EKS-SAH-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	440.3	2.8E-132	113	379	267

Status

Unreviewed

Ensembl Protein

ENSSHAP00000008728

UniProt Accession

G3VZX3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCZ

Gene Synonyms/Alias

PRKCZ;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000007558	ENSSHAP00000008728	ENSSHAT00000008800

Organism

Sarcophilus harrisii

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

QRAYCGQCSE RIWGLGRQGY KCINCKLLVH KRCHILVPLT CKRHMDSVMP SQEPQIDDKN 60

DEVDLPSEET DGHNYISRDE SHESANEDEE DIKPVIDGMD GIKISQGLGL QDFDLIRVIG 120

RGSYAKVLLV RLKKNDQIYA MKVVKKELVH DDEDIDWVQT EKHVFEQASS NPFLVGLHSC 180

FQTTSRLFLV IEYVNGGDLM FHMQRQRKLP EEHARFYAAE ICIALNFLHE RGIIYRDLKL 240

DNVLLDAEGH IKLTDYGMCK EGLGPGDTTS TFCGTPNYIA PEILRGEEYG FSVDWWALGV 300

LMFEMMAGRS PFDIITDNPD MNTEDYLFQV ILEKPIRIPR FLSVKASHVL KGFLNKDPKE 360

RLGCQPQTGF SDIKSHTFFR SIDWDLLEKK QALPPFQPQI TDDYGLDNFD TQFTSEPVQL 420

TPDDEDVIKR IDQSEFEGFE YINPLLLSTE ESV 453

Nucleotide Sequence
(FASTA)

CAGAGAGCAT ACTGTGGCCA GTGCAGCGAA AGGATATGGG GTCTCGGAAG GCAAGGCTAC 60

AAGTGTATCA ACTGCAAATT ACTGGTCCAT AAACGTTGTC ATATACTTGT ACCACTGACC 120

TGCAAAAGGC ATATGGATTC GGTGATGCCT TCCCAAGAAC CTCAAATAGA TGATAAAAAC 180

GATGAAGTCG ACCTTCCCTC CGAAGAAACT GATGGACATA ACTATATATC TAGGGATGAA 240

AGTCATGAGA GTGCAAATGA GGATGAGGAG GACATTAAGC CAGTTATTGA TGGAATGGAT 300

GGAATTAAAA TATCTCAGGG GCTCGGGCTG CAGGACTTCG ATTTAATCAG AGTTATTGGA 360

CGGGGAAGTT ATGCCAAAGT TCTCTTAGTG CGGTTGAAAA AGAATGATCA GATTTATGCC 420

ATGAAGGTAG TCAAAAAGGA GTTGGTCCAC GATGATGAAG ACATCGACTG GGTACAGACA 480

GAGAAGCATG TATTTGAACA GGCCTCCAGC AACCCATTTC TTGTGGGCCT ACATTCCTGC 540

TTCCAGACTA CGAGTCGGTT ATTCCTTGTC ATCGAGTATG TGAATGGAGG GGATCTCATG 600

TTTCATATGC AAAGGCAAAG AAAGCTTCCG GAGGAGCACG CCAGGTTTTA TGCTGCTGAA 660

ATATGTATTG CTCTAAACTT CCTCCATGAA CGGGGAATTA TCTACAGGGA CTTAAAACTA 720

GATAATGTCC TCTTAGATGC GGAAGGTCAC ATCAAATTAA CAGATTACGG AATGTGCAAG 780

GAAGGATTGG GCCCAGGTGA CACAACAAGC ACTTTCTGTG GGACACCAAA TTACATCGCC 840

CCAGAAATCC TAAGGGGAGA AGAATACGGG TTCAGTGTGG ACTGGTGGGC CCTTGGCGTC 900

CTGATGTTTG AGATGATGGC GGGAAGATCG CCATTTGATA TAATCACAGA CAATCCGGAC 960

ATGAACACTG AAGATTACCT CTTCCAAGTT ATCCTTGAGA AGCCTATCCG AATCCCCAGA 1020

TTTCTCTCTG TCAAAGCCTC CCACGTCTTA AAAGGATTTT TAAATAAGGA TCCCAAAGAG 1080

AGGCTTGGTT GCCAACCGCA AACGGGATTT TCAGATATCA AGTCTCACAC GTTCTTCCGC 1140

AGCATAGACT GGGATCTGCT GGAGAAGAAG CAAGCCCTTC CTCCATTTCA GCCTCAGATA 1200

ACCGATGATT ATGGTCTGGA TAACTTTGAT ACACAGTTCA CCAGCGAACC TGTGCAGCTA 1260

ACCCCAGATG ACGAGGATGT AATAAAAAGA ATAGACCAGT CCGAGTTTGA AGGATTTGAA 1320

TACATCAATC CCTTGTTGCT TTCTACAGAA GAGTCAGTAT GA 1362

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 113   FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  172

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g

Q: 173   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  232

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlldaeGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s

Q: 233   IIYRDLKLDNVLLDAEGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  292

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233

         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg

Q: 293   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  352

         **************************999*******************************

S: 234   lltkdpekrlGvk.eegeedikehaff  259

         +l+kdp++rlG++ ++g +dik+h+ff

Q: 353   FLNKDPKERLGCQpQTGFSDIKSHTFF  379

         ************989***********9

Domain Sequence
(FASTA)

FDLIRVIGRG SYAKVLLVRL KKNDQIYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60

FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120

IIYRDLKLDN VLLDAEGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180

VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240

FLNKDPKERL GCQPQTGFSD IKSHTFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013