EKS-SAH-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	449.9	2.4E-135	271	519	249

Status

Unreviewed

Ensembl Protein

ENSSHAP00000012366

UniProt Accession

G3WAB1;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010594	ENSSHAP00000012366	ENSSHAT00000012467

Organism

Sarcophilus harrisii

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE AAKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAASGQG 60

LTVFGGVGSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240

RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300

LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360

ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480

RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQGFL EDYFTATEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TCCAATGTAA GGATAAAGAA GCAGCAAAAC TGACAGAGGA GAGGGATGGC 60

AGCTTAAACC AGAGCTCTGG CTATCGCTAT GGGACAGACC CCACTCCCCA GCACTACCCT 120

AGTTTTGGTG TGACCTCCAT CCCCAACTAC AACAACTTCC ATGCAGCCAG TGGCCAAGGG 180

CTGACTGTCT TCGGAGGCGT TGGTTCTTCT TCTCACACTG GGACCTTGCG GACAAGAGGA 240

GGAACAGGTG TAACCCTTTT TGTGGCCCTT TACGACTATG AGGCACGAAC GGAAGATGAC 300

CTGAGTTTTC ATAAAGGAGA AAAATTTCAA ATACTCAATA GCTCTGAAGG AGACTGGTGG 360

GAAGCCCGTT CCCTGACAAC AGGAGAGACT GGCTATATTC CCAGCAATTA TGTGGCTCCA 420

GTTGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGTCGCAA AGATGCAGAA 480

AGACAACTCT TGTCCTTTGG AAATCCACGA GGTACCTTTC TTATCCGAGA GAGTGAAACC 540

ACCAAAGGTG CCTATTCACT TTCTATCCGT GATTGGGATG ATATGAAGGG AGACCATGTC 600

AAACATTACA AGATCCGAAA ACTTGACAAT GGTGGCTACT ACATCACCAC AAGAGCCCAG 660

TTTGAAACTC TTCAGCAGCT CGTCCAGCAT TACTCAGAGA GAGCTGCAGG CCTTTGCTGC 720

CGCTTAGTAG TCCCCTGTCA TAAAGGAATG CCGAGGCTTA CTGATCTGTC TGTCAAAACC 780

AAAGATGTCT GGGAAATTCC ACGTGAATCC CTTCAGTTGA TCAAGAGACT GGGAAATGGG 840

CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGGAATA CAAAAGTGGC CATCAAGACT 900

CTTAAGCCTG GCACAATGTC TCCAGAATCC TTTCTCGAGG AAGCCCAGAT CATGAAGAAA 960

CTGAAGCATG ATAAACTGGT CCAACTTTAT GCTGTGGTGT CTGAAGAGCC AATCTACATT 1020

GTCACGGAGT ACATGAATAA AGGGAGTTTG CTGGATTTCC TAAAAGATGG AGAAGGGAGA 1080

GCCCTGAAAT TGCCTAATCT GGTGGACATG GCTGCACAGG TTGCTGCAGG TATGGCTTAT 1140

ATTGAGCGGA TGAATTACAT TCATAGAGAT CTGCGATCAG CAAACATTCT GGTCGGGAAT 1200

GGGCTCATAT GCAAGATAGC TGATTTTGGA TTAGCCAGAT TGATTGAAGA CAACGAATAT 1260

ACAGCAAGAC AAGGTGCAAA GTTCCCGATC AAGTGGACAG CCCCAGAAGC AGCCCTCTAC 1320

GGAAGGTTCA CAATTAAGTC TGATGTGTGG TCCTTTGGAA TTTTACTCAC AGAGCTGGTA 1380

ACCAAAGGGA GAGTTCCCTA TCCAGGCATG AATAACCGTG AAGTTTTGGA GCAAGTGGAA 1440

CGTGGGTACA GGATGCCATG TCCTCAGGAC TGCCCTATCT CCTTGCATGA GCTTATGATT 1500

CACTGCTGGA AAAAAGATCC CGAGGAGCGC CCCACGTTTG AGTATTTGCA GGGTTTCCTG 1560

GAAGACTACT TTACTGCAAC AGAACCCCAA TACCAACCTG GTGAAAACCT GTAA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq +

Q: 510   RPTFEYLQGF  519

         *******976

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240

PTFEYLQGF 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013