EKS-SAH-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.7	7.2E-96	1	282	282

Status

Unreviewed

Ensembl Protein

ENSSHAP00000015705

UniProt Accession

G3WJV0;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013384	ENSSHAP00000015705	ENSSHAT00000015833

Organism

Sarcophilus harrisii

Functional Description

Protein Length

923

Protein Sequence
(FASTA)

GGFGQVYRAT WGGQEVAVKA ARRDPEQDPA AAAESVLREA KLFSMLRHPN IIQLLGVCLQ 60

QPNLCLVLEF ARGGALNRAL AAANAAAPSS PPTPAAAAGN PKPSCAASGP RPALRIPPHI 120

LVNWAVQIAR GMLYLHEEAV VPILHRDLKS SNILLLEKIE HDDICNKTLK ITDFGLAREW 180

HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 240

AVNKLTLPIP STCPEPFAKL MKECWEQDPH IRPSFALILE QLTAIEGAVM TEMPQESFHS 300

MQDDWKLEIQ QMFDELRTKE KELRSREEEL TRAALQQKSQ EELLKRREQQ LAEREIDVLE 360

RELNILIFQL NQEKPNVKKR KGKFKRSRLK LKDGHRISLP SDFQHKITVQ ASPNLDKRRS 420

LNSNSSSPPS SPTIIPRLRA IQLTSDESNR TWGKSTASRQ EEFEDVKRNF KKKGCTWGPS 480

SIQTKERTDC KERVRPLSDG SNPWSTILMK NQKTVPLASL FVDQQGISPE QKLFPDGLDN 540

KRPKQMKVTN QAYVDLPLWK DDQGDNTVEP ESFEEGTSAS SAASTPQMTP TNSLSRIPPK 600

KKTESALYGC AALLASVALG LDIRELNKAQ PPDELLPKED KKKRDKIFQR ASKLRRSSSP 660

PTRIQSKRED VNIPSISPSS NTVNLLSMPS ISTKCLLHSD SEDTFVGTCD RDSPIIGVSP 720

VIQGSNCEPT AISGLVTDHS LSKNVPSFPF TKQVSGNVPN NASSEMRASC HRRTVSDGNA 780

FQTSVTCSTN GASELPILQV SGMLHFPSVH QRNQPSEVLL EKQSAVSIIP RPRPSSLRSQ 840

LNSQQLLPES AKPPTTETDS LKGNPGPTAD CLLSTKERTK FHVPSLLDID VEGQNRDYTV 900

PLCRMKSKTN RPSIYELEKE FLS 923

Nucleotide Sequence
(FASTA)

