEPAKK LQFYKEKQQL PALKWTELAT LIGQCMEYTP HLRPSFRAII 780

RDLNSLITSD YELLSDLSPS AVAARDGLWS STHLMAGQDP TLFEERHLKY ISLLGKGNFG 840

SVELCRYDPL GDNTGALVAV KQLQNSGPQQ LRDFQREVQI LKALHSDFIV KYRGVCYGPG 900

RQSLRLVMEY LPNGCLRDYL QRHRAHLDPC FLLLYASQIC KGMEYLGSQR YVHRDLANRN 960

ILVESESHVK IGDFGLAKLL PQDKEYYVVR EPGQSPIFWY APESLSDNIF SRESDVWSFG 1020

VVLYELYTYS DKIHSPSEEF FRMMACDRSM PILCHLLDLL TEGKRLPTPP GCPGEVREIM 1080

RNCWAYNPKD RPSFCALGPR LDALWAGRRG 1110

Nucleotide Sequence
(FASTA)

ATGGCACCTC TGGGTGAGGA GACCCCCCTG ATTGAACAGC GGTCCTACAG CCTGTCCTCC 60

AGTGAGTCTG GCTCTCTGCA AGTGTTCCTG TGTCCCCAGA GCTCAGGGTC CCCACAGATC 120

CTCACCTTCT CCTTTGGGGA ATACTCTGCC GAAGAACTCT GCGTGAAGGC TGCCAAGGCC 180

TGTGGGATCC TGCCTGTATG CCATGCTCTG TTTGCTCTGG CCACGGAAGA TCTGTCCTGC 240

TGGTTCCCAC CCAACCACGT CTTCACAGTG GAGGATTCTA CCATCCAAGT GCTCCTTTAC 300

AGGATCCGCT TTTTCTTTCC CAACTGGTTT GGCCTGGAGA AGTGTTACCG TTTTGGACTG 360

CAGAAGGACA GAGCCAATGC TATTCTGGAC CTCCCAGTCC TTAAGTATCT TTTTGCTCAG 420

TCCCGAAGTG ACTTCATTAA TGGGAGGATG AATCTGACGC TGAATCTAAA GGAGCAGGGA 480

GAGTGTCTGA GCTTGGCAGT GTTGGACCTG ACTCGCATGG CACAGGAGCA GGGCATACGC 540

CCCAAGGAGA TCCTCAGGAG AATCAGCTAT AAGACCTGTA TCCCAGGAAG CTTCAGACGT 600

TTGATCCAGA GCCTCAGCTT CATGACTCGA AAACGTTATC GTCAGATGGT TTCCCGAGCC 660

CTGCAGAGCG TGGCTTCCTG CCAGGCAGAT GTGTACTCCA TCATGCTTAA ATACCTCATG 720

GACCTGGAGA GGCTGAAACC CACCCGGAAT CTGGAGACCT TCACGGGTCG GGCACCAGGG 780

GCTACATCTG GCCAGGACCC CCGCTGTCTC ATCCATGTGG CTGGGGACAG CGGTATCTCC 840

TGGACCCCTG CGGGCAGTCA GAGCCCCCAG CCTTTCTGCG ATTTCCCTGA AATTGTTGAT 900

ATCGGCATCA AGCAGGCCTG CAGGGACGGT CATCTCAGTG AGAACCGGCT GGTCACTGTT 960

ACCAAGACTG ACAACAGGAT CCTGGAGGTT GAATTTCCAA CACTAAGGGA AGCGCTGTCC 1020

TTTATCTCTC TGGTTGATGG CTACTACCGA CTCACCACCG ATGCCCACCA CTACTTCTGC 1080

AAAGAGGTGG CCCCTCCCCA GCTCTTGGAG AACATTGAAA ACCAATGCCA TGGTCCCATC 1140

AAGTCAGAGT TTGCTGTGAA CAAACTGAAG ATGGGGGGGT CTGTTCCAGG GTCCTATGTC 1200

CTTCGGCAAA GCCCACAGGA CTTTGACAGC TTCCTCCTCA CTGTCTGTAT CCAGACGCCC 1260

CTGGGCCCAG ACTACAAGGG CTGCCTGATC CATCGGGATC TGTCAGGGAA CCTCTTCTTG 1320

TCTGGGCTGA GCCAGCCCCA CAGCAGCCTG CGTCAGCTCC TGGAGTCCTC CTGGAGCTGT 1380

GGGCTCCTTG TAGATGGGAC TGCTCTGAGC CTCAGCTGCT GCTACCCTCC CAGGCCCAAA 1440

GAAAAGTCCA ACCTGATCAT AGTAAGGAGG GACTGCAACC AGTTGCCCCC ATCCCCAGCC 1500

CTAGCTGCAG CCCAAGCCTG GCCCCACCCC CAGCGCCAAC TCAGCCAAAT GATGTTCCAC 1560

AAAATCCCCC CTGACAGCTT GGAGTGGCAT GAGAACCTGG GCCACGGCTC CTTCACCAAG 1620

ATATACCGTG GGAGCCGCCT GGACAATGTG GATGGAGAGA CCCACAAGAT AGAGGTTCTG 1680

CTCAAAGTTA TGGACAGCAC ACACCAGAAC TGCATCGAGT CCTTCCTGGA GGCTGCCAGT 1740

GTCATGAGCC AAGTGTCCCA CCAGCATCTG GTGCTGCTGC ATGGTGTCTG CATGGCGGGA 1800

GACAGTATCA TGGTGCAGGA GTTTGTGAGG TGGGGGGCAC TGGATACCCA TTTACGGAAG 1860

TGCGGCCCTC TGGTCCCTGC CAGCTGGAAG CTCCAAGTGG CCAAGCAACT TTCTTATGCC 1920

CTCAACTATC TGGAAGACAA AGGCATCATC CATGGCAATA TCTCCTCCAA GAAGGTCCTC 1980

CTAGCGAGAG AGGGGGCCGG GGGAAGCCCC CCCTTCATCA AACTCAGTGA TCCTGGAGTC 2040

AGTCCCACCG TGCTGACCAA AGAGATGCTC ACTGACCGGA TCCCCTGGGT GGCCCCTGAG 2100

TGTCTATGGG ATGCCAAGCT GCTGAGCCTG GAGTCTGACA AATGGAGCTT TGGGGCAACA 2160

CTCTGGGAGA TATTCAGTGG GGGCACCATG CCCCTAAGTA CCCTGGAGCC TGCCAAGAAA 2220

