EKS-SAH-00407

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00407

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	496.8	1.5E-149	77	343	267

Status

Unreviewed

Ensembl Protein

ENSSHAP00000007570

UniProt Accession

G3VWL5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000006579	ENSSHAP00000007570	ENSSHAT00000007633

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1713

Protein Sequence
(FASTA)

MSQKKISHKL LSMVIKIVVA LLLERVCRLL CKSSLCLCDF SDKNSHSWTP VLPLLLLLKS 60

KPFTQLVKEM QLHRDDFEII KVIGRGAFGE VAVVKMKNTE RIYAMKILNK WEMLKRAETA 120

CFREERDVLV NGDCQWITTL HYAFQDENYL YLVMDYYVGG DLLTLLSKFE DKLPEDMARF 180

YIGEMVLAIH SIHQLHYVHR DIKPDNILLD MNGHIRLADF GSCLKMNDDG TVQSSVAVGT 240

PDYISPEILQ AMEDGMGKYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHEER 300

FQFPSHVTDV SEEAKDLIQR LICSRERRLG QNGIEDFKRH AFFEGINWED IRNLEAPYIP 360

DVSSPSDTSN FDVDDDVLRN PEIVPPGSHT GFSGLHLPFI GFTFTTESCF SDRGSLKSVM 420

QTNAITKDED VQRDLENSLQ IEAYERRIRR LEQEKLELSR KLQESTQTVQ SFHSSARSTG 480

NSNRDKEIKK LNEEIERLKN KISDSNRLER RLEDAVTLRQ EHEDSTHRLK ALEKQLRVLR 540

QEKEDMQKQL VEASERLKSQ TKELKDAHQQ RKLAMQEFSE LNERMADLRS QKQKISRQLR 600

DKEEEVEVIM QKIDSMRQEI RKSEKSRKEL ESRLEDAIAE ASKERKLREH SESFSKQVEG 660

ELEALKIKQG VRGSSVTLEH QQEISKIKSE LEKKVLFYEE ELVRREASHV LEVKNVKKEV 720

HDSESHQLAL QKEILMLKDK LEKSKRERHN EMEEAVGTVK DKYERERAML FEENKKLTTE 780

TERLCAFVDK LTAQNRQLED ELQDLAAKKD SVAHWEAQIA EIIQWVSDEK DARGYLQALA 840

SKMTEELESL RSSSLGSRTL DPLWKVRRSQ KLDMSARLEL QSALDAEIRA KQLIQEELRK 900

VKETNLAFES KLKESEAKNR ELLEEMENLR KKMEEKFKAD TGLKLPDFQE SIFEYFNTSP 960

LAHDLTFRSS STNDQETQIP KPEVSPSTSV SINTEQQEET TRSQQRGPAV SSPTIQSLSL 1020

AVPKPKAHQF SVKSFSSPTQ CSHCTSLMVG LIRQGYACEV CSFSCHVSCK DSAPQVCPIP 1080

PEQSKRPLGV DVQRGIGTAY KGYVKIPKPT GVKKGWQRAY AIVCDCKLFL YDLPEGKSTQ 1140

PGVVASQVLD LRDEEFSVSC VLASDVIHAT RRDIPCIFRV TASLLGTPAK TSSLLILTEN 1200

ENEKKKWVGI LEGLQSILHK NRLKNQVVHI PQEAYDSTLP LIKTILTAAI VDRDRIAIGL 1260

EEGLYVIELT RDVIVRAADC KKVYQIELAP KEKIITLICG RNHHVHLYPW SCLDGSEGNF 1320

DIKLPETKGC QLIVVATIKK SSSTCLFVAV KRLILCYEIQ RTKPFHKKFN EIVAPGNVQW 1380

MTVFKDRLCV GYPSGFSLLS IQGDGQSLNL VNPNDPSLMF LSQQSFDALC AVELSNEEYL 1440

LCFSHMGIYV DSQGRRSRMQ ELMWPATPVA CSCNSSYITV YSEYGVDVFD VHTMEWVQTI 1500

GLRKIRPLNM EGTLNLLNWE PPRLIYFKNK FSGAVLSVPE TSDNSKKQML RTRSKKRFVF 1560

KVPEEERLQQ RREMLRDPEL RSKMISNPTN FNHVAHMGPG DGMQVLMDLP LSVLPSSQEE 1620

KVVPSPANLS RQPQSRSKTY VSWPSSGGGE LGVTMPLRSM SDPDQDFDKE PDSDSTKHST 1680

PSNSSNPSGP PSPNSPHRNQ LTLDGLDQST CDA 1713

Nucleotide Sequence
(FASTA)

