EKS-SAH-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	381.7	1.8E-114	12	265	254

Status

Unreviewed

Ensembl Protein

ENSSHAP00000015937

UniProt Accession

G3WKI2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013575	ENSSHAP00000015937	ENSSHAT00000016068
ENSSHAG00000013575	ENSSHAP00000015936	ENSSHAT00000016067
ENSSHAG00000013575	ENSSHAP00000015935	ENSSHAT00000016066

Organism

Sarcophilus harrisii

Functional Description

Protein Length

971

Protein Sequence
(FASTA)

MAAYIGEKIE DFRVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMHK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE ICHNGEMNRY LKNKMKPFSE SEARQFMHQI 120

TTGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPNEKHYT LCGTPNYISP 180

EVATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSLEAKD 240

LIHQLLRRNP AERLSLSSVL DHPFMCRSSS VRIKDLGTVE DSIDSGHATI STALTGSSSA 300

SISGCLPDKK RLLFGQPLPN KMTIFPKTKN VSNFSSGDGS SFYPQWGVQG QETNHSGRGR 360

LLQDAEERPH SRYLRRAHSS DRSGISSGHS QAKPPAVERC HSADILSKPN RRGWPENERF 420

SPTDSNANMF QVFKENTSNI TGSFERPDKD QAQSSLLHPG KSTFPLSEQT SHSETVQQWF 480

GNLQANAQLK EPTAHINITS GRNVQDHPDL QDTRRNAWTD KMTNRDTDAS DSACCVKQPN 540

AMKCIPAYRH EPETIQPATV FGSHPLSDPS RSRGREPQIG HQKCTLRSMT SPLNAHRLKP 600

IRQKTKKAVV SILDTEEVCV ELLKEFASQE YVKEVLQVSS DGNSITIYYP NDGKGFPLDN 660

RPFPPPKDMI RYNFDSLPEK YWRKYQYASR FVQLVRSKTP KITFFSKYAK CILMENSPHA 720

DFEVWFYDGA KIHKTEDLIN VIEKSGKSYT LKGEAEIESL KEEIKIYVDH ANEGHRLCLA 780

LESVISVEET KSGSVPFFPI IIGRKPGNPS SPQPMTPPSC VDSNSSVKDS ALLNRMMVSS 840

SASSNQAPNI SPSVRFINIE FKIFTYLPLY QMFKSSGIKD YLPKSAQLLK SVFVKNVGWA 900

TQLTSGAVWV QFNDGSQLVV QAGVHSISYT SPNGQTTRYG ENEKLPEFIK EKLQCLSSIL 960

LMFANPASGS H 971

Nucleotide Sequence
(FASTA)

ATGGCGGCTT ACATCGGAGA GAAGATAGAG GATTTCAGAG TTGGAAACCT CCTTGGAAAG 60

GGGTCTTTTG CTGGTGTCTA CAGAGCGGAG TCCATTCACA CAGGTCTAGA AGTGGCGATC 120

AAAATGATTG ATAAAAAGGC TATGCACAAA GCTGGAATGG TCCAGAGAGT CCAGAATGAA 180

GTGAAGATAC ATTGTCAACT GAAACATCCT TCTATTCTGG AGCTTTATAA CTATTTTGAA 240

GATAGCAATT ACGTGTATCT GGTATTAGAA ATATGTCACA ATGGAGAAAT GAATAGATAT 300

CTGAAAAATA AAATGAAACC TTTCTCCGAA AGCGAAGCTC GACAATTCAT GCACCAGATC 360

ACCACAGGAA TGTTGTATCT TCATTCTCAT GGTATATTAC ATCGGGACCT CACACTTTCC 420

AATCTCTTAC TGACACGTAA TATGAATATC AAGATTGCTG ATTTTGGTCT AGCAACTCAA 480

TTGAAAATGC CTAATGAAAA ACACTATACA TTATGTGGAA CTCCTAATTA TATTTCACCA 540

GAAGTTGCCA CAAGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCCT AGGGTGTATG 600

