EKS-SAH-00100
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00100
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec480.21.3E-144402652251
StatusUnreviewed
Ensembl ProteinENSSHAP00000015853
UniProt AccessionG3WK98;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000013506ENSSHAP00000015853ENSSHAT00000015982
OrganismSarcophilus harrisii
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSVDVEK 60
ITCVETVVPE KNPPPERQIP RKGEEASEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQIQNK PLPPEPRGEA SPPNELKRVV ALYDYTPMNA NDLQLQKGEE 240
YLILEESTLP WWRARDKNGR EGYIPNNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF TKSAGDPQGV IRHYVVCSTP QSQYYLAERH LFNTIPELIH 360
YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPR DLTFLKELGT GQFGVVKYGK 420
WRGQYDVAIK MIREGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR PRVQTQQLLE MCRDVCEAMD YLESKQFLHR DLAARNCLVN DQGIVKVSDF 540
GLSRYVLDDE YTSSAGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FSNSETAEHI AKGLRLYRPQ LASERVYAIM YSCWHEKADE RPTFRFLLSN ILDVMDEES 659
Nucleotide Sequence
(FASTA)
ATGGCTGCAG TAATCCTAGA AAGCATCTTC CTGAAGCGAT CACAACAGAA AAAGAAGACC 60
TCCCCTCTGA ACTTTAAGAA ACGACTCTTT CTCTTGACCG TTCAGAAACT CTCTTATTAT 120
GAGTATGACT TTGAGCGTGG GAGACGAGGG AGTAAAAAGG GGTCGGTAGA TGTGGAGAAG 180
ATCACCTGTG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CCCCTGAGCG GCAGATCCCG 240
AGAAAGGGGG AAGAGGCCAG TGAGATGGAG CAGATCTCGA TCATCGAGAG ATTCCCCTAC 300
CCCTTTCAGG TGGTGTATGA TGAAGGCCCT CTCTACGTCT TCTCCCCAAC CGAAGAACTG 360
AGGAAGCGCT GGATTCACCA GCTCAAAAAT GTGATCCGCT ACAACAGTGA CCTTGTGCAG 420
AAATACCACC CTTGTTTCTG GATCGATGGG CAGTACCTCT GCTGCTCTCA GACAGCCAAA 480
AATGCCATGG GCTGTCAAAT CCTGGAGAAT CGCAATGGAA GCTTAAAACC GGGAAGCTCT 540
CACCGGAAGA CCAAAAAGCC TCTTCCTCCA ACCCCCGAGG AGGACCAGAT TCAAAACAAA 600
CCACTGCCCC CTGAGCCAAG AGGAGAGGCC AGCCCCCCAA ATGAGCTCAA GAGGGTCGTT 660
GCCCTTTATG ACTATACGCC AATGAACGCA AATGACCTGC AGTTACAGAA GGGTGAAGAG 720
TATCTTATCC TGGAGGAGAG CACCTTGCCC TGGTGGAGAG CTCGGGACAA AAATGGCCGG 780
GAAGGTTACA TCCCTAACAA CTATGTCACC GAGGCAGAAG ACTCCATCGA GATGTATGAG 840
TGGTATTCCA AACATATGAC TCGGAGTCAA GCAGAACAAC TGCTAAAGCA AGAGGGTAAA 900
GAAGGGGGTT TCATTGTCCG AGATTCCAGC AAAGCAGGAA AATATACTGT GTCTGTTTTT 960
ACCAAATCAG CTGGGGACCC TCAAGGGGTG ATCCGCCATT ATGTCGTGTG CTCCACCCCT 1020
CAGAGCCAAT ACTATCTGGC CGAGAGGCAC CTCTTCAACA CTATTCCCGA ACTCATCCAT 1080
TACCATCAGC ACAACTCTGC TGGACTCATC TCGAGACTCA AGTATCCAGT TTCTCAACAA 1140
AACAAGAATG CTCCCTCCAC GGCGGGGCTG GGCTATGGGT CATGGGAGAT TGATCCAAGG 1200
GACCTGACAT TCTTGAAGGA GCTGGGGACT GGACAGTTTG GGGTGGTGAA GTATGGGAAA 1260
TGGAGAGGCC AATATGACGT GGCCATCAAG ATGATCAGAG AAGGCTCCAT GTCAGAGGAT 1320
GAGTTCATTG AGGAGGCCAA AGTCATGATG AACCTGTCAC ATGAGAAACT GGTCCAGTTA 1380
TATGGGGTCT GCACCAAGCA GCGTCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440
TGCCTCCTGA ACTACCTGAG GGAAATGAGG CCCCGCGTCC AGACCCAACA GTTGCTGGAG 1500
ATGTGCAGGG ACGTCTGTGA GGCTATGGAC TACCTGGAAT CTAAGCAGTT CCTTCACCGA 1560
GATCTAGCCG CTCGAAACTG TTTGGTCAAC GATCAAGGGA TTGTCAAAGT ATCTGACTTC 1620
GGTCTCTCCA GATATGTCTT GGATGATGAA TATACCAGCT CGGCGGGATC CAAATTTCCA 1680
GTTCGGTGGT CTCCACCCGA AGTCCTCATG TATAGCAAGT TCAGTAGCAA ATCTGACATC 1740
TGGGCTTTTG GGGTTTTGAT GTGGGAGATT TACTCTCTGG GAAAGATGCC GTATGAGAGA 1800
TTTAGTAACA GTGAAACAGC AGAACACATT GCCAAAGGCC TCCGGCTCTA CCGGCCTCAG 1860
CTAGCCTCAG AACGAGTGTA TGCCATCATG TACAGCTGCT GGCATGAGAA GGCAGATGAA 1920
CGCCCCACTT TCAGATTTCT TCTGAGCAAC ATTCTGGATG TTATGGATGA AGAATCCTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre++ ++++++llemc+dvce+m+yle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRPRVQTQQLLEMCRDVCEAMDYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ +vkvsdfgl+ryvldd+y+ss+g+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSAGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye++snse++e++++glrlyrp+las++vy +m+scw+ek++er
Q: 582   AFGVLMWEIYSLGKMPYERFSNSETAEHIAKGLRLYRPQLASERVYAIMYSCWHEKADER  641
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ lls++ 
Q: 642   PTFRFLLSNIL  652
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IREGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRP RVQTQQLLEM CRDVCEAMDY LESKQFLHRD 120
LAARNCLVND QGIVKVSDFG LSRYVLDDEY TSSAGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF SNSETAEHIA KGLRLYRPQL ASERVYAIMY SCWHEKADER 240
PTFRFLLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013