ATGTCTCAAA AAAAAATCAG TCATAAATTA CTGAGCATGG TGATCAAAAT AGTGGTAGCA 60

TTGCTTTTGG AAAGAGTATG TCGACTGCTT TGTAAATCAA GTCTCTGTCT TTGTGACTTC 120

TCGGACAAAA ATTCCCATTC TTGGACACCA GTCCTCCCCC TACTCCTTCT CTTAAAATCA 180

AAGCCATTCA CACAACTGGT GAAGGAAATG CAGCTTCATC GAGATGACTT TGAAATAATT 240

AAAGTAATTG GAAGAGGTGC ATTTGGTGAG GTTGCTGTGG TTAAAATGAA AAACACTGAA 300

CGCATTTATG CAATGAAGAT TCTTAATAAG TGGGAAATGC TAAAAAGAGC AGAGACAGCC 360

TGTTTTAGAG AAGAGAGAGA TGTGTTGGTG AACGGTGATT GTCAGTGGAT CACAACCTTA 420

CATTATGCCT TTCAAGATGA AAACTACTTG TACTTGGTAA TGGACTATTA TGTTGGTGGT 480

GATTTACTGA CACTCCTCAG TAAGTTTGAA GACAAACTTC CTGAAGATAT GGCAAGATTT 540

TACATCGGTG AAATGGTGCT GGCCATACAC TCCATTCATC AGCTGCATTA TGTACACAGA 600

GATATTAAAC CTGACAATAT TCTCTTGGAT ATGAATGGTC ACATTCGCTT GGCAGACTTT 660

GGATCATGTT TGAAGATGAA TGACGATGGA ACTGTCCAAT CTTCTGTGGC AGTGGGCACA 720

CCTGACTACA TTTCACCTGA GATTCTACAA GCAATGGAGG ATGGAATGGG AAAATATGGT 780

CCAGAATGTG ATTGGTGGTC TCTAGGTGTT TGCATGTATG AAATGCTATA TGGTGAAACA 840

CCTTTTTATG CAGAATCATT GGTGGAAACT TATGGAAAGA TCATGAATCA TGAAGAGCGA 900

TTTCAGTTTC CTTCTCATGT CACAGATGTA TCTGAAGAGG CAAAAGACCT CATTCAAAGA 960

CTCATCTGTA GTAGAGAACG CCGACTAGGG CAGAATGGAA TAGAAGATTT CAAAAGGCAT 1020

GCATTTTTTG AAGGAATAAA TTGGGAAGAC ATACGGAATC TAGAAGCACC TTATATTCCA 1080

GATGTTAGCA GTCCTTCCGA TACATCAAAT TTTGATGTAG ATGATGATGT GTTAAGAAAT 1140

CCGGAAATAG TACCTCCTGG TTCTCATACT GGCTTTTCTG GATTACATTT GCCATTCATT 1200

GGTTTTACAT TTACAACTGA AAGCTGTTTT TCTGATCGAG GTTCTCTAAA AAGTGTAATG 1260

CAAACTAATG CTATCACCAA AGATGAGGAT GTGCAACGGG ATCTAGAGAA CAGCTTGCAA 1320

ATTGAAGCAT ATGAAAGAAG AATACGAAGG TTAGAACAAG AAAAGCTGGA ATTGAGCAGA 1380

AAATTACAAG AATCCACACA AACTGTACAG TCCTTTCATA GTTCAGCTCG CTCTACAGGA 1440

AACTCAAACA GAGATAAAGA AATCAAAAAG TTAAATGAGG AAATTGAACG GCTAAAGAAT 1500

AAAATATCAG ATTCAAATAG GCTAGAGCGA CGACTTGAGG ATGCAGTGAC ACTTCGCCAG 1560

GAGCATGAAG ATTCCACTCA CAGACTGAAG GCCTTAGAAA AGCAATTGCG TGTACTACGG 1620

CAAGAAAAGG AGGATATGCA AAAGCAATTG GTTGAAGCTT CAGAAAGATT AAAATCTCAG 1680

ACCAAAGAAC TTAAAGATGC CCATCAACAG AGAAAGTTGG CTATGCAGGA GTTTTCAGAG 1740

CTTAATGAGC GGATGGCAGA TCTTCGGTCA CAAAAACAGA AGATATCTCG ACAGCTTCGT 1800

GACAAAGAAG AAGAGGTGGA AGTAATCATG CAGAAAATTG ATTCAATGAG ACAAGAAATC 1860

CGTAAATCTG AGAAGTCCAG AAAGGAGCTG GAATCTCGGC TTGAAGATGC AATTGCAGAA 1920

GCATCAAAAG AACGCAAGCT TCGTGAACAC AGTGAGAGTT TCTCTAAGCA AGTGGAAGGT 1980

