EKS-SAH-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.6	7.5E-150	654	911	258

Status

Unreviewed

Ensembl Protein

ENSSHAP00000009645

UniProt Accession

G3W2J0;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008346	ENSSHAP00000009645	ENSSHAT00000009730

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1152

Protein Sequence
(FASTA)

VCQGTSNKLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY VQKGYDLSFL KTIQEVSGYV 60

LIALNTVEKI PLENLQIIRG NVLYENFYAL SVLSNYDVNK TGVRELPMRS LLEILVGGVR 120

FNNNPALCNV HTIQWKDIVD SSFFNNISID NNNPPKNCEK CNSSCPNGSC WGPGPHNCQT 180

CKYMDFCTYF CTEFLQWTLI IKAIFLIMAW NLSRNLSLFD FTRHGGELFI AKTQLREGKT 240

GQFALVVIVV LTLSLPGLFF CLVVEGWMQY CQLISRTIYL AVQSSLIYEK SLVSGLNKVN 300

EKSIIITKII LLSVCSGKCW RKNPPPPPWE LLLLTLNLLT GFLLIQAWPE NMTDLHAFEH 360

LEIIRGRTKQ HGQFSLAIVG LDITSLGLRS LKEISDGDVV ISRNRQLCYA NTINWTKLFG 420

TKSQKTKITN NKDEKECQAL EHVCHSLCSS DGCWGPKPSH CLSCRHVSRN KKCVAKCNIF 480

EGEPREYMED LKCMQCHPEC LPQVQNQTCT GPGPDKCIEC AHFIDGPHCV KTCPAGIMGE 540

NDTLVWKYAD ANKVCQRCHP NCTYGCEGPG LEGCPTSGPH SSPRIPSIAI GIVGGFLLLM 600

VLSLGIGLFI RRRHIVRKRT LRRLLQEREL VEPLTPSGEA PNQALLRILK ETEFKKIKVL 660

GSGAFGTVYK GLWIPEGEKV KIPVAIKELR EATSPKANKE ILDEAYVMAS VDNPHVCRLL 720

GICLTSTVQL ITQLMPFGCL LDYIREHKDN IGSQYLLNWC VQIAKGMSYL EERRLVHRDL 780

AARNVLVKTP QHVKITDFGL AKLLGAEEKE YHAEGGKVPI KWMALESILH RIYTHQSDVW 840

SYGVTVWELM TFGSKPYDGI PASEISSILE KGERLPQPPI CTIDVYMIMV KCWMIDADSR 900

PKFRELIVEF SKMARDPQRY LVIQGDERMH LPSPTDSKFY RTLMEEEDME DIVDADEYLI 960

PQQGFFNSPS TSRTPLLSSL SATSNNSATV CIDRNGTCPV KEESFIQRYS SDPTTVLFED 1020

NVDDSFQPVP EYINQSAPKN RMGSAIQNPV YHNQPLNPDA SKDSLYQNSH NSSAVDNPEY 1080

LNTTQPNLVK KTFDSNSCWN PTANHPISLD NPDYQQDFFP QEAKPNGVYK VPAAENPEYL 1140

RVAAQQSEFI QA 1152

Nucleotide Sequence
(FASTA)

