EKS-SAH-00162

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00162

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	479.6	2.9E-144	282	540	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000009833

UniProt Accession

G3W328;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCB

Gene Synonyms/Alias

PRKCB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008514	ENSSHAP00000009833	ENSSHAT00000009920

Organism

Sarcophilus harrisii

Functional Description

Protein Length

613

Protein Sequence
(FASTA)

MYTVLSLAVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 60

LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIKAQIDK DVLTVVVRDA 120

KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFKFQ LKEADKDRRL 180

SVEIWDWDLT SRNDFMGSLS FGISELQKAG VDGWFKLLSQ EEGEYFNVPV PPEGEEGNEE 240

LRQKFERAKI GQGTKVTEEK TANAISKIDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 300

RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALAGKP PFLTQLHSCF QTMDRLYFVM 360

EYVNGGDLMY QIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 420

KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 480

FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 540

RYIDWEKLER KEIQPPYKPK ACGRNAENFD RFFTRHPPVL TPPDQEVIRN IDQSEFEGFS 600

FVNSEFLKPE VKS 613

Nucleotide Sequence
(FASTA)

ATGTACACTG TCCTCTCTCT TGCAGTGTGC TGTTTCGTAG TCCATAAGAG ATGCCATGAA 60

TTTGTCACCT TCTCCTGCCC GGGTGCTGAT AAGGGCCCAG CCTCTGATGA TCCACGGAGC 120

AAGCACAAGT TTAAAATTCA TACTTATTCC AGTCCAACAT TTTGTGACCA CTGCGGCTCT 180

TTGCTGTATG GGCTCATTCA CCAAGGAATG AAATGTGACA CCTGCATGAT GAATGTGCAC 240

AAGCGCTGTG TGATGAATGT CCCCAGCCTC TGCGGAACAG ACCACACTGA GCGTCGAGGA 300

CGAATCTACA TCAAGGCCCA GATTGATAAA GATGTTCTCA CTGTTGTTGT AAGAGATGCA 360

AAAAATCTAG TCCCTATGGA TCCTAATGGT TTATCAGATC CTTATGTAAA ACTGAAACTC 420

ATCCCTGATC CCAAGAGTGA GAGCAAGCAG AAGACCAAAA CCATCAAGTG TTCCCTCAAC 480

CCTGAGTGGA ATGAGACTTT TAAATTTCAA CTGAAAGAAG CTGACAAAGA CAGACGACTT 540

TCTGTGGAGA TTTGGGACTG GGATCTGACC AGCAGGAATG ACTTCATGGG GTCCTTGTCC 600

TTTGGGATTT CAGAGCTGCA GAAAGCTGGT GTTGATGGAT GGTTTAAGTT ACTAAGTCAA 660

GAGGAAGGAG AGTATTTTAA TGTTCCAGTT CCTCCTGAAG GAGAAGAAGG CAATGAAGAG 720

CTCAGGCAGA AATTTGAGAG AGCCAAGATT GGCCAGGGAA CCAAGGTTAC CGAAGAAAAA 780

ACAGCCAATG CAATATCTAA AATTGACAAC AATGGAAACC GAGATCGGAT GAAACTGACT 840

GATTTTAACT TCCTCATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA 900

AGAAAAGGCA CTGATGAACT CTATGCTGTG AAGATCCTGA AGAAAGATGT AGTGATCCAG 960

GATGATGATG TGGAATGTAC AATGGTGGAG AAGAGGGTTC TTGCTCTTGC TGGGAAACCT 1020

CCATTCCTGA CACAGTTGCA CTCCTGTTTC CAGACAATGG ATCGCTTGTA TTTTGTGATG 1080

GAATATGTGA ATGGTGGAGA TCTCATGTAT CAGATACAGC AGGTTGGACG ATTTAAAGAA 1140

CCACATGCTG TATTCTATGC AGCAGAAATT GCTATTGGTC TATTCTTCTT ACAAAGCAAA 1200

GGCATCATTT ATCGAGACCT AAAACTTGAC AATGTAATGT TGGATTCTGA AGGCCACATC 1260

AAGATCGCTG ACTTTGGCAT GTGCAAGGAG AACATTTGGG ATGGGGTAAC CACCAAGACA 1320

TTCTGTGGCA CCCCAGACTA CATTGCTCCT GAGATAATTG CCTATCAGCC TTACGGGAAG 1380

TCGGTAGATT GGTGGGCTTT TGGAGTGCTG CTGTATGAAA TGTTGGCTGG CCAGGCTCCT 1440

TTTGAAGGAG AAGATGAAGA TGAGCTTTTC CAGTCTATCA TGGAGCACAA TGTGGCCTAC 1500

CCCAAGTCCA TGTCAAAAGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAGCACCCA 1560

GGTAAACGTC TGGGATGTGG ACCTGAAGGT GAACGAGATA TTAAGGAACA TGCATTTTTC 1620

CGGTATATTG ACTGGGAGAA ACTTGAACGC AAGGAGATTC AGCCCCCATA CAAGCCAAAG 1680

GCTTGTGGGC GAAATGCCGA AAACTTCGAC CGGTTTTTCA CCCGCCATCC ACCCGTCCTA 1740

ACACCTCCTG ACCAGGAAGT CATCAGGAAC ATTGACCAAT CAGAATTCGA AGGATTTTCC 1800

TTTGTTAACT CTGAATTTTT AAAACCTGAA GTCAAGAGCT AA 1842

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlala k+p

Q: 282   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALAGKPP  341

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt+drl+fv+eyvnGGdlm++iq+++++ke++a+fyaaei+++l+fl++kg

Q: 342   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  401

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks

Q: 402   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  461

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p

Q: 462   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  521

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+dikehaff

Q: 522   KRLGCGPEGERDIKEHAFF  540

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALAGKPP 60

FLTQLHSCFQ TMDRLYFVME YVNGGDLMYQ IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240

KRLGCGPEGE RDIKEHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013