EKS-SAH-00370
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00370
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR606.91.3E-182607964358
StatusUnreviewed
Ensembl ProteinENSSHAP00000015487
UniProt AccessionG3WJ82;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000013199ENSSHAP00000015487ENSSHAT00000015614
OrganismSarcophilus harrisii
Functional Description
Protein Length1101
Protein Sequence
(FASTA)
MTFFAESRRD KFSITMGASP WAFLGLGCLL TGPWLTFCQL PLPTVFPNED EKVVQLHSSF 60
TLRCSGDSEV SWQYPMKDEE DQKIEVRNEE NNSGLFVTVL EVVNASAVHT GLYTCYYNHT 120
QTEETEIEGR DIYIYVPDPD VPFVPSAMVD HLIFAEEHDS VTIPCRTTDP QAQVILLNSE 180
EKVVHAFYDS RQGFIGDFAM GQFKCETVIK GKQFQTIPFN IYTITATPEL EVEIEAMKTV 240
YKTGETLVVT CAVLHNEVVD LQWNYPGKVK NKGILKVDEI KVPSLKLVYT LTVPKVTVKD 300
SGDYECAARH ATKETKEIKK VTISVHEKGF IELKPNFSQM ETINLHEVRH FVVDVQAYPP 360
PKIFWLKDNM TVIENLTEII TGLDKIQEIR YQSKLKLIRA KEEDSGYYTI MAQNEDDIKN 420
YTFELTIQVP ASILDLEDDN HGSAGGQMVK CVAEGTPIPN VEWMICKDIT KCNNETSWTL 480
LASNMSDIIT QKHDSSVVKS QVTFDKIEDT MAVRCLAKNS LGTVSRELKL VAPAIRSELT 540
VAASVLVLLV IVIFSLIILI VIWKQKPRYE IRWRVIESIS PDGHEYIYVD PMQLPYDSRW 600
EFPRDGLVLG RILGSGAFGK VVEGTAYGLS RSQPVMKVAV KMLKPTARSS EKQALMSELK 660
IMTHLGPHLN IVNLLGACTK SGPIYIITEY CFYGDLVNYL HKNRDNFLSH HPEKAKKELD 720
IFGMNSADES TRSYVILSFE NNGDYMDMKQ ADTTQYVPML ERKQGSKYSD IQRSMYDRPA 780
SYKKKSVSDP EVKNLLSDDG SEGLSLLDLL SFTYQVARGM EFLASKNCVH RDLAARNVLL 840
AQGKIVKICD FGLARDIMHD SNYVSKGSTF LPVKWMAPES IFDNLYTTLS DVWSYGILLW 900
EIFSLGGTPY PGMMVDSTFY NKIKSGYRMA KPDHATSEVY EIMVKCWNSE PEKRPSFYHL 960
SEIVENLLPG QYKKSYEKIH LDFLKSDHPA VARMRVECDN TYIGVTYKNE DKMKDWEGSY 1020
DEQRLSADSG YIIPLPDIDP IPEDDLGKRN RHSSQTSEES AIETGSSSST FIKREDETIE 1080
DIDMMDDIGI DSSDLVEDSF L 1101
Nucleotide Sequence
(FASTA)
ATGACTTTCT TTGCGGAGTC ACGTAGAGAT AAGTTTTCCA TAACTATGGG TGCTTCCCCA 60
TGGGCGTTCC TGGGCTTGGG ATGTCTCCTC ACAGGGCCGT GGCTCACATT TTGCCAGCTT 120
CCATTACCCA CTGTCTTTCC GAATGAGGAT GAAAAGGTTG TGCAGCTGCA TTCATCTTTT 180
ACCCTAAGAT GCTCTGGGGA CAGTGAAGTG AGCTGGCAGT ACCCCATGAA GGATGAAGAG 240
GACCAAAAAA TAGAAGTCAG AAACGAGGAG AACAACAGTG GCCTTTTTGT GACGGTCCTG 300
GAAGTGGTCA ATGCCTCAGC TGTACACACA GGACTGTACA CTTGTTATTA CAACCACACT 360
CAGACAGAGG AGACTGAGAT CGAAGGCAGA GACATCTACA TCTATGTGCC AGATCCAGAT 420
GTTCCTTTCG TACCTTCAGC CATGGTTGAT CATTTAATTT TTGCGGAGGA ACATGATTCT 480
GTCACTATTC CATGTCGCAC AACTGATCCT CAAGCTCAAG TGATTCTACT CAACAGTGAA 540
