EKS-SAH-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	384.9	2.5E-115	30	329	300

Status

Unreviewed

Ensembl Protein

ENSSHAP00000011391

UniProt Accession

G3W7I5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000009795	ENSSHAP00000011391	ENSSHAT00000011487
ENSSHAG00000009795	ENSSHAP00000011390	ENSSHAT00000011486

Organism

Sarcophilus harrisii

Functional Description

Protein Length

867

Protein Sequence
(FASTA)

MLAGDRKQGL HSMNMMEAAT SEPSLDLDNL KLLELIGRGR YGAVYKGSLD ERPVAVKVFS 60

FTNRQNFINE RNIYRIPLMD HDNIARFIVG DERFTADARM EYLLVMEYYP NGSLCKYLSL 120

HTSDWVSSCR LAHSVTRGLA YLHTELPRGD HYKPAISHRD LNSRNVLVKN DGTCVISDFG 180

LSMRLTGNRL VRPGEEDNAA ISEVGTIRYM APEVLEGAVN LRDCESALKQ VDMYALGLIY 240

WEIFMRCTDL FPAGESVPEY QMAFQTEVGN RPTFEDMQVL VSREKQRPRF PEAWKENSLA 300

VRSLKETIED CWDQDAEARL TAQCAEERMA ELMMIWERNK SVSPTVNPMS TAMQNERNLS 360

HNRRVPKIGP YPDYSSSSYI EDSIHHPDSI VKNISLEHSV SSSTPLTIGE KNRNSINYER 420

QQAQARIPSP ETSVTSLSTN TTTTNTTGLT PSTGMTTISE MPYSDETNLH ATNVAQPVGP 480

TPVCLQLTEE DLETNKLDPK EVDKNLKESS DENLMEHSLK QFSGPDPLSS TSSSLLYPLI 540

KLAVEVTGQQ DFTQAGNGQA CLIPDVPPAQ IYPLPKQQNL PKRPTSLPLN TKNSTKEPRL 600

KFGSKHKSNL KQVETGVAKM NTINAAEPHV VTVTMNGVAG RSHNVNSHVA TAPYANGVVP 660

SGQVPNLVTH RAQEMLQNQF SGEDSRLTIN SSPDEHEPLL RREQQAGHDE GVLDRLVDRR 720

DRPLEGGRTN SNNNNSNPCP GQEVLAVDLQ STGADPGQSK PRRAQRPNSL DLSATNALDS 780

TGMQLGESSQ DGKPGSGEKI KKRVKTPYSL KRWRPSTWVI STEPLDCEVN NNGGDRAAHS 840

KSSTAVYLAE GGTATTRVSQ ETGMNCL 867

Nucleotide Sequence
(FASTA)