GAACTGGAGG CACTTAAGAT AAAGCAAGGA GTCCGTGGAT CAAGTGTTAC TTTAGAACAT 2040

CAGCAGGAAA TTTCTAAAAT AAAATCTGAA CTTGAGAAGA AAGTTTTGTT TTATGAAGAG 2100

GAACTGGTCA GACGAGAGGC CTCCCATGTC CTAGAAGTAA AAAATGTGAA AAAGGAAGTG 2160

CACGATTCAG AAAGTCATCA GTTAGCACTA CAGAAAGAGA TTTTGATGTT AAAAGATAAA 2220

TTGGAAAAGT CAAAACGGGA AAGACATAAT GAGATGGAAG AAGCAGTAGG AACAGTAAAG 2280

GATAAATATG AGCGAGAAAG AGCAATGCTG TTTGAAGAGA ACAAGAAATT AACAACTGAA 2340

ACAGAAAGGC TTTGTGCATT TGTGGATAAA CTAACAGCTC AAAACAGGCA ACTAGAAGAT 2400

GAACTTCAAG ATTTGGCAGC TAAGAAGGAT TCAGTTGCTC ATTGGGAAGC TCAGATTGCA 2460

GAAATTATTC AGTGGGTAAG TGATGAAAAG GATGCTCGGG GATATCTTCA AGCTTTAGCA 2520

TCCAAGATGA CAGAGGAACT CGAATCATTG AGAAGCTCTA GTTTAGGATC AAGGACCCTG 2580

GATCCACTTT GGAAAGTACG TCGTAGTCAA AAATTAGATA TGTCTGCCCG GCTGGAGTTG 2640

CAATCTGCCC TTGATGCAGA GATACGTGCC AAACAGCTCA TTCAGGAAGA GTTAAGGAAA 2700

GTCAAAGAAA CAAATCTAGC CTTTGAAAGT AAACTAAAGG AATCTGAAGC AAAAAATAGA 2760

GAATTATTAG AAGAAATGGA GAATTTGAGG AAAAAAATGG AAGAGAAATT TAAGGCAGAT 2820

ACAGGCCTCA AACTTCCGGA TTTTCAAGAA TCAATTTTTG AGTATTTTAA CACTTCACCT 2880

CTTGCTCATG ATCTGACATT TAGAAGTAGC TCAACTAATG ATCAAGAAAC ACAAATTCCC 2940

AAACCAGAAG TTTCACCATC CACTTCAGTT TCCATAAACA CAGAACAACA AGAAGAAACA 3000

ACTCGTTCTC AACAGAGGGG ACCAGCTGTT TCTTCTCCCA CCATCCAGTC TCTTTCTCTA 3060

GCTGTACCAA AGCCTAAAGC TCACCAATTC AGTGTCAAAT CCTTTTCAAG TCCTACGCAA 3120

TGTAGCCACT GCACTTCACT TATGGTTGGA TTAATTCGAC AAGGTTATGC TTGTGAGGTG 3180

TGTTCCTTCT CATGCCATGT TTCATGCAAA GACAGTGCTC CTCAGGTTTG TCCAATTCCT 3240

CCTGAGCAAT CAAAAAGGCC TCTTGGAGTA GATGTACAGA GGGGGATTGG AACTGCATAC 3300

AAAGGCTACG TCAAGATTCC CAAACCTACA GGGGTGAAGA AAGGATGGCA GAGAGCATAT 3360

GCAATTGTCT GTGACTGTAA ACTTTTTTTA TATGATTTGC CTGAAGGAAA ATCCACCCAG 3420

CCTGGTGTTG TTGCAAGTCA AGTCTTAGAT CTTAGAGATG AAGAGTTTTC TGTGAGCTGT 3480

GTCTTAGCAT CGGATGTTAT ACATGCTACC CGCCGAGATA TTCCTTGTAT ATTTAGGGTG 3540

ACAGCTTCTC TCTTAGGCAC ACCTGCTAAG ACCAGTTCAC TGCTAATTCT AACAGAGAAT 3600

GAAAATGAGA AGAAGAAATG GGTTGGGATC CTAGAAGGAC TACAGTCTAT TCTGCATAAA 3660

AATAGACTTA AAAATCAAGT TGTACATATT CCACAGGAAG CCTATGACAG CACTCTGCCT 3720

CTTATTAAAA CCATCTTAAC AGCTGCAATA GTAGATCGGG ATAGGATAGC CATTGGTTTA 3780

GAAGAAGGAT TGTATGTAAT AGAGTTAACT CGTGATGTGA TTGTTCGAGC TGCTGATTGT 3840

AAGAAGGTGT ACCAGATTGA ACTTGCTCCC AAAGAGAAAA TCATCACCCT CATCTGTGGC 3900

