EKS-SAH-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	352.1	2.5E-105	184	595	412

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016104

UniProt Accession

G3WKZ9;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013711	ENSSHAP00000016104	ENSSHAT00000016237

Organism

Sarcophilus harrisii

Functional Description

Protein Length

634

Protein Sequence
(FASTA)

PGRGRAVVPL RLGFREMLGD DSGSQEYEAK GAEASALPPP PAIDFPQEGS DIRYDESDVP 60

AELQAVRGPL PHSTFPSAVA NQLLLVSLLE HLSHVHEPDP HRSRQVFTLL CQTFTKMGLL 120

SSFACSEEFS SLRLHHNKAI TELMRIAKQR VFEKSCKKKK KKKKIFRAKE VVFEAQTSRY 180

LNEFEEIAVL GKGGYGKVYK VKNKLDRQFY AIKKILIKKA TKKDCMKVLR EVKVLAGLQH 240

PNIVGYHTAW IEHVHSAQPQ DKRLPIVKFP SLQLVSDETE DRDQCHIQSD ESSSSSIIFA 300

DLDSEKEKPF AETCIDNKNN KLVSYTDLIT RDTNEYESQE NCLVNTSTRS LVNHRMLQEN 360

NSYLEENFTS TEESSEENLA LLGQGEVRYH LMLHIQMQLC EISLWDWIND RNKNKGSSVD 420

EPSCPYVMSS VATKIFQELL EGVYYIHNMG VVHRDLKPRN IFLQGPDHHV RIGDFGLACT 480

DIIQKDTEWT NGNGKRLTHT SRVGTSLYAS PEQLQGSEYD AKSDMYSLGV ILLELFQPFG 540

TEMERAEVLT GLRNGQIPES LHQRCPIQAK YIKQLTRSNS SQRPSAGQLL ESELFQNPGN 600

MNYVLQKKVI EQEKEIEKLK ETIRLLSLEK GIKE 634

Nucleotide Sequence
(FASTA)

