EKS-SAH-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	257.9	1.1E-76	198	445	248

Status

Unreviewed

Ensembl Protein

ENSSHAP00000010934

UniProt Accession

G3W679;

Protein Name

Protein Synonyms/Alias

Gene Name

ILK

Gene Synonyms/Alias

ILK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000009423	ENSSHAP00000010934	ENSSHAT00000011028

Organism

Sarcophilus harrisii

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

AGGALISICN KYGEMPVDKA KAPLRESLRE RAEKLGQPMG RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNLMVKLN ENQSGELWKG RWQGNDIVIK MLKIRDWSTR KSRDFNEEYP 240

KLRIFSHPNV LPVLGACQAP PAPHPVLITH WMPYGSLYNV LHEGTNFVVD QTQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEEINR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACCCA GTGCCGGGAG GGTAATGCTG TGGCTGTGCG TTTGTGGCTG 60

GACAACACAG AAAACGACTT GAACCAGGGG GATGACCATG GTTTCTCTCC ATTGCACTGG 120

GCCTGCCGAG AAGGCCGTTC AGCTGTGGTT GAAATGCTGA TCATGAGAGG AGCCCGAATC 180

AACGTAATGA ACAGGGGTGA TGATACCCCA CTCCACTTAG CAGCCAGCCA TGGGCACCGG 240

GACATTGTGC AAAAATTGCT TCAATACAAG GCTGATATAA ATGCAGTGAA CGAGCATGGG 300

AATGTGCCCC TTCATTATGC CTGCTTCTGG GGCCAGGACC AAGTGGCAGA GGATCTTGTT 360

GCTGGCGGAG CACTAATCAG CATTTGTAAC AAGTATGGAG AAATGCCAGT GGACAAGGCT 420

AAAGCCCCAC TTCGAGAGAG CCTCCGAGAA CGGGCTGAGA AGCTGGGCCA GCCAATGGGC 480

CGGATCCCAT ACAAAGACAC GTTCTGGAAA GGAACAACAC GCACTCGACC TCGGAACGGC 540

ACCCTGAATA AACACTCAGG CATCGACTTC AAGCAGCTCA ACCTGATGGT GAAACTCAAC 600

GAGAACCAGT CAGGAGAGCT GTGGAAGGGT CGATGGCAGG GGAATGACAT CGTCATCAAG 660

ATGTTGAAGA TCCGTGACTG GAGTACAAGA AAGAGCAGAG ACTTTAATGA GGAGTATCCT 720

AAGCTGAGGA TCTTTTCCCA CCCCAATGTG CTGCCTGTGT TGGGAGCCTG TCAGGCACCT 780

CCTGCCCCTC ATCCTGTTCT CATCACCCAC TGGATGCCTT ACGGCTCCCT CTACAACGTG 840

CTTCATGAAG GGACCAATTT TGTCGTTGAT CAGACCCAGG CAGTTAAGTT TGCTCTGGAC 900

ATGGCAAGGG GCATGGCCTT CCTGCACACA CTGGAGCCCC TCATACCCCG GCATGCCCTC 960

AACAGCCGAA GTGTCATGAT TGACGAGGAT ATGACTGCCC GTATCAGCAT GGCTGATGTG 1020

AAATTCTCCT TTCAGTGTCC AGGGCGCATG TATGCCCCTG CCTGGGTGGC TCCTGAGGCC 1080

TTGCAGAAGA AGCCCGAGGA GATTAATCGT CGTTCTGCAG ACATGTGGAG TTTTGCTGTG 1140

TTGTTGTGGG AACTGGTGAC AAGGGAAGTA CCATTTGCTG ACCTCTCCAA CATGGAAATT 1200

GGCATGAAGG TTGCTCTGGA AGGTCTCCGA CCCACCATTC CTCCAGGTAT CTCCCCACAT 1260

GTGTGTAAAC TCATGAAGAT CTGCATGAAT GAGGACCCAG CCAAGAGGCC CAAGTTTGAT 1320

ATGATTGTGC CCATCCTGGA AAAGATGCAG GACAAATAA 1359

Domain Profile

S: 6     ligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellGvc  65

         +++++++g+++k++w+++++++K l+ ++++++k++++++e  +l+ +shpn++ +lG+c

Q: 198   KLNENQSGELWKGRWQGNDIVIKMLKIRDWSTRKSRDFNEEYPKLRIFSHPNVLPVLGAC  257

         78999*******************************************************

S: 66    leepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         +++p+   +l+++++++gsL+nvlhe ++ ++d+ ++v++al++ArGma+Lh+ +p  i

Q: 258   QAPPAphPVLITHWMPYGSLYNVLHEGTNFVVDQTQAVKFALDMARGMAFLHTLEPL-IP  316

         ***99745**********************************************997.**

S: 124   hrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs...e  179

         ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +   +

Q: 317   RHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEEinrR  371

         ***********.**********.88888...78999998************999887789

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c+ne

Q: 372   SADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNE  431

         9***********************************************************

S: 240   dpekRpsfseivks  253

         dp+kRp+f++iv +

Q: 432   DPAKRPKFDMIVPI  445

         ***********986

Domain Sequence
(FASTA)

KLNENQSGEL WKGRWQGNDI VIKMLKIRDW STRKSRDFNE EYPKLRIFSH PNVLPVLGAC 60

QAPPAPHPVL ITHWMPYGSL YNVLHEGTNF VVDQTQAVKF ALDMARGMAF LHTLEPLIPR 120

HALNSRSVMI DEDMTARISM ADVKFSFQCP GRMYAPAWVA PEALQKKPEE INRRSADMWS 180

FAVLLWELVT REVPFADLSN MEIGMKVALE GLRPTIPPGI SPHVCKLMKI CMNEDPAKRP 240

KFDMIVPI 248

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009966	; P:regulation of signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013