EKS-SAH-00342

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00342

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	423.7	2.5E-127	239	487	249

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013659

UniProt Accession

G3WE04;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011673	ENSSHAP00000013659	ENSSHAT00000013771

Organism

Sarcophilus harrisii

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MGVVSSKKLA KEKRKNWWTF EKEAPITFPN KPPPPVPPLV VFSHLTTPAP VINPDQEKHY 60

VVVLWDYEAV NDRDLKVVRG EKLQILMKTG DWWLAKSLVT GREGYVPSNF VARVETLEIE 120

KWFFKTITRR DAERRLLDPV NKTGAFLIRE SETNKGAFSL SVKDTTSAGD LIKHYKIRCL 180

DEGGYYISPR ITFPSLQDLV QHYSKKEDGL CQRLTMPCVI LAPQTQWAQD EWEVPRQSLK 240

LVKKLGSGQF GEVWMGYYKN NIKVAIKTLK EGSMSPEAFL AEANLMKTLQ HDKLVRLYAV 300

VTQEPIYIVT EYMAKGSLLD FLKTEEGCKL SLSRLIDIMA QIAEGMAYIE QRNSIHRDLR 360

AANVLVSENL CCKIADFGLA RIVDSEYTAQ EGAKFPIKWT ALEAINFGVF SIKSDVWSFG 420

VLLMEIITYG RIPYPGMTNP EVIRHLEQGY RMPCPDTCPA ELYSIISKCW RSRPEERPTF 480

EYLQSVLEDF YTATEQQYEL QP 502

Nucleotide Sequence
(FASTA)

ATGGGAGTAG TGAGCAGCAA AAAACTTGCT AAGGAGAAAA GAAAGAATTG GTGGACTTTT 60

GAGAAGGAAG CTCCGATCAC CTTCCCAAAT AAGCCTCCCC CACCTGTGCC TCCATTGGTT 120

GTCTTCAGTC ACCTTACTAC ACCAGCTCCT GTTATAAATC CTGATCAAGA AAAGCACTAT 180

GTGGTTGTCT TGTGGGATTA TGAAGCCGTA AATGATCGGG ACCTGAAGGT GGTGAGGGGA 240

GAGAAGCTGC AAATATTGAT GAAAACTGGA GACTGGTGGT TGGCCAAATC ACTTGTCACT 300

GGAAGAGAAG GCTATGTTCC TAGCAATTTT GTTGCTAGAG TAGAGACTCT AGAAATTGAA 360

AAGTGGTTCT TCAAAACAAT TACCCGGAGA GATGCTGAGA GGAGACTCCT CGACCCTGTC 420

AACAAGACTG GTGCATTCCT TATTAGAGAG AGTGAAACAA ACAAAGGTGC CTTTTCCCTG 480

TCTGTGAAAG ACACCACCTC TGCAGGGGAT CTGATCAAAC ATTATAAGAT CCGGTGCCTA 540

GATGAAGGAG GATATTATAT CTCTCCCAGG ATTACCTTCC CTTCACTACA GGATTTGGTT 600

CAACATTATT CTAAGAAAGA GGATGGTTTA TGCCAGAGGC TGACTATGCC CTGTGTGATT 660

CTGGCTCCTC AGACACAGTG GGCCCAGGAT GAATGGGAGG TACCTCGGCA GTCACTGAAA 720

TTGGTGAAGA AACTTGGTTC TGGACAGTTT GGAGAAGTCT GGATGGGTTA TTATAAAAAC 780

AACATAAAGG TGGCCATCAA GACCCTGAAG GAGGGCAGCA TGTCGCCTGA GGCCTTCCTT 840

GCTGAGGCCA ATCTGATGAA AACCCTCCAG CATGACAAAT TGGTCCGTCT CTATGCAGTG 900

GTAACCCAGG AACCCATCTA TATTGTCACA GAGTACATGG CCAAAGGGTC TTTATTGGAT 960

TTCCTAAAGA CAGAAGAAGG TTGCAAGCTA TCATTATCAA GACTGATTGA CATAATGGCC 1020

CAAATTGCAG AAGGGATGGC TTACATCGAG CAAAGGAATT CAATCCACCG AGACTTGAGG 1080

GCAGCCAACG TCCTGGTGTC TGAGAATCTG TGCTGCAAGA TTGCTGACTT TGGCTTGGCC 1140

AGGATTGTGG ACAGTGAATA CACAGCCCAG GAAGGTGCCA AGTTCCCCAT CAAGTGGACG 1200

GCCCTAGAAG CCATTAATTT TGGAGTGTTC TCCATCAAAT CTGACGTCTG GTCCTTTGGA 1260

GTTCTCCTAA TGGAAATCAT TACCTATGGA CGGATTCCTT ACCCAGGCAT GACCAACCCG 1320

GAGGTCATTC GGCATCTGGA ACAAGGCTAT CGAATGCCTT GCCCTGATAC ATGCCCAGCT 1380

GAGCTCTACA GCATCATCAG CAAGTGTTGG CGCAGTAGGC CAGAGGAACG GCCCACCTTT 1440

GAATACTTAC AGTCCGTACT TGAGGATTTC TACACAGCCA CAGAGCAACA ATATGAGCTG 1500

CAGCCCTAG 1509

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g++k+++kva+ktlkeg++speafl+ea+++k+l+h+klv+ly

Q: 239   LKLVKKLGSGQFGEVWMGYYKNNIKVAIKTLKEGSMSPEAFLAEANLMKTLQHDKLVRLY  298

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+makGslldflk+eeg kl+l++l+d+ aq+aeGmay+e++n ihr

Q: 299   AVVTQ-EPIYIVTEYMAKGSLLDFLKTEEGCKLSLSRLIDIMAQIAEGMAYIEQRNSIHR  357

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e+l++k+adfGlar++ d+eyta+egak+PikWta eai++g+f+iksdv

Q: 358   DLRAANVLVSENLCCKIADFGLARIV-DSEYTAQEGAKFPIKWTALEAINFGVFSIKSDV  416

         ************************99.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+t+G++PypGmtn ev++++e+gyr+p+p++cp+ely+++ +cw+++pee

Q: 417   WSFGVLLMEIITYGRIPYPGMTNPEVIRHLEQGYRMPCPDTCPAELYSIISKCWRSRPEE  476

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 477   RPTFEYLQSVL  487

         ********986

Domain Sequence
(FASTA)

LKLVKKLGSG QFGEVWMGYY KNNIKVAIKT LKEGSMSPEA FLAEANLMKT LQHDKLVRLY 60

AVVTQEPIYI VTEYMAKGSL LDFLKTEEGC KLSLSRLIDI MAQIAEGMAY IEQRNSIHRD 120

LRAANVLVSE NLCCKIADFG LARIVDSEYT AQEGAKFPIK WTALEAINFG VFSIKSDVWS 180

FGVLLMEIIT YGRIPYPGMT NPEVIRHLEQ GYRMPCPDTC PAELYSIISK CWRSRPEERP 240

TFEYLQSVL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013