EKS-SAH-00362

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00362

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	323.9	1.0E-96	1071	1335	265

Status

Unreviewed

Ensembl Protein

ENSSHAP00000012819

UniProt Accession

G3WBL4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000010967	ENSSHAP00000012819	ENSSHAT00000012924

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1340

Protein Sequence
(FASTA)

RDMENKETLK GLQKMDDRPE ERMIREKLKA TCMPAWKHEW LERRSRRGPV VVKPIPVKGD 60

GSEINKLTPE SQTEGHTNTS SPTPKGRRSP SPSSSSSSNR TVKSESPGVR RKRVSPVPFQ 120

SGRITPPRRA PSPDGFSPYS PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV 180

FIGPQTCSCG RGTFCIHLLF VMLRVFQLES SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI 240

KAPSRSTIQK FVSRMSNSHT LSSSSTSTSS SENSMKDEEE QMCPICLLGM LDEESLTVCE 300

DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF YSHELPSPVD SPSVLRAAQQ 360

QTVQQPPSVG SQRRNQDSNF NLTHYGVQQI PPAYKDLAEP WIQVFGMELV GCLFSRNWNI 420

REMALRRLSH DVSGALLLAN GESTGNSGNN NGNTPSAGAA SGSSQAGVSG DIVVEACCSV 480

LSMVCADPVY KVYVAALKTL RAMLVYTPCH SLAERIKLQK LLRPVVETIL VKCADANSRT 540

SQLSVSTLLE LCKGQAGELA VGREILKSGS IGIGGIDYVL NCILGSQTES SNWQALLGRL 600

CLIDRMLLEF PAEFYPHIVS GEVLQADAVV DRYKKLLSLL NFALQFIDNS HSMVGKLSRR 660

VFLSAARMVA RVPHVFLKLL EMLSVISSTH YTRMRRRLMA IADEMEIAEA IQLGMEDSLD 720

CRQDGFLQPS APDNSPETTE NNSPQHTVQL EKTRKPLCDA KSSASPEEIS DALAGISVGL 780

PGSVTMEQPK PALQTKGRPH SQCLNSSSSS HPQLLFPTLP SPPSSAPSVP AGSVTDVSKP 840

RTQGFVPCKI PTASPQMQRK FSLQILRNCS EIKEPDKLSP VFTQARPMPS SQIHRPKPSR 900

PTPGDVHKQG EVSKSSMTLD LNNITQCDGG GGAVIPSEET VFTPVEEKGR LDVNTELNSS 960

IEDLLEAMPA SDTTVTFKSE VAVLSPERAE NDDTYKDDVN HNQKCKEKME AEEEEALSIA 1020

MAMSASQDAL PIVPQLQVEN GEDIIIIQQD TPETLPGHTK AKHHYREDAE WLKGQQIGLG 1080

AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN HPNIIRMLGA 1140

TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE NQIIHRDVKG 1200

ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR GQQYGRSCDV 1260

WSVGCAIIEM TCAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR DVTLRCLELQ 1320

PQDRPPSREL LKHPVFRTTW 1340

Nucleotide Sequence
(FASTA)

