EKS-SAH-00437

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00437

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	375.5	1.7E-112	58	344	287

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013598

UniProt Accession

G3WDU3;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011623	ENSSHAP00000013598	ENSSHAT00000013710

Organism

Sarcophilus harrisii

Functional Description

Protein Length

444

Protein Sequence
(FASTA)

MLNPGQQQPY FPSPAPGQAP GPAATAPAQV QAAAAAAVKA HHHQHSHHPQ QQLDIEPDRP 60

IGYGAFGVVW SVTDPRDGKR VALKKMPNVF QNLVSCKRVF RELKMLCFFK HDNVLSALDI 120

LQPPHIDYFE EIYVVTELMQ SDLHKIIVSP QPLSSDHVKV FLYQILRGLK YLHSAGILHR 180

DIKPGNLLVN SNCVLKICDF GLARVEELDE SRHMTQEVVT QYYRAPEILM GSRHYSNAID 240

IWSVGCIFAE LLGRRILFQA QSPIQQLDLI TDLLGTPSLE AMRTACEGAK AHILRGPHKQ 300

PSLPVLYTLS SQATHEAVHL LCRMLVFDPS KRISAKDALA HPYLDEGRLR YHTCMCKCCF 360

STSTGRVYTS DFEPVTNPKF DDTFEKNLSS VRQVKEIIHQ FILEQQKGNR VPLCINPQSA 420

AFKSFISSTV AQPSEMPPSP LVWE 444

Nucleotide Sequence
(FASTA)

ATGTTAAACC CCGGGCAACA ACAGCCATAT TTCCCATCAC CGGCACCAGG TCAGGCCCCT 60

GGACCAGCTG CCACGGCCCC AGCTCAGGTA CAGGCTGCAG CAGCAGCTGC AGTTAAAGCG 120

CACCATCATC AGCACTCACA CCATCCACAG CAGCAACTGG ACATTGAGCC GGACAGACCT 180

ATTGGATATG GAGCCTTTGG TGTTGTCTGG TCAGTAACAG ATCCAAGAGA TGGAAAGAGA 240

GTCGCCCTCA AAAAGATGCC CAACGTCTTC CAGAATCTGG TCTCTTGCAA AAGGGTCTTC 300

CGAGAACTGA AGATGTTGTG TTTTTTTAAA CATGATAACG TACTCTCTGC CCTTGACATA 360

CTCCAACCTC CACACATTGA CTATTTTGAA GAAATATATG TTGTCACAGA ATTGATGCAG 420

AGTGACCTAC ATAAAATTAT CGTCTCTCCT CAACCACTCA GCTCAGATCA TGTCAAAGTT 480

TTTCTTTATC AGATTTTACG AGGTTTGAAA TATCTTCATT CTGCTGGCAT TTTACATCGT 540

GACATTAAGC CAGGGAATCT CCTTGTGAAC AGCAACTGTG TGCTTAAGAT TTGCGATTTT 600

GGATTGGCCA GAGTGGAGGA ATTGGATGAA TCCCGTCACA TGACTCAGGA AGTTGTCACT 660

CAGTATTATC GGGCCCCCGA GATCCTGATG GGCAGCCGCC ATTACAGCAA TGCCATCGAC 720

ATCTGGTCTG TGGGCTGCAT CTTTGCAGAA CTACTGGGAC GAAGAATATT GTTTCAGGCA 780

CAGAGTCCCA TTCAACAGTT GGATTTGATC ACCGACTTAC TGGGCACACC GTCACTGGAA 840

GCAATGAGGA CAGCTTGCGA AGGTGCAAAG GCACACATAC TCAGGGGTCC TCATAAACAG 900

CCATCTCTTC CTGTACTATA TACACTGTCT AGCCAAGCAA CACATGAAGC TGTTCATCTC 960

CTTTGCAGGA TGTTGGTCTT TGATCCATCC AAAAGAATAT CCGCTAAGGA CGCCTTAGCC 1020

CACCCCTACC TAGATGAAGG GCGGCTGCGA TACCACACCT GTATGTGTAA ATGTTGTTTT 1080

TCCACCTCCA CTGGAAGAGT TTACACCAGT GACTTTGAAC CTGTCACCAA TCCCAAATTT 1140

GATGACACTT TTGAGAAGAA TCTCAGTTCT GTTCGGCAGG TAAAAGAAAT TATTCATCAG 1200

TTCATTTTGG AACAGCAGAA AGGAAACCGA GTGCCTCTCT GCATCAACCC TCAGTCTGCT 1260

GCTTTTAAGA GCTTCATTAG TTCCACTGTT GCCCAGCCAT CTGAGATGCC GCCGTCTCCT 1320

CTGGTCTGGG AGTGA 1335

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 58    DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  117

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 118   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  176

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 177   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  236

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 237   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  295

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 296   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  344

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013