EKS-SAH-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	317.3	9.5E-95	907	1176	270

Status

Unreviewed

Ensembl Protein

ENSSHAP00000008797

UniProt Accession

G3W042;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000007617	ENSSHAP00000008797	ENSSHAT00000008870

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1197

Protein Sequence
(FASTA)

KMPLCHCAAR HSDSDGEWGH PSSSGLKVLL HWSNGGDQYV TYNQGTMTAE EVCIHIAQKV 60

GITPLCYNLF ALYDTQAQVW LPPNHLFEIT KDTNQTLQFR MRYYFRNWHG LNTQEPAVYR 120

SMPRGFEVSE EKTRIEQGCA LLDKASFEYL YEQGKFEFVN DVASLSDLHS DAEVQHFKNE 180

SLGMAVLHLS HLALQRGVPL EEVVRKTSFK DCIPCSFSRQ IQQNNSLTKF RLRNVFQKFM 240

RRFHLQTVGP GRFSEQDIMF KYLATLEQLA PRFGTERFLA LTLALPTEAE RDLCYVNSSE 300

QGPTLPPGAT LSLADQAPTH EVLVTGTSGI HWRLLQVEDS DLKVNHSQSS LGKKSKTREA 360

ESRKLSQLPT ERKETVWTYF CDFQDITHIV VKENNVSIHR QDNKCLELTL PSPMVALSLV 420

SLVDGYFRLT ADSSHYLCHE VAPPRLVMSI QNGIHGPLQE PYVLSKLKRE EVEDGLYLIR 480

WSSFDFHRLI LTVARKDQAA GAQGLRYKQF RIEEQGLTFQ LEGWDQAFPS VRELTAALQG 540

CTLRSSSGSG PGSTLESFTL SKCCLPRAGE ISNLIITRQR PKEGPKSLNL SQLSFHQIRK 600

EEITQLAHLG QGTRTNIYEG LLHVGGGMGA EDEEDENIPS EPNNNHRELR VVLKVLDPSH 660

RDIALAFFET ASLMSQVSHI HLAFVHGVCV RGSENIMVAE HVEHGPLDVC LRREKGHVPV 720

AWKITVAQQL ASALSYLEDK NLVHGNVCAK NILLARRGLG DGTQPFIKLS DPGVSVTALS 780

REERVERIPW IAPECVPSGT GLSTAADKWS FGTTLLEICF DGEAPLQGRS PSEKERFYEK 840

KHRLPEPSCK ELATLISQCL TYDASQRPSF RTILRDLTQL QPQNLDITTM SPEFPASDPT 900

IFQKRYLKKI RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK SLKAGCSSQL LSSWQREIEI 960

LRTLYHEHIV KYKGCCSDQG EKMVQLIMEY VPLGSLRDYL PKHSLGLAQI LLFAQQICEG 1020

MAYLHSQHYI HRDLAARNVL LENDNTIKIG DFGLAKAVPE GHDYYCVRED GDSPVFWYAM 1080

ECLKECKFYY ASDVWSFGVT FYELLTRCDC NQTPPLKFIE MIGVTQGQMT VLRLIDLLER 1140

GQRLPCPKDC PCEIYLLMKN CWESEASFRP TFQNLVPLLK TFHEKYRSQA PSVFSVC 1197

Nucleotide Sequence
(FASTA)

