EKS-SAH-00281
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00281
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR449.05.0E-135702958257
StatusUnreviewed
Ensembl ProteinENSSHAP00000006754
UniProt AccessionG3VU99;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000005870ENSSHAP00000006754ENSSHAT00000006813
OrganismSarcophilus harrisii
Functional Description
Protein Length1328
Protein Sequence
(FASTA)
PEVMKGLLVL GWLLHLVGGS ELGSFQGGCP GINVAESQNE TLHQLCGWCE VVMGNLEIVL 60
TGHNFDLSFL KCIREVTGYV LISMNEFSDL SLSNLRLIRG AQVYGRKFAI FVSLNYNTNS 120
SQALRQFCLN QLTEILAGGV YIERNDKLCH MDTSDVRDIV RDQQAEIVIK NNGKNCPPCH 180
ESCGGKCWGP GPGDCQTLTK TICAPQCNGH CFGPNPNQCC HDECAGGCGG PRETDCFACR 240
HFNDSGACVS LCPLPLVYNK LTFQLEPNPH TKYQYGGVCV ASCPHNFVID HTSCVRACPG 300
DKMEVEKNGL KMCEPCGGLC PKACEGTGSG SRFQTVDSSN IDGFVNCTKI LGNLDFLITG 360
LKGDPWHNIP ALDPEKLSVF QTVREITGYL NIQSWPPHMH NFSVFSNLTT IGGRSLYNLG 420
FSLLIMKNLN VTSLGLRSLK EVSAGRIYIS ANKQLCYYHS LNWTRLLRGP KEGRLDIKHN 480
RLKKDCVAEG QVCDPLCSSG GCWGPGPGQC LSCRNYSREG VCVTQCNFLN GEPREFANED 540
ECFSCHPECQ PVEGNVTCYG SGSDACAQCA HFRDGPHCVS SCPHGLLGAK GLIYKYPDAH 600
RECLPCHENC TQGCNGPELH DCLGQPQAIS SKTHVAVGLA VVAGLIVITL ALLLTLLYLR 660
GRKIQKKRAM RRYLERGESL EPLDPGEKAN KVLARIFKET ELRKLKVLGS GVFGTVHKGI 720
WIPEGESIKI PVCIKVIEDR SGRQSFQAVT DHMLAIGSLD HTHIVRLLGL CPGSSLQLVT 780
QFLPLGSVLD HVRQHRGALG PQLLLNWAVQ IAKGMYYLEE HGMVHRNLAA RNVLLKSPSQ 840
VQVADFGVAD LLPPDDKQLL HSEAKTPIKW MALESIHFGK YTHQSDVWSY GVTIWELMTF 900
GDIPYKGLRL AEVPDLLEKG ERLAQPQICT IDVYMVMVKC WMIDENIRPT FKELANEFTR 960
MARDPPRYLV IKRDSGSGLP PGAEIPALTD KELEEVEPEL ELDMELEEEE LASTLGSALS 1020
LPVGTLSRPR GSQSFLSPSS GYMPMNQSNI GGARQGSVTR GSGEQCPCPS SLLQNPRGRL 1080
TSESSEGRGT SSEAELQEAE SLCGSRSPRP RGDSAYHSQR HSLLTPLTPL ITPGLEEEDV 1140
NGYVMPDTHT KGIPSSRDGT LSSSVGISSI LGTEEEEDED DEYEYMNRRR KQSLPRPPRP 1200
GSLEELGYEY MDVGSDLSAS LGSTHSCPLH PVPIMPVPGT TPDEDYEYMN RRHGGGTSGS 1260
DYAAMGACPA AEQGYEEMGS FQSPGHHAPC IHDAHLKPLQ TLEATHSAFD NPDYWHSRLF 1320
SKASTQGT 1328
Nucleotide Sequence
(FASTA)
CCAGAAGTGA TGAAGGGATT ACTGGTATTG GGCTGGCTCC TCCACCTGGT TGGGGGCTCG 60
GAGTTGGGCA GCTTCCAGGG AGGATGTCCA GGAATTAATG TTGCTGAAAG CCAGAACGAG 120
ACCCTGCATC AGCTGTGTGG GTGGTGTGAG GTGGTGATGG GAAACCTGGA AATTGTGCTT 180
ACAGGGCACA ACTTTGACCT CTCCTTTCTG AAGTGTATCC GGGAGGTAAC AGGATATGTC 240
CTAATATCCA TGAATGAGTT TTCAGATCTG TCACTCTCCA ACCTTCGTCT AATAAGAGGA 300
GCCCAGGTCT ATGGTAGGAA GTTTGCCATC TTTGTCAGTC TCAACTATAA TACCAACTCC 360
AGCCAGGCCC TACGCCAGTT CTGCCTCAAT CAGCTCACAG AGATCCTGGC TGGAGGTGTT 420
TACATTGAAA GGAATGATAA ACTTTGTCAC ATGGACACAA GTGACGTGAG AGACATCGTG 480
AGGGACCAAC AGGCTGAGAT TGTGATAAAG AACAATGGCA AAAACTGTCC TCCTTGTCAT 540
GAATCCTGTG GAGGGAAATG CTGGGGTCCC GGACCAGGAG ACTGCCAAAC ATTGACAAAG 600
