EKS-SAH-00133

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00133

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	506.0	2.3E-152	150	408	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000010374

UniProt Accession

G3W4L9;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT1

Gene Synonyms/Alias

AKT1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000008957	ENSSHAP00000010374	ENSSHAT00000010465

Organism

Sarcophilus harrisii

Functional Description

Protein Length

480

Protein Sequence
(FASTA)

MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK SDGTFIGYKE RPQDVDQRES PLNNFSVAQC 60

QLMKTERPKP NTFIIRCLQW TTVIERTFHV ETPEEREEWT KAIQMVADSL KKQEEELMDF 120

RSGSPSDNSG AEEMEVSTTK PKHKVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180

LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240

RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300

KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360

ILMEEIRFPR TLSPDAKSLL SGLLKKDPKQ RLGGGPDDAK EIMQHKFFAG IVWQDVYEKK 420

LVPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDNMEC VDNERRPHFP QFSYSASGTA 480

Nucleotide Sequence
(FASTA)

ATGAACGACG TCGCGATTGT GAAGGAGGGC TGGCTGCATA AGCGAGGAGA ATATATCAAA 60

ACGTGGCGGC CACGCTACTT CTTGCTAAAG AGTGATGGGA CCTTCATTGG CTATAAGGAG 120

CGGCCACAAG ATGTGGACCA GCGGGAATCT CCCCTCAACA ATTTCTCAGT TGCACAATGC 180

CAGCTGATGA AGACAGAGCG ACCCAAACCC AATACATTCA TCATCCGCTG CCTGCAGTGG 240

ACCACGGTAA TTGAGAGAAC GTTTCACGTG GAGACCCCCG AGGAGCGGGA AGAATGGACC 300

AAAGCCATCC AGATGGTGGC TGACAGCCTA AAAAAGCAGG AGGAAGAACT CATGGACTTC 360

CGATCAGGCT CACCCAGTGA CAATTCTGGG GCTGAGGAGA TGGAGGTGTC TACAACAAAG 420

CCCAAACACA AAGTGACAAT GAATGAGTTC GAGTACCTGA AGCTGTTGGG CAAAGGCACA 480

TTTGGGAAGG TGATCCTAGT GAAGGAGAAG GCAACTGGGC GATATTATGC CATGAAGATC 540

CTCAAGAAGG AAGTGATTGT GGCCAAGGAT GAGGTGGCTC ATACACTTAC GGAGAATCGA 600

GTCTTACAGA ACTCCAGGCA CCCATTCCTG ACAGCACTGA AGTACTCGTT CCAGACGCAT 660

GACCGCCTGT GCTTTGTGAT GGAGTATGCC AATGGAGGAG AGCTATTTTT CCATCTCTCT 720

CGAGAACGGG TATTCTCCGA AGACAGAGCC AGGTTCTATG GGGCAGAGAT CGTGTCTGCG 780

CTGGACTACT TGCATTCTGA GAAGAATGTG GTATACAGAG ACCTCAAGTT GGAAAACCTA 840

ATGCTGGACA AAGATGGTCA CATAAAAATC ACTGACTTCG GTCTGTGCAA GGAGGGGATC 900

AAGGATGGTG CTACAATGAA GACCTTCTGC GGGACTCCAG AATATCTGGC CCCTGAGGTG 960

CTAGAGGACA ATGACTATGG CCGGGCAGTG GACTGGTGGG GCCTGGGAGT GGTCATGTAT 1020

GAGATGATGT GCGGCCGGCT GCCCTTCTAC AACCAGGATC ATGAGAAGCT GTTTGAGCTG 1080

ATCCTCATGG AGGAGATCCG ATTTCCTCGA ACGCTGTCCC CGGACGCCAA GTCACTTTTG 1140

TCAGGGTTGC TGAAAAAGGA CCCCAAGCAG AGGTTAGGTG GGGGACCAGA TGATGCAAAA 1200

GAGATTATGC AGCACAAGTT TTTTGCTGGC ATTGTATGGC AAGATGTCTA TGAAAAAAAG 1260

CTGGTGCCTC CGTTTAAGCC ACAGGTCACA TCTGAGACGG ACACCCGGTA TTTTGATGAG 1320

GAGTTTACAG CCCAGATGAT CACAATCACC CCTCCTGACC AAGATGACAA CATGGAATGT 1380

GTGGATAACG AGAGACGGCC CCATTTTCCT CAGTTCTCGT ACTCTGCTAG TGGGACAGCT 1440

TGA 1443

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl++++hpf

Q: 150   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF  209

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119

         l+alkysfqt+++lc+v+ey+nGGelffhls+ervfsedrarfygaeivsaldylhs k+

Q: 210   LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSeKN  269

         ********************************************************9789

S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179

         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dyg+a

Q: 270   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA  329

         ************************************************************

S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239

         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+ls++aksllsGllkkdpk

Q: 330   VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLSPDAKSLLSGLLKKDPK  389

         ************************************************************

S: 240   krlGggkddakeireheff  258

         +rlGgg+ddakei++h+ff

Q: 390   QRLGGGPDDAKEIMQHKFF  408

         ******************9

Domain Sequence
(FASTA)

FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF 60

LTALKYSFQT HDRLCFVMEY ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN 120

VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA 180

VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLSPDAKSL LSGLLKKDPK 240

QRLGGGPDDA KEIMQHKFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013