EKS-SAH-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	519.3	2.0E-156	466	746	281

Status

Unreviewed

Ensembl Protein

ENSSHAP00000013907

UniProt Accession

G3WEQ2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000011893	ENSSHAP00000013907	ENSSHAT00000014024

Organism

Sarcophilus harrisii

Functional Description

Protein Length

807

Protein Sequence
(FASTA)

MQLLPAVLRT LVMATGFLAV HAFTSEEVEQ EPCQAPGPEE LEQHLTLALG QALRLCCGRA 60

NRGGHWYKEG SRLAPSGRVR AWRGRLEIAT LVHEDAGLYL CLSRGSGQIL YNLTISVIDS 120

LASGDDDEDS DGRDLPKGHI YPQQGPYWTH PHRMEKKLHA VPAGNTVKFR CPAAGNPMPT 180

IRWLKNGEDF HGEHRIGGIR LRHQHWSLVM ESVVPSDRGT YTCVVENALG SLRYNYLLDV 240

LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI QWLKHIEVNG SSFGADGFPF 300

VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL PEEGLAWEAA 360

ASEVKATDII MYTLGSLAVI VILLIAGLCW GQTLSSRTAR QPLAVQKLSR FPLIRQFSLE 420

SGSSGKLSSS LVRGGRLSSS CTPMLPGLVE LDLPLDVKWE FPRDRLVLGK PLGEGCFGQV 480

VRAEAYSMDP QQPDGATTVA IKMLKDNASD KDLADLISEM EMMKLIGRHK NIINLLGVCT 540

QEAPPTGPLY VIVEFAAKGN LREYLRARRP PGPDYTLDAL RTPEEQLSFQ DLVSCAYQVA 600

RGMEYLESRK CIHRDLAARN VLVTEDNVMK IADFGLARGV HDIDYYKKTS NGRLPVKWMA 660

PEALFDRVYT HQSDVWSFGI LLWEIFTLGG SPYPGIPVEE LFSLLREGHR MDRPSHCPPE 720

LYMLMRECWH AIPSQRPTFK QLVEALNKIL TAISEEYLDL SMPFEQYSPA GEDTSSTCSS 780

NDSVFTHEPL APGSLGPSPF TYHIVRT 807

Nucleotide Sequence
(FASTA)

