EKS-SAH-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	536.8	8.9E-162	698	965	268

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016224

UniProt Accession

G3WLB9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000013808	ENSSHAP00000016224	ENSSHAT00000016358

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1061

Protein Sequence
(FASTA)

MQECPSGFIR NGSQSMYCSP CEGPCPKVCE GEKKTKTIDS VTSAQMLQGC TVFKGNLLIN 60

IRRGNNIASE LENFMGLIET VTGYVKIRHS HALVSLSFLK NLRYILGEEQ LEGNYSFYVL 120

DNQNLQQLWD WNLHNLTIKE GKMYFAFNPK LCVSEIYRME EVSGTKGRQS KGDINTRNNG 180

ERASCESDVL HFISNTTMKN RIKLTWQRYR PPDYRDLISF TVYFKEAPFK NVTEYDGQDA 240

CGSNSWNMVD VDLPPNKDVK PGILLQGLKP WTQYAIYVKA VTLTMVENDH IRGAKSQIVY 300

IRTKAAVPSI PLDVISASNS SSQLIVKWNP PSLPNGNLSY YIVRWQRQPQ DSYLYRHNYC 360

SKDKVPIRKY ADGTIDVEEV TENPKTEVCG GEKGPCCACP KTEAEKQAEK EEAEYRKVFE 420

NFLHNSIFVP RPERRRRDVF QIANSTLPSR NRNTTMADHF TNVSDTEEIE SEYPFFESRV 480

DNKERTLISH LRPFTLYRID IHSCNHEADT LGCSASNFVF ARTMPAEGAD NIPGPVQWEP 540

RPDNTVYLKW AEPENPNGLI LMYEIKYGQQ VEDQRECVSR QEYRKFGGAR LTRLNPGNYS 600

ARVQATSLSG NGSWTDPVFF YVPAKPPDYE NFLHLMIALP IAGLFILGGI LIMWYVYNKK 660

RNSDRLGNGV LYASVNPEYF SAADVYVPDE WEVPREKITM SRELGQGSFG MVYEGVAKGV 720

VKDEPETRVA IKTVNEAASM RERIEFLNEA SVMKEFNCHH VVRLLGVVSQ GQPTLVIMEL 780

MTRGDLKSYL RSLRPETENN PCQMLPTLKK MIQMAGEIAD GMAYLNANKF VHRDLAARNC 840

MVAEDFTVKI GDFGMTRDIY ETDYYRKGGK GLLPVRWMSP ESLKDGVFTT HSDVWSFGVV 900

LWEIATLAEQ PYQGMSNEQV LRFVMEGGLL EKPDNCPDML FELMRMCWQY NPKMRPSFLE 960

IIGSIKDELD PGFKEVSFFY SEENKPPDTE ELDLETENME SIPLDPSSTL QPADKLSGHK 1020

AENGPGVVVL RASFDERQPY AHMNGGRKNE RALPLPQSSA C 1061

Nucleotide Sequence
(FASTA)

