EKS-SAH-00006

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00006

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	503.6	8.4E-152	628	891	264

Status

Unreviewed

Ensembl Protein

ENSSHAP00000009398

UniProt Accession

G3W1U3;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB3

Gene Synonyms/Alias

EPHB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008131	ENSSHAP00000009398	ENSSHAT00000009479

Organism

Sarcophilus harrisii

Functional Description

Protein Length

997

Protein Sequence
(FASTA)

LSPSASGHVL SLSSLPPGPG SDLALPHLPE TLMDTKWVTS ELAWTSHPET GWEEVSGYDA 60

AMNPIRTYQV CNVRESSQNN WLRTGFVRRR EVQRVYVEIK FTVRDCNSIP NIPGSCKETF 120

NLFYYEADGD VASASSPFWM ENPYVKVDTI APDESFSRLD AGRVNTKVRS FGPLSKAGFY 180

LAFQDQGACM SLISVRVFYK KCARTIASFA LFPETLTGAE PTSLVIAPGT CIPNAVEASV 240

PLKLYCNGDG EWMVPVGACT CAAGYEPAAK ETQCQVGFFK GSLLLFGRVE AGVGGQESAQ 300

IESRACPPGS FKAKQGEGPC LPCPPVPSPP HSVISNVNET SLVLEWSEPR DLGGRDDLLY 360

NVICKKCQGG PGTSGLAACS RCDDNVEFVP RQLGLTERRV HVSRLLAHTR YSFEVQAVNG 420

VSGKSPLPPR YAAVNITTNQ AAPSEVPTMR LHSSSGSSLT LSWAPPERPN GIILDYEMKY 480

FEKSEGIAST VTSQRNSVQL DGLRPDACYV VQVRARTVAG YGQYSHPAEF ETTGERGSGP 540

QQLQEQLPLI VGSATAGLVF LVVVVVIAFV CLRKQRHGSD SEYTEKLQQY TRGRLVAPGM 600

KVYIDPFTYE DPNEAVREFA KEIDVSCVKI EEVIGAGEFG EVCRGRLKQP GRRELFVAIK 660

TLKAGYTERQ RRDFLSEASI MGQFDHPNII RLEGVVTKSR PVMILTEFME NCALDSFLRL 720

NDGQFTVIQL VGMLRGIAAG MKYLSEMNYV HRDLAARNIL VNSNLVCKVS DFGLSRFLED 780

DPADPTYTRV MCPTQGGKIP IRWTAPEAIA YRKFTSASDV WSYGIVMWEV MSYGERPYWD 840

MSNQDVINAV EQDYRLPPPM DCPTALHQLM LDCWVRDRNL RPKFAQIVNT LDKLIRNAAS 900

LKVIASVQSG VSQPLLDRTV PDYTTFTTVG DWLDAIKMGR YKESFISAGF ASFDLVAQMT 960

AEDLLRIGVT LAGHQKKILS SIQDMRLQMN QTLPVQV 997

Nucleotide Sequence
(FASTA)

