EKS-SAH-00409

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00409

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	460.8	1.5E-138	53	315	263

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014314

UniProt Accession

G3WFV9;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012229	ENSSHAP00000014314	ENSSHAT00000014433
ENSSHAG00000012229	ENSSHAP00000014313	ENSSHAT00000014432

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1410

Protein Sequence
(FASTA)

INIFSFIKDG ITSLFFDLDF PALRKNKNIE NFLIRYEKTV TKIRCLQMKA EDFDVIKVIG 60

RGAFGEVQLV RHKASQNVYA MKLLSKFEMI KRSDSAFFWE ERDIMAFANS PWIVQLFCAF 120

QDDRYLYMVM EYMPGGDLVN LMSNYDVPEK WAKFYTAEVV LALDAIHSMG LIHRDVKPDN 180

MLLDKNGHLK LADFGTCMKM DETGMVRCDT AVGTPDYISP EVLKSQGGDG YYGRECDWWS 240

VGVFLFEMLV GDTPFYADSL VGTYSKIMDH KNSLNFPEDA EISKHAKNLI CAFLTDREVR 300

LGRNGVEEIK QHSFFKSDQW NWDNIRETAA PVVPELSSDI DSSNFDDIED DKGDVETFPI 360

PKAFVGNQLP FIGFTYYSEN LLLGDAPSSS TENDSVQSRK NEQSVQIQKK LYLLEEHLKN 420

EIQAKEDLDQ KCKLVSTRLE KITKELEEEV TSRKNVESTL RQLEREKALL QHKNTEYQRK 480

AEHEADKKRN LENDVNSLKD QLEDLKKRNQ NSQISNEQVN QLQRQQQLDE ANALLRTESD 540

TAARLRKNQT ESSKQIQQLE SNNRELQDKN CMLENAKLKL EKDFINLQSA LESERRDRTH 600

GSEMINDLQG RISGLEEDIK NGKISLAKME LEKRQLQERF TDLEKEKSNM EIDMTYKLKV 660

IQQSLEQEEA EHKATKARLA DKNKIYESIE EAKSEAMKEM EKKLLEERTL KQKVENLLLE 720

AEKRCSLLDC DLKQSQQKVN ELLKQKDKLN EDVRNLTLKI EQETQKRCLT QNDLKMQTQQ 780

VNTLKMSEKQ MKQENNHLME IKMSLEKQNI ELRKERQDAD GQMKELQDQL EAEQYFSTLY 840

KTQVRELKEE CQEKTKLCKE MQQKSQELQD ERDSLAAQLE ITLTKADSEQ LARSIAEEQY 900

SDLEKEKIMK ELEIKEMMAR HKQELAEKDA TIASLEEANR TLTSDVANLA NEKEELNNKV 960

KEVQEQISRL KDEETNISVI KTQFEKQLLN ERTLKTQAVN KLAEIMNRKE PPRRGADTDV 1020

RRKEKENRKL HMELKSEREK LTQQMIKYQK ELNEMQAQIA EESQIRIELQ MTLDSKDSDI 1080

EQLRSQLQAL HIGLDSSSIG SGPGEAEADD GFPVHITQSH TMESMSFTYQ RSSTSLNIAT 1140

KPSSSHMLLD SDSDSEEESL SCAPISSEPD SAESRLEGWL SLPVRNNTKK FGWVKKYVIV 1200

SSKKILFYDS EQDKEQSNPY MVLDIDKLFH VRPVTQTDVY RADSKEIPRI FQILYANEGE 1260

SKKEQEFPVE PVGEKSNCIC HKGHEFIPTL YHFPTNCEAC MKPLWHMFKP PPALECRRCH 1320

IKCHKDHMDK KEEIIAPCKV YYDISSAKNL LLLANSTEDQ QKWVSRLIKK IPKKPPAPDP 1380

FARSSPRTSM KVQPNQSIRR PSRQLPPSKP 1410

Nucleotide Sequence
(FASTA)

