EKS-SAH-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	487.9	5.2E-147	634	890	257

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013600

UniProt Accession

G3WDU5;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA2

Gene Synonyms/Alias

EPHA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011625	ENSSHAP00000013600	ENSSHAT00000013712

Organism

Sarcophilus harrisii

Functional Description

Protein Length

995

Protein Sequence
(FASTA)

TAGMDSNPGG RIRLPRGLGG DPCFSPASVT GLRGPLWGLL LGRSMTQAPL FSPDSLAVVL 60

LDFAAAKGEL GWLTHPYNKG WDLMQNIMDD QPIYMYSVCN VVSGDQDNWL RTNWIYRSEA 120

EKVFIELKFT VRDCNSFPGG ASSCKETFNL YYAESDVDYG TNFQKRQFKK IDTIAPDEIT 180

VSSDFENRNV KLNVEERSVG PLTQKGFYLA FQDIGACVAL LSVRIYYKKC PEMLQNLARF 240

PETIAGSDSA NLAKVGGTCV EHASVVPGGE EPTMHCNVEG EWLVPIGQCM GEAGYEKVEE 300

SCQACSPGSF KPDASDSSCS QCPLHTLPSS EGAIICECEE GFFRAAEDPP SSPCTRPPSA 360

PHHLTVIGLG AKVELRWKPP QDTGGREDIT YSVTCEQCWP ETGECQPCEP TVRRGLQVGL 420

SLFGFMAGAC LASSPTSITL RPLSLTCPTE PPKVKLDSRT TTSLSVSWSI PLRQQSRVWK 480

YEVTYHKKKD TNSYNVRRTE DFSITLDDLV PGTTYLVQVQ ALTQEGQGAG SRVHEFQTLF 540

LFPPCSKATE SSSNMAVIGG ILGGLILLLA LALAGLFVHR RRRNLRARQS SEDVYFSKSE 600

QLKPLKTYVD PHTYEDPNQA VLKFTTEIHP SCVTRQKVIG AGEFGEVFKG SLKASGKKEV 660

PVAIKTLKAG YTEKQRVDFL SEASIMGQFN HHNIIHLEGV VSKYKPMMII TEYMENGALD 720

KFLREKDGEF CVIQLVGMLR GIASGMKYLA SMNYVHRDLA ARNILVNSQL VCKVSDFGLS 780

RVLEDDPEAT YTTSGGKIPI RWTAPEAISY RKFTSASDVW SYGIVMWEVM SYGERPYWEL 840

SNHEVMKAIN EGFRLPAPMD CPSAIYQLMM QCWLQERARR PKFPDIVSIL DKLIRAPESL 900

KTLADFDPRV SIRLPSTSGS EGIPFRTVSE WLESIKMHQY TEHFVSSGYN AIEKVVQMTN 960

DDIKRIGVRL PGHQKRIAYS LLGLKEQVNA VGIPI 995

Nucleotide Sequence
(FASTA)

