EKS-SAH-00287
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00287
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk529.41.7E-159429697269
StatusUnreviewed
Ensembl ProteinENSSHAP00000013737
UniProt AccessionG3WE82;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000011747ENSSHAP00000013737ENSSHAT00000013851
OrganismSarcophilus harrisii
Functional Description
Protein Length782
Protein Sequence
(FASTA)
WLFTTCGASG PQGPTQTQCN NAYRNSNLSV VVGSEGALKG VQIWRVPATD TYSISGYGAA 60
GGKGGKNTMM RSHGVSVLGV FDLEKDDFLY ILVGQQGEDA CPSTNEIIQK VCIGENNVIE 120
EEIRANQSVN EWAGGGGGGG GATYIFKMKN GIPVPLIIAA GGGGRAYGAK TDKFHPERLE 180
NNSSVLGLNG ISGAAGGGGG WNDNTSLLWS GKSLLEGATG GHSCPQAMKK WGWETRGGFG 240
GGGGGCSSGG GGGGYIGKDA SRSRCQFPSF SHRGQHQDLM WFLIPLPVPP AQALLGEEAP 300
TSPCDSEHPS RRQRGPRAAA LGGTAAHREK ILSRTNWKDN SHLSISLERQ ASEMGSWKPV 360
PAVPIHKAQC QFKALLKSRL PIFLLKIRCS FNKTNAYRRI CFCKTPGLPL QSFINLDVKI 420
SSLNSNRLSL SRGLGHGAFG EVYEGQVSGI PSDPSPLQVA VKTLPEVCSE QDELDFLMEA 480
LIISKFNHQN IVRCIGVSLQ ALPRFILLEL MAGGDLKSFL RETRPRPNQP SSLAMLDLLH 540
VARDIACGCQ YLEENHFIHR DIAARNCLLT CPGPGRVAKI GDFGMARDIY RASYYRKGGC 600
AMLPVKWMPP EAFMEGIFTS KTDTWSFGVL LWEIFSLGYM PYPSKSNQEV LEFVTSGGRM 660
DPPKNCPGPV YRIMTQCWQH LPEDRPNFGT ILERIEYCTQ DPDVVNTALP IEYGPVAEEE 720
EKVPMRPEDP DRIPPLLVSP QQEKKEDVCP SPGPPPLPTT SSGKPLKSRN KPTSLWNPTY 780
GS 782
Nucleotide Sequence
(FASTA)
TGGCTGTTCA CCACATGTGG AGCCAGCGGG CCCCAGGGCC CCACGCAGAC CCAGTGCAAC 60
AACGCCTACA GGAATTCCAA CCTGAGCGTG GTCGTGGGCA GCGAGGGAGC CCTGAAGGGT 120
GTGCAGATCT GGAGAGTGCC AGCCACCGAC ACATACAGCA TCTCAGGCTA CGGAGCAGCT 180
GGAGGTAAAG GAGGAAAGAA CACTATGATG AGATCCCATG GTGTATCAGT TCTAGGAGTC 240
TTTGATCTGG AGAAGGATGA CTTCTTATAC ATCTTGGTGG GACAGCAAGG GGAAGATGCG 300
TGTCCCAGTA CTAATGAAAT TATCCAGAAG GTTTGCATTG GAGAGAACAA TGTGATAGAA 360
GAAGAAATCC GAGCCAACCA AAGTGTGAAT GAGTGGGCTG GCGGTGGAGG AGGTGGGGGT 420
GGAGCGACCT ACATTTTTAA GATGAAGAAT GGAATACCAG TGCCTCTGAT CATTGCAGCC 480
GGAGGTGGTG GGAGAGCCTA TGGAGCCAAA ACAGATAAAT TCCATCCAGA AAGACTGGAA 540
AATAACTCCT CTGTTCTAGG TCTGAATGGC ATTTCTGGAG CCGCAGGTGG CGGAGGTGGT 600
TGGAATGATA ACACTTCCTT GCTTTGGTCG GGAAAGTCTT TGCTGGAAGG TGCCACAGGA 660
GGACATTCCT GCCCCCAGGC CATGAAGAAG TGGGGGTGGG AGACAAGAGG GGGTTTCGGA 720
GGGGGTGGAG GGGGGTGCTC CTCAGGTGGA GGAGGCGGAG GATACATAGG TAAAGATGCT 780
TCGCGTTCAA GGTGTCAGTT TCCCTCCTTT AGCCATAGAG GACAGCATCA AGACCTCATG 840
TGGTTCTTGA TCCCCCTCCC TGTCCCCCCC GCCCAGGCCT TACTGGGAGA AGAGGCTCCG 900
ACCTCTCCCT GTGACTCTGA GCACCCCTCG AGGCGCCAGA GGGGACCCCG GGCTGCGGCC 960
CTGGGAGGGA CGGCTGCTCA CAGGGAGAAA ATTTTGTCCC GCACTAATTG GAAAGACAAT 1020
AGCCATTTAT CAATATCACT GGAAAGGCAG GCTTCAGAGA TGGGGTCATG GAAGCCTGTC 1080
CCTGCTGTCC CAATCCACAA AGCCCAGTGT CAATTTAAGG CACTTTTAAA ATCTAGACTA 1140
CCTATTTTTC TTTTAAAAAT TAGGTGTAGT TTTAACAAAA CAAATGCTTA TAGAAGAATC 1200
TGTTTTTGCA AAACACCAGG ATTACCTCTT CAATCTTTTA TAAATCTAGA TGTTAAAATT 1260
TCATCATTAA ACAGCAACCG CTTATCTTTG TCCAGGGGTC TGGGCCATGG TGCCTTTGGG 1320
GAAGTGTATG AAGGCCAAGT ATCTGGAATC CCCAGTGACC CCAGCCCACT CCAGGTGGCA 1380
GTTAAGACCC TTCCAGAGGT GTGCTCAGAA CAGGATGAGC TGGATTTCCT CATGGAAGCG 1440
TTGATCATTA GCAAATTCAA CCACCAGAAC ATTGTTCGCT GTATTGGGGT GAGCCTGCAG 1500
