EKS-SAH-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	383.6	4.0E-115	60	311	252

Status

Unreviewed

Ensembl Protein

ENSSHAP00000011388

UniProt Accession

G3W7I3;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000009793	ENSSHAP00000011388	ENSSHAT00000011484

Organism

Sarcophilus harrisii

Functional Description

Protein Length

793

Protein Sequence
(FASTA)

LKWRTRIHRL SRMSTEKHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60

RLLKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPSIV 120

KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH 180

RDLKAENLLL DADMNIKIAD FGFSNEFTIG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240

WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300

SLEQIMKDRW MNVGHEEEEL KPYTEPEPDF NDTKRIDIMV TMGFSRDEIN VSLINQKYDE 360

VMATYLLLGR KPPEFEGSES LSSGNLCQRS RPSSDLNNSS MQSPAHLKVQ RSISANQKQR 420

RFSDHVGPSI PAAVSYTKRA QANSAESEQK EEWDKDVSHK LGSTIVGSKA EMTASPLVGP 480

ERKKSSTMPS NNVFPGSGMT RRNTYVCERT TDRYSAIQNG KDSSLTEMSA SSTSSASSAI 540

TAAPSTRPRH QKSMSASGHP IKVTLPTIKD GTDYRPGTTQ RVPAASPSAH SISATTPDRT 600

RFPRGSSSRS TFHGEQLRER RNATYNGPPA SPSHETGAFS HARRGTSTGI ISKITSKFVR 660

RDPSEGEASG RTDTSRSTSG EPKEREKEDS KDSKPRSLRF TWSMKTTSSM DPNDMMREIR 720

KVLDANNCDY EQKEKFLLFC VHGDARQDSL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF 780

KNIASKIANE LKL 793

Nucleotide Sequence
(FASTA)

