EKS-SAH-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	344.8	3.8E-103	1	265	265

Status

Unreviewed

Ensembl Protein

ENSSHAP00000009713

UniProt Accession

G3W2Q8;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008408	ENSSHAP00000009714	ENSSHAT00000009799
ENSSHAG00000008408	ENSSHAP00000009713	ENSSHAT00000009798

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1278

Protein Sequence
(FASTA)

GGFAFVYEAQ DLGSGKDYAL KRLLSNEEEK NKAIIQEVCF MKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCRG QLVEFLKKVE SKGPLSCDTV LKIFYQTCRA VQHMHKQKPP 120

IIHRDLKVEN MLISNQGTIK LCDFGSATTV SHYPDYNWTA QKRAMVEEEI TRNTTPMYRT 180

PEIIDLYSNF PIGEKQDIWA LGCILYLLCF RQHPFEDGAK LRIVNGKYSI PPNDTRYTVF 240

HDLIRSTLKV NPEERLSITE LVNQLQEIAA ARNVNPKSPI TELLEHNGGY GNNMQHRGSL 300

NLVPQNTKAV GQLSNVYSGG MTVAECDQSY SGFFDILRGG TERFFTNIKD TSSKVIQSVA 360

NYAKGDLDIS YITSRIAVMS FPAEGVESAL KNNIEDVRLF LDSKHPGHYA VYNLSPRTYR 420

PSRFHNRVSE CGWPARRAPN LQNLYNICKN MHLWLKQDHK NVCIVHCIDG RAASAVVVCS 480

FLCFCRLFTT AEAAVYMFSM KRCPPGIWPS HKRYIEYMCD MMAEEPIIPH SKPILIKAVV 540

MTPVPLFSKQ RNGCRPFCEV YVGDERVTTT SQEYDKMKDF KTEDGKAVIP LGITVQGDVL 600

IVIYHARSTL GGRLQAKMAS MKMFQIQFHT GFVPRNATTV KFAKYDLDAC DIQEKYPDLF 660

QVNLEVEVEP RDRPSLETPP WDNLNMKGLN PKILFSSREE QQDILSKFGK PELPRQPGST 720

AQYEAEASQQ SPESVLTESD SPQSNSTDTN NFFHTLDWQE GKVSESGVEN NFLKENHFAL 780

NEDRDGSELS DEDPSTFPGE NKVINVEEET SSAPEKVEDE NLLFDTDYES SAQLQESQQE 840

DSVDLLGLDS EDGSEKIHAT KEIQSSSSNA DLLSNLFVAS ATISEEPTGD LLGAGTDFFF 900

SSPPPPSDNA QSTSQSVAHS SAADPFDPFT MSSSSETQSH SNPDLFEDFL NPSSAPASSS 960

VFPSTHSAPP PSSSSDFLNL GNLPTEQPTK MTTSASHPDL LGGWDSWADS SGIGNIPSPQ 1020

PAKPACEGSQ SGVTSGSSAS QAKPQSFDPF ADLANLSSSI QGSSCGFSPG GFVSKATQSS 1080

KSGSPWQTKP PNYGPSWPSQ AKSQQTKSSP QTKPNYSVNF SVIGGREERG IRAPSFAQKP 1140

KVSENDFEDL LPNQGFSSKS DKKGPKTIAE MRKQEMSKDM DPLRLKLLDW IEGKERNIRA 1200

LISTLHMVLW EGESRWKPVG MADLVTPEQV KKYYRKAVLV VHPDKAAGQP YEQYAKMIFM 1260

ELNDAWSEFE NQGSKSLF 1278

Nucleotide Sequence
(FASTA)