ATGCAGGAGT GTCCCTCTGG GTTCATACGG AATGGGAGCC AAAGTATGTA CTGCAGTCCC 60

TGTGAAGGTC CTTGCCCTAA AGTCTGTGAA GGAGAGAAGA AGACAAAGAC AATTGATTCT 120

GTAACTTCAG CACAAATGCT GCAGGGATGC ACTGTCTTCA AAGGCAATTT GCTTATTAAT 180

ATCCGGCGAG GCAATAACAT AGCCTCTGAG CTGGAAAACT TCATGGGCCT TATTGAGACT 240

GTTACGGGAT ATGTGAAGAT TCGCCATTCA CATGCCTTAG TCTCTCTGTC TTTCTTGAAA 300

AACCTGAGAT ATATTTTAGG AGAAGAACAG CTAGAAGGGA ATTATTCTTT CTACGTCCTT 360

GATAACCAGA ATTTACAGCA GCTCTGGGAC TGGAATCTCC ATAATCTGAC AATCAAAGAA 420

GGGAAAATGT ATTTTGCTTT TAATCCCAAA TTGTGTGTTT CTGAAATTTA TCGAATGGAG 480

GAAGTGTCAG GAACTAAAGG TCGCCAGAGC AAAGGAGACA TAAACACTAG GAACAATGGA 540

GAAAGAGCCT CTTGTGAAAG TGATGTTTTG CATTTCATTT CCAACACTAC AATGAAGAAC 600

CGGATTAAAC TAACATGGCA ACGATATCGT CCTCCTGATT ATAGAGACCT TATTAGCTTT 660

ACTGTTTACT TCAAAGAGGC ACCATTCAAG AATGTCACTG AGTATGACGG GCAAGATGCA 720

TGTGGCTCTA ACAGTTGGAA CATGGTTGAT GTGGACCTTC CTCCAAATAA GGATGTCAAA 780

CCTGGAATTT TACTGCAAGG ACTGAAACCT TGGACTCAGT ATGCCATCTA CGTCAAAGCA 840

GTTACTCTCA CAATGGTGGA GAATGACCAC ATTCGGGGAG CTAAAAGTCA AATTGTGTAT 900

ATTCGTACCA AAGCTGCAGT TCCTTCTATT CCCTTGGATG TTATTTCAGC ATCTAACTCA 960

TCCTCCCAGT TAATTGTGAA GTGGAATCCT CCTTCCCTCC CAAATGGTAA CTTATCTTAC 1020

TACATAGTAA GATGGCAGAG GCAACCTCAA GATAGTTACC TCTACCGACA CAATTACTGC 1080

TCCAAAGACA AAGTTCCAAT TAGAAAGTAT GCCGATGGCA CCATTGATGT TGAAGAGGTT 1140

ACTGAAAACC CCAAAACTGA AGTCTGTGGT GGGGAGAAAG GACCTTGCTG TGCTTGTCCT 1200

AAGACTGAGG CTGAGAAACA AGCAGAGAAA GAAGAAGCTG AATACAGAAA AGTTTTTGAG 1260

AATTTTCTGC ACAACTCCAT CTTTGTACCC AGACCTGAAA GGAGGCGTAG AGATGTCTTT 1320

CAAATTGCGA ATTCTACATT GCCCAGTCGG AACAGGAACA CTACAATGGC GGATCACTTC 1380

ACCAATGTGT CAGACACAGA AGAAATTGAA TCTGAATACC CGTTCTTTGA GAGTAGAGTG 1440

GATAATAAAG AAAGGACTTT AATTTCTCAT CTTAGGCCTT TTACTTTGTA TCGAATTGAT 1500

ATTCATAGCT GCAACCATGA AGCTGATACT CTTGGCTGTA GTGCTTCGAA CTTTGTCTTT 1560

GCCAGGACCA TGCCAGCAGA AGGAGCAGAT AATATTCCTG GGCCAGTGCA GTGGGAGCCA 1620

AGACCAGATA ATACTGTCTA CTTGAAGTGG GCAGAACCTG AAAATCCCAA TGGATTGATA 1680

TTAATGTATG AAATAAAGTA TGGTCAACAA GTAGAGGATC AGCGGGAATG TGTTTCCAGA 1740

CAGGAATACA GGAAATTTGG AGGGGCCAGG CTTACACGGC TGAACCCTGG GAACTATTCA 1800

GCCCGTGTTC AGGCCACCTC TCTTTCTGGG AATGGATCAT GGACTGACCC TGTATTCTTT 1860

TATGTCCCAG CCAAACCACC AGATTATGAA AACTTCCTTC ACTTAATGAT CGCTCTACCC 1920

ATCGCAGGAT TATTTATACT TGGTGGAATA CTGATAATGT GGTATGTCTA CAATAAAAAA 1980

AGAAACAGTG ACAGATTAGG GAATGGAGTT CTATATGCAT CTGTCAATCC AGAGTACTTC 2040

AGTGCTGCAG ATGTGTATGT TCCAGATGAG TGGGAGGTAC CTCGAGAGAA GATCACCATG 2100

AGTCGAGAAC TTGGGCAGGG TTCATTTGGG ATGGTATATG AGGGAGTTGC AAAGGGTGTG 2160

GTGAAAGATG AACCTGAAAC CAGAGTGGCC ATCAAAACAG TCAATGAAGC AGCAAGCATG 2220

CGAGAAAGAA TTGAATTTCT CAATGAAGCT TCAGTAATGA AAGAATTCAA TTGTCATCAC 2280

GTGGTGCGGT TGCTTGGAGT AGTGTCCCAG GGCCAACCAA CTTTAGTCAT CATGGAATTG 2340

ATGACACGAG GGGATCTCAA AAGTTACCTC AGATCTCTGA GGCCAGAAAC AGAGAATAAT 2400

CCATGCCAGA TGCTTCCAAC TTTAAAGAAG ATGATTCAGA TGGCTGGAGA GATTGCTGAT 2460

GGTATGGCAT ATCTCAATGC CAACAAGTTT GTCCACAGGG ATCTCGCTGC AAGGAATTGC 2520

ATGGTTGCCG AAGATTTCAC CGTCAAAATT GGAGATTTTG GTATGACAAG AGATATCTAT 2580

GAGACAGATT ACTACCGAAA AGGAGGTAAA GGATTATTAC CTGTTCGTTG GATGTCTCCA 2640

GAGTCACTTA AGGATGGAGT CTTCACAACA CATTCTGATG TTTGGTCCTT TGGTGTTGTC 2700

CTCTGGGAGA TTGCAACATT AGCAGAGCAG CCCTATCAGG GCATGTCTAA TGAACAAGTT 2760

CTCCGGTTTG TTATGGAGGG TGGCCTTCTA GAGAAACCAG ACAACTGCCC CGATATGCTG 2820

TTTGAATTGA TGCGTATGTG CTGGCAGTAC AATCCCAAAA TGAGACCTTC TTTTCTGGAG 2880

ATCATCGGCA GCATCAAAGA TGAACTGGAC CCCGGCTTCA AGGAGGTCTC CTTCTTCTAC 2940

AGTGAAGAAA ATAAGCCCCC AGACACAGAA GAGCTGGACT TAGAGACTGA GAACATGGAG 3000

AGTATCCCCT TAGACCCTTC CTCCACCCTC CAGCCGGCTG ACAAACTCTC AGGACACAAA 3060

GCCGAGAACG GGCCTGGTGT GGTGGTCCTC AGGGCCAGCT TTGACGAAAG GCAGCCTTAC 3120

GCGCACATGA ATGGAGGACG CAAGAACGAA AGGGCCTTAC CTTTGCCCCA GTCTTCGGCC 3180

TGCTGA 3186

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 698   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  757

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en++    p+l+k+iqma+e

Q: 758   CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPETENNPCQMLPTLKKMIQMAGE  817

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 818   IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  877

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+lekp+ncp

Q: 878   MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCP  937

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei+ ++

Q: 938   DMLFELMRMCWQYNPKMRPSFLEIIGSI  965

         ************************9875

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPET ENNPCQMLPT LKKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGMSN EQVLRFVMEG GLLEKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIIGSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00060	; FN3; 3.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013