EKS-SAH-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	390.2	5.4E-117	17	281	265

Status

Unreviewed

Ensembl Protein

ENSSHAP00000015721

UniProt Accession

G3WJW6;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1

Gene Synonyms/Alias

ULK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013399	ENSSHAP00000015721	ENSSHAT00000015849

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1063

Protein Sequence
(FASTA)

ASPGGRAAEW AVGKFEFSRK DLIGHGAFAV VFKGRHKEKH DLEVAVKCIN KKNLAKSQTL 60

LGKEIKILKE LKHENIVALY DFQEVASSVY LVMEYCNGGD LADYLHSMRT LSEDTIRLFL 120

QQIAGAMKML HSKGIIHRDL KPQNILLSYS GGRKSNPNNI RVKIADFGFA RYLQNNMMAA 180

TLCGSPMYMA PEVIMSQHYD AKADLWSIGT IIYQCLTGKA PFQASSPQDL RLFYEKNKTL 240

LPSHSIPRET SSPLRQLLLG LLQRNHKDRM DFDEFFHHPF LDASSSIKKS PPVPMPSYPS 300

SGSSSSSSSS TSHLASPPSL GEMQQQLQKT LTSPAPDAAG FLHGSKDSAG SSKNSSCDTD 360

DFVMVPAQFP TLADLPGEAA GAKAPQDSLM YSGSSLVTSA GLESQGRTPS PSPPYSGSPS 420

PSGRPSGFSS SRYGPSVPIP VPTQIQNYRR IEQNLQSPNQ YTPPTPRSGM VRRSSSTSPL 480

GFKPGISPPF FPEHGATFPR KASLGGAKPY NPSPQAGTIP ERPGQSRVPS PQGTEMCVVG 540

GGSRVSRPGA SLPEHSPKGL GYRLHSAPNL SDLHVVKPKL PKPPTDPLVA PFTYPQASPP 600

QQHYGLQPCR TLRASPKLPD FMQRNPLPPI LGSPTKAVPA FEFPKTPSSQ NLLTLLAHQG 660

VVVTPTRNRT LPDLREMGHF QSPPSLGLRP VEEIKGPFGR SLSTGRLTDL LLKAAFGSQA 720

PDTGSNESLQ EKPMEIAPSA GYGGNLLPGA RAGGSSSPSP VIFTVGSPPS GTTPPQVPRT 780

RMFSVGSSSS QSSGGSFSSR HLIPGIGGEA VEAPGNLRCY GFTDPITANL EGAVTFEAPD 840

LPEETLMEQE HTDILRSLRF TLAFVHCVME MAAAKGSTGD VGSSMASEYQ LQESIVADQI 900

SLLSREWSYA EQLVLYLKVA ELLSSGLQTA IEQIKAGKLC LSSTVKQVVR KLNELYKSSV 960

SSCHCLNLQL QKFFLDKQKL MDRINSITAE KLIFNYAVQM VRSAALDEMF HHREDCVQRY 1020

HKALLLMEGL QQILTEQADV ENISKCKMCI ERRLSALLSG LCA 1063

Nucleotide Sequence
(FASTA)