CTCAGTCCCT CTGCCTCGGG CCATGTCCTC TCCTTATCTT CTCTGCCTCC CGGCCCAGGG 60

TCTGACCTTG CTCTTCCTCA CCTTCCAGAG ACCCTCATGG ACACAAAGTG GGTGACGTCT 120

GAGCTGGCGT GGACGTCCCA TCCAGAAACT GGGTGGGAAG AGGTCAGCGG GTACGATGCG 180

GCCATGAACC CCATCCGGAC GTACCAGGTG TGCAACGTGC GGGAGAGCAG CCAGAACAAC 240

TGGCTGCGGA CGGGCTTCGT CCGGCGGCGC GAGGTGCAGC GGGTGTACGT GGAGATCAAG 300

TTCACCGTTC GGGACTGCAA CAGCATCCCC AACATCCCCG GCTCCTGCAA AGAGACGTTC 360

AACCTGTTCT ACTACGAGGC GGACGGCGAC GTGGCCTCCG CCTCCAGCCC CTTCTGGATG 420

GAGAACCCCT ACGTCAAGGT GGACACCATC GCGCCCGACG AGAGCTTCTC CCGCCTGGAC 480

GCGGGCCGCG TCAACACCAA GGTGCGCAGC TTCGGGCCCC TCTCCAAGGC CGGCTTCTAC 540

CTGGCCTTCC AGGACCAGGG GGCCTGCATG TCGCTCATCT CCGTGCGCGT CTTCTACAAG 600

AAGTGCGCCC GAACCATCGC CAGCTTCGCC CTCTTCCCGG AGACCCTGAC GGGCGCCGAG 660

CCCACCTCCC TGGTCATCGC TCCCGGCACC TGCATCCCCA ATGCCGTGGA GGCCTCGGTG 720

CCCCTCAAGC TCTACTGCAA CGGGGACGGC GAGTGGATGG TGCCCGTGGG GGCCTGCACC 780

TGTGCCGCCG GCTACGAGCC CGCTGCCAAG GAGACCCAGT GCCAAGTGGG GTTTTTTAAA 840

GGATCATTAT TGCTTTTTGG CCGAGTTGAG GCGGGTGTCG GGGGACAAGA AAGCGCCCAA 900

ATAGAATCCC GGGCCTGCCC CCCCGGGAGT TTCAAGGCGA AACAGGGAGA GGGGCCCTGC 960

CTCCCCTGCC CCCCTGTGCC ATCCCCCCCG CACAGCGTGA TTTCCAACGT GAACGAGACC 1020

TCGCTGGTGC TGGAGTGGAG CGAGCCACGG GACCTGGGGG GCCGGGACGA CCTCCTCTAT 1080

AACGTCATCT GCAAGAAATG CCAGGGGGGC CCCGGGACGT CGGGCCTGGC CGCCTGCTCC 1140

CGCTGCGACG ACAACGTGGA GTTTGTGCCC CGGCAGCTGG GGCTGACGGA GCGGCGGGTG 1200

CACGTGAGCC GTCTGCTGGC CCACACGCGC TACAGCTTCG AGGTGCAGGC TGTTAATGGG 1260

GTCTCCGGCA AGAGCCCCCT GCCCCCGCGC TACGCCGCCG TGAACATCAC CACCAACCAG 1320

GCCGCTCCGT CGGAGGTTCC CACCATGCGT CTGCACAGCA GCTCCGGCAG CAGCCTGACC 1380

CTGTCCTGGG CGCCCCCGGA GCGGCCCAAC GGTATCATCC TAGACTACGA GATGAAGTAT 1440

TTTGAAAAGA GCGAGGGCAT CGCCTCCACG GTGACCAGCC AGAGGAACTC GGTGCAGCTG 1500

GACGGTCTGC GGCCAGACGC CTGCTACGTG GTCCAGGTCC GGGCGCGGAC CGTGGCCGGC 1560

TACGGGCAGT ACAGCCACCC GGCCGAGTTT GAGACCACGG GGGAGAGAGG TTCAGGACCC 1620

CAACAGCTCC AAGAGCAGCT GCCCCTCATC GTGGGCTCGG CTACGGCCGG GCTGGTTTTC 1680

CTCGTGGTGG TCGTGGTCAT CGCTTTCGTC TGCCTCAGGA AGCAGCGCCA CGGCTCTGAC 1740

TCAGAGTACA CGGAGAAGCT GCAGCAGTAC ACCAGGGGAC GGCTTGTTGC TCCCGGCATG 1800

AAGGTTTACA TCGACCCCTT CACTTACGAA GACCCCAACG AGGCCGTGAG GGAGTTTGCC 1860

AAAGAGATTG ACGTCTCTTG CGTCAAGATT GAGGAGGTGA TCGGAGCTGG GGAGTTTGGC 1920

GAGGTGTGCA GGGGCCGGCT GAAGCAGCCG GGCCGCCGGG AGCTCTTCGT GGCCATAAAG 1980

ACCCTGAAGG CCGGCTACAC GGAAAGGCAG CGGCGAGACT TCCTGAGCGA GGCGTCCATC 2040

ATGGGCCAGT TTGACCATCC CAACATCATC CGCCTGGAAG GCGTGGTCAC CAAGAGCCGG 2100

