EKS-SAH-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	559.9	8.5E-169	474	750	277

Status

Unreviewed

Ensembl Protein

ENSSHAP00000011338

UniProt Accession

G3W7D2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000009751	ENSSHAP00000011337	ENSSHAT00000011432
ENSSHAG00000009751	ENSSHAP00000011338	ENSSHAT00000011433

Organism

Sarcophilus harrisii

Functional Description

Protein Length

814

Protein Sequence
(FASTA)

MPEAGRPASG RLPGPSRSLV GGMVTAGCVL VFYLAVAVNS AGAGPGPGLV ISHLEPRPAR 60

RATEQLRSDP RAQEELVFSS GESIELGCEA QDSRMLSWFK DGVAIFPTNR THIGPDLLKI 120

INVSYDDSGV YTCQQKHSSE VLCNFTIRVT GAPYWTRPER MDKKLLAVPA ANTVRFRCPA 180

AGNPTPTIYW LKNGREFKGE HRIGGIKLRH QQWSLVMESV VPSDRGNYTC VVENKYGSIQ 240

QTYTLDVLER SPHRPILQAG LPANQTAVVG SNVEFHCKVY SDAQPHIQWL KHVEVNGSKY 300

GPDGTPYVTV LKTAGVNTTD KELEILYLRN VTFEDAGEYT CLAGNSIGFS HHSAWLMVLP 360

AEEMVEVDDS GNVFTGLLSY GLGFCLFIVV VAVAVAICRL KMPSKKAINT PTVQKVSKFP 420

LKRQVSLESN SSMNSNTPLV RIARLSSSEG PMLANVSELE LPADPKWELC RSRLTLGKPL 480

GEGCFGQVVM AEAIGIDKDK PNKPVTVAVK MLKDDATDKD LSDLVSEMEM MKMIGKHKNI 540

INLLGACTQD GPLYVLVEYA SKGNLREYLR ARRPPGMDYS FDTCKLPEEQ LTFKDLVSCA 600

YQVARGMEYL ASQKCIHRDL AARNVLVTED SVMKIADFGL ARDVHNIDYY KKTTNGRLPV 660

KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGI PVEELFKLLK EGHRMDKPAN 720

CTHDLYMIMR ECWHAVPSQR PTFKQLVEDL DRVLTVTSTD EYLDLSVPFE QYSPTCQDSH 780

STCSSGDDSV FAHDLLPEEP CLPKAPKCNG ALRT 814

Nucleotide Sequence
(FASTA)