CCCGGAAGGG GGCGCGCGGT GGTGCCGCTT CGTCTCGGGT TTCGGGAGAT GCTCGGGGAC 60

GACTCCGGAT CCCAGGAATA TGAAGCGAAG GGTGCCGAAG CTTCCGCGTT GCCACCGCCG 120

CCTGCCATAG ACTTCCCCCA GGAAGGGTCG GATATTCGAT ACGACGAATC GGATGTTCCT 180

GCAGAACTCC AGGCTGTGAG AGGACCTCTT CCACACTCGA CTTTTCCTTC TGCAGTTGCA 240

AACCAATTAT TGCTTGTTTC TTTGTTAGAG CACTTAAGCC ATGTGCATGA ACCAGACCCC 300

CATCGTTCAA GACAAGTGTT CACATTACTT TGTCAGACTT TTACCAAAAT GGGGCTGTTA 360

TCTTCCTTTG CCTGCAGTGA AGAATTTAGT TCTTTGAGAC TGCATCACAA CAAAGCTATT 420

ACTGAATTAA TGAGAATAGC TAAGCAGAGA GTTTTTGAGA AAAGTTGTAA AAAAAAAAAA 480

AAAAAAAAAA AAATTTTTAG AGCAAAAGAA GTGGTCTTTG AAGCACAAAC TTCTCGTTAT 540

CTAAATGAGT TTGAGGAAAT TGCTGTCTTA GGAAAGGGCG GGTATGGAAA AGTATACAAG 600

GTCAAGAATA AATTAGATAG ACAATTTTAT GCAATTAAAA AAATTCTTAT TAAGAAAGCC 660

ACTAAAAAGG ATTGTATGAA GGTACTTCGG GAGGTCAAGG TCCTCGCAGG TTTGCAACAT 720

CCTAACATTG TAGGCTATCA CACAGCTTGG ATAGAACATG TTCATTCAGC TCAGCCACAA 780

GATAAGAGAC TTCCTATTGT CAAGTTTCCA TCTCTCCAGT TGGTATCTGA TGAAACAGAG 840

GACAGAGATC AATGTCATAT TCAGAGTGAT GAAAGTAGTA GCTCGTCCAT TATTTTTGCT 900

GATTTAGACT CAGAAAAAGA AAAACCTTTT GCAGAAACTT GCATTGACAA TAAGAATAAC 960

AAGTTAGTAA GCTATACTGA TTTGATCACA AGAGATACTA ATGAATATGA GTCACAAGAA 1020

AATTGCTTAG TTAATACATC TACTAGATCA CTTGTTAACC ATCGTATGTT GCAAGAGAAT 1080

AATTCGTACC TAGAGGAGAA TTTTACATCC ACTGAAGAAT CTTCTGAAGA AAATTTGGCC 1140

TTGCTTGGAC AAGGTGAGGT GAGGTATCAT CTTATGCTCC ATATTCAGAT GCAGCTATGT 1200

GAAATCTCTC TTTGGGACTG GATTAATGAT CGAAATAAAA ATAAGGGATC ATCTGTAGAT 1260

GAACCTTCCT GTCCTTATGT TATGAGCAGT GTTGCAACAA AAATTTTTCA AGAGCTCTTG 1320

GAAGGTGTAT ATTACATACA TAACATGGGA GTGGTACACA GAGATCTCAA GCCCAGAAAT 1380

ATCTTTCTTC AAGGCCCTGA TCATCATGTA AGAATAGGAG ATTTTGGTCT AGCTTGTACA 1440

GATATCATTC AGAAAGACAC AGAATGGACC AATGGAAATG GGAAAAGATT AACACATACT 1500

TCACGAGTGG GTACAAGTCT GTATGCTTCA CCAGAACAGC TGCAAGGATC TGAATATGAT 1560

GCCAAGTCAG ACATGTATAG TTTGGGTGTG ATTCTTCTAG AACTCTTTCA GCCATTTGGA 1620

ACAGAAATGG AAAGAGCAGA AGTTTTAACA GGCTTAAGAA ATGGTCAGAT CCCAGAATCG 1680

CTGCACCAAA GATGTCCAAT ACAAGCCAAG TACATAAAGC AGTTAACGAG GAGTAATTCT 1740

TCACAGCGAC CATCTGCTGG ACAGCTACTG GAAAGTGAAC TTTTTCAAAA TCCTGGAAAT 1800

ATGAATTATG TCCTACAAAA GAAAGTAATT GAACAAGAAA AAGAAATTGA AAAGCTCAAA 1860

GAAACTATAA GACTCCTTTC TCTGGAAAAA GGTATAAAGG AA 1902

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         feei+vlGkGg+g+V+k+knkld++ yaik+i ++ka+k+ ++kv+revk+La l+hpni

Q: 184   FEEIAVLGKGGYGKVYKVKNKLDRQFYAIKKILIKKATKKdCMKVLREVKVLAGLQHPNI  243

         89**********************************************************

S: 60    vrYfaawleekeesl..................................tdsseveaeae  85

         v Y++aw+e+ ++ +                                  ++ss ++a+ +

Q: 244   VGYHTAWIEHVHSAQpqdkrlpivkfpslqlvsdetedrdqchiqsdesSSSSIIFADLD  303

         ************999************987666666666666666666322445555555

S: 86    leesesseesdtk...............................................  98

         +e+++ + e+  +

Q: 304   SEKEKPFAETCIDnknnklvsytdlitrdtneyesqenclvntstrslvnhrmlqennsy  363

         555555444444488999999999999999999999999999999999999999999999

S: 99    ............................llyiqmelceketLkdwiderk......lles  124

                                     +l+iqm+lce  +L+dwi++r+      ++e

Q: 364   leenftsteesseenlallgqgevryhlMLHIQMQLCE-ISLWDWINDRNknkgssVDEP  422

         999999999*****************************.*********998999988899

S: 125   rselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLatala  178

         ++ +vm     ++f++lleg+ y+H++g++HrdLkp+niFl+  d++v+igDFgLa++++

Q: 423   SCPYVMssvatKIFQELLEGVYYIHNMGVVHRDLKPRNIFLQgPDHHVRIGDFGLACTDI  482

         99999999999*******************************9999**************

S: 179   ealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfst  238

          ++ +++++ + ++  +ht++vgt+ly+sPeql++s+Y++k+D++sLG+il+eL++pf t

Q: 483   IQKDTEWTNGNGKRL-THTSRVGTSLYASPEQLQGSEYDAKSDMYSLGVILLELFQPFGT  541

         *********999999.********************************************

S: 239   emervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         emer+e+lt lr+g+ipe++++++p ++k++++l++ ++++Rpsa +ll+sel+

Q: 542   EMERAEVLTGLRNGQIPESLHQRCPIQAKYIKQLTRSNSSQRPSAGQLLESELF  595

         ***************************************************986

Domain Sequence
(FASTA)

FEEIAVLGKG GYGKVYKVKN KLDRQFYAIK KILIKKATKK DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHSAQPQDKR LPIVKFPSLQ LVSDETEDRD QCHIQSDESS SSSIIFADLD 120

SEKEKPFAET CIDNKNNKLV SYTDLITRDT NEYESQENCL VNTSTRSLVN HRMLQENNSY 180

LEENFTSTEE SSEENLALLG QGEVRYHLML HIQMQLCEIS LWDWINDRNK NKGSSVDEPS 240

CPYVMSSVAT KIFQELLEGV YYIHNMGVVH RDLKPRNIFL QGPDHHVRIG DFGLACTDII 300

QKDTEWTNGN GKRLTHTSRV GTSLYASPEQ LQGSEYDAKS DMYSLGVILL ELFQPFGTEM 360

ERAEVLTGLR NGQIPESLHQ RCPIQAKYIK QLTRSNSSQR PSAGQLLESE LF 412

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013