EKS-SAH-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	326.8	8.9E-98	96	346	251

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016717

UniProt Accession

G3WMR2;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014222	ENSSHAP00000016717	ENSSHAT00000016859

Organism

Sarcophilus harrisii

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

LLPQVSGAPA QLSFPGGGGC LPRFLPLPSE PRPLRSLRLP LSMEPFPFPK RSSLASSPST 60

GLALPLADGL IKSPKPLMKK QAVKRHHHKH NLRHHYEFLE TLGKGTYGKV QKARERSGRL 120

VAIKSIRKDK IKDEQDLLHI RREIEIMSSL NHPHIITIHE VFENSNKIVI VMEYASRGDL 180

YDYISERQRL SEQEARHFFR QIVSAVYYCH KNGIVHRDLK LENILLDAND NIKIADFGLS 240

NLYQQDKLLQ TFCGSPLYAS PEIVNGKPYM GPEVDSWSLG VLLYILVHGM MPFDGQDYKS 300

LVKQISNGEY REPIRPSDAC GLIRWLLMVN PTRRATLEDV ASHWWVNWGY ATPVGEQEAL 360

QESGPPGGDA PRATVAEWLR RSSRPLLENG AKVCSFFKQH TTSGTGLERQ HSLKKSRKEN 420

DMAQSLQGGV GAEPSPGPGK GILKLPKGIL KKKAEGQRES LGEPDPEPAV APISPRHTAP 480

ALPKKGILKK PRQRESGYYS SPEPSDSGDL LDAGDVFVNS FPSVREPSRP PQLPLHRKGI 540

LKHNGKFSGA SQELAVFGSL DELAPALSSA RATRPSGAVS EDSILSTESF DQLDLPERLP 600

NPKLPLRGCV SVDDLVGLDE PGPRSSGAGL RRWRQDPLAD SCFSLTDCQE VTETYRQALA 660

VGMKLS 666

Nucleotide Sequence
(FASTA)