GCCAGCCCGG GAGGGAGGGC GGCTGAGTGG GCGGTGGGAA AGTTTGAGTT CAGCCGGAAG 60

GACCTGATTG GCCACGGGGC CTTCGCCGTG GTCTTTAAAG GGAGGCACAA AGAGAAACAT 120

GATCTGGAGG TGGCAGTCAA GTGCATTAAC AAGAAAAACC TGGCCAAGTC TCAGACCCTG 180

TTGGGGAAGG AAATCAAAAT CCTGAAGGAA CTGAAACATG AAAATATCGT GGCCTTGTAT 240

GATTTCCAGG AGGTGGCCAG CTCGGTGTAC CTGGTTATGG AGTACTGCAA TGGGGGCGAC 300

CTTGCTGACT ACCTGCACTC CATGCGGACC CTGAGTGAGG ATACCATCCG GCTCTTCCTC 360

CAGCAGATCG CAGGTGCCAT GAAGATGCTG CACAGCAAGG GAATCATCCA CAGGGATCTG 420

AAGCCCCAGA ATATCCTCTT GTCCTATTCT GGGGGCCGAA AGTCCAACCC CAACAACATT 480

CGAGTGAAGA TCGCTGATTT TGGATTTGCC CGTTACCTGC AGAACAACAT GATGGCGGCC 540

ACGCTCTGCG GTTCCCCCAT GTACATGGCC CCTGAAGTCA TCATGTCCCA ACACTACGAT 600

GCCAAAGCTG ATCTGTGGAG TATTGGAACA ATCATTTACC AGTGTCTGAC AGGCAAGGCC 660

CCCTTCCAGG CCAGCAGTCC ACAGGATCTT CGGCTGTTCT ATGAGAAGAA CAAAACACTG 720

CTGCCCAGCC ATAGCATCCC TAGGGAGACC TCCAGTCCCC TGAGACAGCT GCTTCTGGGC 780

CTTCTTCAGC GGAACCATAA AGATCGGATG GACTTTGATG AGTTTTTCCA TCACCCTTTC 840

CTAGACGCAA GCTCCTCCAT CAAGAAATCT CCCCCAGTGC CCATGCCCTC GTACCCCAGC 900

TCGGGCAGTT CTTCCTCCAG CAGCAGCTCT ACCTCCCACC TGGCCTCGCC TCCTTCCCTT 960

GGGGAGATGC AGCAGCAGCT GCAAAAGACG CTGACCTCCC CAGCCCCGGA TGCTGCAGGC 1020

TTCCTCCACG GCTCCAAGGA CTCGGCCGGC AGCAGCAAGA ACTCTTCCTG TGATACTGAT 1080

GACTTTGTCA TGGTCCCGGC CCAGTTCCCA ACACTAGCGG ACTTGCCAGG GGAAGCCGCG 1140

GGAGCCAAGG CCCCTCAGGA CAGTCTGATG TACAGCGGGA GTTCCCTGGT CACTTCAGCT 1200

GGGCTGGAGA GCCAGGGACG GACGCCTTCT CCCTCGCCCC CCTACAGTGG TTCTCCCAGC 1260

CCCTCTGGCC GACCCAGCGG TTTCTCCAGC AGCAGATATG GTCCGTCCGT CCCTATCCCC 1320

GTCCCCACTC AGATCCAGAA CTACAGGAGA ATCGAGCAGA ACCTCCAGTC CCCCAACCAG 1380

TACACTCCGC CGACTCCACG GTCCGGCATG GTTCGGAGGT CCAGCAGTAC CAGCCCTCTG 1440

GGCTTTAAGC CGGGGATCTC GCCCCCATTC TTCCCTGAAC ACGGAGCCAC CTTTCCCAGA 1500

AAGGCTTCTT TGGGGGGAGC CAAGCCGTAT AACCCATCTC CTCAAGCTGG AACCATCCCA 1560

GAGCGTCCAG GGCAGAGCAG AGTACCCTCC CCGCAAGGCA CCGAGATGTG TGTAGTTGGC 1620

GGTGGCAGCA GGGTCTCCAG GCCTGGCGCT TCTCTCCCAG AACATTCTCC CAAGGGGCTG 1680

GGCTACCGTC TGCACAGCGC CCCCAACCTC TCCGACCTGC ACGTGGTGAA GCCCAAATTG 1740

CCCAAGCCCC CCACAGACCC TCTGGTGGCC CCTTTTACTT ACCCCCAGGC CAGCCCTCCC 1800

CAGCAGCACT ACGGCCTGCA GCCATGCCGG ACCCTCAGGG CATCCCCGAA GCTGCCTGAC 1860

TTCATGCAGC GGAACCCCCT GCCCCCCATC CTGGGCTCTC CCACCAAGGC TGTACCTGCT 1920

TTTGAGTTCC CCAAGACACC GAGTTCCCAG AACCTGCTCA CTCTCCTCGC CCACCAAGGG 1980

GTTGTGGTCA CCCCCACACG GAACAGGACT CTGCCCGACC TCCGGGAGAT GGGCCACTTC 2040

CAGAGCCCAC CCAGCCTGGG CCTGAGGCCC GTGGAAGAGA TCAAGGGACC CTTTGGCAGG 2100

TCCCTCAGCA CCGGTCGCCT CACTGACCTG CTTCTCAAAG CTGCATTTGG GTCTCAGGCC 2160

CCCGACACGG GGAGCAACGA AAGCCTTCAG GAGAAGCCCA TGGAGATCGC CCCTTCTGCT 2220

