EKS-SAH-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	403.5	3.5E-121	149	408	260

Status

Unreviewed

Ensembl Protein

ENSSHAP00000015599

UniProt Accession

G3WJJ4;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013293	ENSSHAP00000015599	ENSSHAT00000015727

Organism

Sarcophilus harrisii

Functional Description

Protein Length

460

Protein Sequence
(FASTA)

MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG ARGDTFFIIS KGTVNVTRED 60

SPSEDPIFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS 120

NKAYEDAEAK AKYEAEGAFF ANLKLSDFNI IDTLGVGGFG RVELVQLKSE ESKTFAMKIL 180

KKRHIVDTRQ QEHIRSEKQI MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD 240

RGSFEDSTTR FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG 300

KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL TGRSRKESGN NPMRTEMPGK 360

GLISLEDPEK NQGCNCHCLL SSKYSTNPNS HLKKIIYSLS MIQKHQWFEG FNWEGLRKGT 420

LTPPIIPSVA SPTDTSNFDS FPEDNDEPPP DDNSGWDIDF 460

Nucleotide Sequence
(FASTA)

ATGGAGTTTT TGAAAAGTGT TCCCACATTC CAGAGCCTCC CTGAAGAGAT TCTAAGCAAG 60

TTGGCTGATG TTCTGGAAGA GACACACTAT GAGAATGGGG AATATATCAT CAGGCAAGGG 120

GCCCGAGGGG ATACCTTCTT CATCATCAGC AAAGGAACGG TAAATGTCAC TCGAGAAGAT 180

TCTCCAAGTG AAGACCCAAT CTTTCTTCGC ACTTTAGGGA AAGGAGATTG GTTTGGAGAA 240

AAGGCCCTCC AGGGGGAAGA TGTGAGGACT GCCAATGTCA TCGCTGCAGA AGCCGTGACC 300

TGCCTGGTGA TCGACAGAGA CTCCTTCAAG CATTTGATCG GAGGCTTGGA TGATGTTTCT 360

AACAAGGCCT ATGAAGATGC GGAGGCAAAG GCAAAATATG AAGCTGAAGG GGCATTCTTC 420

GCCAACCTGA AGCTATCCGA TTTCAACATC ATCGACACGC TGGGAGTTGG AGGTTTTGGA 480

CGAGTGGAGC TGGTCCAGTT GAAAAGTGAA GAATCAAAAA CATTTGCTAT GAAAATTCTC 540

AAGAAGCGCC ACATTGTGGA CACGAGACAG CAGGAGCACA TCCGTTCTGA AAAGCAGATC 600

ATGCAAGGGG CTCATTCAGA TTTCATTGTT AGACTATATC GGACCTTCAA GGACAGCAAA 660

TATTTGTATA TGTTAATGGA AGCCTGCCTA GGTGGAGAGC TTTGGACGAT TCTCAGGGAC 720

AGAGGTTCAT TTGAAGATTC GACAACCAGA TTTTATACTG CGTGTGTGGT AGAAGCGTTT 780

GCCTATCTGC ATTCCAAAGG AATCATTTAC AGGGACCTCA AGCCAGAAAA CCTCATTCTT 840

GACCACCGAG GTTACGCCAA ACTGGTTGAT TTTGGCTTTG CAAAGAAAAT AGGATTTGGA 900

AAGAAAACAT GGACTTTTTG TGGGACCCCA GAGTACGTAG CTCCTGAGAT CATCCTGAAC 960

AAAGGTCATG ACATTTCGGC GGACTACTGG TCGCTAGGAA TCTTAATGTA TGAACTCCTG 1020

ACTGGCAGAT CCAGAAAAGA ATCAGGAAAT AACCCAATGC GGACAGAAAT GCCTGGAAAA 1080

GGTTTGATTT CTCTTGAAGA TCCAGAAAAG AATCAGGGAT GCAACTGTCA TTGCCTCCTC 1140

TCCAGTAAAT ATTCAACAAA TCCAAATTCC CATTTGAAGA AAATCATATA TTCATTGTCA 1200

ATGATCCAGA AACACCAATG GTTTGAAGGC TTTAATTGGG AAGGCTTACG AAAAGGTACC 1260

TTGACACCGC CTATAATACC AAGTGTTGCA TCCCCCACAG ATACGAGCAA CTTTGACAGT 1320

TTCCCTGAGG ACAATGATGA GCCACCGCCA GATGACAACT CGGGATGGGA CATAGACTTT 1380

TAG 1383

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 149   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  208

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 209   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  268

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 269   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  328

         ************************************************************

S: 182   ywalgilvyelltgkppf.sgvdplktynlilkgidklelp.rkitkeaedlikklcrdn  239

         yw+lgil+yelltg++   sg +p++t ++  kg+  le p ++ + +++ l+ +    n

Q: 329   YWSLGILMYELLTGRSRKeSGNNPMRT-EMPGKGLISLEDPeKNQGCNCHCLLSSKYSTN  387

         **************9876166777877.7889******99955667888999999*****

S: 240   paerlgylkggikdikkhkwf  260

         p   l +    ++ i+kh+wf

Q: 388   PNSHLKKIIYSLSMIQKHQWF  408

         ********************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGRSRKES GNNPMRTEMP GKGLISLEDP EKNQGCNCHC LLSSKYSTNP 240

NSHLKKIIYS LSMIQKHQWF 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013