TTCTATACAT TACTTATTGG TAGACCACCT TTTGACACCG ACACAGTCAA AAACACATTA 660

AATAAAGTGG TATTGGCAGA TTATGAAATG CCAACCTTTT TGTCACTAGA GGCCAAGGAC 720

CTTATTCATC AGTTACTTCG TAGAAATCCA GCAGAGCGTT TAAGTCTGTC ATCAGTGTTG 780

GATCATCCTT TTATGTGTCG AAGTTCTTCA GTGAGAATTA AAGATTTGGG AACTGTGGAA 840

GATTCCATAG ATAGTGGACA TGCTACCATT TCTACAGCAC TTACCGGTTC TTCCAGTGCC 900

AGTATAAGTG GTTGTTTGCC AGACAAGAAA AGACTGTTGT TTGGACAGCC ACTTCCAAAT 960

AAAATGACTA TATTTCCAAA GACTAAGAAT GTGAGTAATT TTTCATCTGG TGATGGAAGT 1020

AGTTTTTATC CTCAATGGGG AGTTCAGGGA CAAGAGACCA ATCATAGTGG CCGAGGAAGA 1080

CTGCTACAAG ATGCTGAAGA AAGGCCACAT TCTCGATACC TACGCAGAGC CCATTCTTCT 1140

GATCGATCGG GTATTTCTAG TGGTCATTCT CAAGCCAAAC CACCTGCTGT GGAACGCTGT 1200

CACTCAGCAG ATATCCTCTC AAAGCCCAAC AGAAGAGGGT GGCCTGAAAA TGAGAGGTTT 1260

TCACCTACAG ACAGCAATGC CAATATGTTT CAAGTATTTA AAGAAAATAC TTCAAATATT 1320

ACTGGTTCTT TTGAAAGACC TGATAAAGAT CAAGCACAGT CTAGTCTTCT CCATCCAGGA 1380

AAATCTACTT TTCCACTTTC AGAGCAGACA TCTCATTCTG AAACAGTTCA GCAATGGTTT 1440

GGAAACTTGC AAGCAAATGC CCAATTAAAA GAGCCCACTG CTCACATCAA CATTACCTCA 1500

GGCAGAAATG TCCAGGATCA TCCAGATTTG CAGGACACAA GGAGAAATGC ATGGACTGAC 1560

AAGATGACTA ACAGGGACAC AGATGCTTCT GACAGTGCCT GTTGTGTCAA ACAGCCAAAT 1620

GCCATGAAAT GTATTCCTGC ATATCGCCAT GAACCTGAAA CCATCCAGCC TGCAACTGTA 1680

TTTGGCTCAC ATCCCCTTTC TGACCCAAGC AGGTCAAGGG GCAGGGAGCC CCAGATAGGC 1740

CACCAGAAGT GTACGTTGAG AAGCATGACC TCTCCTTTGA ATGCCCATCG GCTAAAGCCC 1800

ATCCGGCAAA AAACAAAAAA AGCAGTGGTG AGTATACTTG ATACAGAAGA AGTATGTGTG 1860

GAGCTGCTAA AGGAATTTGC CTCCCAAGAG TATGTGAAAG AAGTTCTTCA AGTTTCCAGT 1920

GATGGAAATT CGATCACAAT TTATTATCCA AATGATGGAA AAGGTTTCCC CCTTGATAAT 1980

AGACCATTCC CTCCTCCCAA AGACATGATT AGGTATAACT TTGATTCTTT ACCAGAAAAA 2040

TACTGGAGAA AGTATCAGTA TGCTTCCAGA TTTGTACAAC TCGTAAGATC TAAAACACCT 2100

AAAATCACTT TTTTTTCAAA ATATGCTAAA TGCATTTTGA TGGAGAATTC CCCTCATGCT 2160

GATTTTGAAG TTTGGTTTTA TGATGGAGCA AAAATACACA AAACAGAAGA CTTAATTAAT 2220

GTGATTGAAA AATCTGGGAA ATCATATACT TTAAAAGGAG AAGCTGAAAT TGAGAGCTTG 2280

AAAGAAGAAA TAAAAATATA TGTAGATCAT GCTAATGAGG GACATCGACT TTGCCTTGCA 2340

CTGGAGTCTG TTATTTCAGT AGAAGAAACA AAAAGTGGAA GTGTTCCCTT CTTTCCTATA 2400

ATTATTGGAA GAAAGCCAGG CAATCCTAGT TCCCCACAGC CTATGACCCC TCCAAGTTGC 2460

GTGGATTCAA ATTCTTCAGT GAAAGATTCA GCATTATTAA ATAGGATGAT GGTGAGCAGC 2520

TCGGCATCTT CAAACCAGGC ACCTAATATT AGTCCTTCAG TAAGATTTAT TAACATCGAA 2580

TTTAAAATAT TCACTTATTT GCCCCTATAC CAAATGTTTA AGTCTTCTGG AATAAAAGAT 2640

TATCTTCCAA AATCAGCCCA ACTGCTGAAG TCTGTTTTTG TGAAAAATGT TGGTTGGGCT 2700

ACACAGTTAA CCAGTGGCGC TGTGTGGGTT CAATTTAATG ATGGATCCCA GTTGGTGGTC 2760

CAGGCTGGAG TGCACTCCAT CAGTTACACA TCACCAAATG GCCAGACAAC TAGGTATGGG 2820

GAAAATGAAA AATTACCAGA ATTCATCAAA GAGAAATTAC AGTGTCTGTC TTCCATCCTG 2880

TTGATGTTTG CTAATCCAGC TTCTGGTTCC CACTGA 2916

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMHKAGMVQRVQNEVKIHCQLKHPS  71

         6789********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk++ k+++e+e+r +++qi +g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEICHNGEMNRYLKNKmKPFSESEARQFMHQITTGMLYLHSHG  131

         *******************************999**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pev+++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPNEKHYTLCGTPNYISPEVATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSLEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         er+sl++vl+++f+

Q: 252   ERLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FRVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMHKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEI CHNGEMNRYL KNKMKPFSES EARQFMHQIT TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPNEKHYTL CGTPNYISPE VATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSLEAKDL IHQLLRRNPA 240

ERLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013