EKS-SAH-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	423.3	4.7E-127	38	326	289

Status

Unreviewed

Ensembl Protein

ENSSHAP00000012745

UniProt Accession

G3WBE0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010907	ENSSHAP00000012745	ENSSHAT00000012849

Organism

Sarcophilus harrisii

Functional Description

Protein Length

375

Protein Sequence
(FASTA)

NSAGPALPRT GASLTQGSAG PRPVEMVKGQ PFDVGPRYTE LQYLGEGADG MVSSAFDHVR 60

KARVAIKKIS PFEHQTYCQR TLREIQILLR CHHENVIGIR DILRAPTLEA MRDVYIVQDL 120

METDLYKLLK SQQLSNDHVC YFLYQILRGL KYIHSANVLH RDLKPSNLLI NTTCDLKICD 180

FGLARIADPE HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI LAEMLSNRPI 240

FPGKHYLDQL NHILGILGSP SQDDLNCIIN MKARNYLQSL PSKPKVPWVK LFPKADSKAL 300

DLLDRMLTFN PNKRITVEDA LAHPYLEQYY DPTDEPVAEE PFTFDMELDD LPKERLKELI 360

FQETARFQPG APGAP 375

Nucleotide Sequence
(FASTA)

AACTCCGCGG GCCCGGCCCT TCCTCGCACC GGGGCTTCCC TCACGCAGGG GAGCGCGGGA 60

CCCAGGCCCG TGGAGATGGT GAAGGGCCAG CCGTTTGACG TGGGACCGCG CTACACAGAG 120

CTGCAGTACC TTGGGGAGGG GGCGGACGGC ATGGTCAGCT CTGCTTTTGA CCATGTTCGA 180

AAGGCTCGAG TAGCCATCAA AAAGATCAGC CCGTTTGAGC ACCAGACATA TTGCCAGCGC 240

ACCCTTCGGG AGATTCAGAT CCTGCTTCGT TGCCACCACG AGAATGTCAT TGGCATCCGT 300

GACATCCTTC GAGCACCCAC GCTGGAAGCC ATGAGGGATG TTTACATTGT TCAGGACCTG 360

ATGGAAACAG ACTTGTATAA GCTGCTCAAG AGCCAGCAGC TGAGTAATGA CCATGTCTGC 420

TACTTCCTGT ACCAAATCCT ACGGGGCCTC AAATATATTC ACTCAGCCAA TGTGCTTCAT 480

CGGGACCTCA AACCCTCCAA TCTGCTCATC AACACCACTT GTGACCTCAA GATCTGTGAC 540

TTTGGCCTGG CCCGAATTGC TGACCCTGAG CACGATCATA CAGGCTTCCT GACTGAGTAT 600

GTGGCTACGC GATGGTATAG AGCACCAGAG ATCATGCTCA ATTCTAAGGG CTATACCAAA 660

TCTATTGATA TCTGGTCTGT GGGCTGTATC CTCGCAGAAA TGCTTTCCAA TCGGCCCATC 720

TTCCCTGGGA AGCACTACCT GGATCAGCTG AACCACATTC TAGGTATCCT AGGTTCTCCG 780

TCCCAGGATG ATCTGAATTG TATCATCAAC ATGAAGGCTC GGAACTACCT ACAGTCACTT 840

CCATCCAAAC CTAAGGTGCC CTGGGTCAAG CTGTTTCCCA AAGCAGACTC CAAAGCCCTG 900

GACCTGCTGG ACCGGATGTT GACCTTTAAC CCTAACAAGC GAATCACAGT GGAGGATGCC 960

CTGGCCCACC CCTACTTGGA GCAGTACTAT GATCCAACTG ATGAGCCAGT GGCAGAAGAA 1020

CCCTTTACTT TTGACATGGA GTTGGATGAC CTGCCAAAGG AACGACTGAA GGAACTCATC 1080

TTCCAAGAGA CAGCCCGATT CCAACCTGGA GCCCCAGGAG CCCCCTGA 1128

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l++lgeGa g+v sa+d+ ++ rvaikk+s pf+++t ++rtlRE+++l + +heN+

Q: 38    YTELQYLGEGADGMVSSAFDHVRKARVAIKKIS-PFEHQTYCQRTLREIQILLRCHHENV  96

         7899****************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + le+++dvY+v++lmetdL+k++ksq+ls++h+ ++lyqilrglky+Hs

Q: 97    IGIRDILRAPT-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHVCYFLYQILRGLKYIHS  155

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++

Q: 156   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  215

         ***********************************99999********************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+++l++i + +arn

Q: 216   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQDDLNCIINMKARN  275

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k ++ +lfpka+++aldLl+++L+++p+kRi+ve+aL+hpYl

Q: 276   YLQSLPSKPKVPWVKLFPKADSKALDLLDRMLTFNPNKRITVEDALAHPYL  326

         **************************************************7

Domain Sequence
(FASTA)

YTELQYLGEG ADGMVSSAFD HVRKARVAIK KISPFEHQTY CQRTLREIQI LLRCHHENVI 60

GIRDILRAPT LEAMRDVYIV QDLMETDLYK LLKSQQLSND HVCYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQDDLNC IINMKARNYL 240

QSLPSKPKVP WVKLFPKADS KALDLLDRML TFNPNKRITV EDALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013