EKS-SAH-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	468.7	1.1E-140	205	518	314

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014912

UniProt Accession

G3WHK7;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012724	ENSSHAP00000014912	ENSSHAT00000015037

Organism

Sarcophilus harrisii

Functional Description

Protein Length

584

Protein Sequence
(FASTA)

GRGGESNVRQ LQGSPGLGAG APRTGVGTGT QSPLTLPPLR SNTTASAVAH AIAGSKHVMN 60

DHLVLGSHAQ LQVQQLFEDN SNKRTVLTTQ PNGLTTVGKT GLPLVQERQL DSVHRRQGSS 120

NSLKSVEGTG KVKAASMTPE QAMKQYVLKL TAFEHHEIFS YPEIYFLGPN AKKRQGTTGG 180

PNNGGYDDDQ GSYVQVPHDH IAYRYEVLKV IGKGSFGQVV KAYDHKVHQH VALKMVRNEK 240

RFHRQAAEEI RILEHLRKQD KDNNMNVIHM LENFTFRNHI CMTFELLSMN LYELIKKNKF 300

QGFSLPLVRK FAHSILQCLD ALHKNRIIHC DLKPENILLK QQGRSGIKVI DFGSSCYEHQ 360

RVYTYIQSRF YRAPEVILGA RYGMPIDMWS LGCILAELLT GYPLLPGEDE GDQLACMIEL 420

LGMPAPKLLD ASKRAKNFVS SKGYPRYCTV TTLSDGSIIL NGGRSRRGKL RGPPESREWG 480

TALKGCDDPL FLDFLKQCLE WDPAIRLTPG QALRHPWLRR RLPKPPTGEK TAAKRITESA 540

GAITSISKLP PPSSSASKLR TNLAQMTDAN GNIQQRTVLP KLVS 584

Nucleotide Sequence
(FASTA)

GGCAGAGGAG GGGAAAGCAA CGTCCGTCAG CTGCAAGGTT CGCCAGGACT CGGAGCTGGG 60

GCTCCCCGGA CCGGAGTGGG AACTGGCACA CAGTCCCCCC TCACCCTGCC GCCTCTCAGG 120

TCCAACACTA CGGCGTCTGC CGTTGCCCAT GCGATTGCTG GTAGCAAGCA CGTTATGAAT 180

GATCACCTGG TCCTTGGCAG CCACGCACAA CTCCAGGTAC AGCAGCTTTT TGAAGATAAT 240

AGTAATAAGA GGACAGTTCT TACTACACAA CCAAACGGGC TTACAACAGT TGGTAAAACC 300

GGATTGCCAC TAGTACAAGA AAGACAATTG GACAGCGTTC ATAGACGGCA AGGGAGCTCC 360

AACTCTTTGA AGTCTGTAGA AGGAACTGGG AAAGTAAAAG CCGCCTCTAT GACACCGGAA 420

CAGGCAATGA AGCAATATGT GCTAAAGCTA ACAGCCTTCG AACACCATGA GATTTTTAGT 480

TACCCTGAAA TATACTTTTT GGGTCCAAAT GCAAAGAAAC GCCAAGGCAC GACAGGCGGG 540

CCAAACAACG GTGGCTACGA CGATGACCAG GGCTCTTACG TGCAAGTGCC TCACGATCAC 600

ATTGCTTATA GGTACGAAGT CCTAAAGGTC ATAGGGAAAG GGAGCTTTGG ACAAGTGGTG 660

AAGGCCTATG ACCACAAAGT GCATCAACAC GTGGCCCTCA AGATGGTGAG GAACGAGAAG 720

CGTTTCCACC GGCAGGCTGC GGAGGAAATC CGGATCCTGG AGCACCTGCG GAAACAGGAC 780

AAGGATAACA ACATGAACGT CATCCACATG CTGGAGAATT TCACTTTCCG CAATCACATA 840

TGCATGACCT TTGAGTTACT GAGTATGAAC CTCTATGAGC TGATCAAGAA AAACAAATTT 900

CAGGGCTTCA GCTTGCCCTT GGTTCGAAAA TTTGCCCATT CAATTTTGCA GTGCTTAGAT 960

GCTTTACACA AAAATAGAAT CATTCACTGT GACCTTAAAC CCGAGAACAT CTTATTAAAA 1020

CAACAGGGTA GGAGTGGTAT TAAGGTGATT GATTTTGGCT CCAGTTGTTA CGAACATCAG 1080

CGTGTCTACA CGTACATTCA GTCGCGTTTT TATCGGGCAC CGGAGGTGAT TCTTGGTGCC 1140

CGGTATGGGA TGCCTATTGA TATGTGGAGC TTGGGCTGTA TTCTAGCAGA GCTCCTGACA 1200

GGTTACCCTC TCTTGCCTGG GGAAGATGAA GGGGACCAGT TGGCTTGTAT GATTGAACTC 1260

TTGGGCATGC CAGCCCCCAA ACTTCTAGAC GCATCCAAAC GAGCCAAAAA TTTTGTGAGC 1320

TCTAAGGGTT ATCCCCGGTA CTGCACTGTT ACAACTCTGT CCGACGGCTC CATCATTCTA 1380

AATGGTGGCC GCTCCCGAAG GGGGAAACTG AGGGGCCCGC CGGAGAGTAG AGAGTGGGGC 1440

ACTGCACTTA AGGGGTGTGA TGATCCACTT TTCCTTGATT TCTTGAAACA GTGTTTGGAA 1500

TGGGATCCTG CCATACGCTT GACCCCCGGC CAGGCGTTGA GACACCCCTG GCTCCGGAGG 1560

CGCCTGCCAA AGCCTCCAAC TGGGGAGAAG ACAGCAGCAA AACGGATAAC GGAAAGCGCT 1620

GGTGCTATAA CGTCTATTTC CAAGTTACCT CCACCTTCAA GCTCAGCATC AAAACTGAGG 1680

ACTAATTTGG CACAAATGAC AGATGCCAAT GGGAATATTC AGCAGAGGAC AGTGTTGCCA 1740

AAACTTGTTA GCTGA 1755

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 205   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNN  264

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 265   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  324

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 325   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  383

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 384   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPAPKLLDASKRAKNFVSSKG  443

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd + +l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 444   YPRYCTVTTLSDGSIILNGGRSRRGKLRGPPESREWGTALKGCDDPLFLDFLKQCLEWDP  503

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 504   AIRLTPGQALRHPWL  518

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNN 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP APKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGSIILNGGR SRRGKLRGPP ESREWGTALK GCDDPLFLDF LKQCLEWDPA 300

IRLTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013