EKS-SAH-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKN	161.8	2.2E-47	660	918	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000007031

UniProt Accession

G3VV26;

Protein Name

Protein Synonyms/Alias

Gene Name

PKN2

Gene Synonyms/Alias

PKN2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000006110	ENSSHAP00000007031	ENSSHAT00000007093

Organism

Sarcophilus harrisii

Functional Description

Protein Length

986

Protein Sequence
(FASTA)

RISNWERGKS EVKLTSASGD ARSLLLPENV STGQKLDFSD TMVQQKLDDI KDRIKREIRK 60

ELKIKEGAEN LRKVTTDKKN LAYVDNILKK SNKKLEELHH KLQELNAHIV VTDPEDLTDC 120

PRTPDTPNSD PRSSTSNNKL MALKKQLDIE LKVKQGAENM IQMYSNGSSK DRKLLATAQQ 180

LLQDSKTKIE VIRMQILQAV QTNELAFDNA KPVISPLELR MEELRHHFRI EFAVAEGAKN 240

VMKLLGSGKV TDRKALSEAQ ARFNESSQKL DLLKYSLEQR LNELPKNHPK SSIIIEELSL 300

VASPTLSPRQ SVISTQNQYS TLCKPAALTG TLEVRLMGCQ DILENVPGRS KATSVTLPGW 360

SPSETRSSFM SRTSKSKSGS SRNLLKTDDL SRDDICAVLK LDNTVVGQTS WKPISNQCWD 420

QKFTLELDRS RELEISVYWR DWRSLCAVKF LRLEDFLDNQ RHGMCLYLEP QGTLFAEVTF 480

FNPVIERRPK LQRQKKIFSK QQGKTFLRAP QMNINIATWG RLVRRAIPTV NHSGTFSPQA 540

PGPTTVPVVD VRIPELTPPA RSDPTVTKLD FELEPETPPA PPRASSFGEI HEPSELRVLD 600

VPGQDSETTF NFENDRNNIA SKKQAEYEPP IPHSGLEYRS VQEPEDRRSP QRFQFSLQDF 660

RCCAVLGRGH FGKVLLAEYK NTNEMFAIKA LKKGDIVARD EVDRLGCKKR CFQYVDKVRL 720

FAFKKFFLTG DRYIYIYTYP VNNDLLLSSK NATLFDSRLL FQIIFLILGF CYFHFSKRVH 780

VKIQNTIDIN SCFFKKIKFC LVKIRVEDNK RDQTLYSQNC MGLPLVILKN IYRQNSKSYF 840

LSVFLYHLPI DNESYKGDYL KYYSSLTLFS IIYDDWLIPM SMKSNHISIL NELLRRNPER 900

RLGAGEKDAE DVKKHPFFRL IDWNALLAKK VKPPFVPTIR GREDVSNFDD EFTSEAPILT 960

PPREPRILSE EEQEMFRDFD YIADWC 986

Nucleotide Sequence
(FASTA)