ACAGCAGGAA TGGATTCCAA CCCTGGAGGG CGCATCCGGC TCCCCAGGGG GCTGGGAGGG 60

GATCCATGCT TCAGTCCTGC GTCTGTGACT GGGTTGAGGG GCCCACTTTG GGGACTCCTG 120

CTGGGGAGAT CTATGACCCA AGCTCCCTTG TTTTCTCCAG ATTCTCTTGC AGTGGTACTG 180

TTGGATTTTG CTGCGGCTAA AGGCGAATTA GGCTGGCTGA CGCACCCTTA CAACAAAGGT 240

TGGGACCTGA TGCAGAATAT CATGGACGAC CAGCCCATCT ACATGTACTC TGTGTGCAAT 300

GTCGTGTCGG GTGACCAGGA CAACTGGCTG CGCACCAACT GGATCTACCG CAGCGAGGCC 360

GAGAAGGTCT TCATTGAGCT CAAGTTCACC GTGCGGGACT GTAACAGCTT CCCAGGGGGG 420

GCCAGCTCCT GCAAGGAGAC CTTCAACCTG TACTACGCCG AGTCCGACGT GGATTACGGC 480

ACCAACTTCC AGAAGCGCCA GTTCAAGAAG ATCGATACCA TCGCCCCGGA TGAAATCACG 540

GTCAGCAGTG ACTTTGAGAA CCGCAACGTG AAGCTCAACG TGGAGGAGCG CTCGGTGGGG 600

CCCCTGACGC AGAAGGGCTT CTACCTGGCC TTCCAGGACA TCGGGGCCTG CGTGGCCCTC 660

CTCTCCGTGC GCATCTACTA TAAGAAATGC CCCGAGATGC TGCAGAACCT GGCCCGCTTC 720

CCGGAGACCA TCGCCGGCTC CGATTCGGCC AACCTTGCCA AGGTCGGGGG CACCTGCGTG 780

GAGCACGCGT CGGTGGTGCC AGGCGGCGAG GAGCCCACGA TGCACTGCAA CGTCGAGGGG 840

GAGTGGCTGG TGCCCATCGG GCAGTGCATG GGCGAGGCGG GCTATGAGAA GGTGGAGGAA 900

TCCTGCCAGG CCTGTTCTCC TGGCTCCTTC AAGCCCGATG CTTCAGACAG CTCCTGCAGC 960

CAGTGCCCCC TGCACACTCT GCCTTCCTCT GAGGGGGCCA TAATCTGTGA GTGTGAAGAG 1020

GGCTTTTTCC GAGCAGCAGA GGACCCTCCA TCCAGCCCCT GTACCCGTCC TCCCTCTGCC 1080

CCTCACCACC TCACCGTGAT TGGCTTGGGG GCCAAGGTGG AACTTCGTTG GAAGCCCCCC 1140

CAGGACACCG GGGGTCGGGA GGACATCACC TACAGTGTCA CGTGTGAACA GTGCTGGCCC 1200

GAGACCGGGG AGTGCCAGCC CTGTGAGCCC ACCGTGCGCA GAGGCCTGCA AGTGGGACTG 1260

TCACTGTTTG GGTTCATGGC CGGGGCCTGT CTTGCCTCTT CCCCCACCTC CATCACCCTC 1320

AGGCCTTTAT CACTCACGTG TCCCACAGAG CCCCCCAAGG TGAAGCTGGA CAGCCGGACC 1380

ACAACCTCCC TCAGTGTGTC CTGGAGCATC CCTCTGAGGC AGCAGAGCCG GGTCTGGAAG 1440

TATGAGGTCA CCTACCACAA GAAGAAAGAC ACCAACAGCT ACAATGTCCG CCGGACAGAG 1500

GACTTCTCTA TCACCCTGGA TGACCTGGTG CCGGGGACCA CCTACCTGGT CCAGGTCCAG 1560

GCCCTGACCC AGGAGGGCCA GGGGGCAGGC AGCCGAGTCC ATGAGTTCCA GACCCTCTTT 1620

CTCTTCCCTC CCTGTTCTAA AGCTACTGAA AGTTCGAGCA ATATGGCAGT GATCGGGGGC 1680

ATACTGGGTG GCCTAATCTT GCTCCTGGCT TTGGCCCTGG CTGGACTTTT CGTTCACCGA 1740

AGGAGGAGGA ACTTGAGAGC CCGGCAGTCA TCCGAGGACG TGTACTTTTC CAAATCGGAA 1800

CAACTAAAAC CCCTGAAAAC CTATGTGGAC CCCCACACCT ATGAGGACCC CAACCAGGCC 1860

GTGCTGAAAT TCACCACAGA GATCCACCCC TCCTGTGTCA CTCGGCAGAA AGTCATCGGT 1920

GCAGGCGAAT TTGGGGAGGT TTTTAAGGGG TCGCTGAAGG CTTCAGGGAA GAAGGAAGTC 1980

CCTGTGGCCA TCAAGACCCT CAAGGCGGGC TACACAGAGA AGCAGCGTGT GGACTTCCTG 2040

AGCGAAGCCA GCATCATGGG CCAGTTTAAC CACCACAACA TTATCCATCT GGAGGGGGTG 2100

GTCTCCAAAT ATAAGCCCAT GATGATCATA ACCGAATACA TGGAGAACGG CGCCCTGGAC 2160

AAATTCCTGC GGGAGAAGGA TGGAGAGTTC TGTGTGATCC AGCTGGTGGG CATGCTACGG 2220