TTGAAGTGGA GAACCAGAAT CCATCGTCTA AGCAGGATGA GCACAGAAAA GCATACATCT 60

GTTGATGGAT ACACTGAACC ACACATCCAG CCTACCAAAT CAAGTAGCCG ACAAAACATA 120

CCACGGTGTA GAAATTCCAT TACGTCTGCT ACAGATGAAC AGCCTCACAT TGGAAATTAT 180

CGTTTGCTAA AAACAATAGG GAAGGGAAAT TTTGCCAAAG TGAAATTGGC AAGACATGTT 240

CTTACTGGTA GAGAGGTTGC AGTTAAAATA ATAGATAAAA CTCAGCTAAA TCCCACCAGT 300

CTACAAAAGT TATTTCGAGA AGTACGAATA ATGAAGATAC TGAATCATCC CAGTATAGTA 360

AAATTATTTG AAGTTATTGA AACAGAGAAG ACACTGTATT TAGTAATGGA ATACGCCAGT 420

GGGGGTGAAG TGTTTGATTA CTTAGTTGCC CATGGAAGAA TGAAGGAGAA AGAGGCCCGT 480

GCAAAATTTA GACAGATTGT ATCTGCAGTA CAGTATTGTC ATCAAAAGTG TATTGTACAC 540

CGTGATCTCA AGGCAGAAAA CCTTCTTCTA GATGCTGATA TGAATATTAA AATTGCTGAC 600

TTTGGTTTTA GTAATGAATT TACAATTGGA AACAAATTAG ACACATTTTG TGGAAGTCCT 660

CCCTATGCAG CTCCTGAACT TTTCCAAGGA AAAAAATATG ATGGTCCTGA AGTAGATGTG 720

TGGAGTCTTG GAGTGATTTT GTATACCTTA GTCAGTGGAT CTTTGCCATT TGATGGTCAG 780

AATCTAAAGG AACTACGGGA GCGAGTCTTA CGAGGAAAGT ATCGTATTCC ATTCTATATG 840

TCTACAGACT GTGAAAATCT TCTGAAAAAA TTATTAGTAC TGAATCCAAT AAAAAGAGGA 900

AGCTTGGAAC AAATAATGAA AGACCGGTGG ATGAATGTTG GTCATGAAGA AGAAGAACTG 960

AAGCCGTATA CTGAGCCTGA ACCAGATTTC AATGACACAA AAAGAATAGA CATTATGGTA 1020

ACAATGGGTT TTTCAAGAGA TGAAATAAAT GTATCCTTAA TAAATCAGAA ATATGATGAA 1080

GTCATGGCTA CTTATCTACT TCTGGGCAGA AAACCACCTG AATTTGAAGG AAGTGAATCT 1140

TTGTCCAGTG GTAATTTGTG TCAGCGATCT CGACCCAGCA GTGACCTAAA CAACAGTTCT 1200

ATGCAATCTC CTGCTCATCT GAAGGTCCAA AGGAGTATAT CAGCAAATCA GAAACAGAGG 1260

CGTTTCAGTG ATCATGTTGG TCCATCAATT CCTGCTGCTG TGTCATACAC CAAAAGGGCT 1320

CAGGCAAACA GTGCGGAAAG TGAGCAAAAA GAGGAGTGGG ACAAAGATGT ATCTCATAAA 1380

CTTGGCAGCA CTATAGTTGG ATCCAAAGCA GAGATGACAG CAAGTCCTCT TGTAGGACCC 1440

GAAAGAAAAA AATCTTCTAC TATGCCAAGT AACAATGTTT TTCCTGGAAG TGGTATGACA 1500

AGAAGGAACA CCTACGTTTG TGAAAGAACC ACAGATCGCT ATTCTGCAAT ACAGAATGGG 1560

AAAGACAGCA GTCTGACAGA AATGTCTGCA AGTAGCACAT CTTCTGCAAG CTCTGCTATC 1620

ACTGCTGCAC CATCCACACG ACCTCGACAC CAGAAGTCTA TGTCTGCCTC TGGCCACCCT 1680

ATAAAAGTCA CATTGCCAAC CATCAAAGAT GGCACTGATT ATCGACCAGG TACAACTCAG 1740

AGAGTTCCTG CTGCTTCCCC ATCTGCTCAT AGTATTAGTG CTACTACACC AGACCGAACT 1800

CGCTTTCCTC GTGGGAGTTC AAGTCGAAGT ACTTTTCATG GTGAACAGCT CCGAGAACGA 1860

CGTAATGCTA CTTATAATGG ACCACCTGCT TCACCATCAC ATGAAACTGG TGCATTTTCA 1920

CATGCTAGAA GAGGAACATC AACTGGTATA ATAAGCAAAA TAACTTCCAA GTTTGTTCGC 1980

AGGGATCCAA GTGAAGGCGA AGCCAGTGGC AGAACTGACA CCTCAAGAAG TACTTCTGGG 2040

GAACCAAAAG AAAGAGAAAA AGAGGATAGT AAAGATTCCA AGCCACGTTC TTTGCGGTTT 2100

ACTTGGAGCA TGAAGACCAC TAGTTCCATG GACCCAAATG ATATGATGAG AGAGATCCGA 2160

AAAGTGTTGG ATGCAAATAA CTGTGATTAT GAACAAAAAG AAAAGTTTTT GCTCTTCTGT 2220

GTACACGGAG ATGCCAGACA AGATAGTCTT GTTCAGTGGG AGATGGAAGT CTGCAAGTTG 2280

CCTCGCTTGT CACTTAATGG GGTCCGCTTC AAAAGAATAT CTGGAACTTC TATTGCATTT 2340

AAGAACATTG CATCCAAAAT TGCAAATGAG CTTAAACTAT AA 2382

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hp i

Q: 60    YRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPSI  119

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 120   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  179

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 180   HRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  239

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 240   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  299

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 300   GSLEQIMKDRWM  311

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPSI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTI GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013