EKS-SAH-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	243.5	2.2E-72	1	167	167

Status

Unreviewed

Ensembl Protein

ENSSHAP00000009790

UniProt Accession

G3W2Y5;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008473	ENSSHAP00000009790	ENSSHAT00000009876

Organism

Sarcophilus harrisii

Functional Description

Protein Length

760

Protein Sequence
(FASTA)

MNQHGMVHRA LSPHNILLDQ EEHIKLAKFG LYHMTAHGVD VDFPIGYPSY LAPEVIAQGI 60

IKTSDHTSSE KPLPSGPKSD VWSLGIILFE LCMGRKLFQG LDISERLKFL LTLGCMDDTL 120

TVLAEEHGCL DTIKELPENI INLLKKCLTF HPSKRPTPDE LLQDKVFSEV SPLYTPFHKP 180

ASLFSSSLRC ADLTLPEDIS QLCKDADSDY LAERSIEEVY YLWCLAGGDL EKELVNKEII 240

RSKPPICTLP NFLFEDGESF GQDRDRSSLL DDTTVTLSLC QLRNRLKDVG GEAFYPLLED 300

DQSNLPHSNS NNDLSAAVTL PLIIRERDTE YQLNRIVLFD RLLKAYPYKK NQIWKEARVD 360

IPPLMRGLTW AALLGVEGAI HAKYDAIDKD TPIPTDRQIE VDIPRCHQYD ELLSSPEGHA 420

KFRRVLKAWV VSHPDLVYWQ GLDSLCAPFL YLNFNNEALA YACMSAFIPK YLYNFFLKDN 480

SHVIQEYLTV FSQMIAFHDP ELSNHLNEIG FIPDLYAIPW FLTMFTHVFP LHKIFHLWDT 540

LLLGNSSFPF CIGVAILQQL RDRLLANGFN ECILLFSDLP EIDIERCVHE SINLFCWTPK 600

SATYRQHAQP PKRSSDNNGV RNSLPYFSAE SQDAPKTNLS RESIQLNDLK SEVSPRISAE 660

DLIDLCELTG TGHFKTPTKK TKSSKPKLLV VDIRNTEDFN RGHISGSISI PFNSAFTTEG 720

ELSQSPSTAI LQNFKGKVIV IVGNVTKHTA EEGRKEGRKK 760

Nucleotide Sequence
(FASTA)

