EKS-SAH-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	377.0	6.0E-113	212	472	261

Status

Unreviewed

Ensembl Protein

ENSSHAP00000011922

UniProt Accession

G3W917;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCH

Gene Synonyms/Alias

PRKCH;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010229	ENSSHAP00000011922	ENSSHAT00000012020

Organism

Sarcophilus harrisii

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

ATLQRDRIFK HFTRKRQRAM RRRVHQINGH KFMATYLRQP TYCSHCKEFI WGLFGKQGYQ 60

CQVCTCVVHK RCHHLIVTAC TCQNINKMDA KNSEQRFGIN IPHKFSVHNY KVPTFCDHCG 120

SLLWGIMRQG LQCKICKMNV HKRCQANVAP NCGVNAVELA KTLAGMGLQP GNISPASKLI 180

SRSPLKRQGK ESIKEGNGIG VSSSNRFGFE DFEFIRMLGK GSFGKVMLAR IKETGNLYAV 240

KVLKKDVILQ DDDVECTMTE KRILALARNH PFLTQLFCCF QTPHKLYFVQ NSLNAKFVLN 300

HTQKLLRIFK EEVYFYIKSL LIDLIFLIDK KIFYSRDLKL DNVLLDHEGH CKLADFGMCK 360

EGICEGITTA TFCGTPDYIA PEILQEMLYG PAVDWWAMGV LLYEMLCGHA PFEAENEDDL 420

FEAILNDEVV YPTWLHEDAT GILKAFMTKN PNMRLGSVTQ GGEHTILKHP FFKEINWVQL 480

NQRQLEPPFR PRIKSREDVS NFDLDFIREE PVLTPLDEGH LPMINQEEFR NFSYVSPELQ 540

S 541

Nucleotide Sequence
(FASTA)