CGAATTTCTA ATTGGGAACG GGGGAAGAGT GAAGTAAAAC TCACTAGTGC CTCTGGGGAT 60

GCTCGAAGCC TTCTCCTTCC TGAAAATGTG AGCACTGGCC AAAAGTTAGA CTTTTCAGAC 120

ACAATGGTGC AACAGAAATT GGATGATATC AAGGATCGTA TCAAACGAGA AATAAGGAAA 180

GAACTGAAAA TAAAAGAAGG AGCTGAAAAT CTCAGGAAGG TCACAACAGA CAAAAAAAAT 240

TTGGCTTATG TGGACAATAT TTTGAAAAAA TCAAATAAAA AATTAGAAGA ATTACATCAT 300

AAACTGCAGG AATTAAATGC CCATATTGTT GTAACAGATC CAGAAGATCT TACAGATTGT 360

CCAAGGACCC CAGATACTCC AAATAGTGAT CCTCGTAGTT CTACTAGCAA TAATAAATTG 420

ATGGCCTTAA AAAAACAATT GGACATAGAA CTGAAGGTAA AACAAGGAGC AGAGAATATG 480

ATACAGATGT ATTCAAATGG CTCTTCAAAG GATCGAAAAC TCCTTGCCAC CGCTCAACAG 540

CTGCTTCAGG ACAGCAAGAC AAAAATAGAA GTCATAAGGA TGCAGATTCT TCAGGCAGTC 600

CAGACCAATG AACTGGCTTT TGATAATGCA AAACCTGTGA TAAGTCCTCT TGAACTTCGG 660

ATGGAAGAAT TACGGCATCA TTTTAGGATA GAATTTGCAG TAGCAGAAGG TGCAAAGAAT 720

GTGATGAAAT TACTTGGATC TGGAAAAGTA ACAGACAGAA AAGCACTTTC AGAAGCTCAA 780

GCGAGATTTA ATGAATCAAG TCAAAAGTTG GATCTTTTAA AGTATTCATT AGAACAAAGA 840

TTGAACGAAC TTCCGAAAAA TCATCCCAAA AGCAGTATTA TTATTGAAGA GCTATCTCTT 900

GTTGCATCAC CAACACTAAG TCCACGGCAG AGTGTAATAT CTACACAAAA CCAGTATAGT 960

ACACTATGCA AACCAGCAGC ACTAACAGGT ACTTTGGAAG TTCGACTCAT GGGCTGCCAA 1020

GATATACTAG AGAATGTCCC TGGACGTTCA AAAGCAACAT CAGTTACACT GCCTGGCTGG 1080

AGCCCAAGTG AAACAAGATC ATCCTTCATG AGCAGAACAA GCAAAAGTAA AAGTGGGAGT 1140

AGTCGAAACC TTCTAAAAAC AGATGACTTG TCCAGAGATG ACATCTGTGC AGTTTTGAAG 1200

CTGGACAATA CCGTGGTTGG TCAAACTAGC TGGAAACCCA TTTCTAATCA GTGTTGGGAC 1260

CAGAAGTTTA CACTGGAACT TGATAGGTCA CGTGAACTGG AAATTTCAGT TTATTGGCGT 1320

GATTGGCGAT CTCTCTGTGC AGTAAAATTT CTAAGGTTAG AAGATTTTTT AGACAACCAG 1380

CGACATGGCA TGTGTCTTTA TCTGGAACCC CAGGGTACTT TATTTGCAGA GGTTACCTTT 1440

TTTAATCCAG TTATTGAAAG AAGACCAAAG CTTCAAAGAC AAAAGAAAAT TTTTTCAAAA 1500

CAACAAGGCA AAACATTTCT CAGAGCTCCT CAAATGAATA TTAATATTGC CACTTGGGGA 1560

AGGCTGGTGA GAAGAGCAAT TCCAACGGTA AATCATTCTG GCACCTTTAG TCCTCAGGCT 1620

CCTGGGCCTA CAACAGTACC TGTGGTTGAT GTGCGTATTC CAGAACTAAC ACCGCCAGCA 1680

AGAAGTGACC CTACAGTAAC CAAATTGGAC TTTGAACTTG AACCAGAAAC ACCTCCAGCC 1740

CCACCACGTG CATCTTCCTT TGGAGAAATA CATGAACCTT CAGAGTTAAG AGTTTTGGAT 1800

GTACCAGGAC AGGATTCAGA AACAACTTTT AATTTTGAAA ATGACAGAAA TAATATTGCT 1860

TCAAAAAAAC AAGCTGAATA TGAGCCTCCT ATCCCTCATT CAGGCCTAGA GTACAGAAGT 1920

GTTCAAGAAC CTGAGGATAG AAGATCTCCA CAGAGGTTTC AGTTTAGTCT TCAAGACTTT 1980

AGGTGTTGTG CTGTATTGGG TAGAGGGCAT TTTGGAAAGG TGCTTTTGGC TGAATACAAA 2040

AATACAAATG AGATGTTTGC CATAAAAGCC TTAAAGAAAG GAGATATTGT TGCTCGAGAT 2100

GAAGTAGACA GGTTAGGGTG TAAGAAAAGG TGTTTTCAGT ATGTTGACAA AGTTAGGTTA 2160

TTTGCCTTCA AGAAGTTCTT TCTAACAGGA GATAGATATA TATATATATA TACATACCCT 2220

GTAAACAATG ATCTTCTATT GAGCAGCAAA AATGCCACAT TATTTGACAG TAGACTTTTG 2280