ATGAACCAGC ATGGAATGGT CCATCGAGCC CTATCCCCTC ACAACATTCT GTTGGATCAA 60

GAGGAACATA TTAAACTGGC TAAATTTGGA CTTTATCATA TGACAGCTCA TGGTGTAGAT 120

GTTGATTTTC CAATTGGGTA CCCATCTTAC CTGGCACCTG AGGTCATTGC ACAAGGAATC 180

ATCAAAACCA GTGACCACAC ATCAAGTGAA AAACCATTGC CTTCTGGCCC CAAATCTGAT 240

GTATGGTCCC TTGGAATTAT TTTATTTGAA CTTTGTATGG GAAGAAAGTT GTTTCAGGGC 300

CTGGATATTT CCGAAAGGCT AAAGTTTTTG CTTACATTAG GTTGTATGGA TGATACTTTA 360

ACAGTCTTGG CTGAGGAACA TGGTTGTCTG GACACTATAA AGGAGCTCCC TGAAAATATA 420

ATAAATCTGT TGAAGAAATG CCTCACTTTC CACCCTTCTA AGAGGCCAAC TCCAGATGAA 480

TTACTACAGG ACAAGGTATT CAGTGAAGTG TCACCTTTAT ATACACCCTT CCACAAACCT 540

GCCAGTCTAT TCTCATCTTC TTTAAGATGT GCTGATTTAA CTCTGCCTGA AGACATTAGT 600

CAACTATGTA AAGATGCTGA CAGTGATTAC CTAGCAGAAA GATCAATTGA AGAAGTTTAT 660

TACCTTTGGT GTTTAGCTGG AGGAGATTTG GAGAAAGAGC TTGTCAACAA GGAAATCATT 720

CGCTCCAAAC CACCTATCTG CACGCTCCCC AACTTTCTAT TTGAAGATGG TGAGAGCTTT 780

GGGCAAGATC GTGATAGAAG TTCACTTTTA GATGATACCA CTGTGACATT GTCACTCTGC 840

CAGCTAAGAA ATAGACTAAA AGATGTTGGC GGAGAAGCAT TTTACCCATT GCTTGAGGAT 900

GACCAGTCCA ATTTACCTCA TTCAAACAGT AATAATGACT TGTCTGCAGC TGTCACTCTT 960

CCTTTGATCA TCCGAGAGAG AGACACAGAG TACCAGCTCA ACAGAATTGT TCTCTTTGAC 1020

AGGCTACTGA AGGCTTACCC ATACAAAAAA AATCAAATCT GGAAAGAAGC CAGAGTTGAT 1080

ATTCCTCCAC TCATGAGAGG TTTAACCTGG GCTGCCCTCC TAGGAGTTGA GGGTGCCATT 1140

CATGCCAAGT ATGATGCTAT TGATAAAGAC ACTCCAATTC CTACTGACCG ACAAATTGAG 1200

GTGGATATTC CACGCTGCCA TCAGTATGAT GAGTTGTTGT CATCTCCTGA GGGCCATGCA 1260

AAGTTTAGGA GGGTATTAAA GGCTTGGGTT GTTTCCCATC CAGATCTTGT GTATTGGCAA 1320

GGTCTTGATT CTCTCTGTGC TCCATTCCTG TATTTAAATT TTAACAATGA GGCTCTTGCT 1380

TATGCTTGTA TGTCTGCTTT TATTCCAAAA TACCTATATA ACTTCTTTTT GAAAGACAAC 1440

TCTCATGTCA TACAAGAGTA TCTGACAGTA TTTTCTCAGA TGATTGCATT CCATGACCCA 1500

GAGCTGAGTA ACCATCTCAA CGAGATTGGC TTTATTCCAG ACCTTTATGC CATTCCTTGG 1560

TTCCTCACCA TGTTTACCCA TGTTTTTCCA TTACACAAGA TTTTTCATCT CTGGGATACA 1620

TTACTGCTAG GAAATTCTTC TTTCCCATTC TGCATTGGAG TAGCCATACT CCAGCAACTA 1680

CGAGACCGGC TCTTAGCTAA TGGCTTCAAT GAGTGCATTC TGCTCTTCTC TGACTTACCA 1740

GAAATTGACA TCGAGCGTTG TGTCCATGAG TCAATCAATT TGTTCTGCTG GACTCCAAAA 1800

AGTGCTACTT ATAGACAACA TGCACAACCA CCCAAACGAT CTTCTGACAA CAATGGAGTG 1860

AGAAATTCCC TGCCTTATTT TTCTGCTGAG TCTCAGGATG CTCCCAAGAC AAATCTGTCC 1920

AGAGAATCTA TCCAGCTGAA TGACCTGAAG TCAGAAGTGT CACCACGGAT ATCAGCAGAG 1980

GATCTGATTG ACTTGTGTGA GCTGACTGGC ACAGGGCATT TCAAAACGCC CACCAAGAAA 2040

ACAAAATCCA GTAAACCCAA GCTGCTGGTG GTTGATATTC GAAACACTGA AGATTTTAAT 2100

AGAGGCCACA TTTCAGGCAG CATCAGCATT CCTTTCAACT CTGCATTCAC CACAGAAGGG 2160

GAACTCTCCC AAAGCCCTTC TACTGCCATA CTCCAGAATT TCAAAGGGAA GGTTATTGTC 2220

ATTGTGGGAA ATGTGACAAA ACATACAGCA GAGGAAGGAA GAAAAGAGGG AAGGAAGAAG 2280

TAA 2283

Domain Profile

S: 90    lnkhnivhralepksilldrkgqkvkLakyGLyhltayGkdvdfpigygsylaPerilqd  149

         +n+h++vhral+p++illd++++ +kLak+GLyh+ta+G dvdfpigy+sylaPe+i+q+

Q: 1     MNQHGMVHRALSPHNILLDQEEH-IKLAKFGLYHMTAHGVDVDFPIGYPSYLAPEVIAQG  59

         799********************.************************************

S: 150   .........edkllaatvksDvWsLglillelilgikLfaeldlserlkillklstvdet  200

                  ++k+l++++ksDvWsLg+il+el++g+kLf+ ld+serlk+ll+l++ d+t

Q: 60    iiktsdhtsSEKPLPSGPKSDVWSLGIILFELCMGRKLFQGLDISERLKFLLTLGCMDDT  119

         ************************************************************

S: 201   liklaeekkcldiikklderleallkkCLtllpskRpspdellkekvf  248

         l +laee++cld ik+l+e++++llkkCLt++pskRp+pdell++kvf

Q: 120   LTVLAEEHGCLDTIKELPENIINLLKKCLTFHPSKRPTPDELLQDKVF  167

         **********************************************98

Domain Sequence
(FASTA)

MNQHGMVHRA LSPHNILLDQ EEHIKLAKFG LYHMTAHGVD VDFPIGYPSY LAPEVIAQGI 60

IKTSDHTSSE KPLPSGPKSD VWSLGIILFE LCMGRKLFQG LDISERLKFL LTLGCMDDTL 120

TVLAEEHGCL DTIKELPENI INLLKKCLTF HPSKRPTPDE LLQDKVF 167

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013