EKS-SAH-00359

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00359

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.0	1.2E-108	693	949	257

Status

Unreviewed

Ensembl Protein

ENSSHAP00000014955

UniProt Accession

G3WHQ0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

MAP3K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000012760	ENSSHAP00000014955	ENSSHAT00000015080

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1385

Protein Sequence
(FASTA)

MSAEDSEGIT FPVPPFSPPG FCTFPEGGCS RRGGAAAAAA PGEGSPFPPP PPPAGSFWNV 60

EGSGASVTCT GGISAAAVAS GAPSAPRSRG NSTGAGGGSR RTTVAYVINE ASQGQLVVAE 120

SEALQCLREA CEAVGAALET LHFGKLDFGE TAVLDRFYNA DIAVVEMSDA FRQPSLFYHL 180

GVRESFSMAN NIILYCDTNS DSLQSLKEII CQKNTMCTGN YTFVPYMITP HNKVYCCDSS 240

FMKGLTELMQ PNFELLLGPI CLPLVDRFIQ LLKVAQANSS QYFRESILSD IRKARNLYTG 300

KELAAELERI RQRVDNIEVL SADIVINLLL SYRDIQDYDS IVKLVETLEK LPTFDLASHH 360

HVKFHYAFAL NRRNLLGDRE KALSIMIPLV QCEGQVASDM YCLVGRIYKD MFLDSNFTDT 420

ESRDHGASWF KKAFESEPTL QSGINYAVLL LAAGHQFESS FELRKVGVKL SSLLGKKGNL 480

EKLQSYWEVG FFLGASVLAN DHLRVIQASE KLFKLKTPAW YLKSIVETIL IYKHFMKLTT 540

EPHGAKQELV DFWMDFLVEA TKTDVTVVRF PVLILEPTKI YQPSYLSINN EADEKTISIW 600

HVLPDDKKGI HEWNFSATSV RGVSISKFEE RCCFLYVLHN SDDFQIYFCT ELHCKKFFEM 660

VNTITEEKGK STEEGECDSD SLEYDYEYDE NGDRVILGKG TYGIVYAGRD LSNQVRIAIK 720

EIPERDSRYS QPLHEEIALH KHLKHKNIVQ YLGSFSENGF IKIFMEQVPG GSLSALLRSK 780

WGPLKDNEQT IGFYTKQILE GLKYLHDNQI VHRDIKGDNV LINTYSGVLK ISDFGTSKRL 840

AGINPCTETF TGTLQYMAPE IIDKGPRGYG KAADIWSLGC TIIEMATGKP PFYELGEPQA 900

AMFKVGMFKI HPEIPESMSA EAKAFILHCF EPDPDKRACA NDLLLDEFLK VSSKKKKTQP 960

KLSALSAGSN EYLRSISLPV PVLVEDTSSS SEYGSVSPDT DLKVDPFSFK TRAKSCGEKD 1020

GKGIRTLFLG IPDENFEDHS APPSPEEKDS GFFMLRKDSE RRATLHRILT EDQDEVARNL 1080

MESLAQGPEA PKLRWEHITT LVSSLREFVR STDRKIIATT LSKLKLELDF DSHGISQVQV 1140

VLFGFQDAVN KVLRNHNIKP HWMFALDSII RKAVQTAITI LVPELRPHFS LASESDTADQ 1200

DDLDVEEDRD EQPPTQTNRR PQAVIEDAVA TSGVSTLSST VSHDSQGAHR SLNVQLGRMK 1260

IETNRLLEEL VRKEREFQAL LHQAIEEKDQ EIKHLKLKSQ PIDIPGLYVC HLNSPGIGAE 1320

DSELIDWLRE NGADEDTISR FLAEDYTLVD VLYCVTRDDL KCLRLRGGML CTLWKAISDF 1380

REKKP 1385

Nucleotide Sequence
(FASTA)