ATGCTGGCAG GAGATCGTAA GCAAGGTCTT CACAGTATGA ACATGATGGA AGCAGCCACC 60

TCTGAGCCCT CTCTGGACCT AGATAATCTA AAACTTCTGG AGCTGATTGG TCGAGGACGA 120

TATGGAGCAG TATATAAAGG TTCCTTGGAT GAGCGTCCAG TGGCTGTAAA AGTTTTTTCT 180

TTTACCAATC GTCAAAATTT TATCAATGAG AGGAACATTT ATCGAATTCC TCTTATGGAT 240

CATGATAACA TTGCTCGCTT CATTGTTGGA GACGAAAGAT TCACTGCAGA TGCAAGAATG 300

GAGTATTTAT TAGTGATGGA ATATTACCCC AATGGTTCTT TGTGCAAGTA TTTGAGTCTT 360

CATACCAGTG ACTGGGTAAG CTCTTGTCGG TTGGCACATT CTGTTACCAG AGGCCTGGCA 420

TACCTTCATA CAGAATTACC AAGAGGAGAT CATTACAAAC CTGCGATTTC TCATCGAGAC 480

TTAAATAGCC GAAATGTTCT TGTAAAGAAT GATGGAACCT GTGTCATTAG TGACTTTGGA 540

TTGTCCATGA GGCTAACTGG AAATAGACTT GTCCGCCCTG GGGAAGAGGA CAATGCAGCA 600

ATAAGTGAGG TTGGCACAAT CCGATACATG GCACCAGAAG TGCTAGAAGG AGCAGTTAAT 660

CTGAGGGACT GTGAATCTGC TCTAAAACAA GTAGACATGT ATGCACTTGG CCTAATCTAC 720

TGGGAAATAT TTATGAGATG TACTGATCTC TTTCCAGCAG GTGAATCTGT GCCAGAGTAC 780

CAGATGGCCT TCCAGACAGA AGTAGGGAAC CGCCCCACTT TTGAAGACAT GCAGGTCCTG 840

GTGTCTAGGG AAAAGCAGAG GCCCAGATTC CCAGAAGCTT GGAAAGAAAA CAGTCTGGCT 900

GTGAGATCAC TGAAGGAAAC AATCGAGGAC TGTTGGGATC AGGATGCAGA GGCTCGGCTT 960

ACTGCTCAGT GTGCTGAGGA GAGGATGGCT GAACTCATGA TGATTTGGGA AAGGAACAAG 1020

TCAGTCAGTC CAACAGTCAA TCCAATGTCT ACTGCTATGC AGAATGAACG CAACCTGTCA 1080

CACAACAGGC GTGTGCCAAA GATTGGCCCT TATCCCGATT ATTCTTCTTC TTCATACATA 1140

GAAGACTCCA TTCATCACCC TGACAGCATT GTGAAGAATA TCTCCTTAGA ACATTCAGTG 1200

TCCAGCAGCA CACCTCTAAC TATAGGCGAA AAGAACCGAA ACTCAATTAA CTATGAACGG 1260

CAGCAAGCAC AGGCCCGGAT TCCCAGTCCT GAAACTAGCG TCACCAGTCT GTCCACAAAC 1320

ACCACCACTA CAAACACCAC CGGCCTTACT CCCAGCACTG GCATGACCAC CATCTCAGAG 1380

ATGCCCTACT CCGATGAAAC AAACCTCCAC GCCACAAACG TGGCCCAGCC CGTTGGGCCA 1440

ACCCCCGTCT GCCTGCAGCT CACCGAAGAG GACTTGGAGA CCAATAAGTT GGACCCAAAA 1500

GAAGTTGACA AAAATCTAAA GGAGAGCTCT GATGAGAATC TCATGGAGCA CTCACTTAAA 1560

CAGTTCAGTG GACCAGACCC CCTGAGCAGC ACCAGCTCCA GCTTGCTTTA CCCATTGATA 1620

AAACTGGCAG TGGAGGTAAC TGGACAGCAG GACTTCACTC AGGCTGGTAA TGGTCAGGCG 1680

TGTTTGATCC CTGATGTCCC ACCTGCTCAA ATCTATCCTC TCCCTAAGCA ACAGAACCTT 1740

CCTAAGAGGC CTACTAGTCT ACCCCTGAAC ACCAAAAACT CAACAAAAGA GCCCCGGCTG 1800

AAATTTGGCA GCAAGCACAA ATCAAACTTG AAGCAAGTTG AAACTGGAGT TGCCAAGATG 1860

AATACAATCA ATGCTGCAGA ACCCCACGTA GTGACAGTCA CCATGAACGG CGTGGCAGGC 1920

AGAAGCCACA ATGTGAACTC ACATGTTGCC ACAGCCCCGT ATGCCAATGG TGTGGTGCCA 1980

TCTGGGCAGG TGCCCAACTT GGTGACCCAC AGAGCCCAGG AGATGCTGCA GAACCAGTTC 2040

AGCGGAGAGG ACAGCCGGCT AACTATCAAC TCCAGCCCCG ACGAGCACGA GCCTCTCCTG 2100

AGACGGGAGC AGCAGGCCGG CCACGATGAA GGCGTCCTGG ATCGCCTGGT GGACAGGAGA 2160

GATCGGCCCC TGGAAGGTGG TCGCACAAAC TCCAATAACA ACAACAGCAA TCCGTGTCCC 2220

GGGCAGGAGG TGCTTGCTGT TGACCTTCAG AGCACAGGGG CAGACCCTGG GCAGTCAAAG 2280

CCCAGGAGGG CTCAGCGGCC TAATTCCTTG GACCTGTCAG CCACCAATGC CCTGGACAGC 2340

ACTGGTATGC AGTTAGGTGA GTCATCACAA GATGGCAAAC CAGGATCGGG TGAAAAGATC 2400

AAGAAACGTG TGAAAACCCC CTATTCCCTT AAGCGGTGGC GCCCTTCCAC CTGGGTCATC 2460

TCCACGGAAC CACTGGACTG TGAGGTCAAC AACAATGGTG GTGATAGGGC TGCTCATTCC 2520

AAATCCAGCA CTGCTGTTTA CCTTGCGGAA GGGGGCACTG CCACAACCAG GGTGTCTCAA 2580

GAGACGGGAA TGAACTGTCT ATGA 2604

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +E++iy+ +l+ h+ni +fi+

Q: 30    LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFTNRQNFINERNIYRIPLMDHDNIARFIV  89

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 90    GDErFTADARMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  149

         **9899**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 150   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  208

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee...vdeeveeyklpfeevv  231

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++   ++e+v+ey+++f+++v

Q: 209   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfpAGESVPEYQMAFQTEV  268

         *****************99************************999**************

S: 232   gsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkr  290

         g++P++e+m+ +v ++k+rP++peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r

Q: 269   GNRPTFEDMQVLVSREKQRPRFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEER  328

         ****************************9999*************************998

S: 291   l  291

Q: 329   M  329

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFTNRQNFIN ERNIYRIPLM DHDNIARFIV 60

GDERFTADAR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPAGESVPE YQMAFQTEVG 240

NRPTFEDMQV LVSREKQRPR FPEAWKENSL AVRSLKETIE DCWDQDAEAR LTAQCAEERM 300

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013