EKS-SAH-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	418.6	1.3E-125	192	478	287

Status

Unreviewed

Ensembl Protein

ENSSHAP00000011826

UniProt Accession

G3W8S1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010152	ENSSHAP00000011827	ENSSHAT00000011924
ENSSHAG00000010152	ENSSHAP00000011826	ENSSHAT00000011923

Organism

Sarcophilus harrisii

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWEKD RTNRTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDNPEV YFCCCEGNMC NERFFYFPEM 120

EITIPTSNPV TPKPPLFSTL LYSLVPIMLI AGIVLLSFWM YRHHKLAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEIKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPI LRECWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERII 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCCG CTGCAAAGTT GGCGTTTGCT GTCTTTCTTA TCTCTTGTTC TTCAGGTGCT 60

ATACTTGGCA GATCAGAAAC GCAGGAGTGC ATCTTCTATA ATGCTAATTG GGAAAAAGAT 120

AGAACGAATC GTACTGGTGT TGAACCTTGT TATGGTGACA AAGATAAACG ACGACACTGC 180

TTTGCAACGT GGAAAAATAT TTCTGGCTCA ATTGAAATAG TAAAGCAAGG TTGTTGGTTG 240

GATGATATTA ACTGTTATGA CAGAAATGAT TGCATTGAAA AAAAGGACAA CCCCGAAGTT 300

TATTTCTGTT GCTGTGAAGG CAACATGTGT AATGAAAGGT TTTTCTATTT TCCGGAGATG 360

GAGATTACAA TACCAACTTC CAATCCAGTT ACACCGAAAC CACCTTTATT CAGCACCTTG 420

CTGTATTCAT TGGTACCTAT CATGCTAATT GCAGGAATTG TGCTACTTTC ATTTTGGATG 480

TATAGGCATC ACAAGTTGGC ATACCCTCCT GTACTTGTTC CAACCCAAGA TCCAGGACCA 540

CCCCCACCTT CTCCTCTACT AGGCTTGAAG CCTCTACAGT TATTAGAAAT AAAAGCAAGG 600

GGAAGATTTG GTTGTGTCTG GAAAGCTCAA TTACTCAATG AGTATGTAGC TGTTAAGATA 660

TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATATG AAGTATATAG TCTTCCTGGA 720

ATGAAACATG AGAACATATT GCAGTTTATT GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 780

GTTGATCTCT GGCTAATCAC CGCATTTCAT GAAAAGGGTT CACTAACTGA TTTTCTCAAG 840

GCTAATGTGG TCTCTTGGAA TGAATTGTGC CATATTGCTG AAACTATGGC CAGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGTTTA AAAGATGGTC ACAAACCTGC TATATCACAC 960

AGGGACATCA AAAGCAAAAA TGTATTGTTG AAAAACAATC TTACAGCTTG TATTGCTGAT 1020

TTTGGTTTGG CATTAAAATT TGAGGCAGGG AAGTCTGCTG GTGATACCCA TGGACAGGTT 1080

GGCACCCGAA GATATATGGC TCCAGAAGTT TTAGAGGGTG CTATAAACTT TCAGAGGGAT 1140

GCATTTTTGA GAATAGATAT GTATGCCATG GGATTAGTCC TGTGGGAACT TGCCTCTCGT 1200

TGCACTGCTG CAGATGGTCC CGTGGATGAG TACATGTTGC CATTTGAAGA GGAAATTGGC 1260

CAGCATCCAT CCCTTGAAGA TATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGACCTATT 1320

TTAAGGGAGT GTTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC AATAGAAGAA 1380

TGTTGGGATC ACGATGCAGA AGCCAGGTTA TCAGCTGGCT GTGTAGGAGA AAGGATTATT 1440

CAAATGCAAA GACTAACAAA TATTATCACA ACAGAGGACA TTGTGACTGT GGTCACTATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCCAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLTDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPIL RECWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013