EKS-SAH-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.8	3.3E-134	235	522	288

Status

Unreviewed

Ensembl Protein

ENSSHAP00000006518

UniProt Accession

G3VTL3;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000005672	ENSSHAP00000006518	ENSSHAT00000006574

Organism

Sarcophilus harrisii

Functional Description

Protein Length

533

Protein Sequence
(FASTA)

MTQLSIYITF WGAYLLIIFY VQGQNPDSRF LHGTEMKSDQ NQKKQENGVT LAPEDTLPFL 60

KCHCSGHCPD DAINNTCITN GHCFAIIEED DQGETTLASG CMKYEGSDFQ CKDSPKAQLR 120

RTIECCRTNL CNQYLQPTLP PVVIGPFFDG SIRWLAVLVS MAVCIIAMII IFSCFCYKHH 180

CKRIARSRCY NRDLEQDEAF IPVGESLKDL IDQSQSSGSG SGLPLLVQRT IAKQIQMVRQ 240

VGKGRYGEVW MGKWRGEKVA VKVFFTTEEA SWFRETEIYQ TVLMRHENIL GFIAADIKGT 300

GSWTQLYLIT DYHENGSLYD FLKCTTLDTR ALLKLAYSAA CGLCHLHTEI YGTQGKPAIA 360

HRDLKSKNIL IKKNGSCCIA DLGLAVKFNS DTNEVDVPLN TRVGTKRYMA PEVLDESLNK 420

NHFQPYIMAD IYSFGLIMWE MARRCVTGGI AEEYQLPYYN MVPHDPSYED MREVVCVKRL 480

RPIVSNRWNS DECLRAILKL MSECWAHNPA SRLTALRIKK TLAKMVESQD VKI 533

Nucleotide Sequence
(FASTA)

ATGACTCAAC TAAGCATTTA TATCACATTT TGGGGAGCCT ATCTGCTCAT CATTTTTTAT 60

GTTCAAGGAC AGAATCCAGA CAGTCGATTC CTTCATGGCA CAGAAATGAA GTCAGACCAA 120

AATCAGAAAA AGCAGGAAAA TGGAGTAACC TTAGCACCAG AGGATACTTT GCCTTTTTTG 180

AAATGCCACT GTTCAGGACA TTGCCCAGAT GATGCTATTA ATAACACATG CATAACTAAT 240

GGTCATTGCT TTGCCATCAT AGAAGAAGAT GATCAAGGAG AAACTACATT AGCTTCAGGC 300

TGTATGAAGT ATGAAGGTTC AGATTTTCAG TGCAAGGATT CACCAAAAGC TCAGCTACGG 360

AGAACAATTG AATGTTGCCG AACCAATTTG TGTAATCAAT ATTTACAGCC TACGCTACCC 420

CCTGTTGTCA TAGGTCCGTT TTTTGATGGT AGTATTCGTT GGCTAGCTGT CCTTGTTTCT 480

ATGGCTGTGT GTATAATTGC TATGATCATC ATCTTCAGCT GCTTTTGTTA CAAGCACCAC 540

TGCAAAAGAA TAGCAAGAAG CCGTTGCTAT AATCGTGACT TGGAACAGGA TGAAGCTTTT 600

ATACCAGTTG GAGAGTCATT GAAAGACCTT ATTGATCAGT CACAAAGTTC TGGCAGCGGA 660

TCCGGACTTC CTTTGCTGGT TCAACGAACT ATTGCCAAGC AGATTCAGAT GGTTCGGCAG 720

GTGGGAAAGG GTCGCTATGG AGAGGTGTGG ATGGGAAAAT GGAGAGGTGA AAAAGTGGCG 780

GTCAAAGTAT TCTTCACTAC TGAAGAGGCC AGTTGGTTTC GGGAAACAGA GATCTACCAG 840

ACTGTTCTGA TGCGACACGA GAATATTCTT GGTTTTATCG CGGCTGACAT CAAGGGCACC 900

GGCTCTTGGA CACAGCTGTA CCTGATCACC GACTACCACG AGAATGGATC TCTGTACGAC 960

TTCCTGAAAT GTACCACTCT GGACACCAGG GCCCTCCTCA AGTTGGCGTA TTCAGCGGCT 1020

TGTGGTCTGT GTCATCTCCA CACAGAGATC TATGGTACCC AAGGAAAGCC CGCGATTGCC 1080

CACCGAGATC TGAAGAGCAA AAATATCCTA ATCAAGAAAA ATGGGAGTTG TTGTATCGCT 1140

GACTTGGGCC TTGCTGTGAA ATTTAACAGT GATACAAATG AAGTTGATGT TCCTTTGAAC 1200

ACCAGAGTAG GTACAAAGCG TTACATGGCC CCAGAAGTCC TCGATGAAAG CCTGAATAAA 1260

AATCACTTTC AGCCATACAT CATGGCTGAC ATCTATAGCT TTGGACTGAT CATGTGGGAG 1320

ATGGCTCGTC GCTGTGTCAC AGGAGGCATT GCAGAAGAGT ACCAATTGCC TTACTACAAC 1380

ATGGTGCCTC ATGATCCTTC CTATGAAGAT ATGCGTGAGG TGGTGTGTGT TAAGCGACTG 1440

CGGCCCATCG TGTCTAACCG ATGGAATAGT GATGAATGTC TAAGAGCTAT CTTGAAGCTA 1500

ATGTCAGAAT GCTGGGCTCA CAATCCTGCT TCAAGACTTA CCGCGTTGAG AATCAAAAAG 1560

ACACTTGCCA AGATGGTTGA ATCCCAAGAT GTAAAGATTT GA 1602

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 235   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  294

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk +tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 295   ADIKGTGSWTQLYLITDYHENGSLYDFLKCTTLDTRALLKLAYSAACGLCHLHTEIYGTQ  354

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 355   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  412

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + ++++eey+lp++++v++dPs+e+m

Q: 413   VLDESLNKNHFQPYIMADIYSFGLIMWEMARRCVT-GGIAEEYQLPYYNMVPHDPSYEDM  471

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 472   REVVCVKRLRPIVSNRWNSDECLRAILKLMSECWAHNPASRLTALRIKKTL  522

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC TTLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIMWEMARR CVTGGIAEEY QLPYYNMVPH DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAILKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013