EKS-SAH-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.5	2.2E-168	331	607	277

Status

Unreviewed

Ensembl Protein

ENSSHAP00000007157

UniProt Accession

G3VVF1;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000006217	ENSSHAP00000007156	ENSSHAT00000007218
ENSSHAG00000006217	ENSSHAP00000007155	ENSSHAT00000007217
ENSSHAG00000006217	ENSSHAP00000007157	ENSSHAT00000007219

Organism

Sarcophilus harrisii

Functional Description

Protein Length

672

Protein Sequence
(FASTA)

MRAPYWTHTE KMEKRLHAVP AANTVKFRCP AGGNPVPSMR WLKNGKEFKQ EHRIGGYKVR 60

NQHWSLIMES VVPSDKGNYT CIVENEYGSI NHTYHLDVVE RSPHRPILQA GLPANASTVV 120

GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK VLKAAGVNTT DKEIEVLYIR 180

NVTFEDAGEY TCLAGNSIGI SFHSAWLTVL PAPVREKEIT ASPEYLEIAI YCIGVFLIAC 240

MVVTVVLCRM KTTTKKPDFS SQPAVHKLTK RIPLRRQVSA DSSSSMNSNT PLVRITTRLS 300

SAPDAPMLAG VSEYELPEDP KWEFPRDKFR LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE 360

AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVIVEYASKG 420

NLREYLRARR PPGMEYSFDI NRVPEEQMTF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR 480

NVLVTENNVM KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG 540

VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF 600

KQLVEDLDRI LTLTTNEEYL DLSGPLEQYS PSYPDTRSSC SSGDDSVFSP DPMPYEPCLP 660

KYQHINGTVK RR 672

Nucleotide Sequence
(FASTA)

ATGCGAGCAC CATATTGGAC CCATACAGAG AAGATGGAAA AACGGTTACA TGCTGTTCCA 60

GCAGCTAATA CGGTGAAATT TCGTTGTCCT GCTGGAGGAA ACCCAGTACC AAGTATGAGA 120

TGGTTAAAGA ATGGAAAAGA ATTCAAGCAA GAGCACCGAA TTGGTGGATA TAAGGTACGA 180

AACCAGCACT GGAGTCTTAT CATGGAGAGT GTGGTTCCAT CTGACAAAGG GAATTATACC 240

TGTATAGTTG AAAATGAATA TGGATCCATC AATCACACAT ACCACCTTGA TGTTGTTGAA 300

CGATCTCCCC ACCGGCCCAT CCTCCAAGCA GGACTGCCAG CAAATGCTTC TACAGTGGTT 360

GGGGGGGATG TGGAGTTTGT CTGCAAAGTC TACAGTGATG CTCAGCCCCA CATTCAATGG 420

ATCAAACATG TGGAAAAGAA CGGCAGTAAA TATGGGCCAG ATGGATTACC CTACCTTAAG 480

GTTCTGAAGG CCGCCGGTGT TAACACCACG GACAAAGAGA TTGAGGTTCT CTATATTCGG 540

AATGTAACTT TTGAGGATGC TGGGGAGTAT ACGTGCTTGG CGGGTAATTC TATTGGGATA 600

TCCTTTCACT CTGCATGGTT GACAGTTCTG CCAGCACCTG TAAGAGAAAA GGAGATTACA 660

GCTTCCCCAG AGTACCTGGA GATAGCCATT TACTGCATAG GGGTCTTCTT AATTGCCTGT 720

ATGGTGGTGA CGGTTGTGTT ATGTCGCATG AAGACAACCA CTAAGAAGCC GGACTTCAGT 780

AGCCAACCAG CTGTGCACAA GCTGACCAAG CGCATCCCCC TGCGGAGACA GGTGTCCGCT 840

GACTCCAGCT CTTCCATGAA CTCCAATACA CCGTTGGTGA GAATAACAAC TCGCTTGTCT 900

TCAGCACCTG ATGCCCCAAT GTTGGCAGGG GTCTCTGAAT ACGAATTGCC TGAGGACCCA 960

AAATGGGAAT TTCCAAGAGA CAAGTTTAGG CTGACGCTGG GCAAACCCCT TGGGGAAGGT 1020

TGTTTTGGGC AAGTTGTAAT GGCAGAAGCA GTGGGGATTG ACAAAGACAA GCCTAAGGAA 1080

GCAGTTACCG TGGCAGTGAA GATGTTGAAA GATGATGCTA CAGAGAAAGA TCTTTCTGAC 1140

CTAGTATCAG AGATGGAGAT GATGAAGATG ATTGGAAAAC ACAAAAATAT TATAAATCTT 1200

CTTGGAGCCT GTACCCAGGA TGGTCCATTG TATGTGATTG TTGAGTATGC TTCTAAAGGA 1260

AACCTACGAG AATACCTCCG AGCCCGGAGA CCCCCTGGTA TGGAATATTC ATTTGACATT 1320

AACCGGGTAC CAGAAGAACA GATGACTTTC AAAGACTTGG TATCCTGCAC ATACCAACTA 1380

GCAAGAGGCA TGGAATACTT AGCATCACAA AAATGCATTC ACCGAGACTT AGCAGCCAGA 1440

AATGTTTTGG TGACAGAAAA TAATGTGATG AAAATAGCAG ATTTTGGCTT GGCCAGAGAT 1500

ATCAACAACA TAGATTACTA TAAAAAAACC ACAAATGGAC GACTCCCTGT CAAGTGGATG 1560

GCTCCTGAGG CCCTTTTTGA TCGGGTGTAC ACACATCAAA GTGACGTCTG GTCATTTGGG 1620

GTATTAATGT GGGAGATCTT CACTTTAGGA GGGTCACCCT ATCCAGGAAT CCCAGTGGAG 1680

GAACTCTTTA AGCTGCTTAA GGAAGGCCAC AGGATGGATA AACCAGCCAA CTGCACCAAT 1740

GAGCTGTATA TGATGATGCG GGATTGTTGG CATGCGGTAC CCTCTCAAAG ACCAACATTT 1800

AAGCAGTTGG TAGAAGACTT AGATCGAATT CTCACTCTTA CAACTAATGA GGAATACTTG 1860

GACCTGAGTG GACCTCTGGA ACAGTATTCA CCTAGTTATC CTGACACAAG AAGCTCATGT 1920

TCTTCAGGAG ATGACTCTGT ATTTTCTCCA GATCCTATGC CTTATGAACC ATGCCTTCCC 1980

AAGTATCAAC ACATAAATGG CACTGTTAAA AGAAGG 2016

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 331   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  390

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s d ++++eeq+t+

Q: 391   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  450

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 451   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  510

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 511   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  570

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 571   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  607

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013