CCCGTCATGA TCCTCACAGA GTTCATGGAG AACTGCGCCC TCGACTCCTT CCTCCGGCTG 2160

AACGACGGGC AGTTCACCGT GATCCAGCTG GTGGGCATGT TACGGGGCAT CGCGGCGGGC 2220

ATGAAGTACC TGTCGGAGAT GAACTACGTG CACCGGGACC TGGCCGCCCG CAACATCCTG 2280

GTCAACAGCA ATCTGGTCTG CAAAGTGTCC GACTTCGGCC TCTCGCGCTT TCTCGAGGAC 2340

GACCCCGCTG ACCCCACCTA CACCAGGGTA ATGTGCCCAA CCCAGGGCGG GAAGATCCCC 2400

ATCCGATGGA CGGCCCCGGA AGCCATCGCT TACCGCAAGT TCACGTCGGC CAGCGACGTC 2460

TGGAGTTATG GGATCGTCAT GTGGGAAGTG ATGAGTTACG GAGAACGGCC CTACTGGGAC 2520

ATGAGCAATC AAGATGTGAT CAATGCCGTG GAGCAGGACT ACCGCCTGCC GCCCCCCATG 2580

GACTGCCCCA CCGCCCTGCA CCAGCTTATG CTGGACTGCT GGGTGCGGGA CCGCAACCTG 2640

AGACCCAAGT TTGCCCAGAT CGTCAACACT TTGGACAAGC TCATCCGCAA CGCCGCCAGC 2700

CTGAAGGTCA TCGCCAGCGT GCAGTCTGGG GTGTCCCAGC CCCTGTTAGA CCGCACTGTT 2760

CCTGACTACA CCACCTTCAC CACGGTGGGG GACTGGCTGG ACGCCATCAA GATGGGGAGG 2820

TACAAGGAAA GCTTCATCAG CGCCGGCTTC GCCTCCTTCG ACCTCGTGGC CCAGATGACG 2880

GCAGAGGACC TGCTCCGGAT TGGAGTGACT TTGGCGGGAC ACCAGAAGAA GATCCTGAGC 2940

AGCATCCAGG ATATGCGGCT GCAGATGAAC CAAACGCTGC CGGTGCAGGT CTGA 2994

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlkag+te+qrrdflseasi+Gqfdhp

Q: 628   VKIEEVIGAGEFGEVCRGRLKQPGRRELFVAIKTLKAGYTERQRRDFLSEASIMGQFDHP  687

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m

Q: 688   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  747

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaayt.....tsggkipirwtape  174

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt     t+ggkipirwtape

Q: 748   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPaDPTYTrvmcpTQGGKIPIRWTAPE  807

         ***********************************9****97777678************

S: 175   aiayrkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaaly  234

         aiayrkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+

Q: 808   AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALH  867

         ************************************************************

S: 235   qlmldcwqkdraerpkfeqivsil  258

         qlmldcw +dr+ rpkf+qiv++l

Q: 868   QLMLDCWVRDRNLRPKFAQIVNTL  891

         *********************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KQPGRRELFV AIKTLKAGYT ERQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPADPTY TRVMCPTQGG KIPIRWTAPE 180

AIAYRKFTSA SDVWSYGIVM WEVMSYGERP YWDMSNQDVI NAVEQDYRLP PPMDCPTALH 240

QLMLDCWVRD RNLRPKFAQI VNTL 264

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013