ATGAGCGCCG AGGATAGCGA GGGCATCACT TTCCCCGTTC CCCCGTTTAG CCCCCCGGGC 60

TTTTGCACCT TCCCGGAGGG CGGCTGCAGC CGAAGGGGCG GAGCGGCAGC AGCTGCGGCT 120

CCAGGCGAGG GGAGTCCGTT CCCACCACCG CCCCCACCCG CCGGTAGCTT CTGGAATGTG 180

GAAGGCAGTG GCGCCTCTGT CACCTGCACT GGGGGCATCT CGGCCGCCGC AGTTGCGAGC 240

GGGGCCCCGA GCGCCCCCCG GAGTCGGGGC AACTCGACTG GCGCTGGCGG TGGCAGTCGG 300

AGAACCACGG TGGCATACGT GATTAACGAA GCCAGCCAGG GGCAGCTGGT GGTAGCTGAG 360

AGCGAGGCCC TGCAGTGCCT GCGGGAGGCA TGCGAGGCGG TGGGCGCTGC GCTGGAGACC 420

CTACATTTTG GCAAACTGGA CTTCGGGGAA ACCGCGGTTT TGGATCGTTT CTACAATGCA 480

GATATCGCTG TGGTCGAGAT GAGTGATGCT TTCCGTCAGC CTTCCTTGTT TTATCATCTT 540

GGGGTGAGGG AGAGCTTCAG CATGGCCAAC AATATCATCC TCTACTGTGA TACCAATTCA 600

GATTCTCTTC AGTCATTGAA GGAAATCATT TGTCAAAAGA ATACCATGTG CACTGGGAAT 660

TACACATTTG TTCCATACAT GATAACCCCC CATAACAAGG TCTACTGCTG CGATAGTAGC 720

TTTATGAAGG GGTTGACAGA GCTAATGCAG CCTAATTTTG AACTACTTCT TGGACCCATC 780

TGCTTACCTT TAGTGGATCG TTTTATTCAA CTTTTGAAGG TGGCACAAGC TAATTCAAGC 840

CAGTATTTCC GAGAATCCAT ACTCAGTGAT ATCAGGAAAG CCCGTAACCT CTACACAGGT 900

AAAGAATTGG CAGCTGAGCT GGAAAGAATC CGACAGCGAG TAGATAATAT TGAAGTCTTG 960

TCAGCAGATA TTGTCATAAA TCTACTCCTC TCCTATAGAG ATATTCAGGA CTATGATTCT 1020

ATTGTGAAGC TTGTAGAAAC TTTAGAAAAG CTGCCAACCT TTGATTTGGC CTCCCATCAT 1080

CATGTGAAGT TCCATTATGC ATTTGCACTG AACAGGCGAA ATCTCCTTGG AGATAGAGAA 1140

AAAGCTCTTA GTATTATGAT TCCTCTGGTG CAATGTGAAG GCCAGGTTGC TTCTGATATG 1200

TATTGTCTTG TGGGTCGAAT CTACAAAGAT ATGTTTTTGG ACTCCAATTT TACAGACACA 1260

GAAAGCAGAG ATCATGGAGC TTCCTGGTTC AAAAAGGCAT TTGAATCTGA GCCAACACTA 1320

CAGTCAGGAA TTAATTATGC AGTCCTCCTT CTGGCAGCTG GACACCAGTT CGAATCTTCC 1380

TTTGAGCTAC GGAAAGTTGG AGTGAAACTA AGTAGTCTGC TTGGTAAAAA GGGAAACCTG 1440

GAAAAACTCC AGAGCTACTG GGAAGTTGGA TTTTTCCTTG GTGCCAGTGT ACTTGCTAAT 1500

GATCACTTGA GAGTGATACA AGCTTCTGAA AAGCTTTTTA AACTGAAGAC ACCTGCATGG 1560

TACCTCAAAT CTATTGTAGA AACCATTTTG ATATATAAGC ATTTTATGAA ACTGACTACA 1620

GAACCACATG GAGCCAAGCA AGAGCTTGTG GATTTCTGGA TGGATTTCCT GGTTGAAGCC 1680

ACAAAGACAG ATGTGACTGT AGTTAGGTTT CCGGTTTTAA TATTAGAACC AACAAAAATC 1740

TACCAACCTT CCTATTTGTC TATCAACAAT GAAGCTGATG AAAAAACGAT ATCTATCTGG 1800

CATGTGCTTC CTGATGACAA GAAAGGTATT CACGAGTGGA ATTTTAGTGC AACTTCCGTC 1860

AGGGGAGTAA GTATTTCAAA GTTTGAGGAA CGATGCTGCT TTTTATACGT GCTTCACAAC 1920

TCGGATGATT TTCAAATCTA TTTCTGTACA GAACTTCACT GCAAAAAGTT TTTTGAAATG 1980

GTGAATACTA TTACTGAAGA AAAAGGAAAA AGTACAGAAG AAGGGGAATG TGATAGTGAT 2040

TCTTTGGAGT ATGACTATGA ATATGATGAA AATGGTGACA GAGTCATTTT AGGGAAGGGC 2100

ACTTATGGTA TAGTTTATGC TGGACGTGAC CTGAGCAATC AAGTCAGAAT TGCTATTAAA 2160

GAAATCCCTG AGCGAGACAG CAGATATTCC CAACCTTTAC ATGAGGAAAT AGCATTACAT 2220

AAGCATCTGA AACACAAAAA TATTGTCCAG TATCTGGGTT CATTCAGTGA GAATGGCTTC 2280

ATTAAAATTT TCATGGAACA GGTTCCAGGA GGAAGCCTTT CTGCTCTTCT TCGATCAAAA 2340

TGGGGTCCCT TAAAAGATAA TGAGCAAACT ATTGGCTTTT ATACAAAACA AATTCTTGAA 2400

GGTTTAAAAT ATCTCCATGA CAATCAGATT GTACATCGGG ATATAAAGGG TGACAATGTG 2460

