EKS-SAH-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.5	1.1E-185	410	688	279

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014789

UniProt Accession

G3WH84;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012625	ENSSHAP00000014789	ENSSHAT00000014914

Organism

Sarcophilus harrisii

Functional Description

Protein Length

719

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVVSGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SEPSRGRKRK AENQSESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQNSHS HSTPSSCVRP NSPSPTALAF GDHPITQPKQ LSFKIIQTDL TMLKLAALEN 180

NKNQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LASREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTTNN SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPVKPVVSNE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTAPT PPSSSIISY 719

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAGCTTCA CAGCTTAGAT CCAAGAAGGC AAGAATTATT GGAAGCTCGA 60

TTTACAGGAG TTGTAAGTGG AAGCACTGGA AGTACTGGCA GTTGCAGTGT TGGAGCTAAA 120

GCCTCAACAA ACAATGAAAG CTCTAATCAC AGTTTTGGAA GCTTAGGATC TCTAAGTGAT 180

AAAGAATCTG AGACTCCAGA GAAGAAACAG TCAGAACCAT CCAGAGGAAG AAAGAGGAAA 240

GCAGAAAACC AAAGTGAAAG CAGTCAGGGA AAAAGTATCG GGGGACGTGG CCACAAAATT 300

AGTGACTATT TTGAATATCA AGGTGGGAAT GGCTCCAGTC CAGTAAGGGG AATACCTCCT 360

GCTATCCGAT CGCCTCAGAA TTCACATTCA CATTCCACTC CTTCCTCTTG TGTTCGGCCG 420

AATAGCCCTT CTCCTACTGC ATTAGCTTTT GGGGACCACC CTATTACACA ACCAAAGCAG 480

TTATCTTTTA AAATTATTCA GACTGATCTC ACAATGCTGA AATTAGCTGC ACTAGAAAAT 540

AATAAAAACC AGGATCTGGA AAAGAAAGAA GGTCGTATAG ATGATTTGCT CAGGGCTAAC 600

TGTGATCTTA GACGTCAAAT AGACGAACAG CAAAAACTAC TTGAAAAATA CAAAGAAAGA 660

TTAAATAAAT GCATTTCAAT GAGTAAGAAG CTTTTAATAG AAAAGAGCAC ACAAGAAAAG 720

CTGGCAAGCA GGGAAAAGAG TATGCAAGAC AGACTACGCC TTGGGCATTT TACAACAGTT 780

AGACACGGTG CTTCATTTAC TGAACAGTGG ACAGATGGTT TTGCCTTTCA GAATCTTGTG 840

AAACAACAAG AATGGGTAAA TCAGCAAAGG GAGGATATTG AAAGACAAAG AAAACTCCTG 900

GCAAAGAGAA AACCACCGAC TACTAATAAT TCTCAGGCAC CTTCTACCAA TTCTGAACCA 960

AAACAAAGGA AAAACAAAGC TGTCAATGGA GCAGAAAATG ATCCTTTTGT TAGACCTAAT 1020

TTACCACAAC TGCTGACTTT AGCAGAGTAC CATGAACAAG AAGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAAGCAGAA ATCCAGGCAG AACTTGAGCG TTTGGAAAGA 1140

GTCAGAAATC TTCACATACG GGAACTCAAA AGGATAAACA ATGAAGACAA TTCACAGTTT 1200

AAAGATCATC CCACATTAAA TGAACGATAC TTATTACTTC ATCTGCTTGG TAGAGGTGGC 1260

TTTAGTGAAG TATATAAGGC TTTTGATCTT TATGAACAAA GATATGCTGC TGTGAAGATC 1320

CACCAGCTTA ATAAGAGCTG GAGGGATGAG AAGAAGGAAA ACTACCACAA ACATGCCTGC 1380

AGAGAGTATA GAATACACAA AGAACTGGAC CACCCCAGGA TAGTTAAACT CTATGATTAT 1440

TTCTCCTTGG ATACAGACAC GTTTTGTACA GTGTTAGAAT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TCAAACAACA TAAATTAATG TCAGAGAAGG AAGCTAGGTC CATTGTTATG 1560

CAAATAGTAA ATGCACTAAG ATATCTCAAT GAGATCAAAC CCCCTATTAT CCATTATGAT 1620

CTTAAACCAG GAAATATCCT TTTAGTAGAT GGAACAGCAT GTGGAGAAAT CAAAATTACT 1680

GATTTTGGCC TGTCCAAAAT TATGGATGAT GATAGTTATG GTGTGGATGG AATGGATCTA 1740

ACTTCCCAAG GAGCAGGGAC TTATTGGTAT TTACCTCCAG AATGTTTTGT AGTTGGCAAA 1800

GAGCCTCCAA AGATTTCCAA CAAGGTTGAT GTATGGTCTG TCGGAGTTAT CTTTTTTCAA 1860

TGTCTATATG GTCGAAAGCC ATTTGGTCAC AACCAGTCTC AACAAGACAT CTTACAAGAA 1920

AACACAATAT TAAAAGCCAC AGAAGTCCAG TTCCCTGTGA AACCTGTTGT AAGCAATGAA 1980

GCCAAGGCTT TCATAAGACG TTGTTTAGCA TATCGTAAAG AGGATCGATT TGATGTCCAC 2040

CAACTGGCTA ATGATCCTTA CCTTCTCCCA CATATGAGAA GATCAAATTC TTCAGGGAAT 2100

TTACATATGG CTGGACTGAC AGCCCCTACC CCTCCTTCAT CAAGTATAAT TTCTTATTGA 2160

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvs+eakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSN EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013