EKS-SAH-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	293.5	1.3E-87	11	259	249

Status

Unreviewed

Ensembl Protein

ENSSHAP00000012034

UniProt Accession

G3W9C9;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010319	ENSSHAP00000012034	ENSSHAT00000012132

Organism

Sarcophilus harrisii

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

VGDYDELLKY YELYETIGTE NSGGFAKVKL ARHILTGEKV AIKIMDKNTL GNDLPRVKIE 60

IDAMKNLSHQ HICRLYHVLE TDNKIFMVME YCPGGELFDY IIAKDRLSEE ETRVFFRQIV 120

SAVAYVHSQG YAHRDLKPEN LLIDEYHKLK LIDFGLCAKP KSNKDYHLQT CCGSPAYAAP 180

ELIQGKSYIG SEADVWSMGI LLYALLCGFL PFDDDNVMAL YKKITRGKYD IPKWLSPGSI 240

LLLQQMLQII LIKKVALDSF IENSPCLFQD FLWGNYFKKQ NKPFIYSVTV SDQLNVFITY 300

QHSERRQTVT GLILEWQYDQ LTATYHLLLA KKSHGKPVRL RLPSVSGEQT STSLLEELQS 360

LNWNLKRVTH KNNYVFETLE FPLIYEAFED ISFAKMVLKS PKLAKHWTES NDVESKPLTP 420

ILCRAAKKKL ENKENVCMPK SAKSAMKDEE HFVLPIPKTP VSKSVHERGI LTVPNPPPYK 480

ERNQCKEEIL IKSTNPEKSK ELPTAIISPE RRCRSVELDL NQAHRDSPQK RKGTKMFGSL 540

ERGLDKMITM LTPNKKKGST RDGPRRLRAH YNVTTTRLVN PDQLLAEIIS ILPQKHVDFV 600

QKGYKLKCQT QSDFGKVTMQ FELEVCQLSK PEVVGIRRQR LKGDAWVYKR LVEDILSSCK 660

V 661

Nucleotide Sequence
(FASTA)

