EKS-SAH-00157
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00157
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb442.26.4E-133437697261
StatusUnreviewed
Ensembl ProteinENSSHAP00000016380
UniProt AccessionG3WLS5;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000013938ENSSHAP00000016380ENSSHAT00000016517
OrganismSarcophilus harrisii
Functional Description
Protein Length808
Protein Sequence
(FASTA)
MEEGGGGSSS CSDGGGGVST IAIAAGTSAD AGDQLLTVKH ELRTANLTGH TEKVGIENFE 60
LLKVLGTGAY GKVFLVRKIS GHDAGKLYAM KVLKKATIVQ KAKTAEHTKT ERQVLEHIRL 120
SPFLVTLHYA FQTETKLHLI LDYINGGELF THLSQRERFT ENEVQIYIGE IVLALEHLHK 180
LGIIYRDIKL ENILLDNNGH VVLTDFGLSK EFLADETERA YSFCGTIEYM APDIVRGGDT 240
GHDKAVDWWS LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDII 300
QHLLVKDPKK RLGCGPRDAD EIKEHPFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE 360
EFTEMDPTYS PAALPQSSER LFQGYSFVAP SILFKRNAAV IDPLQFHMEI ERPGVTNVAR 420
SAMMKDSPFY QHYDLDLKDK PLGEGSFSIC RKCLHRKSNQ EYAVKIISKR MEANTQKEIT 480
ALKLCEGHPN IVKLYEVYHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS 540
AVSHMHDVGV VHRDLKPENL LFTDENDNLE IKVIDFGFAR LKPPDNQPLK TPCFTLHYAA 600
PELLNHNGYD ESCDLWSLGV ILYTMLSGQV PFQSHDKSLT CTSAVEIMKK IKKGDFSFEG 660
ESWKNVSQEA KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA 720
VHTCVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS 780
HGKTTPTKTL QPSNPDSNNP ETIFQFSD 808
Nucleotide Sequence
(FASTA)
ATGGAGGAGG GTGGCGGCGG CAGCAGTAGC TGCAGCGACG GCGGTGGCGG TGTCAGCACC 60
ATCGCCATCG CTGCGGGGAC CAGCGCGGAC GCAGGGGACC AGCTCTTAAC TGTCAAACAC 120
GAGCTGCGAA CCGCTAATTT AACAGGACAC ACGGAGAAAG TGGGAATTGA AAATTTTGAA 180
CTTCTGAAGG TTCTAGGAAC AGGAGCCTAT GGAAAAGTAT TCCTGGTTCG TAAAATAAGT 240
GGTCATGATG CTGGAAAGCT GTATGCTATG AAAGTTCTGA AGAAAGCCAC AATTGTTCAG 300
AAAGCCAAGA CAGCAGAGCA CACAAAGACA GAACGGCAGG TGCTGGAGCA CATTAGGTTA 360
TCACCCTTTT TGGTTACATT GCATTACGCT TTCCAGACAG AGACAAAGCT GCATCTCATT 420
CTAGATTACA TAAATGGTGG AGAACTTTTT ACTCATCTTT CTCAAAGAGA ACGTTTCACG 480
GAAAATGAAG TACAGATATA CATTGGGGAA ATTGTGCTCG CCCTTGAACA TCTCCATAAG 540
TTGGGCATTA TATACCGTGA CATTAAACTG GAGAATATTC TACTTGATAA TAATGGCCAT 600
GTAGTACTGA CAGATTTTGG TCTAAGTAAG GAGTTCCTTG CTGATGAAAC TGAAAGAGCA 660
TATTCCTTTT GTGGAACTAT AGAATACATG GCACCTGATA TTGTCAGAGG AGGAGATACA 720
GGACATGATA AGGCAGTGGA CTGGTGGAGT TTAGGCGTTC TTATGTATGA GTTACTTACT 780
GGAGCATCTC CATTTACTGT TGATGGAGAG AAAAATTCCC AAGCTGAAAT ATCTAGGAGA 840
ATATTAAAAA GTGAACCTCC ATATCCCCAA GAAATGAGTG CTTTAGCTAA AGATATAATT 900
CAGCATCTCT TGGTGAAAGA TCCTAAGAAA AGATTGGGTT GTGGTCCACG AGATGCAGAT 960
GAAATCAAAG AGCATCCATT CTTTCAGAAA ATAAATTGGG ATGATTTAGC TGCCAAAAAA 1020