CTCCAGTTCT ACAAAGAGAA ACAGCAGCTG CCGGCCCTAA AATGGACAGA GCTGGCCACC 2280

CTGATTGGCC AGTGCATGGA GTACACCCCC CACTTGCGGC CCTCCTTCCG AGCTATCATC 2340

CGGGATCTCA ATAGCCTCAT CACCTCAGAT TATGAGCTCC TCTCAGATCT CTCACCCAGT 2400

GCAGTGGCGG CTCGGGATGG ACTCTGGAGC AGTACTCACC TGATGGCTGG TCAGGACCCC 2460

ACCCTCTTTG AGGAGAGACA CCTTAAATAT ATCTCCCTGC TGGGCAAGGG AAATTTTGGC 2520

AGTGTGGAAT TGTGCCGCTA TGACCCACTG GGAGATAACA CTGGAGCATT AGTGGCCGTC 2580

AAGCAGCTAC AGAATAGTGG TCCCCAGCAG CTGCGAGACT TCCAACGGGA GGTGCAGATT 2640

CTGAAAGCTT TACACAGTGA CTTCATAGTC AAATACCGAG GCGTATGCTA TGGTCCAGGC 2700

CGACAGAGTC TGCGACTCGT TATGGAATAC CTCCCCAATG GCTGCCTCCG GGATTACCTG 2760

CAGCGTCACC GGGCCCACCT AGACCCCTGT TTCCTCCTTC TCTATGCTTC CCAGATTTGC 2820

AAGGGGATGG AGTACCTGGG ATCTCAGCGA TATGTTCACA GGGATTTAGC CAACAGGAAT 2880

ATCTTGGTGG AGAGTGAGAG CCACGTAAAG ATCGGAGACT TTGGTCTAGC CAAACTTCTT 2940

CCCCAGGACA AAGAATACTA CGTGGTCAGA GAGCCTGGCC AGAGCCCCAT CTTCTGGTAT 3000

GCCCCAGAGT CCTTATCAGA CAACATTTTC TCCAGGGAGT CGGATGTGTG GAGTTTTGGT 3060

GTGGTCCTCT ATGAGCTTTA TACGTATAGT GACAAAATCC ACAGCCCTTC AGAGGAGTTT 3120

TTCCGAATGA TGGCTTGTGA CCGTTCTATG CCCATCCTGT GCCACCTCCT GGATCTGCTC 3180

ACAGAGGGCA AGAGGCTGCC CACTCCTCCT GGCTGCCCAG GAGAGGTTAG AGAGATCATG 3240

AGGAACTGCT GGGCTTACAA CCCCAAGGAC CGGCCCTCCT TCTGTGCCCT GGGCCCCCGA 3300

CTTGATGCTT TGTGGGCTGG GCGAAGAGGG TAG 3333

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk+i+ Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+++ rdf+re++il++l+++

Q: 828   LKYISLLGKGNFGSVELCRYDPLGDNTGALVAVKQLQNSGPQQLRDFQREVQILKALHSD  887

         799*********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk++gvc+ +g++  rlVmey+++G+L++yL++++++l+   ll +a+q++k+meYL+

Q: 888   FIVKYRGVCYGPGRQslRLVMEYLPNGCLRDYLQRHRAHLDPCFLLLYASQICKGMEYLG  947

         ************************************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         ++++vhrd+a rn+Lve+es+      vk++d+glak+++qd eYy+vre+++s+i+w+a

Q: 948   SQRYVHRDLANRNILVESESH------VKIGDFGLAKLLPQDkEYYVVREPGQSPIFWYA  1001

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225

         pe+ls++  +s++sdvWsFgv+lyel+t  +k +sp     r++ ++       ++l ll

Q: 1002  PESLSDNI-FSRESDVWSFGVVLYELYTySDKIHSPseefFRMMACDrsmpilcHLLDLL  1060

         ********.*******************8888899999*9999999999999********

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264

         +e++rlp+p+ cp e+ e+m+nc++y+p++rpsF a+  +

Q: 1061  TEGKRLPTPPgCPGEVREIMRNCWAYNPKDRPSFCALGPR  1100

         **********************************998766

Domain Sequence
(FASTA)

LKYISLLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQNSG PQQLRDFQRE VQILKALHSD 60

FIVKYRGVCY GPGRQSLRLV MEYLPNGCLR DYLQRHRAHL DPCFLLLYAS QICKGMEYLG 120

SQRYVHRDLA NRNILVESES HVKIGDFGLA KLLPQDKEYY VVREPGQSPI FWYAPESLSD 180

NIFSRESDVW SFGVVLYELY TYSDKIHSPS EEFFRMMACD RSMPILCHLL DLLTEGKRLP 240

TPPGCPGEVR EIMRNCWAYN PKDRPSFCAL GPR 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775	; Tyr_kinase_non-rcpt_Jak3.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01826	; JANUSKINASE3.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013