AGGAATCATC ATGTTCATCT ATATCCCTGG TCCTGTCTTG ATGGTTCAGA AGGCAATTTT 3960

GATATCAAAC TTCCAGAAAC TAAAGGCTGC CAGCTTATAG TAGTTGCCAC AATAAAGAAA 4020

AGCTCTTCAA CTTGTTTGTT TGTGGCTGTG AAACGACTGA TTCTTTGTTA TGAAATTCAA 4080

AGAACTAAAC CTTTCCACAA AAAATTCAAT GAAATTGTGG CTCCAGGAAA TGTACAGTGG 4140

ATGACAGTGT TCAAGGACAG GCTCTGTGTT GGCTACCCTT CTGGGTTCTC TCTGTTGAGC 4200

ATCCAGGGAG ATGGACAATC TCTAAACCTG GTAAATCCTA ATGATCCCTC GCTTATGTTC 4260

CTCTCACAGC AGTCTTTTGA TGCCCTTTGT GCTGTGGAAC TCAGTAATGA GGAATACCTG 4320

CTTTGCTTCA GCCATATGGG AATATACGTG GATTCACAAG GTCGGAGGTC ACGCATGCAG 4380

GAGTTAATGT GGCCTGCAAC TCCTGTTGCC TGTAGTTGTA ACTCTTCTTA CATCACAGTA 4440

TATAGTGAAT ATGGAGTTGA TGTTTTTGAT GTTCATACTA TGGAATGGGT CCAGACTATT 4500

GGCCTGAGGA AGATCAGACC CCTTAACATG GAAGGAACAC TCAATCTCCT TAACTGGGAA 4560

CCTCCACGGT TAATATACTT CAAGAACAAG TTTTCAGGAG CTGTACTCAG TGTGCCAGAA 4620

ACTTCTGATA ACAGCAAAAA ACAAATGCTT CGGACCAGAA GTAAAAAGCG ATTTGTCTTT 4680

AAGGTTCCTG AAGAAGAGAG ATTACAGCAG AGACGAGAGA TGCTCAGAGA CCCAGAATTG 4740

AGATCAAAGA TGATATCAAA CCCAACTAAC TTCAACCATG TTGCTCATAT GGGTCCAGGA 4800

GATGGAATGC AAGTGCTCAT GGATCTCCCT CTGAGTGTAT TGCCTTCCTC ACAAGAAGAA 4860

AAAGTTGTCC CATCCCCAGC CAACCTCTCC CGGCAACCAC AATCAAGAAG TAAGACCTAC 4920

GTTTCATGGC CCTCTTCAGG TGGAGGTGAA CTGGGAGTGA CCATGCCTCT AAGAAGTATG 4980

TCTGATCCTG ACCAGGATTT TGACAAAGAG CCGGATTCTG ATTCCACCAA ACACTCTACT 5040

CCATCGAACA GCTCTAATCC AAGTGGCCCC CCCAGCCCCA ATTCTCCACA CAGAAATCAG 5100

CTTACACTAG ATGGACTAGA TCAATCAACC TGTGATGCCT AA 5142

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 77    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  136

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla++s+h+l+

Q: 137   ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLH  196

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnilld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 197   YVHRDIKPDNILLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM  256

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 257   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  316

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+k+h+ff

Q: 317   LIQRLICSRERRLGQNGIEDFKRHAFF  343

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIHSIHQLH 120

YVHRDIKPDN ILLDMNGHIR LADFGSCLKM NDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKRHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013