GGCTATGGAG GAAATCTGCT CCCTGGGGCG AGGGCCGGGG GCTCCTCCAG CCCCTCCCCT 2280

GTCATCTTCA CGGTGGGCTC CCCTCCCAGT GGAACAACCC CACCCCAGGT CCCTCGGACG 2340

CGGATGTTCT CAGTGGGCTC CTCCAGTTCC CAGAGCTCGG GCGGCTCCTT CAGTAGTCGC 2400

CACCTGATCC CTGGCATAGG GGGCGAGGCA GTGGAGGCCC CGGGCAACCT GCGTTGCTAT 2460

GGCTTCACCG ATCCCATCAC TGCCAACCTG GAGGGGGCTG TGACCTTCGA GGCCCCGGAT 2520

CTGCCTGAGG AGACACTCAT GGAGCAAGAG CACACGGACA TCCTCCGCAG CCTCCGATTC 2580

ACGCTGGCCT TTGTCCACTG CGTCATGGAG ATGGCCGCCG CCAAGGGCAG CACGGGCGAC 2640

GTGGGAAGCT CCATGGCCTC CGAGTACCAG CTGCAGGAGA GCATTGTGGC CGACCAGATC 2700

AGCCTGCTGA GCCGAGAGTG GAGTTACGCA GAGCAGCTGG TGTTGTATCT CAAGGTGGCC 2760

GAGCTGCTCT CCTCTGGGCT GCAGACGGCC ATCGAGCAGA TCAAGGCTGG GAAACTCTGC 2820

CTGTCCTCCA CCGTCAAGCA GGTCGTGCGG AAACTGAATG AGCTTTACAA GTCAAGTGTG 2880

TCCTCCTGCC ATTGCCTGAA CCTGCAGCTG CAGAAATTCT TCCTGGACAA GCAGAAGCTC 2940

ATGGACCGAA TCAACAGCAT CACTGCCGAG AAGTTGATCT TCAACTACGC CGTGCAGATG 3000

GTGCGCTCTG CCGCCCTGGA TGAGATGTTC CACCACCGCG AAGACTGCGT CCAGCGCTAC 3060

CACAAGGCCT TGCTGCTCAT GGAGGGCCTG CAGCAGATCC TCACAGAGCA GGCGGATGTC 3120

GAGAACATCA GCAAATGCAA GATGTGCATT GAGCGGAGAC TCTCGGCCTT GCTGTCTGGC 3180

CTTTGTGCCT GA 3192

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         +s ++ iG+G+favv+kgr+++k++ +vA+k+++kk+l+ks++ l keikilkelkheni

Q: 17    FSRKDLIGHGAFAVVFKGRHKEKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI  76

         7889********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+d++e +++vylvmeyc+ggdLa++l+++++Lsedt+r flqq+a a+k+Lhsk+i+

Q: 77    VALYDFQEVASSVYLVMEYCNGGDLADYLHSMRTLSEDTIRLFLQQIAGAMKMLHSKGII  136

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsy+ ++k + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 137   HRDLKPQNILLSYSGGRKsNPNNIRVKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMS  196

         **************999989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvlepp..ipkeisselkd  237

         q+ydakaDlWSiGti+y++l+Gk+Pf+a+s+++L+ ++ekn++l p+  ip+e+ss l++

Q: 197   QHYDAKADLWSIGTIIYQCLTGKAPFQASSPQDLRLFYEKNKTLLPShsIPRETSSPLRQ  256

         *****************************************999887679**********

S: 238   llqsLLqrdpkkRisfeelfahpfl  262

         ll +LLqr++k+R++f+e+f+hpfl

Q: 257   LLLGLLQRNHKDRMDFDEFFHHPFL  281

         ***********************96

Domain Sequence
(FASTA)

FSRKDLIGHG AFAVVFKGRH KEKHDLEVAV KCINKKNLAK SQTLLGKEIK ILKELKHENI 60

VALYDFQEVA SSVYLVMEYC NGGDLADYLH SMRTLSEDTI RLFLQQIAGA MKMLHSKGII 120

HRDLKPQNIL LSYSGGRKSN PNNIRVKIAD FGFARYLQNN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTIIYQCL TGKAPFQASS PQDLRLFYEK NKTLLPSHSI PRETSSPLRQ 240

LLLGLLQRNH KDRMDFDEFF HHPFL 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013