EKS-SAH-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	435.0	8.8E-131	239	489	251

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013714

UniProt Accession

G3WE58;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011725	ENSSHAP00000013713	ENSSHAT00000013826
ENSSHAG00000011725	ENSSHAP00000013714	ENSSHAT00000013827

Organism

Sarcophilus harrisii

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

PRMGCVKSKF THNGGKVFQK ESETNTQGPV YVPDPTSPGK KVSKTFRFGE RNSENMDITV 60

VALYDYEAIH NEDLSFRKGD QMAILEKSGE WWKARSLATR KEGYIPSNYV AQINSLETEE 120

WFFKDISRKG AERHLLAPGN VLGSFMIRDS ETTKGSYSLS IRDYDPQHQD AVKHYKIRTL 180

DNGGFYISPR NTFSTLQDLV AHYKKGSDGL CQKLTMPCVV PKPQKPWEKD AWEIPRESLR 240

LEKKLGAGQF GEVWMATYNK HTKVAVKTMK PGSMSVEAFL AEANLMKSLQ HDKLVKLHAV 300

VTKEEPIYII TEFMAKGSLL DFLKTEEGRQ QPLPKLIDFS AQIAEGMAFI ELRNYIHRDL 360

RAANILVSSA LVCKIADFGL ARLIEDNMYN AREGAKFPIK WTAPEAINFG SFTIKSDVWS 420

FGILLMEIVT YGRIPYPGMS NPEVIRCLDR GYRMPRTENC PEELYSIMTR CWMNKPEDRP 480

TFEYLQSVLE DFYTATESQY QKQP 504

Nucleotide Sequence
(FASTA)

CCCAGGATGG GGTGTGTGAA ATCCAAGTTT ACCCATAATG GAGGAAAGGT TTTCCAAAAA 60

GAGTCTGAAA CAAACACCCA GGGTCCTGTA TATGTGCCAG ATCCAACATC CCCTGGAAAA 120

AAGGTGAGCA AGACTTTCAG ATTTGGTGAG AGGAATTCTG AAAACATGGA CATCACAGTC 180

GTGGCGCTGT ATGACTATGA GGCCATCCAC AATGAGGACC TCAGCTTCCG GAAGGGTGAT 240

CAGATGGCGA TCTTAGAAAA ATCTGGAGAG TGGTGGAAAG CACGATCCCT TGCAACCCGG 300

AAGGAGGGTT ATATTCCAAG TAATTATGTA GCCCAGATCA ACTCACTGGA GACAGAGGAA 360

TGGTTCTTCA AAGACATCAG TCGAAAGGGT GCAGAACGTC ACCTGCTGGC ACCTGGGAAT 420

GTACTGGGTT CCTTCATGAT TCGGGACAGT GAAACCACCA AAGGCAGCTA TTCCTTATCG 480

ATACGGGACT ATGATCCCCA GCATCAGGAT GCAGTGAAAC ATTATAAGAT TCGGACATTG 540

GACAATGGCG GTTTCTATAT CTCCCCAAGG AACACTTTCA GCACTCTGCA AGATCTAGTG 600

GCTCATTACA AGAAAGGAAG TGATGGCTTA TGCCAGAAGC TAACAATGCC CTGTGTGGTC 660

CCCAAACCCC AAAAACCTTG GGAGAAGGAT GCCTGGGAGA TCCCCAGGGA ATCCCTAAGG 720

TTGGAGAAGA AACTGGGAGC TGGGCAATTT GGAGAAGTCT GGATGGCTAC CTACAACAAG 780

CACACCAAGG TGGCTGTGAA GACCATGAAA CCGGGGAGCA TGTCTGTGGA AGCCTTCTTG 840

GCTGAGGCCA ATCTGATGAA ATCTCTGCAA CATGACAAGC TGGTGAAACT GCATGCTGTG 900

GTCACTAAGG AAGAGCCCAT CTACATTATC ACTGAGTTCA TGGCAAAAGG AAGCCTGCTG 960

GACTTTCTGA AAACTGAAGA AGGCCGACAA CAACCCCTGC CAAAACTCAT CGATTTCTCA 1020

GCCCAGATTG CTGAAGGAAT GGCCTTCATT GAGCTGAGGA ACTACATCCA CCGCGATCTC 1080

CGAGCAGCCA ACATCCTCGT GTCCTCAGCT CTGGTGTGTA AGATTGCTGA CTTCGGCTTA 1140

GCTCGACTCA TTGAGGACAA CATGTACAAT GCCAGAGAAG GAGCCAAGTT TCCCATCAAA 1200

TGGACAGCTC CAGAAGCCAT CAACTTCGGC TCCTTTACCA TCAAATCAGA TGTGTGGTCC 1260

TTTGGCATCC TCCTGATGGA GATTGTCACT TATGGCCGGA TTCCCTATCC AGGAATGTCT 1320

AACCCTGAAG TGATCCGTTG CCTAGATCGT GGATACCGGA TGCCTCGTAC AGAAAACTGC 1380

CCAGAAGAGT TATACAGCAT CATGACTCGC TGCTGGATGA ATAAACCTGA GGATCGGCCT 1440

ACATTTGAGT ATCTCCAGAG TGTGCTGGAG GACTTCTACA CTGCCACTGA GAGCCAGTAC 1500

CAAAAGCAGC CATGA 1515

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+

Q: 239   LRLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLH  298

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk+eeg++++lpkl+d++aq+aeGma++e +n+ihr

Q: 299   AVVTKEEPIYIITEFMAKGSLLDFLKTEEGRQQPLPKLIDFSAQIAEGMAFIELRNYIHR  358

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+  lv+k+adfGlarlied+ y+a+egak+PikWtaPeai++g+ftiksdv

Q: 359   DLRAANILVSSALVCKIADFGLARLIEDNMYNAREGAKFPIKWTAPEAINFGSFTIKSDV  418

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+G++PypGm+n ev++ ++rgyr+pr+e+cpeely+++++cw ++pe+

Q: 419   WSFGILLMEIVTYGRIPYPGMSNPEVIRCLDRGYRMPRTENCPEELYSIMTRCWMNKPED  478

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 479   RPTFEYLQSVL  489

         ********986

Domain Sequence
(FASTA)

LRLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKS LQHDKLVKLH 60

AVVTKEEPIY IITEFMAKGS LLDFLKTEEG RQQPLPKLID FSAQIAEGMA FIELRNYIHR 120

DLRAANILVS SALVCKIADF GLARLIEDNM YNAREGAKFP IKWTAPEAIN FGSFTIKSDV 180

WSFGILLMEI VTYGRIPYPG MSNPEVIRCL DRGYRMPRTE NCPEELYSIM TRCWMNKPED 240

RPTFEYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013