EKS-SAH-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	394.8	2.4E-118	86	379	294

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014662

UniProt Accession

G3WGV7;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012515	ENSSHAP00000014662	ENSSHAT00000014786

Organism

Sarcophilus harrisii

Functional Description

Protein Length

409

Protein Sequence
(FASTA)

ELLAIISKVT IISLLPPVGI AIAVIVIFYC YRVHRRRKLS TTWESSKSRK LVECSDRCAM 60

MMDDDRSDIS STCANNLNHN TELLPIELDT LVGKGRFAEV YKAKLKQNTS EQFETVAVKI 120

FPYEEYASWK TEKEIFSDIN LKHENILQFL TAEERKMDLG KQYWLITAFH ARGNLQEYLT 180

RHVISWEDLW KLGSSLSRGI AHLHSDHTPC GRPKTAIVHR DLKSSNILVK NDLTCCLCDF 240

GLSLRLDPTL SVDDLANSGQ VGTARYMAPE VLESRMNLEN MESFKQTDVY SMALVLWEMT 300

SRCNEIGEVK EYEPPFGSKV REHPCVESMK DNVLRDRGRP EIPNTWLSHR GIQMVCETLA 360

ECWDHDPEAR LTAQCVAERF EELSDLDRLS GRSCSEEKIP EDCSLSTPK 409

Nucleotide Sequence
(FASTA)

GAGCTTTTGG CCATCATCTC CAAAGTGACC ATCATCAGCC TCCTTCCGCC CGTGGGCATC 60

GCTATCGCCG TGATTGTCAT CTTCTACTGC TACCGGGTAC ACCGCAGGAG AAAGCTGAGT 120

ACCACCTGGG AGAGCAGCAA GTCGCGGAAG CTGGTAGAGT GCAGCGACCG CTGTGCCATG 180

ATGATGGATG ACGACCGCTC GGACATAAGC TCCACCTGCG CCAACAACCT CAATCACAAC 240

ACAGAGCTGC TGCCCATCGA GCTGGACACC CTGGTGGGCA AGGGGCGCTT TGCTGAGGTC 300

TACAAGGCCA AGCTGAAACA GAACACTTCC GAGCAGTTCG AGACGGTGGC GGTCAAGATC 360

TTTCCCTATG AGGAATATGC CTCCTGGAAG ACTGAAAAGG AGATCTTCTC GGACATCAAC 420

CTCAAGCATG AGAACATCCT TCAGTTCCTG ACGGCGGAGG AGCGGAAGAT GGACTTGGGA 480

AAGCAGTATT GGCTCATCAC CGCCTTCCAT GCCAGGGGCA ACCTGCAGGA GTACCTCACC 540

AGGCACGTCA TCAGCTGGGA GGACCTGTGG AAGCTGGGCA GCTCCCTGTC CAGGGGCATC 600

GCCCATCTCC ATAGCGACCA CACTCCCTGC GGGAGACCAA AAACAGCCAT CGTTCACAGA 660

GACCTGAAGA GCTCCAACAT CCTAGTGAAA AACGACCTGA CCTGCTGCCT CTGTGACTTT 720

GGGCTGTCCC TGAGATTGGA CCCGACCCTC TCTGTGGATG ACTTGGCCAA CAGCGGGCAG 780

GTTGGGACAG CAAGATATAT GGCTCCTGAG GTTTTGGAAT CCAGAATGAA CTTGGAAAAT 840

ATGGAGTCCT TCAAGCAAAC AGATGTATAT TCCATGGCCC TGGTTCTCTG GGAAATGACG 900

TCTCGCTGCA ATGAGATAGG AGAGGTCAAG GAATATGAGC CGCCATTTGG TTCCAAAGTG 960

AGAGAGCATC CCTGCGTCGA GAGCATGAAG GACAACGTGC TGAGAGACCG GGGTCGGCCT 1020

GAGATCCCCA ACACGTGGCT CAGCCACCGA GGTATACAGA TGGTTTGTGA GACTTTGGCC 1080

GAGTGCTGGG ACCACGATCC AGAAGCACGG CTGACCGCCC AGTGCGTGGC CGAACGTTTT 1140

GAAGAACTGA GCGATCTGGA TCGGCTGTCG GGGAGAAGCT GTTCAGAGGA GAAGATCCCT 1200

GAGGACTGCT CCCTGAGCAC CCCCAAGTAA 1230

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ekei++ ++l+hen

Q: 86    IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKEIFSDINLKHEN  145

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++d+ ++++l+t++h +g+L++yL+r+++++e+l +l +sl++G+ahLH+

Q: 146   ILQFLTAEERKMDLGKQYWLITAFHARGNLQEYLTRHVISWEDLWKLGSSLSRGIAHLHS  205

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K ai+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 206   D-HTPCGRPKTAIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  264

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+e  +ev+ey++pf ++v+++

Q: 265   RYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNE-IGEVKEYEPPFGSKVREH  323

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w ++  +++++++l ecWd+dpeaRlta++v++r

Q: 324   PCVESMKDNVLRDRGRPEIPNTWLSHRGIQMVCETLAECWDHDPEARLTAQCVAER  379

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKEI FSDINLKHEN 60

ILQFLTAEER KMDLGKQYWL ITAFHARGNL QEYLTRHVIS WEDLWKLGSS LSRGIAHLHS 120

DHTPCGRPKT AIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENMESFK QTDVYSMALV LWEMTSRCNE IGEVKEYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPNT WLSHRGIQMV CETLAECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004872	; F:receptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013