EKS-SAH-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	428.6	1.2E-128	205	492	288

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013281

UniProt Accession

G3WCX6;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVRL1

Gene Synonyms/Alias

ACVRL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011355	ENSSHAP00000013281	ENSSHAT00000013390

Organism

Sarcophilus harrisii

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

EVLSPPGMDL LVLLLALGLA DGGSTMSSPN SLLTCACENF NCKGSSTCQG SWCTVWLIKE 60

AGGQPREYRG CSNQHHQETC LGLPTEAFAH HCCYQPLCNL NITLKLATTP ATPEEPHRTN 120

QLPLILGPGL ALLILLGLGA LGLWHLSRRR EKQRALNSDL GESSLILKAS ELGDSTLWDL 180

LDSDCTTGSG SGLPFLVQRT VARQIALVEC VGKGRYGEVW RGLWHGENVA VKIFSSRDEQ 240

SWFRETEIYN TVLLRHDNVL GFIASDMTSR NSSTQLWLIT HYHEHGSLYD FLQRQPLDRG 300

LALRLAHSIA CGLAHLHVEI FGTQGKPAIA HRDLKSRNVL VKSNLQCCIA DLGLAVMHSQ 360

GSDSLDIGNN PRVGTKRYMA PEVLDEQLRT DCFESYKWTD IWAFGLVLWE IARRTIVNGI 420

VEDYRPPFFD MVPNDPSFEE MKKVVCVDQQ TPNIPNRLAA DPFLSGLAQM MRECWYPNPS 480

ARLTALRIKK TLQKLCANLE KPKMIH 506

Nucleotide Sequence
(FASTA)

GAGGTCCTGA GTCCCCCTGG GATGGACCTG CTCGTGCTGC TGCTGGCTCT GGGCCTGGCT 60

GATGGTGGTT CTACGATGTC CTCACCCAAC TCTCTCTTGA CCTGTGCCTG TGAGAACTTT 120

AACTGCAAGG GATCTTCCAC CTGCCAGGGG TCTTGGTGCA CTGTGTGGCT GATAAAAGAG 180

GCAGGAGGAC AACCCCGAGA GTATCGGGGC TGCAGTAACC AGCACCACCA AGAGACATGT 240

CTGGGACTGC CCACTGAGGC CTTTGCCCAT CATTGCTGCT ACCAGCCTCT CTGCAACCTC 300

AACATCACCC TGAAATTAGC AACCACACCA GCCACACCAG AGGAACCCCA TCGAACTAAC 360

CAACTGCCAC TGATTTTGGG CCCTGGGTTG GCTCTGCTGA TCCTTCTGGG GCTGGGGGCC 420

CTGGGCCTGT GGCACCTCAG TCGAAGGCGT GAGAAACAAA GAGCCTTGAA CAGTGACCTG 480

GGAGAATCCA GCCTCATCCT GAAGGCATCG GAGCTGGGGG ACAGCACACT GTGGGATCTT 540

CTGGACAGTG ACTGCACTAC AGGCAGTGGC TCTGGTCTTC CTTTCCTGGT CCAGCGGACA 600

GTAGCCCGGC AAATTGCTCT GGTGGAGTGT GTGGGCAAGG GCCGCTATGG GGAAGTGTGG 660

AGGGGCTTGT GGCATGGTGA AAATGTGGCT GTCAAAATCT TCTCCTCCAG GGATGAGCAG 720

TCCTGGTTCC GAGAGACAGA AATCTACAAC ACGGTGCTAC TCAGACATGA CAATGTTCTC 780

GGTTTCATTG CTTCTGACAT GACATCCCGT AATTCCAGTA CCCAGCTGTG GCTGATCACC 840

CACTATCATG AGCATGGCTC CTTGTATGAC TTCCTGCAGC GGCAGCCACT GGACCGAGGA 900

TTGGCCCTGC GGCTGGCCCA CTCCATTGCC TGTGGTCTGG CCCACCTTCA CGTGGAGATC 960

TTTGGAACCC AGGGCAAGCC AGCCATCGCC CACCGGGACC TGAAGAGCCG CAATGTCTTG 1020

GTTAAAAGCA ACCTACAGTG TTGCATAGCG GACCTGGGCC TGGCAGTAAT GCATTCTCAA 1080

GGCAGTGACT CCCTGGACAT TGGCAACAAC CCTCGGGTGG GCACCAAGAG GTACATGGCG 1140

CCAGAAGTAC TGGATGAGCA GCTTCGCACT GACTGCTTTG AATCCTATAA GTGGACAGAC 1200

ATCTGGGCCT TTGGTCTAGT GCTATGGGAG ATAGCCCGCC GGACCATAGT GAACGGTATT 1260

GTGGAGGACT ATAGGCCGCC CTTCTTTGAC ATGGTTCCCA ACGACCCCAG TTTTGAAGAA 1320

ATGAAAAAAG TGGTTTGTGT CGATCAGCAG ACACCCAACA TTCCCAACCG TCTGGCTGCA 1380

GATCCGTTTC TTTCAGGTCT GGCACAAATG ATGCGGGAAT GTTGGTACCC CAACCCTTCA 1440

GCTCGCCTCA CAGCCCTGCG TATCAAAAAA ACCCTACAGA AACTCTGTGC AAACCTAGAG 1500

AAGCCCAAAA TGATACACTA G 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+n+l+fia

Q: 205   IALVECVGKGRYGEVWRGLWHGENVAVKIFSSRDEQSWFRETEIYNTVLLRHDNVLGFIA  264

         6799********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+d+L+r+ ld   +lrla+s+a+GlahLH ei+gt+

Q: 265   SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQPLDRGLALRLAHSIACGLAHLHVEIFGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ +++ld+ +n +vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDSLDIGNNPRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+l +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf ++v++dPs+eem

Q: 383   VLDEQLRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFFDMVPNDPSFEEM  441

         *********************************99.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+++++ P+ip+++ +++ l+ l+++++ecW+ +p+aRltalr+kk+l

Q: 442   KKVVCVDQQTPNIPNRLAADPFLSGLAQMMRECWYPNPSARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IALVECVGKG RYGEVWRGLW HGENVAVKIF SSRDEQSWFR ETEIYNTVLL RHDNVLGFIA 60

SDMTSRNSST QLWLITHYHE HGSLYDFLQR QPLDRGLALR LAHSIACGLA HLHVEIFGTQ 120

GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQGSDS LDIGNNPRVG TKRYMAPEVL 180

DEQLRTDCFE SYKWTDIWAF GLVLWEIARR TIVNGIVEDY RPPFFDMVPN DPSFEEMKKV 240

VCVDQQTPNI PNRLAADPFL SGLAQMMREC WYPNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013