EKS-SAH-00200

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00200

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	461.1	1.1E-138	13	297	285

Status

Unreviewed

Ensembl Protein

ENSSHAP00000007449

UniProt Accession

G3VW95;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000006474	ENSSHAP00000007449	ENSSHAT00000007511
ENSSHAG00000006474	ENSSHAP00000007450	ENSSHAT00000007512

Organism

Sarcophilus harrisii

Functional Description

Protein Length

874

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHSDILK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILSGVL LDLMKNLLKL DPADRYLTEQ CLNHPSFQTQ 300

RLLDRCGTSP SRSAKRKPYH VESNTLSNRN QASKNTALQA HHRSNSKDIQ NLSVGLPRNE 360

DVLPASESFL NGNLSGASHS PMHTKPYQTS NPPGSANKDL TNNNIPHLLS PKESKAKTEF 420

DFSIDQKTSE GPGTKYLKSN SRSQQNRHSF MESSQSKTGT LQPGEKHGRH SYIDTIPQSS 480

KSPSYRAKAK SHGVLTDSKS VSNLSEARVQ ISDPSSSRYF PSSCLDLNSP TSPIPPRHSD 540

SRTLLSPSGR TNRSEGTLDS RRTTARHSKT MEELKLPDHM DGSHSHSLSA PHESFSYGLG 600

YTSPFSSQQR PHRHSMYVTR DKVRAKGSDG GLNIGQGMAV RANSLQLLSP QPGEQIPTEL 660

SVSRSSAKET SREGTSSFHS RQKSEGGAYH DPHSDDGGAT KENRHLYNDP VPRRVGSFYR 720

VPSPRPDNSF HENNVPSRVA SLPSESSSGT NHSKRQTTFD PWKSPENISH AEQLKEKEKQ 780

SFFRSMKKKK KKSQTVPNTD SQDLLALQKA IHSTNHQSSR PKEWRPEKIS DLQVHSQPLK 840

SLRKLLHLSS ASNHPTSSDP RFQHLFSKAI TREM 874

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTAAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAAACAAC TTTACGAGAG 180

CTTAAAATGC TTCGAACTCT AAAACAGGAA AATATAGTGG AGCTAAAGGA AGCTTTCCGA 240

AGAAGAGGGA AATTATATTT GGTGTTTGAA TATGTGGAAA AAAATATGCT TGAATTGTTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTTAAAA GCTATATCTA CCAACTAATC 360