ATGCCTGAGG CTGGCCGGCC TGCGAGCGGG CGGCTTCCCG GGCCCTCCCG GAGCCTAGTC 60

GGAGGAATGG TGACCGCGGG CTGCGTCTTG GTCTTCTACC TGGCTGTGGC CGTGAATAGT 120

GCCGGTGCCG GCCCGGGTCC CGGACTGGTC ATTTCTCACC TGGAGCCTCG ACCTGCCAGG 180

AGAGCCACAG AGCAATTGAG GAGTGACCCC AGGGCTCAGG AGGAATTGGT CTTCTCAAGT 240

GGGGAGAGCA TCGAGCTCGG CTGTGAGGCT CAAGACTCTC GCATGCTGTC CTGGTTCAAG 300

GATGGGGTGG CAATCTTCCC CACTAACAGG ACCCACATTG GGCCCGACCT GCTGAAGATC 360

ATCAATGTGT CTTATGATGA CTCTGGCGTG TACACCTGCC AGCAGAAGCA TTCAAGTGAG 420

GTTCTCTGCA ACTTTACCAT CCGAGTGACC GGTGCCCCAT ACTGGACTCG CCCTGAGAGA 480

ATGGATAAGA AACTTCTCGC TGTTCCGGCT GCAAACACGG TTCGCTTCCG GTGTCCGGCC 540

GCTGGCAACC CCACCCCCAC CATCTACTGG CTGAAGAATG GCAGAGAGTT CAAAGGAGAA 600

CATCGAATTG GGGGGATTAA GCTGAGACAC CAGCAGTGGA GTCTGGTCAT GGAGAGTGTG 660

GTACCCTCGG ACCGGGGGAA CTATACCTGC GTGGTGGAGA ACAAGTATGG CAGCATACAG 720

CAAACCTACA CGCTGGATGT CCTGGAGAGA TCCCCACATC GGCCCATTCT GCAGGCCGGC 780

CTCCCGGCCA ATCAGACCGC GGTCGTGGGG AGCAACGTGG AGTTCCACTG TAAGGTGTAC 840

AGCGATGCCC AGCCCCACAT TCAGTGGCTG AAACACGTGG AGGTGAATGG CAGCAAGTAT 900

GGCCCAGATG GAACACCCTA CGTCACCGTC CTCAAGACGG CAGGAGTTAA CACAACGGAT 960

AAGGAACTAG AAATTCTCTA TTTGCGCAAT GTCACCTTTG AGGATGCGGG GGAGTATACT 1020

TGTCTTGCTG GGAATTCTAT TGGGTTCTCA CACCACTCTG CTTGGCTGAT GGTCCTCCCA 1080

GCTGAAGAAA TGGTTGAAGT GGATGATTCG GGCAATGTCT TTACCGGCCT CCTCAGTTAC 1140

GGGCTTGGGT TTTGTCTCTT CATTGTGGTG GTGGCCGTGG CCGTGGCCAT TTGTCGGCTG 1200

AAGATGCCCT CCAAGAAGGC CATCAACACT CCCACTGTCC AGAAGGTGTC CAAGTTCCCG 1260

CTCAAGCGAC AGGTGTCCCT GGAATCGAAC TCGTCTATGA ATTCCAACAC CCCCCTGGTG 1320

AGAATTGCCC GCCTGTCCTC CAGCGAGGGG CCCATGTTGG CCAACGTGTC TGAGCTGGAG 1380

CTCCCCGCCG ATCCCAAGTG GGAGCTGTGC AGATCCCGTC TCACCTTGGG AAAACCTCTT 1440

GGCGAAGGCT GCTTTGGCCA AGTGGTCATG GCAGAAGCCA TCGGCATCGA TAAAGACAAG 1500

CCCAATAAAC CTGTCACCGT GGCTGTGAAG ATGCTGAAAG ATGATGCCAC AGATAAAGAC 1560

CTGTCTGACT TAGTCTCTGA GATGGAAATG ATGAAAATGA TTGGAAAACA CAAAAACATC 1620

ATTAATTTAT TGGGAGCCTG CACACAGGAT GGTCCCCTCT ACGTCCTTGT TGAATATGCA 1680

TCCAAGGGGA ACCTCAGGGA GTATCTGCGA GCTCGAAGAC CCCCAGGGAT GGATTACTCC 1740

TTTGATACCT GCAAGCTTCC AGAAGAACAG CTGACCTTCA AGGACCTAGT GTCCTGTGCC 1800

TACCAAGTGG CCCGAGGCAT GGAGTACCTG GCATCCCAGA AGTGCATTCA CCGGGACCTG 1860

GCAGCCCGAA ATGTTCTTGT TACCGAAGAT AGCGTGATGA AGATTGCAGA CTTCGGCTTG 1920

GCCAGGGACG TGCACAACAT TGACTACTAC AAAAAAACCA CCAATGGGCG GCTGCCTGTG 1980

AAGTGGATGG CTCCGGAGGC CCTGTTTGAC CGGGTGTACA CTCACCAGAG CGATGTCTGG 2040

TCTTTCGGTG TCCTGCTCTG GGAAATCTTT ACACTAGGAG GTTCCCCCTA CCCTGGGATT 2100

CCCGTGGAGG AACTCTTCAA GCTGTTAAAA GAGGGCCATC GGATGGACAA GCCCGCCAAC 2160

TGTACCCATG ATCTGTACAT GATCATGCGA GAGTGCTGGC ACGCGGTCCC ATCCCAGAGA 2220

CCCACCTTCA AGCAGCTGGT TGAAGACTTA GATCGAGTTC TCACAGTCAC ATCCACAGAT 2280

GAGTACCTGG ACCTGTCTGT ACCCTTTGAA CAATACTCCC CAACCTGCCA GGACAGCCAC 2340

AGCACCTGCT CCTCCGGAGA TGACTCGGTG TTTGCCCACG ACCTGCTCCC TGAAGAGCCC 2400

TGCCTCCCCA AAGCCCCGAA GTGTAACGGC GCCCTCAGGA CGTGA 2445

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkdk++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 474   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  533

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k +eeqlt+

Q: 534   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvted+v+kiadfGlardvh+idyykkt

Q: 594   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDSVMKIADFGLARDVHNIDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh

Q: 654   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  713

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 714   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  750

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDSVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013