GTTTGCCAAG GAACAAGTAA TAAGCTGACC CAGTTGGGTA CTTTTGAAGA CCACTTCTTG 60

AGTCTCCAAA GGATGTTTAA TAATTGTGAG GTAGTACTTG GAAATTTGGA AATTACCTAT 120

GTCCAGAAAG GTTATGACCT TTCCTTCCTA AAAACCATCC AGGAGGTTTC TGGCTATGTG 180

CTTATTGCTC TCAATACAGT AGAGAAGATT CCTTTGGAAA ATTTGCAGAT CATCAGAGGA 240

AATGTGTTAT ATGAAAACTT TTATGCACTT TCTGTGCTCT CCAATTATGA TGTGAATAAA 300

ACAGGAGTGA GGGAATTGCC CATGAGGAGT CTCCTCGAAA TTCTTGTTGG TGGTGTTCGG 360

TTCAACAATA ACCCAGCTCT GTGTAATGTG CATACAATCC AGTGGAAGGA TATTGTGGAC 420

TCCAGCTTTT TCAACAATAT CTCAATAGAC AATAACAATC CTCCTAAGAA TTGTGAAAAG 480

TGTAATTCTA GTTGTCCCAA TGGAAGCTGT TGGGGTCCTG GACCACACAA TTGCCAGACT 540

TGTAAGTATA TGGATTTTTG TACTTATTTT TGCACTGAGT TTCTTCAATG GACACTAATT 600

ATAAAAGCTA TTTTTCTGAT AATGGCTTGG AACCTATCTA GGAATCTTAG CTTATTTGAC 660

TTCACCAGGC ATGGTGGTGA ACTTTTCATT GCTAAAACTC AATTAAGGGA AGGTAAGACT 720

GGCCAATTCG CACTGGTAGT GATTGTTGTG CTGACTCTTA GCCTTCCCGG ATTGTTCTTC 780

TGTCTGGTTG TTGAAGGCTG GATGCAATAT TGTCAGCTGA TTTCAAGAAC GATCTATCTT 840

GCTGTACAAT CTTCCTTAAT TTATGAAAAA TCTCTAGTGT CAGGCCTGAA CAAGGTCAAT 900

GAAAAAAGTA TAATCATCAC AAAGATTATT CTTCTCAGTG TTTGTAGTGG AAAATGCTGG 960

AGAAAAAACC CCCCCCCCCC CCCTTGGGAA CTACTACTGC TAACTCTAAA TCTACTTACA 1020

GGATTTTTGC TGATTCAGGC TTGGCCTGAA AACATGACTG ACCTTCATGC TTTTGAACAT 1080

CTGGAAATTA TACGGGGCCG AACAAAGCAA CATGGTCAAT TTTCTCTTGC TATTGTTGGT 1140

TTGGACATAA CTTCCTTGGG CTTACGTTCC CTTAAGGAAA TCAGTGATGG CGATGTCGTC 1200

ATTTCAAGAA ACAGACAACT CTGCTATGCA AACACAATAA ACTGGACTAA ACTGTTTGGA 1260

ACAAAAAGTC AGAAAACCAA AATCACCAAC AACAAAGATG AAAAAGAGTG TCAGGCTCTG 1320

GAGCATGTTT GTCATTCATT GTGCTCATCT GATGGTTGCT GGGGTCCAAA ACCAAGCCAC 1380

TGCTTGTCCT GTCGCCATGT AAGCCGTAAC AAGAAATGTG TCGCAAAATG CAACATTTTT 1440

GAAGGAGAAC CAAGAGAATA CATGGAAGAT CTGAAATGTA TGCAATGCCA CCCTGAGTGT 1500

CTGCCTCAGG TCCAGAATCA AACCTGCACA GGACCGGGTC CTGACAAATG TATAGAGTGT 1560

GCTCACTTTA TAGATGGTCC ACACTGTGTT AAGACTTGTC CAGCTGGAAT CATGGGAGAA 1620

AATGATACCT TGGTCTGGAA ATATGCTGAT GCAAATAAGG TTTGCCAACG ATGCCATCCC 1680

AATTGTACCT ATGGGTGTGA AGGTCCAGGT CTTGAAGGAT GTCCCACATC TGGTCCTCAT 1740

TCTAGCCCCA GGATTCCTTC CATTGCTATT GGAATTGTCG GTGGCTTTCT TTTATTAATG 1800

GTTTTGAGCC TTGGTATTGG TCTCTTCATT CGAAGGCGCC ATATTGTCCG TAAACGTACA 1860

CTACGCAGGC TGCTACAAGA AAGAGAGCTA GTTGAGCCTC TCACCCCCAG TGGAGAAGCT 1920

CCCAATCAGG CTCTTTTACG GATCCTCAAG GAGACAGAAT TTAAAAAGAT CAAAGTCCTT 1980

GGCTCTGGAG CTTTTGGCAC AGTGTATAAG GGACTGTGGA TTCCAGAAGG AGAGAAGGTG 2040