ATTAACATTT TTTCCTTTAT TAAAGATGGC ATAACTTCCT TGTTCTTTGA TTTGGATTTT 60

CCTGCTCTGA GGAAAAACAA GAATATAGAA AATTTCTTAA TTAGATATGA AAAAACTGTG 120

ACAAAAATTA GATGCCTACA GATGAAGGCA GAAGATTTTG ATGTTATTAA AGTTATTGGA 180

AGAGGTGCTT TTGGTGAAGT TCAGTTGGTT CGTCATAAAG CATCACAAAA TGTTTATGCC 240

ATGAAGCTTC TTAGTAAATT TGAAATGATA AAAAGATCAG ATTCTGCTTT CTTTTGGGAA 300

GAACGAGATA TCATGGCTTT TGCCAATAGT CCCTGGATTG TTCAGCTCTT TTGTGCCTTT 360

CAAGATGATA GATATCTTTA TATGGTAATG GAATACATGC CTGGTGGAGA CCTTGTAAAT 420

CTTATGAGTA ACTATGATGT ACCTGAAAAA TGGGCCAAAT TTTATACAGC TGAAGTTGTT 480

CTGGCTTTGG ATGCAATACA CTCCATGGGT TTAATACACA GAGATGTGAA GCCCGACAAC 540

ATGCTTTTAG ATAAAAATGG ACATCTGAAA TTAGCAGATT TTGGCACTTG TATGAAAATG 600

GATGAAACAG GAATGGTACG TTGTGATACA GCAGTTGGAA CACCTGATTA TATATCACCT 660

GAAGTTCTGA AGTCACAAGG TGGTGATGGC TACTATGGAC GAGAGTGTGA TTGGTGGTCT 720

GTGGGTGTTT TCCTTTTTGA GATGCTTGTT GGGGACACTC CATTTTATGC AGATTCACTT 780

GTGGGAACAT ATAGTAAAAT CATGGATCAT AAAAATTCAC TAAATTTTCC AGAAGATGCA 840

GAAATATCCA AGCATGCAAA GAATCTCATA TGTGCTTTCT TGACTGATAG GGAGGTGCGA 900

CTTGGGAGAA ATGGGGTAGA AGAAATCAAA CAGCACTCTT TCTTTAAAAG TGATCAGTGG 960

AATTGGGATA ACATAAGAGA AACTGCAGCT CCAGTAGTAC CTGAACTCAG CAGTGACATA 1020

GATAGCAGCA ATTTTGATGA CATTGAAGAT GATAAAGGAG ATGTGGAAAC CTTTCCAATT 1080

CCTAAAGCCT TTGTGGGAAA TCAACTGCCT TTTATAGGTT TTACCTATTA TAGCGAAAAT 1140

TTGTTATTAG GTGATGCTCC TTCTTCCAGT ACAGAAAATG ATTCAGTACA ATCAAGGAAA 1200

AATGAGCAAT CTGTACAGAT TCAAAAAAAA CTATATTTAT TAGAAGAACA CCTCAAAAAT 1260

GAGATACAAG CCAAAGAGGA TCTGGACCAG AAGTGCAAAT TGGTTAGCAC TCGACTAGAG 1320

AAGATAACAA AAGAACTAGA AGAAGAGGTA ACCTCAAGAA AGAATGTAGA ATCTACATTA 1380

AGACAATTGG AAAGAGAGAA GGCTCTTCTT CAACACAAAA ATACAGAATA TCAGCGGAAG 1440

GCAGAACATG AAGCAGACAA AAAACGGAAT CTGGAAAATG ATGTTAACAG TTTGAAAGAT 1500

CAGCTTGAAG ATTTGAAAAA AAGAAATCAA AACTCTCAAA TATCTAATGA ACAAGTCAAT 1560

CAGCTCCAAA GACAACAACA GTTGGATGAA GCCAATGCTT TGCTGCGAAC TGAGTCTGAT 1620

ACTGCAGCCA GGTTACGGAA AAACCAGACA GAAAGTTCAA AACAAATTCA GCAGCTGGAA 1680

TCTAATAATA GGGAGTTACA AGACAAAAAT TGCATGCTAG AGAATGCTAA ACTGAAACTT 1740

GAAAAGGACT TCATCAATCT TCAGTCAGCT CTAGAATCAG AACGGAGAGA TAGAACCCAT 1800

GGATCTGAGA TGATTAATGA TTTACAAGGT AGAATATCTG GTTTGGAAGA AGATATTAAA 1860

AATGGTAAAA TTTCATTAGC AAAAATGGAA TTAGAGAAGA GACAACTACA GGAGAGATTT 1920

ACAGATTTAG AAAAGGAAAA AAGTAATATG GAAATAGACA TGACATACAA ACTGAAAGTT 1980

ATACAACAAA GCTTGGAACA GGAAGAAGCA GAACATAAAG CTACAAAAGC ACGGTTAGCA 2040

GATAAGAATA AGATATATGA ATCTATCGAG GAGGCTAAGT CTGAAGCTAT GAAGGAAATG 2100

GAGAAGAAAC TCCTAGAGGA AAGAACTTTA AAGCAAAAGG TGGAAAACCT TCTCTTGGAA 2160

GCCGAAAAAA GATGTTCACT GTTAGACTGT GATCTCAAAC AGTCCCAACA GAAAGTCAAC 2220

GAACTCTTAA AACAGAAGGA CAAACTGAAT GAAGATGTCA GGAATTTGAC CTTAAAAATA 2280

GAACAAGAAA CACAAAAGCG CTGCCTCACA CAAAATGACC TGAAGATGCA AACACAACAA 2340

GTCAACACAC TGAAAATGTC TGAAAAACAA ATGAAACAAG AAAATAATCA TCTTATGGAA 2400

ATCAAAATGA GTCTGGAAAA GCAAAATATT GAACTTCGGA AAGAACGGCA AGATGCAGAT 2460

GGACAAATGA AAGAGCTCCA AGATCAGCTT GAAGCAGAAC AATATTTCTC AACTCTGTAT 2520

AAAACACAAG TTCGAGAGCT TAAAGAAGAA TGTCAAGAGA AGACCAAGCT TTGCAAAGAA 2580

ATGCAGCAGA AGAGCCAGGA ATTACAGGAT GAAAGGGACT CCTTGGCTGC GCAACTTGAG 2640