GGTGGGTTTG CTTTTGTATA TGAAGCTCAA GATCTTGGAA GCGGTAAAGA TTATGCTTTA 60

AAGAGGCTGC TGTCCAATGA AGAGGAAAAG AACAAAGCAA TCATTCAAGA AGTTTGTTTT 120

ATGAAAAAAC TTTCTGGGCA TCCTAACATT GTCCAGTTCT GCTCTGCTGC ATCAATAGGA 180

AAAGAAGAAT CTGATACTGG ACAAGCTGAG TTTCTTCTGC TCACTGAACT CTGCAGAGGA 240

CAGCTGGTGG AATTCTTAAA GAAAGTTGAA TCCAAAGGTC CTCTCTCCTG TGACACGGTT 300

TTGAAGATAT TTTATCAGAC ATGCAGAGCA GTACAACATA TGCATAAACA GAAGCCCCCT 360

ATAATCCATC GGGATCTCAA GGTTGAAAAT ATGCTGATTA GTAACCAAGG AACAATTAAA 420

CTATGTGATT TTGGCAGTGC TACAACCGTG TCACATTATC CTGACTACAA CTGGACTGCT 480

CAGAAGAGAG CAATGGTTGA AGAAGAGATC ACAAGGAATA CAACACCGAT GTACAGGACG 540

CCAGAAATAA TAGACTTATA CTCAAACTTT CCAATTGGTG AAAAGCAAGA TATCTGGGCC 600

TTGGGCTGTA TCCTATACCT GTTGTGCTTC AGGCAGCATC CTTTTGAAGA TGGAGCAAAA 660

CTTCGGATAG TTAATGGAAA ATATTCAATT CCACCAAATG ACACAAGATA CACAGTTTTT 720

CATGATCTCA TTCGCTCCAC ATTGAAGGTG AACCCAGAAG AAAGGTTGTC AATCACAGAA 780

CTTGTGAATC AGCTACAAGA GATAGCAGCT GCTAGAAATG TGAATCCAAA GTCACCTATC 840

ACAGAGCTTC TGGAACACAA TGGCGGTTAT GGAAATAACA TGCAACATAG AGGTTCTCTC 900

AATTTAGTGC CACAAAATAC TAAGGCCGTG GGGCAGCTCA GCAATGTGTA CAGTGGAGGC 960

ATGACAGTTG CAGAGTGTGA TCAGTCCTAT AGCGGTTTCT TTGACATACT TAGAGGAGGA 1020

ACAGAACGAT TTTTTACTAA CATCAAAGAT ACTTCTTCCA AAGTTATTCA ATCTGTTGCT 1080

AATTATGCTA AAGGAGATTT GGATATTTCA TACATCACAT CCAGAATTGC TGTGATGTCA 1140

TTTCCGGCAG AAGGTGTAGA ATCAGCTCTC AAAAATAACA TAGAAGATGT GAGGTTGTTT 1200

TTAGACTCTA AGCATCCTGG GCATTATGCT GTTTACAATC TCTCCCCAAG AACATACAGG 1260

CCTTCTAGAT TTCATAATCG GGTTTCAGAA TGTGGTTGGC CAGCAAGACG TGCACCAAAC 1320

CTTCAAAACC TTTATAATAT CTGCAAGAAT ATGCATTTAT GGCTAAAACA AGATCACAAA 1380

AATGTTTGCA TTGTGCATTG CATTGATGGA AGAGCAGCAT CAGCAGTTGT TGTTTGCTCC 1440

TTTTTATGTT TCTGTCGTCT TTTCACCACT GCTGAGGCTG CAGTTTATAT GTTTAGTATG 1500

AAGCGCTGTC CACCTGGCAT CTGGCCATCT CATAAAAGGT ATATAGAGTA CATGTGTGAC 1560

ATGATGGCAG AAGAGCCTAT TATCCCTCAT AGTAAACCAA TCCTTATTAA AGCAGTGGTG 1620

ATGACACCAG TGCCCCTGTT CAGCAAGCAG AGAAATGGCT GTAGACCCTT TTGTGAAGTC 1680

TATGTGGGAG ATGAACGAGT AACCACTACA TCTCAGGAGT ATGATAAAAT GAAGGATTTT 1740

AAAACTGAGG ATGGAAAAGC AGTCATTCCA TTAGGCATAA CAGTCCAAGG TGATGTACTC 1800

ATTGTAATTT ATCATGCAAG ATCGACTCTA GGAGGAAGAT TGCAAGCTAA GATGGCTTCA 1860

ATGAAGATGT TTCAGATTCA GTTCCACACA GGCTTTGTGC CCCGAAATGC TACAACTGTG 1920

AAGTTTGCCA AGTATGATCT GGATGCATGT GACATTCAAG AGAAATATCC TGATTTATTT 1980

CAAGTGAATC TTGAAGTAGA AGTGGAACCT AGAGACAGGC CAAGTCTTGA GACGCCACCA 2040

TGGGATAACT TAAATATGAA GGGACTGAAT CCAAAAATTC TGTTTTCCAG CCGAGAGGAG 2100

CAGCAAGACA TTTTGTCTAA ATTTGGTAAA CCAGAACTTC CTAGACAGCC TGGATCCACG 2160

GCCCAGTATG AGGCAGAAGC TTCCCAGCAG TCCCCTGAAA GTGTGCTCAC AGAGTCAGAT 2220

TCTCCACAGA GTAACAGCAC CGACACAAAC AACTTTTTTC ATACATTGGA CTGGCAAGAA 2280

GGAAAAGTAT CAGAATCTGG AGTAGAAAAT AACTTTCTTA AAGAAAACCA TTTTGCCCTG 2340

AATGAAGACA GGGATGGAAG TGAGTTGTCT GATGAAGATC CTTCTACTTT CCCTGGTGAG 2400

AACAAAGTAA TTAATGTTGA AGAAGAAACG TCAAGTGCCC CTGAAAAAGT AGAAGATGAA 2460

AATTTACTTT TCGATACAGA TTATGAATCC TCAGCCCAGC TGCAAGAGTC ACAGCAAGAA 2520

GACAGTGTTG ATTTGCTAGG TTTGGACTCT GAAGATGGTT CAGAGAAAAT CCATGCCACC 2580

AAAGAAATTC AGAGCTCTTC TAGTAATGCT GATCTGTTAA GCAATCTGTT TGTTGCCAGT 2640

GCAACCATTT CAGAAGAACC TACTGGGGAC TTGCTTGGGG CAGGGACAGA TTTCTTTTTC 2700

