EKS-SAH-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	458.7	8.4E-138	175	462	288

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014109

UniProt Accession

G3WFA4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012059	ENSSHAP00000014109	ENSSHAT00000014226

Organism

Sarcophilus harrisii

Functional Description

Protein Length

473

Protein Sequence
(FASTA)

ALICSCTNCV HTNYTCETDG VCMVSISNMD GMEHHSRTCI PQAELVPVGK PFYCLSSDHV 60

RNTHCCRTDF CNKIDLRVPS GHLKDTPSMW GPVELVAVIA GPVFLLFLII IVVVFVIHHH 120

QRVYHNRQRL DMEDPSCEMC LSKDKTLQDL VYDLSTSGSG SGLPLFVQRT VARTIVLQEI 180

IGKGRFGEVW RGRWRGGDVA VKIFSSREER SWFREAEIYQ TVMLRHENIL GFIAADNKDN 240

GTWTQLWLVS DYHEHGSLFD YLNRYTVTIE GMIRLALSAA SGLAHLHMEI VGTQGKPGIA 300

HRDLKSKNIL VKKNGMCAIA DLGLAVRHDS STDTIDIAPN QRVGTKRYMA PEVLDETINM 360

KHFDSFKCAD IYALGLVYWE IARRCNSGGI HEEYQLPYYD LVPSDPSIEE MRKVVCDQKL 420

RPNIPNWWQS YEALRVMGKM MRECWYANGA ARLTALRIKK TLSQLSVQED VKI 473

Nucleotide Sequence
(FASTA)

GCTCTGATAT GTTCATGTAC AAACTGTGTG CATACCAACT ACACATGCGA AACAGATGGG 60

GTCTGCATGG TTTCTATTTC CAACATGGAT GGGATGGAGC ACCATTCTCG AACCTGTATC 120

CCCCAGGCTG AGCTGGTCCC AGTAGGAAAG CCCTTCTATT GCCTCAGCTC AGATCATGTT 180

CGAAATACAC ACTGCTGTCG TACTGACTTC TGTAACAAGA TTGACCTGAG GGTGCCCAGT 240

GGTCACCTGA AAGATACCCC ATCCATGTGG GGTCCTGTGG AACTAGTCGC TGTCATTGCT 300

GGCCCAGTGT TCCTCCTATT TCTCATCATC ATTGTCGTCG TCTTTGTTAT TCACCATCAT 360

CAGCGAGTTT ATCACAACCG CCAGCGGCTG GACATGGAAG ATCCCTCGTG TGAAATGTGT 420

CTGTCCAAAG ACAAGACTCT TCAGGATCTT GTCTACGATC TGTCTACTTC AGGGTCTGGC 480

TCAGGGTTAC CACTCTTTGT CCAGCGCACG GTGGCTCGTA CAATTGTTCT ACAAGAGATC 540

ATAGGCAAGG GCCGATTTGG GGAAGTATGG CGTGGCCGGT GGCGGGGTGG AGATGTGGCT 600

GTGAAAATTT TCTCCTCCCG GGAAGAACGG TCTTGGTTTC GAGAAGCAGA AATATACCAG 660

ACAGTCATGT TGCGTCATGA AAATATTCTT GGATTTATTG CCGCTGACAA CAAAGATAAT 720

GGTACGTGGA CTCAGCTGTG GCTTGTTTCT GATTATCACG AACATGGTTC CTTGTTTGAT 780

TACCTTAACC GGTACACAGT GACTATCGAG GGGATGATTA GGCTGGCTTT GTCTGCTGCT 840

AGTGGGTTGG CACACCTACA CATGGAGATC GTAGGTACCC AGGGGAAGCC TGGAATTGCA 900

CATAGAGACT TGAAATCAAA GAACATCTTG GTGAAGAAAA ATGGAATGTG TGCAATTGCT 960

GACCTGGGTC TTGCTGTCCG TCATGATTCA AGCACTGATA CTATTGACAT CGCCCCAAAT 1020

CAAAGGGTGG GGACCAAGAG ATATATGGCT CCTGAAGTGC TGGATGAAAC CATCAACATG 1080

AAACACTTTG ATTCTTTCAA ATGTGCTGAT ATTTATGCCT TAGGATTGGT ATATTGGGAG 1140

ATTGCCCGAA GATGCAATTC AGGAGGAATC CATGAGGAAT ATCAGCTTCC ATATTATGAT 1200

CTTGTGCCCT CTGATCCTTC CATTGAAGAA ATGCGGAAGG TAGTATGTGA CCAAAAGCTG 1260

CGGCCCAACA TCCCTAACTG GTGGCAAAGC TATGAGGCAC TACGGGTGAT GGGAAAGATG 1320

ATGCGAGAAT GCTGGTACGC CAACGGGGCG GCACGTCTGA CCGCCCTCCG CATTAAGAAG 1380

ACTCTTTCAC AGCTCAGTGT GCAAGAAGAT GTGAAGATCT AG 1422

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 175   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  234

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e ++rlals+asGlahLH+eivgt+

Q: 235   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIRLALSAASGLAHLHMEIVGTQ  294

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 295   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDSSTDTIDIAPNQRVGTKRYMAPE  352

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 353   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGIHEEYQLPYYDLVPSDPSIEEM  411

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 412   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  462

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIR LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDSSTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGIHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013