ATCACCTTGA CAAAAGCTGA TTCAGAACAG CTAGCTCGTT CTATTGCTGA AGAGCAGTAT 2700

TCTGATTTGG AAAAAGAAAA GATCATGAAA GAGTTGGAAA TTAAAGAGAT GATGGCGCGA 2760

CACAAACAAG AACTTGCAGA AAAAGATGCT ACAATAGCAT CTCTTGAGGA GGCTAATAGG 2820

ACACTAACTA GTGATGTGGC TAATCTTGCA AATGAGAAGG AAGAACTGAA TAATAAAGTT 2880

AAGGAAGTCC AAGAGCAAAT CTCAAGGTTG AAAGATGAAG AAACAAATAT ATCAGTTATT 2940

AAAACACAAT TTGAGAAACA ACTATTAAAT GAGAGAACAC TGAAAACTCA GGCTGTGAAT 3000

AAATTGGCTG AGATTATGAA TCGAAAAGAA CCTCCCAGGC GTGGTGCTGA CACAGATGTG 3060

AGAAGGAAAG AGAAGGAGAA CAGAAAGCTG CATATGGAAC TAAAATCAGA ACGTGAAAAA 3120

TTAACTCAGC AAATGATCAA ATATCAGAAA GAATTAAATG AAATGCAAGC TCAAATAGCT 3180

GAAGAAAGCC AAATTCGAAT TGAATTGCAA ATGACGCTGG ACAGTAAAGA CAGTGATATT 3240

GAACAGCTTC GATCACAACT CCAGGCCTTG CATATTGGCC TGGATAGTTC CAGTATAGGC 3300

AGTGGACCAG GAGAAGCTGA GGCAGATGAT GGGTTCCCAG TCCATATTAC TCAGTCACAT 3360

ACTATGGAAT CCATGTCTTT CACCTATCAA CGTTCTTCTA CCTCTCTCAA TATTGCTACT 3420

AAGCCTTCCA GTTCTCACAT GCTTCTCGAC TCTGATTCTG ACTCAGAGGA AGAATCCTTA 3480

TCTTGTGCAC CCATTTCTTC GGAACCTGAT AGTGCAGAAT CAAGATTAGA GGGATGGCTT 3540

TCATTGCCCG TACGAAACAA TACAAAGAAG TTTGGATGGG TTAAAAAGTA TGTAATTGTA 3600

AGCAGCAAGA AGATTCTTTT CTATGATAGT GAACAAGATA AAGAACAGTC TAATCCCTAC 3660

ATGGTGTTAG ATATAGACAA GTTGTTCCAT GTCAGGCCAG TCACACAGAC AGATGTTTAT 3720

AGAGCTGATT CCAAAGAGAT TCCAAGGATA TTCCAGATTC TGTATGCTAA TGAAGGGGAA 3780

AGCAAAAAAG AACAAGAATT TCCCGTGGAA CCAGTTGGGG AGAAGTCAAA CTGCATCTGT 3840

CACAAAGGAC ATGAATTTAT TCCCACTCTT TATCATTTCC CAACTAACTG TGAAGCCTGT 3900

ATGAAGCCAC TTTGGCACAT GTTTAAACCT CCACCTGCTC TTGAATGCCG CCGCTGCCAT 3960

ATCAAATGCC ATAAAGACCA CATGGACAAA AAGGAGGAAA TCATAGCACC TTGCAAAGTA 4020

TACTATGACA TTTCATCGGC AAAGAATCTG CTGTTATTAG CTAATTCTAC AGAGGACCAG 4080

CAGAAGTGGG TTAGTCGGTT AATAAAAAAG ATACCTAAGA AACCCCCAGC ACCAGATCCT 4140

TTTGCTCGAT CATCTCCTAG AACTTCTATG AAGGTACAGC CTAACCAATC TATAAGACGG 4200

CCAAGTCGAC AGCTTCCTCC AAGCAAACCA 4230

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+++kviGrGafgev++vr+ka+++vyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 53    FDVIKVIGRGAFGEVQLVRHKASQNVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  112

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         ivql++afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g

Q: 113   IVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  170

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+

Q: 171   LIHRDVKPDNMLLDKNGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLKSQG-GD  229

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l

Q: 230   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDAEISKHAKNL  289

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h+ff

Q: 290   ICAFLTDREVRLGRNGVEEIKQHSFF  315

         *************************9

Domain Sequence
(FASTA)

FDVIKVIGRG AFGEVQLVRH KASQNVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

IVQLFCAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120

HRDVKPDNML LDKNGHLKLA DFGTCMKMDE TGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLNFPEDAEI SKHAKNLICA 240

FLTDREVRLG RNGVEEIKQH SFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013