ATGCAGCTAC TGCCGGCAGT GTTGCGAACT CTCGTGATGG CAACTGGATT TCTGGCTGTT 60

CATGCTTTTA CCTCTGAAGA AGTGGAACAG GAGCCTTGCC AAGCCCCGGG CCCAGAAGAG 120

CTAGAACAGC ACCTGACCCT GGCCCTGGGC CAGGCACTAC GACTCTGCTG TGGTCGGGCC 180

AATCGGGGTG GCCACTGGTA TAAAGAAGGT AGTCGCCTAG CGCCTTCAGG TCGTGTGCGA 240

GCCTGGCGAG GCCGTCTGGA AATTGCCACT CTAGTACATG AGGATGCTGG CCTCTACCTG 300

TGTCTGTCAC GAGGATCTGG CCAAATTCTG TACAATCTTA CCATCTCTGT CATAGATTCT 360

CTGGCTTCAG GGGATGATGA CGAAGACAGT GACGGCAGGG ACCTTCCCAA GGGGCACATT 420

TATCCACAGC AAGGCCCCTA CTGGACACAT CCCCATCGCA TGGAGAAGAA ACTTCATGCA 480

GTACCAGCTG GCAACACAGT CAAGTTCCGG TGCCCAGCCG CGGGCAACCC CATGCCCACC 540

ATTCGCTGGC TGAAAAATGG AGAAGACTTC CATGGGGAAC ACCGAATTGG GGGTATCCGG 600

CTCAGACATC AGCATTGGAG TCTCGTTATG GAAAGTGTGG TGCCCTCCGA CCGCGGAACC 660

TACACCTGTG TGGTAGAGAA TGCCTTGGGG AGTCTCCGGT ACAACTACCT CCTAGATGTG 720

CTGGAGCGCT CCCCACACCG GCCCATCCTG CAGGCTGGCC TTCCTGCCAA CACCACAGCT 780

GTGGTTGGCA GCGACGTCGA GCTTCTGTGC AAAGTCTACA GCGATGCCCA GCCCCACATC 840

CAGTGGCTGA AACACATCGA GGTCAACGGG AGCAGCTTTG GGGCTGATGG CTTCCCCTTC 900

GTCCAGGTGC TCAAGACCGC TGATATCAAC AGCTCAGAGG TAGAAGTCCT GTACTTGCGT 960

AACGTGTCAG CGGAGGACGC AGGAGAATAC ACCTGCCTCG CTGGCAACTC CATTGGCCTG 1020

TCCTACCAGT CTGCCTGGCT CACTGTGCTG CCCGAGGAGG GACTGGCCTG GGAAGCTGCC 1080

GCCTCGGAAG TTAAGGCCAC GGACATCATC ATGTACACGT TGGGCTCGTT GGCTGTGATT 1140

GTGATCCTGC TCATTGCCGG GCTGTGCTGG GGGCAGACGC TGTCTAGCCG GACGGCCCGC 1200

CAGCCCCTCG CCGTGCAGAA ACTCTCTCGC TTCCCCCTCA TCAGACAGTT CTCCCTGGAG 1260

TCAGGCTCCT CAGGGAAGCT GAGTTCCTCC CTCGTTCGGG GCGGACGCCT GTCCTCCAGC 1320

TGTACCCCTA TGCTTCCTGG CCTTGTGGAG CTGGATCTGC CACTTGATGT CAAGTGGGAG 1380

TTTCCCCGGG ACAGGCTGGT GCTAGGGAAG CCCCTTGGTG AGGGTTGTTT TGGGCAGGTG 1440

GTGCGGGCAG AGGCCTATAG CATGGACCCT CAGCAACCAG ATGGGGCCAC CACGGTGGCC 1500

ATCAAAATGC TGAAAGATAA TGCCTCCGAC AAGGACCTGG CAGACCTGAT CTCGGAGATG 1560

GAAATGATGA AGCTCATTGG CCGGCACAAG AATATCATCA ATCTGCTGGG TGTCTGCACC 1620

CAGGAAGCTC CTCCCACAGG GCCCTTGTAC GTGATTGTAG AATTTGCCGC TAAAGGCAAC 1680

CTCCGGGAGT ATCTTCGGGC AAGAAGACCA CCTGGTCCTG ACTACACCTT GGATGCACTC 1740

AGGACCCCCG AGGAACAGCT GTCTTTCCAG GACCTGGTCT CCTGTGCCTA CCAAGTGGCT 1800

CGGGGCATGG AGTACCTGGA GTCGCGAAAG TGCATACACA GGGACCTGGC TGCCCGAAAC 1860

GTGCTGGTCA CTGAGGACAA TGTGATGAAG ATTGCAGACT TTGGCCTGGC CCGGGGGGTT 1920

CATGATATTG ACTACTACAA GAAGACCAGC AACGGCCGCC TGCCTGTCAA GTGGATGGCA 1980

CCTGAGGCCC TGTTTGACCG AGTCTACACT CATCAGAGTG ATGTTTGGTC CTTCGGAATC 2040

CTGCTGTGGG AGATTTTTAC CCTGGGTGGC TCCCCATACC CTGGCATCCC AGTAGAAGAG 2100

CTCTTCTCAC TGCTGAGAGA AGGACATCGT ATGGACCGGC CTTCCCACTG CCCCCCAGAG 2160

CTGTACATGC TGATGCGTGA GTGCTGGCAT GCAATACCCT CCCAGAGACC TACCTTCAAG 2220

CAACTGGTTG AGGCCCTGAA CAAGATCTTG ACAGCCATCT CTGAGGAGTA CTTGGACCTC 2280

TCGATGCCCT TTGAACAATA CTCCCCAGCC GGCGAGGATA CCAGCAGCAC CTGTTCTTCT 2340

AATGATTCTG TTTTCACCCA TGAACCCCTG GCCCCTGGGA GTCTGGGCCC AAGCCCCTTC 2400

ACCTACCACA TTGTGAGGAC ATGA 2424

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+aea  +d ++++ ++tva+kmlk++a+dkdladl+seme++kl

Q: 466   LVLGKPLGEGCFGQVVRAEAYSMDPQQPDGATTVAIKMLKDNASDKDLADLISEMEMMKL  525

         79**********************************************************

S: 61    iGkhkniinllGactqe....GplyviveyaakGnlreflrarrpkgeeaskdkskasee  116

         iG+hkniinllG+ctqe    Gplyvive+aakGnlre+lrarrp+g +++ d+ +++ee

Q: 526   IGRHKNIINLLGVCTQEapptGPLYVIVEFAAKGNLREYLRARRPPGPDYTLDALRTPEE  585

         ****************7666699*************************************

S: 117   qltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidy  176

         ql+++dlvs+ayqvarGmeyl+s+kcihrdlaarnvlvtednv+kiadfGlar+vh+idy

Q: 586   QLSFQDLVSCAYQVARGMEYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHDIDY  645

         ************************************************************

S: 177   ykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkll  236

         ykkt+nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll

Q: 646   YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL  705

         ************************************************************

S: 237   keGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         +eGhrm++p++c+ ely+lmrecwha +s+rptfkqlve+l

Q: 706   REGHRMDRPSHCPPELYMLMRECWHAIPSQRPTFKQLVEAL  746

         **************************************986

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVRAEA YSMDPQQPDG ATTVAIKMLK DNASDKDLAD LISEMEMMKL 60

IGRHKNIINL LGVCTQEAPP TGPLYVIVEF AAKGNLREYL RARRPPGPDY TLDALRTPEE 120

QLSFQDLVSC AYQVARGMEY LESRKCIHRD LAARNVLVTE DNVMKIADFG LARGVHDIDY 180

YKKTSNGRLP VKWMAPEALF DRVYTHQSDV WSFGILLWEI FTLGGSPYPG IPVEELFSLL 240

REGHRMDRPS HCPPELYMLM RECWHAIPSQ RPTFKQLVEA L 281

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013