CGAGATATGG AGAATAAAGA AACTCTCAAG GGATTGCAGA AAATGGATGA CCGCCCAGAA 60

GAACGAATGA TCAGGGAAAA ACTCAAGGCC ACATGTATGC CAGCCTGGAA ACATGAATGG 120

CTGGAAAGGA GGAGTAGGAG AGGCCCTGTG GTAGTAAAAC CAATTCCTGT CAAAGGAGAT 180

GGTTCTGAAA TCAACAAGTT AACACCAGAA TCTCAAACTG AAGGGCATAC AAATACTTCT 240

TCACCTACTC CAAAAGGAAG GCGAAGTCCT TCTCCAAGTA GCTCTTCTTC TTCAAATCGT 300

ACTGTTAAAT CAGAATCTCC TGGGGTAAGA AGAAAAAGAG TATCTCCAGT GCCTTTTCAG 360

AGTGGGAGAA TCACACCACC CCGAAGAGCT CCATCTCCAG ATGGCTTCTC TCCATATAGT 420

CCTGAGGAAA CAAATCGTCG AGTCAACAAA GTCATGAGGG CTCGGTTGTA CTTACTGCAG 480

CAGATAGGAC CCAACTCTTT CCTCATTGGA GGAGATAGCC CAGACAATAA ATACAGGGTG 540

TTTATTGGGC CTCAGACCTG TAGCTGTGGG CGTGGAACAT TTTGTATCCA TTTGTTATTT 600

GTTATGCTCC GAGTATTTCA ACTAGAATCC TCAGATCCAA TGTTGTGGAG GAAAACTTTG 660

AAAAATTTTG AGGTTGAAAG TTTGTTCCAG AAATATCACA GTAGGCGTAG CTCAAGGATC 720

AAAGCTCCAT CTCGTAGCAC CATCCAGAAG TTTGTATCAC GCATGTCAAA CTCTCATACG 780

TTGTCATCAT CTAGTACTTC TACATCTAGT TCAGAAAACA GTATGAAGGA TGAAGAGGAA 840

CAGATGTGCC CCATTTGTCT GTTAGGAATG CTTGATGAAG AGAGCCTTAC AGTATGTGAA 900

GATGGCTGTA GGAACAAGTT GCACCACCAC TGCATGTCAA TTTGGGCAGA AGAATGTAGA 960

AGAAATAGAG AGCCTCTGAT ATGTCCTCTT TGTAGATCCA AGTGGAGGTC CCATGATTTC 1020

TACAGTCATG AATTGCCAAG TCCTGTGGAT TCTCCTTCTG TTCTCCGAGC TGCCCAACAA 1080

CAAACTGTAC AGCAGCCACC TTCTGTTGGA TCACAAAGAA GAAACCAGGA CAGTAACTTT 1140

AACCTTACTC ATTATGGAGT TCAGCAGATC CCTCCTGCCT ACAAAGATTT AGCTGAGCCA 1200

TGGATTCAGG TATTTGGAAT GGAGCTTGTG GGCTGCTTAT TTTCTCGAAA CTGGAATATA 1260

AGAGAGATGG CACTCAGGCG TCTTTCCCAT GATGTTAGTG GTGCTCTGCT ATTGGCTAAT 1320

GGGGAAAGCA CTGGAAATTC TGGGAACAAC AATGGAAACA CCCCAAGTGC TGGAGCAGCA 1380

AGTGGGTCAT CTCAGGCCGG TGTCTCTGGA GACATTGTTG TGGAGGCTTG CTGCAGTGTT 1440

CTGTCAATGG TGTGTGCTGA CCCTGTCTAC AAAGTCTATG TTGCTGCTTT AAAAACATTA 1500

AGAGCCATGT TGGTGTACAC TCCTTGCCAC AGTTTGGCAG AAAGAATAAA ACTTCAGAAA 1560

CTTCTTAGGC CAGTTGTAGA AACCATATTA GTCAAATGTG CAGATGCCAA TAGCCGCACA 1620

AGTCAGCTTT CAGTTTCAAC ACTGTTGGAA CTCTGCAAAG GCCAAGCAGG AGAACTGGCA 1680

GTTGGCAGAG AAATACTTAA ATCAGGATCC ATTGGTATTG GTGGTATTGA TTATGTTTTA 1740

AATTGTATTC TTGGAAGCCA AACTGAATCA AGTAACTGGC AAGCACTATT GGGGCGCCTT 1800

TGTCTTATAG ACAGAATGTT GTTGGAGTTT CCTGCAGAAT TTTATCCCCA TATTGTTAGT 1860

GGAGAAGTCT TACAAGCTGA TGCTGTAGTA GACAGATATA AGAAGCTGCT GTCCCTCTTG 1920

AACTTTGCTT TGCAATTCAT TGATAATTCC CACTCAATGG TTGGTAAACT GTCCCGAAGA 1980

GTGTTTTTAA GTGCTGCAAG AATGGTTGCC AGAGTACCCC ATGTGTTTTT AAAACTCTTG 2040

GAAATGTTGA GTGTTATAAG CTCTACACAT TACACAAGGA TGCGTCGTCG TTTGATGGCT 2100

ATTGCAGATG AGATGGAAAT TGCTGAAGCC ATCCAGCTGG GCATGGAAGA TTCTTTGGAT 2160

TGCAGGCAGG ATGGCTTTTT GCAGCCATCC GCCCCAGATA ACTCCCCAGA AACAACAGAA 2220

AACAATTCTC CTCAGCACAC AGTCCAGTTA GAGAAAACCA GAAAGCCTTT GTGTGATGCA 2280

AAATCAAGTG CCAGTCCAGA AGAGATCTCG GATGCCTTAG CTGGCATTTC TGTGGGACTT 2340