AAGGCAATTC ACTGGTGCCA TAAGAACGAT ATTGTTCATC GAGATATAAA ACCAGAAAAT 420

CTCTTAATCA GCCATAGTGA CATCCTGAAG CTCTGTGATT TTGGTTTTGC TCGGAATCTA 480

TCAGAAGGCA ACAATGCTAA TTATACAGAG TATGTGGCCA CCAGATGGTA CCGTTCTCCT 540

GAACTCTTAC TTGGAGCTCC CTATGGAAAA TCTGTAGATA TGTGGTCTGT GGGCTGTATT 600

CTTGGGGAGC TTAGTGATGG GCAACCTTTA TTTCCTGGAG AAAGTGAAAT TGACCAACTT 660

TTTACTATTC AGAAGGTTCT AGGACCACTT CCATCTGAGC AGATGAAGCT CTTCTACAGC 720

AATCCTCGTT TCCATGGGCT TCGGTTCCCA GCTGTTAATC ATCCCCAGTC TTTGGAGAGA 780

AGATATTTAG GAATTTTAAG TGGTGTTTTG CTTGACTTAA TGAAGAATTT ATTGAAGTTG 840

GATCCAGCAG ATAGATACTT GACAGAACAG TGTTTGAACC ATCCTTCATT TCAAACCCAG 900

AGACTCTTGG ATCGTTGTGG AACTTCACCT TCACGATCAG CAAAGAGAAA ACCATACCAT 960

GTTGAAAGCA ACACATTATC TAATAGAAAT CAAGCCAGCA AAAATACTGC TTTGCAGGCA 1020

CATCACAGAT CTAACAGTAA GGATATACAG AACCTGAGTG TTGGACTTCC ACGGAATGAA 1080

GATGTTCTTC CAGCAAGTGA AAGCTTCCTC AATGGAAACC TTTCTGGAGC TTCTCATAGT 1140

CCCATGCACA CCAAACCCTA TCAAACAAGT AACCCACCTG GATCCGCAAA CAAAGATCTC 1200

ACCAATAACA ACATTCCACA TCTTCTTAGC CCCAAAGAAT CAAAAGCAAA AACAGAATTT 1260

GATTTCAGTA TTGACCAAAA GACTTCTGAG GGCCCAGGCA CAAAATACCT TAAGTCAAAC 1320

AGTAGGTCTC AGCAGAACCG CCACTCATTT ATGGAAAGTT CCCAAAGCAA AACTGGAACA 1380

TTACAACCTG GTGAAAAGCA TGGACGACAT AGCTACATAG ATACTATTCC CCAATCCTCT 1440

AAGAGTCCTT CTTATAGAGC AAAGGCCAAA AGTCATGGGG TTCTGACTGA CTCCAAATCT 1500

GTGAGTAACC TTTCTGAAGC CAGAGTTCAG ATTTCTGATC CCAGTAGCAG CAGGTATTTT 1560

CCATCTAGCT GCCTAGACTT GAATTCTCCC ACCAGCCCAA TCCCTCCCAG GCACAGTGAC 1620

AGTAGAACTT TGCTTAGTCC TTCTGGGAGA ACTAACCGAA GTGAGGGCAC CTTGGACTCA 1680

AGGCGAACAA CAGCAAGACA TTCCAAAACA ATGGAAGAGT TGAAACTACC TGACCACATG 1740

GATGGAAGCC ATTCACACTC ACTCTCTGCA CCCCATGAAT CTTTTTCCTA TGGTCTAGGG 1800

TATACCAGCC CTTTCTCTTC CCAGCAACGG CCTCATAGGC ATTCCATGTA CGTGACTCGG 1860

GACAAAGTGA GAGCGAAAGG CTCAGATGGA GGCTTGAACA TAGGGCAAGG GATGGCAGTC 1920

AGAGCCAACA GCCTTCAACT CTTATCACCA CAGCCAGGAG AACAGATCCC CACAGAACTA 1980

AGTGTATCAC GGTCTTCAGC TAAAGAAACC TCTCGAGAGG GTACATCTTC ATTTCATTCA 2040

AGACAAAAAT CTGAGGGTGG AGCCTATCAT GACCCCCATT CAGATGATGG AGGCGCCACA 2100

AAAGAAAATA GACATCTATA TAATGATCCT GTTCCAAGAA GAGTTGGTAG CTTTTACCGA 2160

GTTCCATCTC CACGTCCGGA TAATTCATTT CATGAAAATA ATGTACCATC CAGAGTCGCT 2220

TCTTTGCCAT CAGAGAGCAG CTCTGGGACA AACCACTCAA AAAGACAAAC AACATTTGAT 2280

CCATGGAAAA GTCCAGAAAA TATTAGTCAT GCTGAACAAC TCAAGGAGAA GGAGAAGCAA 2340

AGCTTTTTTA GATCCATGAA AAAGAAAAAG AAGAAATCTC AAACAGTGCC CAATACAGAT 2400

AGTCAGGATC TTCTGGCATT ACAAAAAGCC ATTCATTCGA CTAATCACCA AAGCAGCCGG 2460

CCAAAGGAGT GGCGTCCTGA GAAGATCTCA GATCTTCAAG TTCATAGTCA GCCATTAAAA 2520

TCACTCCGTA AGCTGTTACA TCTCTCTTCT GCCTCAAACC ATCCCACTTC CTCAGACCCC 2580

CGCTTCCAGC ATCTGTTCTC CAAGGCCATA ACAAGAGAAA TG 2622

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+s+++klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHSDILKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   l+ vlldl+k++lkldpa+r+++e++l+h+ f

Q: 252   VNHPQSLERRYLgILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSF  297

         ***********98899***************************987

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHSDILKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILSGVLLD LMKNLLKLDP ADRYLTEQCL NHPSF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013