EKS-SAH-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.42.1E-155619878260
StatusUnreviewed
Ensembl ProteinENSSHAP00000014687
UniProt AccessionG3WGY2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000012536ENSSHAP00000014687ENSSHAT00000014811
OrganismSarcophilus harrisii
Functional Description
Protein Length984
Protein Sequence
(FASTA)
VRPHYVFCSL ILCILLAETL MDSTTATAEL GWIVHPSSGW EEVSGYNENM NTIRTYQVCN 60
VFESNQNNWL RTRYIRRRGA QRIHVEMKFS VRDCSSIPNV PGSCKETFNL YYYEADFDSA 120
TKTFPNWMEN PWVKVDTIAA DESFSQVDLG GRVMKINTEV RSFGPVSRNG FYLAFQDYGG 180
CMSLIAVRVF YRKCPRVIQN GAVFQETLSG AESTSLVAAR GTCIPNAEEV DVPIKLYCNG 240
DGEWLVPIGR CMCKAGYESV ENGTICRGCP SGTFKANQGD EGCTHCPINS RTTSEGATNC 300
VCRNGYYRAD LDPLEMPCTT IPSAPQAVIS SINETSLMLE WTPPRDSGGR EDLVYNIICK 360
SCGSGRGACT RCGDNVQFAP RQLGLTEPRI YISDLLAHTQ YTFEIQAVNG VTDQSPFSPQ 420
FASINITTNQ AAPSAVSIVH QVSRTVDSMT LSWSQPDQPN GVILDYELQY YEKDLSEHNA 480
TAVKSPTNTV TVQGLKAGTI YVFQVRARTV AGYGRYSGKM YFQTMTEAEY QTSIQEKLPL 540
IIGSSAAGLV FLIAVVVIAI VCNRRRGFER ADSEYTDKLQ HYTSGHMTPG MKIYIDPFTY 600
EDPNEAVREF AKEIDISCVK IEQVIGAGEF GEVCSGHLKL PGKREIFVAI KTLKSGYTEK 660
QRRDFLSEAS IMGQFDHPNV IHLEGVVTKS TPVMIITEFM ENGSLDSFLR QNDGQFTVIQ 720
LVGMLRGIAA GMKYLADMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE DDTSDPTYTS 780
ALGGKIPIRW TAPEAIQYRK FTSASDVWSY GIVMWEVMSY GERPYWDMTN QDVINAIEQD 840
YRLPPPMDCP NALHQLMLDC WQKDRNHRPK FGQIVNTLDK MIRNPNSLKA MAPLSSGINL 900
PLLDRTVPDY TSFNTVDEWL EAIKMGQYKE SFASAGFTSF DVVSQMMMED ILRVGVTLAG 960
HQKKILNSIQ VMRAQMNQIQ SVEV 984
Nucleotide Sequence
(FASTA)
GTTAGGCCCC ATTATGTCTT CTGTTCCCTA ATACTGTGTA TTCTCCTTGC AGAAACGCTG 60
ATGGACTCCA CCACAGCCAC CGCGGAGCTT GGCTGGATTG TGCATCCTTC ATCTGGGTGG 120
GAGGAGGTGA GCGGATACAA TGAAAACATG AACACCATCC GAACCTATCA GGTGTGCAAC 180
GTCTTTGAGT CCAATCAGAA CAACTGGCTC CGCACCAGGT ATATCCGGAG ACGAGGAGCT 240
CAGCGCATCC ATGTGGAGAT GAAGTTCTCC GTCCGGGACT GCAGCAGCAT CCCCAACGTC 300
CCTGGCTCCT GTAAGGAGAC CTTCAACCTC TATTACTACG AAGCCGACTT TGACTCGGCC 360
ACCAAAACCT TTCCCAACTG GATGGAGAAC CCCTGGGTCA AAGTGGATAC GATCGCAGCG 420
GACGAAAGCT TTTCCCAGGT GGATCTCGGG GGCAGGGTGA TGAAAATTAA CACGGAGGTT 480
CGGAGCTTTG GGCCGGTCTC CAGGAACGGC TTCTACCTAG CCTTCCAAGA CTATGGTGGC 540
TGCATGTCGC TCATCGCCGT TCGGGTGTTC TACCGCAAGT GCCCCCGTGT GATCCAGAAC 600
GGGGCTGTCT TCCAGGAGAC CCTGTCTGGG GCCGAGAGCA CGTCTCTGGT GGCTGCCCGG 660
GGCACCTGCA TCCCAAATGC GGAAGAAGTA GACGTGCCCA TTAAGCTTTA CTGCAATGGG 720
GACGGGGAAT GGCTGGTGCC CATTGGGAGG TGCATGTGCA AGGCCGGCTA CGAATCGGTG 780
GAGAACGGGA CCATTTGCCG AGGCTGCCCT TCTGGGACCT TCAAGGCCAA CCAAGGAGAC 840
GAAGGATGCA CTCACTGCCC CATCAACAGC CGCACTACTT CAGAAGGAGC CACTAACTGT 900
GTTTGCCGCA ACGGGTACTA CCGAGCTGAC TTGGACCCGC TGGAGATGCC ATGCACCACC 960
ATCCCCTCTG CGCCACAGGC TGTCATCTCC AGCATCAATG AGACTTCACT CATGCTAGAG 1020
TGGACGCCGC CCCGGGACTC GGGTGGCAGA GAGGACCTGG TTTACAACAT CATCTGCAAA 1080
AGCTGCGGCT CAGGCCGGGG AGCCTGCACC CGCTGCGGGG ACAACGTGCA GTTTGCCCCA 1140
CGTCAGCTGG GTCTGACGGA GCCAAGGATC TATATCAGCG ACCTCCTGGC CCACACCCAG 1200
TACACCTTCG AGATCCAGGC AGTGAATGGA GTCACTGACC AGAGTCCCTT CTCACCCCAG 1260
TTTGCTTCCA TCAATATTAC CACCAATCAG GCAGCCCCAT CCGCTGTATC CATCGTACAC 1320