TTTCAAATCA TTTTTCTAAT ATTAGGTTTC TGTTATTTTC ATTTTTCAAA AAGGGTTCAT 2340

GTTAAGATTC AAAACACCAT AGACATCAAC TCTTGCTTTT TTAAAAAAAT AAAATTTTGT 2400

TTAGTTAAAA TAAGGGTGGA GGACAACAAA AGAGACCAAA CATTATATTC TCAGAACTGC 2460

ATGGGACTTC CTCTAGTCAT TCTCAAGAAC ATTTATAGAC AAAATAGCAA ATCATACTTT 2520

CTATCAGTAT TTTTGTATCA TCTTCCTATA GATAATGAAA GCTATAAAGG TGACTACTTG 2580

AAATATTATA GTAGCTTGAC TCTCTTTAGT ATTATTTATG ATGATTGGTT GATACCCATG 2640

TCAATGAAAT CCAATCATAT ATCTATATTA AATGAACTAC TGAGAAGAAA TCCAGAGCGG 2700

CGCCTGGGAG CTGGTGAGAA AGATGCAGAG GATGTAAAAA AGCACCCATT TTTCCGGCTA 2760

ATTGATTGGA ATGCTTTGCT GGCCAAGAAA GTAAAGCCAC CCTTTGTTCC TACCATCAGA 2820

GGACGAGAGG ATGTAAGTAA TTTTGATGAT GAATTTACCT CAGAAGCACC TATTCTGACC 2880

CCACCTCGGG AACCAAGGAT ACTTTCAGAA GAGGAGCAAG AAATGTTTCG AGATTTTGAC 2940

TACATTGCAG ATTGGTGTTG A 2961

Domain Profile

S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60

         fr++avlgrghfgkvll+eyk+t+e++aikalkkgdi+ardev+ l c+kr ++ v++vr

Q: 660   FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDRLGCKKRCFQYVDKVR  719

         9*******************************************************9998

S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120

            l ++   f t +  +++  y +  dl+l  ++  + ++r +f +  ++lg+ ++h

Q: 720   ---LFAFKKFFLTGDRYIYIYTYPVNNDLLLSSKNATLFDSRLLFQIIFLILGFCYFHFS  776

         ...67788899*************************************************

S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180

         k v+  +k++n +  +  + k   f l+k  +    r  t+     +  p v+ ++ y +

Q: 777   KRVH--VKIQNTIDINSCFFKKIKFCLVKIRVEDNKRDQTLYSQNCMGLPLVILKNIYRQ  834

         9986..8999*9999999******************************************

S: 181   avdwwglgvllyemlvgespfpgddeee....vfdsivndevryprflsveaieilrrll  236

             + l v+ly + + +  + gd  +      + si+ d+  +p  +  + i+il+ ll

Q: 835   NSKSYFLSVFLYHLPIDNESYKGDYLKYysslTLFSIIYDDWLIPMSMKSNHISILNELL  894

         ************************7543111145699***********************

S: 237   rknpekrlgaserdaedvkkqpff  260

         r+npe+rlga+e+daedvkk+pff

Q: 895   RRNPERRLGAGEKDAEDVKKHPFF  918

         ***********************9

Domain Sequence
(FASTA)

FRCCAVLGRG HFGKVLLAEY KNTNEMFAIK ALKKGDIVAR DEVDRLGCKK RCFQYVDKVR 60

LFAFKKFFLT GDRYIYIYTY PVNNDLLLSS KNATLFDSRL LFQIIFLILG FCYFHFSKRV 120

HVKIQNTIDI NSCFFKKIKF CLVKIRVEDN KRDQTLYSQN CMGLPLVILK NIYRQNSKSY 180

FLSVFLYHLP IDNESYKGDY LKYYSSLTLF SIIYDDWLIP MSMKSNHISI LNELLRRNPE 240

RRLGAGEKDA EDVKKHPFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF02185	; HR1; 3.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00239	; C2; 1.
SM00742	; Hr1; 3.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013