GGCGGCTTTG GGCAGGTTTA CCGGGCCACC TGGGGCGGCC AAGAGGTGGC GGTGAAGGCG 60

GCGCGACGGG ACCCCGAGCA GGATCCCGCG GCGGCCGCCG AGAGTGTGCT GCGGGAGGCG 120

AAGCTCTTCT CCATGCTGCG GCACCCCAAC ATTATCCAGC TGCTTGGCGT CTGCTTGCAG 180

CAGCCCAACC TCTGCCTCGT CCTCGAGTTC GCCCGCGGGG GGGCCCTCAA TCGGGCTCTG 240

GCCGCCGCCA ACGCCGCCGC CCCCTCCTCG CCCCCGACCC CGGCGGCCGC CGCCGGGAAC 300

CCCAAGCCCT CATGCGCCGC TTCGGGCCCG CGCCCAGCCC TCCGCATCCC TCCGCACATC 360

CTGGTCAACT GGGCAGTGCA GATCGCTCGC GGGATGCTCT ACCTGCACGA GGAGGCCGTC 420

GTGCCCATCT TGCACCGGGA CCTTAAGTCC AGCAACATTT TACTACTTGA GAAGATAGAG 480

CATGATGACA TCTGCAATAA AACATTGAAG ATTACAGATT TTGGTCTGGC TAGGGAATGG 540

CATAGAACAA CCAAAATGAG TGCAGCAGGT ACATATGCAT GGATGGCACC TGAAGTTATC 600

AAGTCATCCT TATTTTCTAA AGGAAGTGAT ATCTGGAGTT ACGGAGTGTT GCTGTGGGAA 660

TTGCTTACAG GAGAAGTTCC CTATCGCGGC ATTGATGGCC TTGCTGTGGC TTATGGAGTA 720

GCTGTCAATA AGCTCACTTT ACCAATTCCG TCTACCTGTC CTGAGCCATT TGCTAAGCTA 780

ATGAAAGAAT GCTGGGAGCA AGATCCACAC ATTCGGCCGT CATTTGCTTT AATCCTTGAA 840

CAGCTGACTG CCATTGAAGG TGCAGTTATG ACTGAAATGC CTCAAGAGTC CTTCCATTCT 900

ATGCAAGATG ACTGGAAACT AGAAATTCAG CAAATGTTTG ATGAATTGAG AACTAAGGAA 960

AAGGAGCTGC GATCCCGCGA AGAGGAGCTA ACTAGAGCAG CTCTTCAGCA GAAGTCTCAG 1020

GAAGAATTGT TAAAAAGGCG TGAGCAACAA CTAGCTGAAC GAGAAATTGA TGTTTTAGAG 1080

CGAGAACTTA ATATTTTGAT ATTCCAATTA AATCAAGAGA AGCCAAATGT AAAAAAGAGG 1140

AAAGGAAAAT TTAAGAGAAG CCGTTTAAAA CTGAAAGATG GACATCGGAT TAGTTTACCC 1200

TCAGATTTCC AGCACAAAAT AACAGTTCAG GCTTCCCCAA ATTTGGACAA ACGAAGAAGT 1260

TTAAACAGTA ACAGTTCTAG CCCACCAAGT AGTCCAACAA TAATTCCTCG CCTTCGAGCT 1320

ATACAGCTCA CCTCAGATGA AAGCAATAGA ACCTGGGGCA AAAGTACTGC TTCTCGTCAA 1380

GAAGAATTTG AAGATGTGAA GAGAAACTTC AAAAAGAAGG GTTGTACATG GGGACCAAGT 1440

TCAATTCAAA CAAAAGAGCG TACTGACTGC AAAGAAAGAG TAAGACCCCT TTCAGATGGC 1500

AGTAATCCTT GGTCAACTAT CTTAATGAAA AACCAGAAAA CTGTGCCTTT AGCTTCATTA 1560

TTTGTGGACC AACAAGGTAT CTCTCCAGAG CAGAAACTTT TCCCAGATGG ACTGGACAAC 1620

AAAAGACCAA AGCAAATGAA AGTGACGAAT CAGGCCTATG TTGATCTACC TCTTTGGAAA 1680

GATGATCAGG GAGATAACAC TGTAGAACCT GAAAGCTTTG AAGAGGGAAC CTCTGCAAGT 1740

TCTGCAGCCA GCACTCCCCA AATGACTCCC ACAAATAGTC TTAGCAGAAT ACCCCCCAAA 1800

AAGAAAACTG AATCTGCATT ATATGGGTGT GCTGCATTAT TGGCTTCTGT AGCTTTGGGA 1860

TTGGATATTA GGGAACTAAA TAAGGCACAA CCTCCTGATG AATTGTTGCC CAAAGAGGAT 1920

AAGAAGAAAC GTGATAAAAT ATTTCAGCGT GCTTCTAAAT TACGAAGAAG TTCCAGTCCT 1980

CCTACTAGAA TACAATCTAA AAGAGAAGAT GTTAACATCC CATCAATAAG CCCATCATCA 2040

AACACTGTGA ACCTCCTGTC CATGCCTTCC ATCTCCACAA AATGTTTGCT ACACTCAGAC 2100

AGTGAAGACA CATTTGTGGG TACTTGTGAT AGAGACAGTC CCATTATAGG AGTTTCCCCT 2160

GTAATTCAGG GAAGTAACTG TGAGCCCACT GCAATTTCAG GACTTGTGAC TGATCACAGC 2220

TTGTCAAAGA ATGTGCCTTC CTTTCCTTTC ACAAAGCAAG TATCTGGAAA TGTGCCAAAT 2280

AATGCTTCAT CAGAAATGAG GGCATCATGT CACAGACGGA CTGTATCTGA TGGAAATGCT 2340

TTTCAGACTT CAGTTACTTG CTCAACCAAT GGAGCCTCAG AGCTGCCAAT TCTTCAAGTT 2400

TCTGGAATGC TTCACTTCCC ATCTGTTCAT CAGAGAAATC AACCAAGTGA GGTCCTACTT 2460

GAAAAACAAA GTGCTGTCAG TATCATACCC AGACCTCGCC CTTCTTCTCT GAGAAGTCAA 2520

TTGAATTCTC AGCAACTTCT TCCAGAAAGT GCAAAGCCTC CTACTACTGA GACTGACTCT 2580

TTAAAAGGTA ATCCAGGACC AACTGCTGAC TGTCTACTTA GTACCAAGGA AAGAACTAAA 2640

TTCCATGTGC CCTCACTATT GGACATTGAT GTGGAAGGTC AAAACAGGGA TTACACTGTG 2700

CCTCTATGCA GAATGAAGAG CAAAACAAAT CGGCCGTCTA TATATGAACT GGAGAAAGAA 2760

TTTCTATCTT AA 2772

Domain Profile

S: 10    gafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniiellGvcle  67

         g fg+vy+a+w ++evavK++r++ e+  ++++e++ reakl+s+l+hpnii+llGvcl+

Q: 1     GGFGQVYRATWGGQEVAVKAARRDPEQdpAAAAESVLREAKLFSMLRHPNIIQLLGVCLQ  60

         789************************99999****************************

S: 68    epnlllvmeyveggsLsnvlhe............................kskreidlev  99

         +pnl+lv+e+++gg+L+++l++                            +   +i+++

Q: 61    QPNLCLVLEFARGGALNRALAAanaaapsspptpaaaagnpkpscaasgpRPALRIPPHI  120

         *********************99***********************99999999******

S: 100   lvswalqiArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarel  152

         lv+wa+qiArGm YLh+ea+++i+hrdLks+n+Ll       +  +ktlki+dFG are+

Q: 121   LVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREW  180

         ***************************************999999***************

S: 153   skstkmsaagtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykv  212

         +++tkmsaagt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+v

Q: 181   HRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV  240

         ************************************************************

S: 213   alkglrlpipsscpeklkkLmkecwnedpekRpsfseivksl  254

         a+++l+lpips+cpe+++kLmkecw++dp+ Rpsf+ i+++l

Q: 241   AVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILEQL  282

         **************************************9986

Domain Sequence
(FASTA)

GGFGQVYRAT WGGQEVAVKA ARRDPEQDPA AAAESVLREA KLFSMLRHPN IIQLLGVCLQ 60

QPNLCLVLEF ARGGALNRAL AAANAAAPSS PPTPAAAAGN PKPSCAASGP RPALRIPPHI 120

LVNWAVQIAR GMLYLHEEAV VPILHRDLKS SNILLLEKIE HDDICNKTLK ITDFGLAREW 180

HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 240

AVNKLTLPIP STCPEPFAKL MKECWEQDPH IRPSFALILE QL 282

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013