AGCAGCCCTC CTCCTCCTTC AGATAATGCA CAGAGTACTT CACAAAGTGT AGCACACTCT 2760

TCAGCTGCTG ATCCATTTGA TCCATTCACG ATGTCATCCA GTTCAGAAAC TCAGAGTCAT 2820

TCCAATCCAG ATCTGTTTGA AGATTTTCTT AATCCCAGTT CTGCACCAGC CTCATCCAGT 2880

GTGTTTCCTT CTACACACAG CGCACCTCCT CCTTCTTCCA GCTCTGACTT TTTAAATTTA 2940

GGAAATTTGC CAACAGAGCA GCCTACCAAA ATGACAACTT CTGCCAGTCA CCCTGATCTC 3000

TTGGGAGGAT GGGACTCCTG GGCTGATTCC TCTGGGATTG GCAATATACC ATCACCACAG 3060

CCTGCCAAAC CTGCATGTGA AGGAAGCCAG TCAGGTGTTA CCTCTGGCTC ATCTGCCAGC 3120

CAAGCTAAAC CTCAGAGCTT TGATCCCTTT GCTGACCTTG CTAACCTCAG TTCAAGTATT 3180

CAAGGTTCTT CTTGTGGCTT TTCTCCTGGG GGATTTGTCT CCAAAGCAAC TCAGTCTTCA 3240

AAAAGTGGAA GCCCGTGGCA AACAAAGCCT CCAAACTATG GTCCATCGTG GCCTTCCCAG 3300

GCAAAATCAC AACAAACCAA ATCGAGTCCA CAGACGAAAC CTAATTATTC TGTGAACTTC 3360

AGTGTTATTG GAGGACGAGA AGAGAGAGGC ATTAGAGCTC CCAGTTTTGC TCAAAAGCCA 3420

AAAGTTTCAG AAAATGATTT TGAAGATCTG TTACCCAATC AGGGATTTTC ATCGAAATCT 3480

GATAAAAAAG GACCAAAGAC AATTGCCGAG ATGAGGAAGC AAGAGATGTC TAAAGATATG 3540

GATCCTCTCA GGCTAAAGCT TCTTGATTGG ATTGAAGGAA AAGAGAGAAA TATAAGGGCA 3600

CTAATTTCCA CACTGCACAT GGTACTCTGG GAAGGAGAAA GCAGGTGGAA GCCAGTTGGC 3660

ATGGCAGACC TGGTGACTCC TGAACAGGTG AAGAAATACT ATCGAAAAGC TGTGCTGGTG 3720

GTTCATCCAG ACAAGGCCGC CGGGCAGCCA TATGAGCAGT ATGCCAAAAT GATCTTCATG 3780

GAGTTAAATG ATGCCTGGTC AGAGTTTGAA AATCAGGGAT CCAAATCCCT TTTTTAA 3837

Domain Profile

S: 10    GGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivklv..dssv  67

         GGfa+vy a+d+ +g+ yalKr+l+neee++++i++E+++mkklsgh+niv+++  +s

Q: 1     GGFAFVYEAQDLGSGKDYALKRLLSNEEEKNKAIIQEVCFMKKLSGHPNIVQFCsaASIG  60

         9*****************************************************877888

S: 68    keekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtravaalHalsv  127

         kee+d+g++e+lll+e+c+ g+lv++l+k ++kg ls++++lki+++++rav+++H++++

Q: 61    KEESDTGQAEFLLLTELCR-GQLVEFLKKVESKGPLSCDTVLKIFYQTCRAVQHMHKQKP  119

         999***************9.8***************************************

S: 128   pliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeieknttlsyr  184

         p+iHRDlkveN+l+s++g+++lcD+GSatt ++ ++   ++q++++++eei++ntt++yr

Q: 120   PIIHRDLKVENMLISNQGTIKLCDFGSATTVSHYPDynwTAQKRAMVEEEITRNTTPMYR  179

         ***********************************999999*******************

S: 185   sPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensrysek  244

         +PE+idlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP+n++ ++

Q: 180   TPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPNDTRYTV  239

         ************************************************************

S: 245   lkslikkmlevdpeeRptiaqvlell  270

         +++li++ l+v+peeR++i++++++l

Q: 240   FHDLIRSTLKVNPEERLSITELVNQL  265

         **********************9986

Domain Sequence
(FASTA)

GGFAFVYEAQ DLGSGKDYAL KRLLSNEEEK NKAIIQEVCF MKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCRG QLVEFLKKVE SKGPLSCDTV LKIFYQTCRA VQHMHKQKPP 120

IIHRDLKVEN MLISNQGTIK LCDFGSATTV SHYPDYNWTA QKRAMVEEEI TRNTTPMYRT 180

PEIIDLYSNF PIGEKQDIWA LGCILYLLCF RQHPFEDGAK LRIVNGKYSI PPNDTRYTVF 240

HDLIRSTLKV NPEERLSITE LVNQL 265

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013