ACAATCTGTG CCCCACAATG CAATGGCCAC TGCTTTGGGC CCAATCCCAA CCAGTGCTGC 660
CATGATGAGT GTGCAGGTGG ATGTGGAGGT CCCCGGGAGA CAGACTGCTT CGCATGTCGA 720
CACTTCAATG ACAGTGGAGC CTGTGTGTCT TTGTGTCCTC TTCCCCTTGT CTACAACAAG 780
CTCACCTTCC AACTAGAGCC CAATCCCCAT ACTAAGTACC AGTATGGAGG GGTCTGTGTG 840
GCCAGCTGTC CCCATAACTT TGTGATAGAT CACACCTCCT GTGTCAGGGC TTGTCCTGGG 900
GACAAGATGG AGGTAGAAAA GAACGGGCTG AAGATGTGTG AACCCTGTGG AGGGCTGTGT 960
CCCAAAGCCT GTGAGGGGAC AGGCTCAGGG AGCCGATTTC AGACTGTGGA TTCTAGCAAC 1020
ATTGATGGGT TTGTGAACTG TACCAAGATC TTGGGAAACC TGGACTTCCT TATCACCGGC 1080
CTCAAAGGAG ACCCCTGGCA CAACATTCCT GCCCTGGATC CTGAGAAACT CAGTGTCTTC 1140
CAGACAGTTC GGGAGATTAC AGGTTACCTG AACATCCAGT CATGGCCCCC TCACATGCAC 1200
AACTTTAGTG TCTTCTCCAA CCTGACAACC ATAGGTGGCC GAAGCCTCTA CAATCTGGGT 1260
TTCTCACTGC TGATCATGAA AAATTTGAAT GTGACATCAT TGGGCCTCCG GTCCCTCAAA 1320
GAAGTCAGCG CTGGGCGTAT TTATATCAGT GCCAACAAGC AGCTCTGCTA CTACCACTCT 1380
CTGAACTGGA CCAGGCTGCT TCGGGGCCCA AAGGAAGGGA GGCTGGATAT CAAGCACAAT 1440
CGCCTCAAAA AGGACTGTGT GGCAGAGGGT CAAGTGTGTG ACCCACTGTG CTCATCTGGG 1500
GGTTGCTGGG GCCCTGGTCC TGGCCAGTGT TTATCCTGTC GAAACTACAG CAGAGAGGGA 1560
GTCTGTGTGA CCCAATGCAA CTTCCTGAAT GGAGAACCCC GAGAGTTTGC CAATGAGGAT 1620
GAGTGCTTCT CCTGCCATCC CGAGTGCCAG CCTGTGGAGG GCAATGTCAC CTGCTATGGC 1680
TCGGGCTCAG ATGCTTGTGC TCAGTGTGCC CACTTCCGGG ATGGACCACA CTGTGTGAGC 1740
AGCTGCCCCC ATGGCCTCCT GGGAGCCAAA GGACTCATCT ACAAGTACCC AGATGCTCAT 1800
AGAGAGTGTC TACCTTGCCA TGAGAACTGC ACTCAAGGGT GCAATGGACC AGAACTCCAT 1860
GACTGTTTGG GACAACCACA GGCCATCAGC AGTAAGACCC ACGTGGCTGT GGGTCTAGCT 1920
GTGGTAGCAG GGCTGATAGT GATCACTTTG GCCTTGCTAC TTACCTTGCT CTACTTGAGA 1980
GGGCGGAAGA TCCAGAAGAA GAGAGCAATG AGGCGCTACT TGGAGCGGGG TGAGAGCCTG 2040
GAACCTCTGG ACCCTGGTGA AAAGGCCAAT AAGGTCTTGG CCCGAATTTT CAAGGAGACA 2100
GAGCTGAGGA AACTTAAAGT TCTTGGCTCA GGCGTCTTTG GAACTGTGCA CAAGGGCATA 2160
TGGATCCCAG AGGGTGAGTC CATCAAGATC CCAGTCTGCA TTAAGGTCAT CGAAGACCGG 2220
AGTGGACGGC AGAGTTTCCA GGCTGTAACT GATCACATGT TAGCCATTGG CAGCTTAGAT 2280
CATACGCACA TTGTTCGGCT GTTGGGGCTA TGTCCAGGAT CATCTCTGCA GCTAGTCACC 2340
CAATTTCTGC CATTGGGATC AGTGTTAGAC CACGTGCGAC AACATCGGGG GGCTCTGGGA 2400
CCACAATTAC TTCTCAATTG GGCTGTGCAG ATTGCCAAGG GTATGTACTA CCTGGAAGAA 2460
CATGGCATGG TACACAGAAA TCTGGCTGCT CGAAATGTGC TCCTGAAGTC CCCAAGTCAG 2520
GTGCAAGTTG CTGATTTTGG AGTGGCTGAT CTGCTACCAC CTGATGATAA ACAACTGTTG 2580
CACAGTGAGG CTAAGACACC AATCAAGTGG ATGGCCCTGG AGAGCATCCA TTTTGGAAAA 2640
TATACACACC AGAGTGATGT CTGGAGTTAT GGTGTGACGA TATGGGAATT GATGACATTT 2700
GGGGACATAC CCTATAAAGG GCTTCGCCTA GCTGAAGTGC CTGACCTGCT GGAGAAGGGA 2760
GAGCGTCTAG CACAACCGCA GATCTGCACT ATTGATGTCT ACATGGTCAT GGTTAAGTGC 2820
TGGATGATTG ATGAGAACAT ACGACCAACA TTCAAAGAAC TGGCCAATGA ATTCACCCGA 2880
ATGGCCCGAG ATCCACCACG ATATTTGGTT ATCAAGAGGG ATAGTGGTTC TGGGCTGCCT 2940