GTGGGAGATT ATGATGAACT TCTCAAATAT TATGAATTAT ATGAAACTAT TGGGACAGAA 60

AATTCAGGTG GCTTTGCAAA GGTTAAGCTT GCCCGCCATA TTCTCACTGG AGAAAAGGTA 120

GCAATAAAAA TCATGGACAA GAATACACTC GGGAATGATT TGCCTCGGGT GAAAATAGAG 180

ATTGATGCTA TGAAGAATCT AAGTCATCAG CATATTTGTC GTCTTTACCA TGTACTTGAG 240

ACTGACAACA AAATATTTAT GGTTATGGAG TACTGTCCTG GAGGAGAGCT GTTTGATTAT 300

ATAATTGCCA AAGATCGTCT CTCGGAGGAG GAAACACGTG TCTTCTTCCG GCAGATTGTG 360

TCAGCTGTTG CTTATGTACA TAGTCAAGGT TATGCTCATA GGGATCTCAA ACCAGAAAAT 420

TTGCTGATTG ATGAATACCA TAAATTGAAG TTGATTGACT TCGGTCTTTG TGCAAAGCCC 480

AAAAGTAACA AGGATTACCA TCTACAGACA TGTTGTGGGA GTCCAGCTTA TGCAGCCCCT 540

GAACTAATCC AAGGCAAATC CTATATTGGA TCAGAGGCAG ATGTTTGGAG CATGGGAATT 600

CTCTTATATG CACTACTATG TGGATTTCTA CCATTTGATG ATGATAATGT AATGGCTTTA 660

TACAAGAAGA TCACTCGAGG AAAATATGAC ATTCCAAAGT GGCTGTCTCC TGGTAGTATT 720

CTGCTTCTTC AACAGATGTT ACAGATCATC CTTATAAAAA AAGTTGCACT GGATTCTTTC 780

ATTGAGAATT CTCCTTGCTT GTTCCAAGAT TTTCTCTGGG GAAATTATTT TAAAAAACAG 840

AATAAGCCTT TTATTTACAG TGTAACTGTA TCTGACCAAC TTAATGTATT CATCACATAT 900

CAACATTCTG AGAGAAGACA AACAGTAACA GGTTTAATAT TAGAGTGGCA ATATGATCAA 960

CTTACAGCTA CCTATCATCT ACTTCTTGCT AAGAAATCTC ATGGAAAACC AGTTCGATTA 1020

AGACTCCCAT CTGTCAGTGG AGAACAAACA AGTACTTCTT TATTGGAAGA ATTACAGAGC 1080

TTAAATTGGA ACCTTAAAAG AGTGACTCAC AAAAATAATT ATGTATTTGA AACCTTAGAA 1140

TTCCCACTTA TTTATGAAGC ATTTGAAGAT ATTTCATTTG CAAAGATGGT TTTAAAGTCT 1200

CCCAAACTTG CAAAACACTG GACAGAATCA AACGATGTGG AATCTAAGCC GTTAACTCCA 1260

ATATTGTGCA GAGCAGCCAA AAAGAAATTG GAGAACAAAG AAAATGTGTG CATGCCTAAG 1320

TCTGCTAAGT CTGCTATGAA GGATGAAGAA CATTTTGTAC TGCCAATTCC AAAGACTCCT 1380

GTTAGCAAGA GTGTTCATGA AAGAGGAATA TTAACTGTAC CAAATCCTCC TCCTTATAAA 1440

GAGAGAAATC AGTGCAAAGA AGAAATACTG ATTAAAAGTA CAAATCCAGA GAAATCAAAG 1500

GAATTACCAA CAGCCATTAT TAGTCCTGAG AGACGATGCC GTTCAGTGGA ATTGGATCTT 1560

AATCAAGCAC ATAGAGACAG TCCTCAAAAG AGAAAAGGAA CCAAAATGTT TGGAAGTCTT 1620

GAAAGGGGGT TAGATAAAAT GATTACAATG CTTACTCCAA ACAAAAAGAA GGGATCTACT 1680

AGAGATGGAC CAAGAAGACT AAGGGCTCAC TATAATGTGA CCACGACCAG ATTAGTTAAT 1740

CCAGATCAAC TTTTGGCTGA AATAATTTCT ATCCTTCCAC AAAAACATGT TGACTTTGTG 1800

CAGAAAGGCT ATAAACTGAA GTGTCAAACA CAGTCAGATT TTGGCAAAGT GACAATGCAG 1860

TTTGAGCTAG AAGTTTGCCA ACTTAGCAAA CCTGAGGTGG TAGGTATCAG GAGGCAAAGG 1920

CTTAAGGGTG ATGCTTGGGT TTATAAGAGA TTAGTTGAAG ATATTCTTTC TAGCTGCAAG 1980

GTGTAA 1986

Domain Profile

S: 1     ykllktlGe...gsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkh  57

         y+l +t+G+   g f+kVkla+h +t+ekva+Ki++k++l ++ l ++k Ei+++k+l+h

Q: 11    YELYETIGTensGGFAKVKLARHILTGEKVAIKIMDKNTLGND-LPRVKIEIDAMKNLSH  69

         777888885333889**********************999755.89**************

S: 58    pniikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhsk  117

         ++i++l++v+et++k+++v+ey+ ggeLfdyi +k rl+e+e+r +f+q+vsav Y+hs+

Q: 70    QHICRLYHVLETDNKIFMVMEYCPGGELFDYIIAKDRLSEEETRVFFRQIVSAVAYVHSQ  129

         ************************************************************

S: 118   givHrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYe  175

         g +HrDlKpeNll+d+ +++k++DFGl+++ k++   +l+t+cGsp+YaaPel++gk+Y

Q: 130   GYAHRDLKPENLLIDEYHKLKLIDFGLCAKPKSNkdYHLQTCCGSPAYAAPELIQGKSYI  189

         *****************************665554489**********************

S: 176   gpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvv  235

         g+++DvWs+G++Lyal++g lPfd++n+ +l++ki++gk++ipk+ls+  + Ll+++L+

Q: 190   GSEADVWSMGILLYALLCGFLPFDDDNVMALYKKITRGKYDIPKWLSPGSILLLQQMLQI  249

         ***********************************************************9

S: 236   dpekRatiee  245

            k++ +++

Q: 250   ILIKKVALDS  259

8888877765

Domain Sequence
(FASTA)

YELYETIGTE NSGGFAKVKL ARHILTGEKV AIKIMDKNTL GNDLPRVKIE IDAMKNLSHQ 60

HICRLYHVLE TDNKIFMVME YCPGGELFDY IIAKDRLSEE ETRVFFRQIV SAVAYVHSQG 120

YAHRDLKPEN LLIDEYHKLK LIDFGLCAKP KSNKDYHLQT CCGSPAYAAP ELIQGKSYIG 180

SEADVWSMGI LLYALLCGFL PFDDDNVMAL YKKITRGKYD IPKWLSPGSI LLLQQMLQII 240

LIKKVALDS 249

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013