AAAATTCCTG TCGCCATTAA AGAGTTAAGA GAGGCTACTT CTCCGAAAGC CAATAAGGAA 2100

ATTCTTGATG AAGCCTATGT AATGGCCAGT GTGGACAATC CCCATGTGTG TCGTCTCCTG 2160

GGAATCTGTC TGACCTCTAC AGTCCAACTC ATAACACAGC TCATGCCATT CGGCTGCCTC 2220

CTGGACTACA TACGGGAACA CAAGGACAAC ATTGGCTCCC AGTATCTTCT CAACTGGTGT 2280

GTGCAGATAG CCAAGGGTAT GAGTTACCTA GAAGAGCGCC GCTTGGTACA CCGTGACTTA 2340

GCAGCCAGAA ATGTCCTTGT GAAGACACCT CAACACGTCA AAATTACAGA TTTTGGGCTG 2400

GCAAAATTGC TTGGTGCTGA AGAAAAAGAA TACCATGCAG AAGGAGGCAA GGTGCCTATT 2460

AAGTGGATGG CTTTGGAATC GATTTTACAC CGAATTTATA CCCACCAAAG TGATGTCTGG 2520

AGCTATGGTG TCACAGTTTG GGAGCTAATG ACATTTGGAT CCAAACCTTA TGATGGAATT 2580

CCTGCAAGTG AAATTTCATC TATATTAGAA AAGGGGGAAC GCCTTCCCCA GCCACCTATC 2640

TGCACTATTG ATGTGTACAT GATCATGGTC AAATGCTGGA TGATAGATGC TGATAGTCGC 2700

CCTAAATTTC GTGAGTTAAT TGTAGAATTC TCTAAAATGG CCCGAGATCC TCAGCGCTAC 2760

CTTGTTATAC AGGGAGATGA AAGAATGCAC TTGCCAAGCC CCACAGACTC CAAATTTTAT 2820

CGCACCCTGA TGGAAGAGGA GGACATGGAA GATATCGTAG ATGCAGATGA GTACCTCATT 2880

CCGCAGCAAG GTTTCTTCAA CAGCCCCTCC ACATCCCGCA CGCCTCTTCT AAGCTCTCTG 2940

AGTGCTACCA GCAATAATTC TGCCACAGTT TGCATTGATA GAAATGGGAC TTGTCCTGTG 3000

AAGGAAGAAA GCTTCATTCA GCGATACAGT TCTGATCCCA CCACTGTCTT ATTTGAAGAC 3060

AATGTGGATG ATAGCTTCCA GCCTGTACCC GAATATATAA ACCAGTCGGC TCCCAAAAAC 3120

CGCATGGGTT CTGCCATCCA GAACCCTGTC TATCACAACC AGCCTTTAAA CCCAGATGCC 3180

TCTAAAGACT CTCTGTACCA AAACTCACAC AACAGCAGTG CAGTGGACAA CCCTGAGTAT 3240

CTCAACACAA CCCAGCCTAA CTTAGTCAAA AAGACCTTCG ACAGCAATTC TTGCTGGAAC 3300

CCAACAGCCA ACCACCCAAT CAGTCTGGAC AACCCTGACT ACCAGCAGGA CTTCTTCCCC 3360

CAGGAAGCCA AGCCAAATGG GGTTTATAAA GTTCCTGCTG CGGAAAATCC TGAGTATCTC 3420

AGAGTAGCAG CACAACAAAG TGAATTCATT CAAGCT 3456

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 654   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  713

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGmsylee+

Q: 714   PHVCRLLGICLTSTVQLITQLMPFGCLLDYIREHKDNIGSQYLLNWCVQIAKGMSYLEER  773

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 774   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  833

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 834   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  893

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 894   MIDADSRPKFRELIVEFS  911

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY IREHKDNIGS QYLLNWCVQI AKGMSYLEER 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIVEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013