AAGATGCCAT TATGTCACTG TGCTGCAAGA CACAGTGACT CTGATGGAGA GTGGGGCCAT 60

CCCAGCAGCA GCGGGCTCAA GGTTCTTCTC CACTGGAGCA ATGGGGGTGA CCAGTATGTG 120

ACCTACAATC AGGGTACCAT GACTGCAGAG GAAGTCTGCA TTCACATTGC ACAGAAAGTG 180

GGAATCACTC CACTCTGCTA CAACCTCTTT GCATTATATG ATACCCAGGC TCAAGTCTGG 240

CTGCCTCCTA ACCACCTCTT TGAGATCACC AAGGATACCA ATCAAACCCT GCAGTTTCGA 300

ATGAGGTATT ACTTCAGGAA CTGGCATGGG CTGAACACTC AGGAGCCAGC TGTGTACAGA 360

AGCATGCCTC GAGGTTTTGA GGTCTCTGAA GAGAAGACCC GGATTGAGCA GGGGTGTGCT 420

TTGCTGGACA AAGCCTCCTT CGAGTACCTC TACGAACAGG GAAAGTTTGA GTTTGTCAAT 480

GATGTCGCAT CCCTTTCGGA CCTGCACAGT GACGCAGAGG TTCAGCACTT CAAGAACGAG 540

AGCTTGGGCA TGGCCGTGCT GCACCTTTCC CACCTTGCTC TGCAGCGCGG CGTGCCCCTG 600

GAAGAGGTGG TGAGGAAGAC CAGCTTCAAA GACTGCATCC CCTGTTCCTT CAGCCGACAA 660

ATCCAGCAGA ACAATTCCCT GACTAAGTTC CGCCTAAGGA ACGTTTTCCA GAAGTTTATG 720

CGACGATTCC ATCTGCAGAC AGTGGGTCCG GGGCGTTTTA GTGAACAGGA CATTATGTTC 780

AAATACCTGG CTACACTGGA ACAGCTGGCC CCGCGCTTTG GCACTGAACG CTTCCTTGCC 840

CTGACCTTGG CGTTGCCCAC GGAGGCTGAA AGGGATCTGT GCTATGTCAA CAGCAGTGAG 900

CAAGGGCCTA CGCTTCCACC GGGAGCTACT CTCTCTCTCG CTGACCAGGC TCCTACCCAT 960

GAGGTTCTAG TGACTGGGAC AAGTGGTATC CATTGGCGGC TTCTTCAGGT GGAGGACTCT 1020

GACTTGAAAG TCAACCACTC CCAAAGCTCC CTTGGTAAGA AGTCCAAGAC CCGGGAGGCA 1080

GAAAGCCGGA AGCTGAGCCA GTTGCCCACT GAGAGGAAAG AGACTGTCTG GACATATTTT 1140

TGTGACTTCC AAGATATCAC CCATATTGTG GTCAAGGAGA ACAACGTCAG CATCCACCGT 1200

CAGGACAACA AGTGCCTGGA ACTGACTCTC CCTTCACCTA TGGTGGCACT CTCTCTGGTA 1260

TCCCTGGTTG ATGGCTACTT CAGGCTGACA GCAGACTCCA GCCACTACCT GTGCCATGAG 1320

GTGGCCCCCC CGAGGCTGGT GATGAGCATT CAAAATGGCA TCCATGGGCC CCTGCAGGAG 1380

CCTTATGTAC TGTCCAAACT GAAGCGAGAG GAAGTAGAGG ATGGCCTCTA CCTTATCCGC 1440

TGGAGTTCCT TTGACTTCCA CCGCCTCATC CTGACTGTGG CCCGGAAAGA CCAGGCAGCT 1500

GGAGCACAGG GTCTCCGTTA CAAGCAGTTC CGCATTGAAG AGCAGGGCCT GACCTTCCAG 1560

CTTGAAGGCT GGGATCAAGC CTTTCCCAGT GTTCGTGAGC TCACTGCAGC CCTACAAGGC 1620

TGCACACTGC GATCCAGCTC TGGCTCTGGT CCTGGCTCTA CCCTAGAGAG CTTCACACTC 1680

AGCAAATGCT GCCTGCCTCG AGCAGGAGAA ATTTCCAATC TGATCATTAC TCGGCAGCGT 1740

CCTAAGGAGG GTCCCAAATC ACTTAACTTG TCCCAGCTCA GCTTCCATCA GATCCGAAAG 1800

GAAGAAATCA CCCAGCTGGC TCACCTGGGC CAAGGCACCC GGACCAATAT TTACGAGGGA 1860

CTCCTGCACG TGGGGGGTGG AATGGGAGCT GAGGATGAGG AAGATGAAAA CATTCCCTCA 1920

GAACCCAACA ACAACCATCG GGAGCTTCGA GTAGTGCTAA AGGTGTTGGA TCCAAGTCAC 1980

CGCGATATTG CTCTGGCATT TTTTGAGACA GCCAGCCTAA TGAGCCAGGT CTCCCACATC 2040

CACCTGGCCT TCGTCCATGG TGTTTGTGTC CGGGGCTCTG AGAACATCAT GGTGGCAGAA 2100

CATGTAGAAC ATGGGCCCCT GGATGTATGT CTGCGGCGGG AGAAGGGCCA TGTGCCAGTG 2160

GCCTGGAAGA TTACTGTGGC CCAGCAGCTT GCCAGTGCTC TCAGCTACCT AGAGGACAAA 2220

AACCTGGTTC ACGGCAACGT CTGTGCCAAG AACATCCTGC TGGCAAGGCG AGGCCTTGGG 2280

GATGGCACTC AACCCTTCAT CAAACTCAGT GATCCTGGCG TCAGCGTCAC GGCCCTCTCC 2340

AGGGAGGAGC GGGTAGAGCG CATTCCCTGG ATCGCCCCCG AGTGTGTCCC CAGCGGGACG 2400

GGTCTCAGCA CAGCCGCTGA CAAGTGGAGC TTTGGAACGA CACTGTTAGA GATCTGCTTT 2460