CCTGGGGCAG AGATACCTGC TTTGACTGAC AAGGAACTGG AGGAGGTAGA GCCGGAGCTA 3000
GAGCTGGACA TGGAGCTGGA AGAGGAAGAA CTGGCAAGCA CATTAGGCTC TGCCCTCAGT 3060
TTGCCTGTTG GTACGCTGTC CCGACCACGT GGGAGTCAGA GCTTCCTAAG TCCTTCATCT 3120
GGATATATGC CAATGAACCA GAGCAACATT GGAGGGGCTA GACAGGGGTC TGTGACCCGT 3180
GGGAGTGGTG AGCAGTGCCC CTGCCCATCC TCTCTGCTCC AGAACCCGCG AGGCCGACTC 3240
ACTTCTGAAT CATCAGAAGG CCGGGGGACA AGCTCTGAGG CTGAGCTGCA AGAGGCAGAA 3300
TCTCTGTGTG GCAGCCGGAG CCCTCGACCT CGAGGTGACA GTGCCTATCA CTCCCAGCGC 3360
CACAGCCTGC TCACCCCCCT CACTCCGCTC ATCACGCCAG GCCTGGAGGA GGAAGATGTC 3420
AATGGTTATG TGATGCCGGA CACCCATACC AAAGGTATTC CTTCTTCTCG GGATGGCACT 3480
TTGTCATCAT CTGTGGGTAT CAGTTCCATT CTGGGCACTG AAGAGGAAGA AGATGAAGAT 3540
GATGAGTATG AATATATGAA TCGGAGAAGA AAGCAGAGTC TGCCAAGACC CCCAAGGCCA 3600
GGATCTCTGG AGGAGTTGGG CTATGAGTAC ATGGACGTAG GATCGGACCT CAGTGCCTCC 3660
TTAGGCAGCA CCCATAGCTG CCCACTCCAT CCTGTACCCA TCATGCCTGT TCCAGGAACT 3720
ACTCCCGATG AGGATTATGA GTATATGAAT CGTCGACATG GTGGAGGAAC TTCTGGCAGC 3780
GATTATGCAG CCATGGGGGC TTGCCCAGCA GCTGAGCAAG GTTATGAGGA AATGGGATCA 3840
TTTCAGAGCC CTGGGCACCA TGCCCCATGC ATCCATGATG CCCACCTCAA GCCGCTTCAA 3900
ACCCTTGAAG CCACTCACTC TGCCTTTGAC AACCCCGACT ACTGGCATAG CCGGCTCTTC 3960
TCCAAGGCCA GTACTCAGGG GACATAA 3987
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kGiwipege++kipv+ikv+e+++g++++++++d++l+++sldh
Q: 702   LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDRSGRQSFQAVTDHMLAIGSLDH  761
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         +++vrllglc  s+lqlvtq+lplG++ld+vr+h+++lG+q llnw+vqiakGm+ylee+
Q: 762   THIVRLLGLCPGSSLQLVTQFLPLGSVLDHVRQHRGALGPQLLLNWAVQIAKGMYYLEEH  821
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 822   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  881
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG+ py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 882   THQSDVWSYGVTIWELMTFGDIPYKGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  941
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 942   MIDENIRPTFKELANEF  958
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGIW IPEGESIKIP VCIKVIEDRS GRQSFQAVTD HMLAIGSLDH 60
THIVRLLGLC PGSSLQLVTQ FLPLGSVLDH VRQHRGALGP QLLLNWAVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTIWELMTFG DIPYKGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-EQC-00291
EKS-FEC-00285
EKS-GAM-00190
EKS-GAG-00250
EKS-GAA-00372
EKS-HOS-00303
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORA-00263
EKS-ORC-00282
EKS-ORL-00361
EKS-OTG-00305
EKS-PAT-00282
EKS-PES-00266
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-TAG-00313
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-VIP-00031
EKS-XET-00373
EKS-XIM-00380
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013