GCCCTGCCCC GATTTATCCT CCTAGAGCTG ATGGCTGGAG GAGACCTCAA ATCCTTCCTT 1560
CGGGAGACTC GCCCTCGCCC AAACCAGCCC TCCTCCCTGG CCATGCTAGA CCTGCTGCAT 1620
GTGGCTCGTG ACATTGCCTG TGGCTGTCAG TATCTGGAAG AAAACCACTT CATTCACCGG 1680
GATATTGCTG CTAGGAACTG TCTCTTGACC TGTCCTGGAC CAGGCAGAGT GGCCAAGATT 1740
GGAGACTTTG GAATGGCTAG GGACATCTAC CGTGCAAGCT ACTACAGGAA GGGAGGATGT 1800
GCCATGCTTC CAGTTAAGTG GATGCCCCCA GAGGCCTTCA TGGAAGGGAT ATTTACATCC 1860
AAAACGGATA CCTGGTCCTT TGGTGTGCTT CTTTGGGAGA TATTCTCTCT TGGATATATG 1920
CCATACCCAA GCAAAAGCAA TCAGGAGGTC CTGGAGTTTG TCACCAGTGG AGGACGGATG 1980
GATCCACCCA AAAATTGCCC GGGGCCTGTG TACCGGATCA TGACTCAGTG CTGGCAGCAC 2040
CTGCCCGAGG ACCGGCCCAA CTTTGGCACC ATCTTAGAGA GAATTGAGTA CTGTACCCAG 2100
GATCCAGATG TGGTTAATAC TGCTTTGCCA ATAGAATACG GTCCAGTGGC TGAAGAGGAA 2160
GAGAAGGTGC CCATGAGGCC AGAAGACCCA GATAGAATAC CGCCTCTCTT AGTCTCTCCA 2220
CAGCAAGAGA AAAAGGAGGA CGTGTGTCCA TCACCCGGTC CCCCTCCACT GCCCACCACT 2280
TCCTCTGGCA AGCCCTTGAA ATCAAGAAAC AAACCAACCA GTCTTTGGAA TCCCACTTAT 2340
GGTTCT 2346
Domain Profile
S: 2     elvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfnh  61
          l r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfnh
Q: 429   SLSRGLGHGAFGEVYEGQVSGIPSDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH  488
         5789********************************************************
S: 62    enivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvakG  121
         +nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+G
Q: 489   QNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLAMLDLLHVARDIACG  548
         ************************************************************
S: 122   ckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkwm  181
         c+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkwm
Q: 549   CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWM  608
         ************************************************************
S: 182   ppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeipg  241
         ppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++pg
Q: 609   PPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG  668
         ************************************************************
S: 242   svyrimtdcwkhepedrpkfvsilerlqa  270
         +vyrimt+cw+h pedrp+f +iler+++
Q: 669   PVYRIMTQCWQHLPEDRPNFGTILERIEY  697
         **************************986
Domain Sequence
(FASTA)
SLSRGLGHGA FGEVYEGQVS GIPSDPSPLQ VAVKTLPEVC SEQDELDFLM EALIISKFNH 60
QNIVRCIGVS LQALPRFILL ELMAGGDLKS FLRETRPRPN QPSSLAMLDL LHVARDIACG 120
CQYLEENHFI HRDIAARNCL LTCPGPGRVA KIGDFGMARD IYRASYYRKG GCAMLPVKWM 180
PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG RMDPPKNCPG 240
PVYRIMTQCW QHLPEDRPNF GTILERIEY 269
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00050
EKS-ANC-00292
EKS-BOT-00308
EKS-CAE-00256
EKS-CAJ-00312
EKS-CAF-00313
EKS-CAP-00341
EKS-DRM-00153
EKS-FEC-00287
EKS-GAG-00253
EKS-HOS-00307
EKS-ICT-00290
EKS-LAC-00314
EKS-LOA-00317
EKS-MEG-00248
EKS-MOD-00295
EKS-MUM-00338
EKS-MUP-00298
EKS-MYL-00306
EKS-NOL-00278
EKS-ORA-00265
EKS-ORC-00284
EKS-OTG-00308
EKS-POA-00292
EKS-RAN-00317
EKS-SUS-00272
EKS-TAG-00316
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013