GATGGGGAAG CGCCTCTCCA GGGTCGTAGC CCTTCTGAGA AGGAGCGATT TTATGAAAAG 2520

AAGCATCGGC TCCCTGAGCC CTCATGCAAG GAGCTGGCCA CGCTCATCAG CCAGTGCCTC 2580

ACCTATGATG CCAGCCAGCG GCCCTCCTTC CGAACCATCC TGCGTGATCT CACGCAGCTG 2640

CAGCCCCAGA ATCTTGACAT CACCACCATG AGCCCAGAGT TCCCAGCCTC AGATCCCACC 2700

ATTTTTCAGA AACGCTACCT GAAGAAGATC CGGGACCTGG GAGAGGGCCA CTTTGGCAAG 2760

GTGAGCCTCT ACTGCTATGA CCCAACTAAT GATGGCACAG GGGAGATGGT GGCTGTGAAG 2820

TCTCTCAAGG CTGGCTGCAG TTCCCAGCTC CTGAGCAGCT GGCAGCGGGA GATTGAGATC 2880

CTCCGGACGC TCTACCACGA GCACATCGTC AAGTATAAGG GCTGCTGCAG TGACCAAGGG 2940

GAGAAGATGG TCCAGCTGAT CATGGAGTAT GTGCCACTGG GCAGCTTGCG GGATTATCTC 3000

CCCAAACACA GCTTGGGGCT GGCCCAGATT CTGCTGTTTG CTCAGCAGAT CTGTGAGGGC 3060

ATGGCCTACC TCCATTCCCA ACACTACATC CACCGAGACC TGGCAGCCCG AAATGTCCTT 3120

CTGGAGAATG ACAACACTAT CAAGATTGGG GACTTTGGTC TGGCCAAGGC TGTGCCAGAG 3180

GGCCACGATT ATTACTGTGT CCGGGAGGAT GGAGACAGCC CTGTCTTCTG GTATGCTATG 3240

GAGTGTCTCA AGGAGTGTAA GTTCTACTAC GCCTCCGACG TCTGGTCCTT TGGGGTCACC 3300

TTCTACGAAC TGCTGACACG CTGTGACTGC AATCAAACCC CACCCTTGAA ATTCATCGAA 3360

ATGATTGGGG TCACCCAGGG CCAGATGACA GTGCTGAGGC TCATAGACCT GCTAGAGAGA 3420

GGCCAAAGAC TGCCTTGTCC CAAGGACTGT CCCTGTGAGA TCTATCTTCT CATGAAGAAT 3480

TGCTGGGAAT CTGAAGCCTC CTTCCGCCCA ACCTTCCAGA ACCTTGTTCC CCTCCTCAAG 3540

ACATTCCATG AGAAGTATAG AAGTCAAGCT CCCTCTGTGT TTAGTGTATG CTGA 3594

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk  ++ +  ++++re+eil++l+h

Q: 907   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKSLKaGCSSQLLSSWQREIEILRTLYH  966

         6899*********************************99*********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         ehivk+kg+c ++ge+  +l+meyv+ GsL++yL+k+  +l l++ l +a+q++++m+YL

Q: 967   EHIVKYKGCCSDQGEKmvQLIMEYVPLGSLRDYLPKH--SLGLAQILLFAQQICEGMAYL  1024

         ************************************9..9********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvL+e+++       +k++d+glakav+++ +Yy vre++ds+++w+

Q: 1025  HSQHYIHRDLAARNVLLENDNT------IKIGDFGLAKAVPEGhDYYCVREDGDSPVFWY  1078

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         a ecl+e+k +++asdvWsFgvt yellt c+ +++p    +++++ +       r++ l

Q: 1079  AMECLKECK-FYYASDVWSFGVTFYELLTrCDCNQTPplkfIEMIGVTqgqmtvlRLIDL  1137

         *********.****************************77766666668899999*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         le+++rlp+pk cp+e++ lm+nc++ e+s+rp+F++++

Q: 1138  LERGQRLPCPKdCPCEIYLLMKNCWESEASFRPTFQNLV  1176

         ************************************986

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKSLKAGC SSQLLSSWQR EIEILRTLYH 60

EHIVKYKGCC SDQGEKMVQL IMEYVPLGSL RDYLPKHSLG LAQILLFAQQ ICEGMAYLHS 120

QHYIHRDLAA RNVLLENDNT IKIGDFGLAK AVPEGHDYYC VREDGDSPVF WYAMECLKEC 180

KFYYASDVWS FGVTFYELLT RCDCNQTPPL KFIEMIGVTQ GQMTVLRLID LLERGQRLPC 240

PKDCPCEIYL LMKNCWESEA SFRPTFQNLV 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013