GAAAAAGTGG TCCATGCTTT CTATGATAGC AGACAAGGTT TTATTGGAGA CTTTGCCATG 600
GGACAATTCA AATGTGAAAC AGTTATCAAA GGGAAACAAT TCCAAACAAT TCCTTTCAAC 660
ATTTATACGA TAACGGCTAC TCCAGAGCTT GAAGTTGAGA TAGAGGCAAT GAAAACTGTT 720
TACAAAACAG GAGAGACTCT TGTTGTAACT TGTGCTGTCT TGCACAATGA AGTGGTTGAC 780
CTTCAGTGGA ATTATCCAGG AAAAGTGAAA AACAAAGGCA TTTTGAAAGT TGATGAGATC 840
AAAGTTCCAT CTCTCAAGTT GGTGTACACG CTGACGGTCC CTAAGGTGAC AGTGAAAGAT 900
AGTGGAGACT ATGAATGTGC TGCCCGTCAT GCTACCAAGG AAACTAAGGA AATTAAGAAA 960
GTCACCATTT CTGTTCATGA GAAGGGATTT ATTGAGCTCA AACCCAACTT CAGTCAGATG 1020
GAAACCATTA ACTTGCATGA AGTCCGCCAT TTTGTAGTGG ATGTGCAAGC GTATCCACCA 1080
CCAAAGATAT TCTGGCTTAA GGACAATATG ACCGTAATTG AGAATCTGAC CGAAATCATC 1140
ACTGGCTTAG ATAAGATCCA GGAAATAAGA TATCAAAGCA AATTAAAACT GATTCGTGCT 1200
AAGGAAGAAG ATAGTGGATA TTATACAATT ATGGCTCAAA ATGAGGATGA TATTAAGAAC 1260
TATACTTTTG AACTTACAAT TCAGGTTCCT GCTTCTATTC TGGACCTGGA GGATGACAAC 1320
CATGGCTCTG CAGGTGGTCA GATGGTCAAA TGTGTAGCAG AAGGGACTCC AATTCCAAAT 1380
GTGGAATGGA TGATTTGCAA GGATATTACA AAGTGTAATA ATGAAACTTC ATGGACACTC 1440
TTGGCCAGCA ACATGTCCGA TATAATCACA CAGAAACACG ATAGTAGCGT GGTGAAGAGC 1500
CAAGTGACCT TCGACAAAAT TGAAGACACC ATGGCCGTAC GATGCCTAGC GAAGAACTCG 1560
CTTGGGACAG TGAGCCGGGA ACTGAAGCTC GTGGCTCCTG CTATTCGTTC AGAATTGACA 1620
GTGGCTGCCT CGGTCCTTGT GTTACTAGTG ATTGTCATCT TTTCCCTCAT TATCCTGATT 1680
GTCATATGGA AACAGAAACC GAGGTATGAA ATTCGATGGA GAGTTATTGA GTCCATTAGC 1740
CCTGATGGCC ACGAGTACAT TTATGTGGAT CCAATGCAAC TGCCTTATGA TTCAAGATGG 1800
GAGTTTCCTA GAGATGGGCT AGTCCTTGGC CGAATCCTGG GCTCAGGTGC GTTTGGAAAA 1860
GTGGTCGAAG GGACTGCATA CGGATTAAGC CGTTCCCAGC CTGTGATGAA GGTGGCCGTG 1920
AAAATGCTAA AACCCACAGC CAGATCCAGT GAAAAACAGG CCCTCATGTC AGAACTCAAG 1980
ATTATGACTC ACCTGGGACC TCATTTAAAT ATTGTAAATC TTCTAGGAGC CTGTACCAAG 2040
TCAGGTCCCA TTTATATCAT CACTGAATAT TGCTTCTATG GGGATTTGGT CAACTATCTG 2100
CATAAGAACA GAGACAATTT CCTGAGCCAC CATCCAGAGA AGGCAAAGAA AGAGCTAGAT 2160
ATCTTTGGGA TGAATTCAGC TGATGAAAGC ACAAGGAGCT ATGTCATTTT ATCCTTCGAA 2220
AACAATGGGG ATTATATGGA CATGAAGCAA GCCGATACCA CACAGTATGT TCCCATGCTG 2280
GAAAGGAAAC AGGGCTCGAA ATATTCAGAT ATTCAAAGAT CGATGTATGA CCGACCAGCA 2340
TCATACAAAA AGAAATCTGT GTCAGATCCA GAAGTCAAAA ACCTCCTTTC AGATGACGGC 2400
TCCGAAGGTC TCAGTCTCTT GGATCTGTTG AGCTTCACTT ACCAAGTTGC CCGAGGAATG 2460
GAGTTTTTGG CTTCAAAAAA TTGTGTTCAC CGTGACCTGG CTGCTCGCAA TGTGCTTCTG 2520
