EKS-SAH-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.6	1.5E-122	189	476	288

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014641

UniProt Accession

G3WGT7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012498	ENSSHAP00000014642	ENSSHAT00000014765
ENSSHAG00000012498	ENSSHAP00000014641	ENSSHAT00000014764

Organism

Sarcophilus harrisii

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MTAPWVTFAL LWGSLCAGPG RGEVETRECI YYNANWELEK TNQSGLERCE GEKDKRLHCY 60

ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVF FCCCEGNFCN EKFTHLPEVT 120

GPEVTYEPPS TVPLLTVLAY ALLPIGGLSL AIVIAFWMYR HRKPPYGHVD VNEDPGPPPP 180

SPLVGLKPLQ LLEIKARGRF GCVWKAQLMN DYVAVKIFPL QDKQSWQSER DIFSTPGMKH 240

ENLLQFIAAE KRGSNLEVEL WLITAFHDKG SLTDYLKGNI VTWNELCHVA ETMSRGLSYL 300

HEDVPWCRGE GHKPAIAHRD FKSKNVLLKS DLTAVLADFG LAVRFEPGKP PGDTHGQVGT 360

RRYMAPEVLE GAINFQRDAF LRIDMYAMGL VLWELVSRCT AVDGPVDEYM LPFEEEIGQH 420

PSLEDLQEVV VHKKMRPAFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERVSLI 480

RKSVNGTTSD CLVSLVTSVT NVDLPPKESS I 511

Nucleotide Sequence
(FASTA)

ATGACGGCGC CTTGGGTCAC TTTCGCCCTG CTTTGGGGGT CGCTTTGCGC AGGTCCAGGA 60

CGTGGGGAGG TTGAGACCAG GGAATGCATC TACTACAATG CCAACTGGGA ACTGGAAAAG 120

ACAAACCAGA GTGGTTTGGA ACGTTGTGAG GGGGAGAAGG ACAAGCGCCT TCATTGCTAC 180

GCCTCTTGGA GGAATAGCTC CGGCACCATT GAGCTCGTGA AGAAGGGCTG TTGGCTGGAT 240

GACTTCAATT GTTATGACAG GCAGGAATGT GTGGCCACTG AAGAGAACCC CCAGGTCTTC 300

TTCTGTTGCT GTGAAGGAAA CTTCTGCAAT GAAAAGTTCA CACATTTACC TGAGGTCACT 360

GGCCCCGAAG TTACCTATGA GCCACCCTCG ACTGTCCCCC TACTCACAGT ACTTGCATAT 420

GCCTTGCTGC CTATTGGGGG CCTCTCTTTG GCCATTGTCA TTGCATTCTG GATGTACCGA 480

CATCGAAAGC CTCCCTACGG TCATGTGGAC GTCAATGAGG ACCCGGGTCC TCCACCCCCT 540

TCACCACTTG TGGGCCTGAA GCCTTTGCAA CTCCTGGAGA TCAAGGCCCG GGGACGTTTT 600

GGTTGTGTCT GGAAGGCTCA GCTTATGAAT GACTATGTGG CAGTGAAGAT TTTTCCATTA 660

CAGGACAAAC AGTCCTGGCA GAGTGAACGG GACATCTTCA GCACACCAGG CATGAAACAC 720

GAAAACCTGC TCCAGTTTAT CGCAGCGGAA AAGAGAGGTT CCAACCTGGA GGTGGAGCTG 780

TGGCTCATCA CAGCCTTCCA TGACAAGGGT TCTCTCACTG ATTACCTAAA AGGGAACATT 840

GTGACCTGGA ACGAGCTGTG TCATGTAGCT GAGACCATGT CCCGAGGCTT GTCCTACCTG 900

CATGAGGATG TGCCCTGGTG CCGAGGAGAG GGGCACAAGC CAGCCATTGC CCACAGGGAT 960

TTCAAGAGCA AGAATGTCTT ACTGAAGAGT GACCTCACAG CGGTCCTGGC TGACTTTGGA 1020

CTGGCTGTGC GGTTTGAACC AGGAAAGCCT CCTGGGGACA CCCATGGGCA GGTAGGAACC 1080

AGGCGGTACA TGGCTCCAGA GGTGCTGGAA GGAGCAATCA ACTTCCAGAG AGATGCTTTC 1140

CTGAGGATTG ATATGTACGC AATGGGGCTG GTACTGTGGG AGCTGGTGTC TAGATGCACA 1200

GCTGTGGATG GGCCTGTGGA TGAGTATATG TTACCTTTTG AGGAAGAGAT TGGTCAACAT 1260

CCATCCCTAG AAGACCTGCA AGAGGTAGTG GTGCATAAAA AGATGCGTCC TGCCTTCAAA 1320

GATCACTGGT TGAAGCATCC TGGGTTAGCA CAGCTTTGTG TGACGATCGA GGAATGTTGG 1380

GACCATGATG CTGAGGCCAG ACTTTCTGCA GGCTGTGTGG AGGAACGGGT GTCCTTGATC 1440

CGCAAATCTG TCAATGGCAC TACCTCGGAC TGCCTCGTCT CCCTCGTGAC ATCTGTCACC 1500

AATGTGGACT TGCCCCCCAA AGAGTCGAGT ATCTAA 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E++i++t+ ++hen+lqfia

Q: 189   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPLQDKQSWQSERDIFSTPGMKHENLLQFIA  248

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 249   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIVTWNELCHVAETMSRGLSYLHEDVPWCR  308

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 309   GeGHKPAIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  366

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc++vd+ v+ey+lpfee++g++Psle+

Q: 367   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCTAVDGPVDEYMLPFEEEIGQHPSLED  425

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 426   LQEVVVHKKMRPAFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  476

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PLQDKQSWQS ERDIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIVTWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPAIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CTAVDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPA FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013