GGCATCGCGT CGGGCATGAA GTACCTCGCC AGCATGAACT ACGTGCACCG CGACCTGGCC 2280

GCCCGCAACA TCCTCGTCAA CAGCCAGCTG GTGTGCAAGG TGTCCGACTT CGGGCTCTCC 2340

CGGGTCCTGG AGGACGACCC CGAAGCCACC TACACGACCA GTGGAGGGAA GATCCCCATC 2400

CGATGGACAG CCCCGGAGGC CATCTCCTAC CGCAAGTTCA CCTCCGCCAG CGATGTGTGG 2460

AGCTACGGTA TTGTCATGTG GGAGGTGATG AGCTATGGAG AGAGACCCTA CTGGGAGCTG 2520

TCCAACCATG AGGTCATGAA GGCCATCAAT GAGGGCTTCA GGCTGCCGGC TCCCATGGAC 2580

TGCCCCTCGG CCATTTACCA GCTAATGATG CAGTGCTGGC TGCAGGAGCG GGCACGGAGG 2640

CCCAAGTTCC CCGACATAGT CAGCATTCTG GACAAACTCA TCCGGGCCCC CGAGTCTCTC 2700

AAGACCCTGG CGGACTTTGA CCCCAGGGTC TCCATCCGGC TGCCCAGCAC CAGCGGCTCC 2760

GAGGGCATTC CCTTCCGCAC CGTGTCTGAG TGGCTCGAGT CCATCAAGAT GCACCAGTAC 2820

ACAGAGCACT TCGTGTCGTC GGGTTACAAC GCCATCGAAA AGGTGGTGCA GATGACCAAC 2880

GACGACATCA AGAGGATCGG GGTCCGCCTG CCTGGCCACC AGAAGCGAAT CGCCTACAGC 2940

CTCCTGGGTC TTAAGGAGCA GGTGAACGCC GTGGGGATCC CCATCTGA 2988

Domain Profile

S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61

         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n

Q: 634   TRQKVIGAGEFGEVFKGSLKASGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFNHHN  693

         6789********************************************************

S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121

         ii+leGvv+k kp+mi+teymengald+flr+kdg+f viqlvgmlrGiasgmkyl++m+

Q: 694   IIHLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFCVIQLVGMLRGIASGMKYLASMN  753

         ************************************************************

S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181

         yvhrdlaarnilvns+lvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf

Q: 754   YVHRDLAARNILVNSQLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  813

         ************************************************************

S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241

         tsasdvwsyGiv+wev+syGerpyw++sn++v+kai+eg+rlp+pmdcp+a+yqlm++cw

Q: 814   TSASDVWSYGIVMWEVMSYGERPYWELSNHEVMKAINEGFRLPAPMDCPSAIYQLMMQCW  873

         ************************************************************

S: 242   qkdraerpkfeqivsil  258

          ++ra+rpkf +ivsil

Q: 874   LQERARRPKFPDIVSIL  890

         **************985

Domain Sequence
(FASTA)

TRQKVIGAGE FGEVFKGSLK ASGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFNHHN 60

IIHLEGVVSK YKPMMIITEY MENGALDKFL REKDGEFCVI QLVGMLRGIA SGMKYLASMN 120

YVHRDLAARN ILVNSQLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180

TSASDVWSYG IVMWEVMSYG ERPYWELSNH EVMKAINEGF RLPAPMDCPS AIYQLMMQCW 240

LQERARRPKF PDIVSIL 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013