GCTCAAGGAA AAATCGTGAA GATCTGTGAC TTTGGCCTGG CCAGAGACAT CATGCATGAT 2580
TCCAACTATG TGTCCAAGGG CAGTACTTTT CTGCCAGTGA AGTGGATGGC TCCTGAAAGT 2640
ATCTTTGACA ATCTGTATAC CACGCTGAGC GACGTCTGGT CTTATGGCAT CCTGCTGTGG 2700
GAGATTTTTT CTCTTGGAGG CACACCCTAT CCTGGAATGA TGGTGGATTC TACTTTCTAT 2760
AATAAAATCA AAAGTGGATA CCGCATGGCC AAACCCGACC ACGCCACCAG TGAAGTTTAC 2820
GAGATCATGG TGAAGTGCTG GAATAGTGAG CCCGAGAAGA GACCTTCCTT CTACCACCTG 2880
AGTGAGATTG TGGAAAACCT GCTTCCTGGC CAGTATAAGA AGAGTTATGA GAAAATCCAC 2940
CTGGACTTCC TGAAGAGTGA CCATCCTGCT GTTGCTCGCA TGAGAGTGGA GTGTGACAAT 3000
ACTTACATTG GTGTCACCTA CAAAAATGAG GATAAGATGA AGGACTGGGA AGGCAGCTAT 3060
GATGAACAAC GGTTGAGTGC TGACAGTGGC TATATCATCC CTCTGCCTGA TATTGACCCT 3120
ATCCCAGAAG ATGACCTAGG CAAGAGAAAC AGACACAGTT CCCAGACATC TGAGGAAAGT 3180
GCCATTGAGA CAGGTTCCAG CAGTTCCACC TTCATCAAGA GAGAGGATGA AACCATTGAG 3240
GACATCGACA TGATGGATGA CATTGGGATA GACTCCTCAG ACTTGGTTGA AGACAGCTTC 3300
CTGTAA 3306
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 607   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  666
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl+++ ek    ++eld+++
Q: 667   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLSHHPEK---AKKELDIFG  723
         **********************************************99...567778888
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         +  ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 724   MnSADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkqgskYSDIQRSMYDRPASYK  783
         8789***********************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+ + evk+ l+++ se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 784   KKSVSDPEVKNLLSDDGSEGLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  843
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 844   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  903
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 904   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  963
         *********************************************************998
S: 344   l  344
         +
Q: 964   V  964
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLSHHPEKAK KELDIFGMNS 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKQGS KYSDIQRSMY DRPASYKKKS 180
VSDPEVKNLL SDDGSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013