GTGCCAGCAC CATTTAAACC AGTAATCCGG GATGAGTTAG ATGTCAGTAA TTTTGCAGAG 1080
GAATTTACAG AAATGGATCC CACATATTCT CCTGCAGCTC TGCCTCAGAG TTCAGAGAGG 1140
CTATTTCAGG GATATTCTTT TGTTGCTCCT TCTATCTTAT TTAAACGCAA TGCAGCTGTC 1200
ATAGATCCTC TTCAGTTTCA CATGGAAATT GAACGTCCAG GAGTGACAAA TGTTGCTAGG 1260
AGTGCAATGA TGAAGGACTC TCCTTTTTAT CAGCACTATG ACCTAGATCT TAAAGACAAG 1320
CCATTGGGAG AAGGAAGTTT TTCAATTTGT CGAAAATGCT TGCACAGAAA AAGCAACCAA 1380
GAATATGCAG TCAAAATAAT AAGTAAAAGA ATGGAAGCCA ACACTCAGAA AGAAATAACA 1440
GCTTTGAAAC TCTGTGAAGG ACACCCCAAT ATAGTGAAGT TGTATGAAGT TTATCATGAT 1500
CAGCTTCACA CATTTCTGGT GATGGAACTT CTGAACGGAG GAGAACTCTT TGAACGAATT 1560
AAGAAAAAGA AACATTTCAG TGAAACCGAA GCCAGTTATA TTATGCGGAA GCTTGTTTCA 1620
GCTGTAAGCC ACATGCATGA TGTGGGCGTG GTACATAGAG ATCTGAAGCC TGAGAATTTA 1680
TTGTTCACTG ATGAAAATGA TAATTTGGAA ATTAAGGTAA TTGATTTTGG ATTTGCACGT 1740
TTAAAGCCAC CTGATAATCA GCCTCTTAAG ACGCCATGCT TTACCCTTCA TTATGCTGCT 1800
CCAGAACTCT TAAATCATAA TGGCTATGAT GAATCTTGTG ATCTGTGGAG CTTAGGAGTC 1860
ATTTTGTATA CAATGCTATC AGGACAAGTT CCATTCCAGT CTCATGACAA AAGTTTAACA 1920
TGTACCAGTG CAGTAGAAAT CATGAAAAAA ATTAAAAAAG GTGATTTCTC TTTCGAAGGA 1980
GAATCTTGGA AGAATGTATC CCAGGAAGCC AAAGATTTGA TTCAAGGGCT TCTTACAGTG 2040
GATCCCAATA AGAGACTTAA AATGTCTGGC TTGAGGTACA ATGAATGGCT TCAAGATGGC 2100
AGTCAGCTAT CTTCAAATCC TTTGATGACT CCAGATATAC TAGGATCTTC AGGAGCTGCT 2160
GTGCATACCT GTGTAAAAGC AACCTTTCAT GCCTTTAACA AATACAAGAG GGAGGGATTC 2220
TGCCTTCAGA ATGTTGATAA AGCTCCTCTT GCAAAGAGAA GGAAAATGAA GAAAACCAGC 2280
ACAAGTACGG AGACCCGCAG CAGTTCAAGT GAAAGTTCTC ACTCTTCTTC CTCTCATTCT 2340
CATGGTAAAA CAACACCGAC AAAGACACTA CAGCCAAGTA ATCCTGATAG CAATAATCCA 2400
GAAACCATCT TCCAGTTCTC TGACTGA 2427
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c+h+++nqe+avkii+k+ +++t++ei++l+++e+hpniv+l +
Q: 437   LKDKPLGEGSFSICRKCLHRKSNQEYAVKIISKRmEANTQKEITALKLCEGHPNIVKLYE  496
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vy+d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 497   VYHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  556
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 557   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  615
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Ge+w++vs+eakdl++
Q: 616   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGESWKNVSQEAKDLIQ  675
         *****************98888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 676   GLLTVDPNKRLKMSGLRYNEWL  697
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCLHR KSNQEYAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLYE 60
VYHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKKGDF SFEGESWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013