TTAATCAACA CATATAGTGG TGTTTTAAAG ATCTCTGATT TTGGCACATC AAAGAGACTT 2520

GCTGGCATCA ATCCCTGTAC TGAAACTTTC ACTGGTACTC TTCAATATAT GGCACCAGAA 2580

ATAATAGATA AAGGACCAAG AGGATATGGA AAAGCAGCAG ACATATGGTC TTTGGGCTGT 2640

ACAATCATTG AAATGGCTAC AGGAAAACCA CCATTTTATG AATTGGGAGA ACCTCAAGCA 2700

GCCATGTTCA AGGTGGGAAT GTTCAAGATA CACCCAGAGA TCCCTGAGTC TATGTCTGCA 2760

GAGGCCAAGG CTTTCATATT GCACTGTTTT GAACCAGATC CTGACAAGAG GGCCTGTGCC 2820

AATGATTTGC TTCTTGATGA ATTCTTAAAA GTTTCCAGCA AAAAGAAGAA GACACAGCCT 2880

AAACTTTCAG CTCTTTCAGC TGGATCAAAT GAATATCTTA GGAGCATATC TTTGCCAGTC 2940

CCTGTACTAG TAGAAGACAC AAGCAGCAGC AGTGAATATG GATCCGTTTC ACCTGACACA 3000

GATTTAAAAG TGGATCCCTT TTCTTTCAAA ACAAGAGCCA AATCCTGTGG AGAAAAAGAT 3060

GGGAAAGGAA TCCGGACCCT CTTTCTGGGC ATTCCAGATG AGAATTTTGA AGACCACAGT 3120

GCTCCCCCTT CTCCTGAAGA AAAAGATTCT GGATTCTTTA TGCTGAGAAA AGACAGTGAG 3180

CGAAGAGCTA CTCTGCATAG GATATTAACA GAAGACCAGG ATGAAGTTGC GAGAAACCTA 3240

ATGGAATCAT TGGCTCAGGG ACCTGAGGCA CCTAAACTAA GATGGGAACA CATCACAACT 3300

TTAGTCTCAA GCCTCAGAGA GTTTGTGAGG TCAACAGATC GAAAAATCAT AGCCACCACA 3360

CTGTCAAAAC TGAAACTGGA GCTGGATTTT GATAGCCATG GAATCAGTCA AGTCCAAGTG 3420

GTTCTGTTTG GTTTCCAAGA TGCTGTCAAT AAAGTCCTTC GGAATCACAA CATCAAGCCT 3480

CATTGGATGT TTGCCTTAGA CAGCATCATT CGAAAAGCGG TCCAGACAGC CATTACCATT 3540

CTAGTTCCAG AACTGAGGCC ACACTTTAGT CTTGCATCTG AAAGTGATAC AGCTGATCAG 3600

GACGACCTGG ATGTTGAAGA AGACCGTGAT GAACAGCCTC CCACTCAAAC TAATCGAAGA 3660

CCTCAGGCAG TCATTGAAGA TGCTGTGGCC ACCTCTGGGG TGAGCACACT CAGTTCCACA 3720

GTATCTCATG ATTCCCAGGG TGCTCACAGG TCTCTGAATG TCCAGCTTGG GAGAATGAAA 3780

ATAGAAACAA ATAGATTGCT AGAGGAATTA GTTCGAAAAG AGAGAGAATT CCAAGCACTC 3840

CTTCATCAAG CAATTGAAGA AAAAGATCAA GAAATTAAAC ATCTGAAGCT TAAGTCACAA 3900

CCAATAGATA TTCCTGGACT GTATGTTTGT CACCTAAATT CTCCTGGCAT AGGAGCTGAA 3960

GACTCTGAAC TTATCGACTG GTTGAGAGAG AATGGAGCTG ATGAGGACAC TATAAGCAGG 4020

TTTTTGGCTG AAGATTATAC TCTAGTTGAT GTTCTCTACT GTGTTACTCG TGATGATCTG 4080

AAATGCCTAC GGCTAAGGGG AGGGATGCTG TGTACGCTGT GGAAAGCTAT CAGTGACTTT 4140

CGAGAAAAAA AACCTTGA 4158

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r ++gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 693   DRVILGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  747

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 748   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  807

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 808   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  864

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 865   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSAEAKA  924

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ +c+e dp+kr++a++LL +efl

Q: 925   FILHCFEPDPDKRACANDLLLDEFL  949

         ********************99996

Domain Sequence
(FASTA)

DRVILGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKIHP EIPESMSAEA KAFILHCFEP 240

DPDKRACAND LLLDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013