CAGGTGAGCC GGACGGTAGA CAGCATGACC TTGTCCTGGT CCCAGCCTGA CCAGCCCAAT 1380
GGCGTCATCC TCGACTATGA ACTACAGTAC TATGAAAAGG ACCTGAGCGA ACACAACGCC 1440
ACTGCGGTCA AAAGCCCCAC CAACACCGTG ACCGTGCAGG GCCTGAAAGC GGGCACCATC 1500
TATGTCTTCC AGGTGCGGGC ACGCACCGTC GCGGGCTACG GGCGCTACAG TGGCAAGATG 1560
TACTTCCAGA CGATGACCGA AGCCGAGTAC CAGACGAGCA TCCAGGAGAA GCTGCCTCTC 1620
ATCATCGGCT CGTCCGCGGC AGGGCTGGTC TTCCTCATCG CCGTGGTGGT CATTGCCATC 1680
GTGTGTAACA GAAGGCGGGG GTTTGAGCGT GCCGATTCCG AGTACACCGA CAAACTACAG 1740
CATTACACCA GCGGCCACAT GACTCCAGGC ATGAAAATCT ACATTGATCC CTTCACCTAT 1800
GAGGACCCCA ACGAAGCTGT TCGAGAGTTT GCCAAGGAAA TTGACATCTC TTGTGTCAAA 1860
ATTGAGCAGG TGATTGGAGC AGGGGAATTT GGTGAAGTCT GCAGTGGCCA CCTGAAGCTG 1920
CCAGGCAAAA GAGAGATTTT TGTGGCCATC AAGACCCTCA AATCAGGCTA CACAGAGAAG 1980
CAGCGCCGGG ACTTCCTGAG TGAAGCCAGC ATCATGGGCC AGTTTGACCA CCCCAACGTC 2040
ATCCACCTAG AAGGCGTGGT CACCAAGAGC ACACCAGTCA TGATCATCAC CGAGTTCATG 2100
GAAAATGGTT CCCTGGACTC CTTCCTCCGG CAAAATGACG GGCAATTCAC AGTAATCCAG 2160
CTGGTGGGCA TGCTTCGGGG CATTGCTGCA GGCATGAAGT ACCTGGCAGA CATGAACTAT 2220
GTACATCGAG ACTTGGCTGC CCGCAATATT CTGGTCAATA GCAACTTGGT CTGCAAGGTG 2280
TCCGACTTCG GACTCTCACG CTTCCTGGAG GATGATACCT CTGACCCCAC CTATACAAGT 2340
GCCCTGGGTG GGAAGATCCC GATACGCTGG ACAGCTCCAG AGGCCATCCA GTACAGGAAA 2400
TTCACATCTG CCAGTGATGT GTGGAGTTAT GGAATAGTCA TGTGGGAAGT CATGTCCTAT 2460
GGGGAGAGGC CATACTGGGA TATGACCAAT CAGGATGTAA TCAATGCCAT AGAGCAAGAC 2520
TACCGGCTGC CCCCTCCCAT GGACTGCCCT AACGCCTTGC ACCAGCTCAT GCTGGACTGT 2580
TGGCAGAAGG ACCGGAACCA CCGACCCAAG TTTGGGCAGA TTGTGAACAC GCTGGACAAA 2640
ATGATTCGAA ACCCCAATAG CCTCAAAGCT ATGGCACCCC TCTCCTCTGG GATCAACCTC 2700
CCCTTGCTGG ACCGCACGGT CCCCGACTAC ACCAGCTTTA ACACGGTGGA CGAGTGGCTG 2760
GAGGCCATCA AGATGGGCCA GTACAAGGAG AGTTTTGCCA GTGCCGGCTT CACGTCCTTC 2820
GATGTTGTCT CCCAGATGAT GATGGAGGAC ATTCTTCGTG TGGGCGTCAC TCTAGCTGGT 2880
CATCAAAAGA AAATTCTAAA CAGTATTCAG GTGATGCGAG CGCAAATGAA CCAGATCCAG 2940
TCGGTGGAAG TTTGA 2955
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 619   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  678
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 679   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  738
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 739   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  798
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 799   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLML  858
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 859   DCWQKDRNHRPKFGQIVNTL  878
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPNALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAF-00005
EKS-CAP-00004
EKS-CII-00002
EKS-CIS-00001
EKS-DAR-00002
EKS-DRM-00001
EKS-EQC-00005
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-ICT-00004
EKS-LOA-00005
EKS-MAM-00005
EKS-MEG-00004
EKS-MIM-00001
EKS-MOD-00005
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-NOL-00005
EKS-ORN-00004
EKS-ORC-00004
EKS-ORL-00005
EKS-OTG-00003
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SUS-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XET-00003
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013