CCCGGTTCAG TAACAATGGA GCAACCAAAG CCAGCCCTTC AGACGAAAGG TAGACCCCAC 2400

AGTCAGTGTT TGAACTCTTC TTCATCCAGT CACCCCCAGT TATTGTTCCC AACTTTGCCC 2460

TCCCCTCCTT CCTCTGCCCC ATCTGTACCA GCTGGCTCTG TAACAGATGT CTCTAAACCC 2520

AGAACTCAGG GATTTGTTCC CTGCAAAATA CCCACAGCTT CTCCACAAAT GCAAAGAAAA 2580

TTTTCTCTAC AGATTCTTAG AAACTGTTCT GAAATCAAAG AACCAGATAA ACTTTCCCCA 2640

GTTTTTACGC AGGCAAGACC CATGCCTTCC AGTCAGATAC ACAGGCCAAA GCCTTCTCGG 2700

CCCACTCCAG GAGATGTGCA CAAGCAGGGA GAAGTCTCCA AAAGTAGCAT GACCCTGGAC 2760

CTGAACAACA TCACCCAGTG CGATGGCGGT GGTGGTGCCG TCATCCCCAG TGAAGAGACG 2820

GTGTTCACCC CGGTGGAGGA GAAGGGCCGC TTAGATGTCA ACACGGAGCT CAACTCCAGC 2880

ATCGAGGATC TGCTTGAGGC CATGCCCGCC AGTGACACCA CCGTGACCTT CAAGTCAGAA 2940

GTGGCTGTCC TTTCTCCCGA GAGGGCCGAA AATGATGACA CCTACAAAGA TGATGTAAAT 3000

CACAATCAGA AGTGCAAAGA GAAGATGGAA GCGGAAGAAG AGGAAGCGTT ATCCATCGCC 3060

ATGGCAATGT CTGCCTCCCA GGATGCCCTG CCAATAGTTC CTCAGCTACA AGTTGAAAAT 3120

GGAGAGGATA TAATCATTAT ACAGCAAGAT ACGCCAGAGA CTCTTCCAGG ACACACCAAA 3180

GCAAAGCACC ATTATAGAGA AGATGCCGAG TGGCTCAAAG GTCAGCAGAT AGGTCTCGGA 3240

GCATTTTCTT CTTGTTATCA AGCTCAAGAT GTAGGAACTG GAACTTTAAT GGCTGTGAAA 3300

CAGGTGACAT ATGTCAGGAA TACATCTTCT GAGCAAGAGG AGGTAGTTGA AGCTCTGAGA 3360

GAAGAGATCA GGATGATGAG CCACCTGAAT CATCCTAATA TCATTCGAAT GTTGGGTGCT 3420

ACATGTGAGA AGAGCAATTA TAATCTTTTC ATAGAATGGA TGGCAGGAGG ATCTGTGGCT 3480

CATTTATTGA GTAAATATGG AGCTTTCAAG GAGTCAGTAG TTATTAACTA TACTGAGCAA 3540

TTGCTTCGTG GCCTTTCTTA TCTCCATGAG AATCAGATCA TTCACAGAGA TGTCAAAGGT 3600

GCCAATTTAC TAATTGACAG CACAGGTCAG AGATTGAGAA TTGCTGACTT TGGAGCTGCA 3660

GCTAGATTGG CATCAAAAGG AACGGGCGCT GGAGAGTTTC AGGGACAGTT GTTGGGAACA 3720

ATTGCATTTA TGGCACCTGA GGTACTAAGA GGTCAACAGT ATGGTAGGAG TTGTGATGTA 3780

TGGAGTGTTG GCTGTGCTAT TATAGAAATG ACTTGTGCTA AACCACCTTG GAATGCAGAA 3840

AAACACTCTA ATCATCTTGC TTTGATATTT AAGATTGCTA GTGCAACTAC TGCTCCTTCA 3900

ATACCCTCCC ATCTATCTCC TGGCTTACGA GATGTGACTC TTCGTTGTTT AGAACTTCAA 3960

CCTCAGGACA GACCTCCTTC AAGAGAGCTA CTGAAGCATC CAGTCTTCCG TACTACCTGG 4020

TAG 4023

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1071  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1130

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1131  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1190

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1191  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1250

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem ++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1251  GQ--QYGRSCDVWSVGCAIIEMTCAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1308

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1309  LRDVTLRCLELQPQDRPPSRELLKHPV  1335

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM TCAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVTLRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013