CTGCTCCCGC AAGTGTCCGG GGCCCCGGCG CAGCTGAGCT TTCCCGGCGG CGGCGGCTGC 60

TTGCCGCGTT TTCTCCCTCT TCCTTCCGAA CCGCGTCCCC TGCGGAGTCT CCGCCTCCCT 120

CTCTCCATGG AGCCTTTCCC TTTCCCCAAA CGCTCCAGCC TGGCTTCTTC CCCTTCCACG 180

GGGCTCGCCC TGCCCCTGGC AGACGGGCTC ATCAAGTCTC CCAAGCCCCT GATGAAGAAG 240

CAGGCGGTGA AGCGGCACCA CCACAAGCAC AACTTGCGGC ACCACTACGA GTTCCTGGAG 300

ACCTTGGGCA AAGGCACCTA CGGAAAGGTG CAGAAAGCGA GAGAGCGGTC GGGAAGACTG 360

GTGGCCATCA AGTCCATCCG GAAAGATAAA ATCAAAGATG AGCAGGACCT ACTGCACATC 420

CGGAGGGAGA TTGAAATCAT GTCATCTCTT AACCACCCAC ATATCATCAC CATCCATGAA 480

GTGTTTGAAA ACAGCAACAA GATTGTCATT GTCATGGAGT ACGCCAGCCG GGGAGACTTG 540

TACGACTACA TTAGTGAACG GCAGCGTCTC AGTGAGCAAG AAGCCCGGCA TTTCTTCCGA 600

CAGATTGTCT CAGCAGTGTA CTACTGCCAC AAAAATGGGA TTGTCCACCG GGATCTAAAG 660

CTGGAGAATA TCCTCCTGGA TGCTAATGAC AATATCAAGA TCGCAGACTT CGGCCTCTCC 720

AATCTCTACC AGCAGGACAA GCTCCTGCAG ACCTTCTGTG GGAGCCCCCT CTATGCTTCT 780

CCAGAGATTG TCAATGGGAA GCCATACATG GGCCCAGAGG TGGACAGCTG GTCTCTGGGT 840

GTTCTCCTCT ATATCCTGGT TCATGGCATG ATGCCTTTTG ACGGACAGGA TTACAAGAGC 900

CTTGTGAAAC AGATCAGCAA CGGGGAATAC CGAGAGCCCA TCAGACCTTC TGATGCTTGT 960

GGACTGATCC GGTGGCTGCT GATGGTGAAC CCCACCCGCA GGGCCACCCT GGAGGACGTG 1020

GCCAGCCATT GGTGGGTCAA CTGGGGCTAC GCCACGCCAG TCGGGGAGCA GGAGGCCCTT 1080

CAGGAAAGCG GACCTCCAGG GGGGGATGCG CCCCGGGCCA CCGTGGCCGA ATGGCTCCGC 1140

CGTTCCTCTC GGCCCCTCTT GGAGAACGGC GCCAAGGTGT GCAGCTTCTT TAAGCAGCAC 1200

ACAACCAGCG GGACTGGGCT GGAGCGCCAG CACTCGCTCA AGAAATCCCG CAAGGAGAAC 1260

GATATGGCTC AGTCTCTCCA GGGCGGGGTG GGGGCAGAGC CCTCCCCTGG CCCGGGCAAG 1320

GGCATTCTCA AGCTGCCCAA GGGCATCCTC AAGAAGAAGG CAGAGGGACA GAGGGAGAGC 1380

TTGGGGGAGC CTGACCCAGA GCCCGCCGTG GCCCCCATCA GTCCCAGGCA CACTGCCCCG 1440

GCCCTCCCCA AGAAGGGCAT TCTCAAGAAA CCTCGGCAGA GGGAGTCGGG CTATTACTCC 1500

TCCCCCGAGC CGAGTGATTC AGGGGACCTT TTGGATGCGG GCGACGTGTT TGTGAACAGC 1560

TTCCCCAGTG TCAGGGAGCC CTCGAGGCCC CCACAGCTTC CCCTCCACCG AAAGGGCATC 1620

CTCAAGCACA ATGGCAAATT CTCGGGGGCC TCACAAGAGC TCGCTGTCTT TGGGTCTCTG 1680

GACGAGCTGG CCCCGGCCCT CTCCTCCGCT CGGGCCACCC GCCCCTCGGG GGCCGTGAGC 1740

GAGGACAGCA TCCTGTCCAC AGAGTCCTTT GACCAGCTGG ACCTGCCGGA ACGCTTGCCC 1800

AACCCTAAGC TGCCCCTGCG TGGCTGCGTG TCGGTGGACG ACCTGGTGGG CCTGGATGAG 1860

CCAGGGCCTC GGAGCTCTGG TGCAGGGCTC AGGAGGTGGA GGCAGGATCC CCTTGCCGAC 1920

AGCTGCTTCT CCCTGACGGA CTGTCAGGAG GTGACTGAGA CATACCGGCA GGCGCTGGCT 1980

GTTGGCATGA AGCTCAGCTG A 2001

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkV++a+++  ++ va+K i+k+k+ +e+ l +i+rEiei+++l+hp+

Q: 96    YEFLETLGKGTYGKVQKARER-SGRLVAIKSIRKDKIkDEQDLLHIRREIEIMSSLNHPH  154

         99****************987.799**********996667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+++k+++v+eyas+g+L+dyi+e++rl+e+ear++f+q+vsav Y+h++gi

Q: 155   IITIHEVFENSNKIVIVMEYASRGDLYDYISERQRLSEQEARHFFRQIVSAVYYCHKNGI  214

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+nl++++kll+tfcGsp Ya+Pe+++gk+Y gp+v

Q: 215   VHRDLKLENILLDANDNIKIADFGLSNLYQQDKLLQTFCGSPLYASPEIVNGKPYMGPEV  274

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g +Pfd++++k+l+++i++g+++ p   s ++  L+r lL+v+p++

Q: 275   DSWSLGVLLYILVHGMMPFDGQDYKSLVKQISNGEYREPIRPS-DACGLIRWLLMVNPTR  333

         ***************************************9965.5668************

S: 240   Ratieeilkhewl  252

         Rat+e++ +h w+

Q: 334   RATLEDVASHWWV  346

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVQKARE RSGRLVAIKS IRKDKIKDEQ DLLHIRREIE IMSSLNHPHI 60

ITIHEVFENS NKIVIVMEYA SRGDLYDYIS ERQRLSEQEA RHFFRQIVSA VYYCHKNGIV 120

HRDLKLENIL LDANDNIKIA DFGLSNLYQQ DKLLQTFCGS PLYASPEIVN GKPYMGPEVD 180

SWSLGVLLYI LVHGMMPFDG QDYKSLVKQI SNGEYREPIR PSDACGLIRW LLMVNPTRRA 240

TLEDVASHWW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013