GCAACTCTCC AGAGAGACAG AATCTTCAAG CATTTTACTC GGAAGCGCCA GAGAGCTATG 60

CGAAGACGAG TTCATCAAAT TAATGGGCAT AAGTTTATGG CAACATATCT GAGACAACCT 120

ACCTATTGTT CACATTGCAA GGAGTTTATA TGGGGCTTAT TTGGGAAACA AGGCTATCAG 180

TGCCAAGTCT GCACCTGTGT TGTTCATAAA CGCTGCCATC ATCTTATAGT TACTGCCTGC 240

ACTTGCCAAA ATATAAATAA AATGGATGCA AAGAATTCTG AACAGAGATT TGGAATCAAC 300

ATTCCCCACA AATTCAGTGT TCACAACTAT AAAGTTCCCA CCTTCTGCGA TCACTGTGGA 360

TCCCTGCTTT GGGGAATAAT GAGACAGGGA CTTCAGTGTA AAATCTGTAA AATGAATGTA 420

CATAAAAGAT GCCAAGCCAA TGTGGCACCC AACTGTGGGG TGAATGCAGT GGAATTAGCA 480

AAGACGTTGG CAGGAATGGG CCTTCAACCC GGAAATATTT CTCCAGCTTC GAAGCTAATT 540

TCCAGATCAC CCCTGAAACG ACAAGGAAAG GAAAGTATAA AAGAAGGCAA TGGAATTGGT 600

GTAAGCTCAT CTAACCGATT CGGTTTTGAA GATTTTGAGT TCATCCGAAT GTTGGGAAAG 660

GGCAGTTTTG GGAAGGTAAT GCTTGCCAGA ATAAAAGAGA CTGGCAACCT CTATGCTGTG 720

AAAGTGTTGA AGAAGGATGT GATCCTCCAG GATGATGATG TAGAGTGCAC AATGACAGAG 780

AAAAGGATCC TGGCCCTGGC CCGAAATCAC CCTTTCCTTA CCCAGTTATT CTGCTGCTTT 840

CAGACTCCTC ATAAATTGTA TTTTGTACAA AACTCTTTAA ATGCCAAATT TGTCCTGAAC 900

CACACTCAGA AACTGCTGAG GATTTTTAAG GAGGAAGTAT ATTTCTATAT CAAAAGTTTG 960

CTTATTGATC TAATTTTTCT GATAGACAAA AAAATATTTT ATTCCAGAGA TCTGAAACTG 1020

GATAATGTAT TGTTGGACCA CGAAGGTCAT TGTAAATTGG CCGACTTTGG AATGTGCAAG 1080

GAGGGCATCT GTGAAGGCAT CACCACTGCA ACATTCTGCG GCACACCTGA CTACATTGCC 1140

CCAGAGATTC TCCAGGAAAT GCTCTATGGT CCTGCTGTGG ATTGGTGGGC AATGGGAGTG 1200

CTGCTCTATG AGATGCTGTG TGGCCATGCT CCCTTCGAAG CTGAAAATGA AGATGATCTT 1260

TTTGAAGCCA TATTGAATGA TGAAGTTGTT TACCCTACAT GGCTCCATGA GGATGCCACG 1320

GGAATCTTAA AAGCTTTCAT GACCAAGAAT CCCAATATGC GCTTGGGAAG TGTGACTCAA 1380

GGTGGTGAGC ATACCATCTT GAAACATCCA TTCTTTAAAG AAATTAACTG GGTCCAACTG 1440

AACCAGCGCC AACTAGAACC ACCCTTCAGA CCCAGAATTA AATCCCGAGA AGATGTCAGT 1500

AATTTTGATC TTGACTTTAT AAGAGAAGAG CCAGTTTTAA CTCCACTTGA TGAGGGACAT 1560

CTTCCTATGA TTAACCAGGA AGAATTTAGA AACTTTTCCT ATGTATCTCC AGAATTGCAA 1620

TCATAG 1626

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fe++++lGkGsfgkv+la+ k+t +lya+kvlkkdv+lqdddve+t++ekr+lala+++p

Q: 212   FEFIRMLGKGSFGKVMLARIKETGNLYAVKVLKKDVILQDDDVECTMTEKRILALARNHP  271

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+qlf+cfqt ++l+fv + +n   ++ h qk  ++ +e+  fy   +++ l fl +k

Q: 272   FLTQLFCCFQTPHKLYFVQNSLNAKFVLNHTQKLLRIFKEEVYFYIKSLLIDLIFLIDKK  331

         ************************************************************

S: 121   iiy.rdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygk  179

         i y rdlkldnvlld+eGh+kladfG+cke+i+eg tt+tfcGtPdyiaPeil+e+ yg

Q: 332   IFYsRDLKLDNVLLDHEGHCKLADFGMCKEGICEGITTATFCGTPDYIAPEILQEMLYGP  391

         **999*******************************************************

S: 180   svdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdp  239

         +vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il++ev+yP++l+++a+ ilk+++tk+p

Q: 392   AVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKAFMTKNP  451

         ************************************************************

S: 240   ekrlGvk.eegeedikehaff  259

         ++rlG+  + ge++i +h+ff

Q: 452   NMRLGSVtQGGEHTILKHPFF  472

         *****965999*********9

Domain Sequence
(FASTA)

FEFIRMLGKG SFGKVMLARI KETGNLYAVK VLKKDVILQD DDVECTMTEK RILALARNHP 60

FLTQLFCCFQ TPHKLYFVQN SLNAKFVLNH TQKLLRIFKE EVYFYIKSLL IDLIFLIDKK 120

IFYSRDLKLD NVLLDHEGHC KLADFGMCKE GICEGITTAT FCGTPDYIAP EILQEMLYGP 180

AVDWWAMGVL LYEMLCGHAP FEAENEDDLF EAILNDEVVY PTWLHEDATG ILKAFMTKNP 240

NMRLGSVTQG GEHTILKHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013